{"product_id":"mirror-image-asymmetry-isbn-9780470387597","title":"Mirror-Image Asymmetry","description":"\u003cb\u003eAn overview of the importance and consequences of asymmetry from molecules to the macroscopic world\u003c\/b\u003e  \u003cp\u003eAs scientists have become more capable of probing the structure of three-dimensional objects at the molecular level, the need to understand the concept and the consequences of mirror-image asymmetry—chirality—has increased enormously. Written at an introductory level, \u003ci\u003eMirror-Image Asymmetry\u003c\/i\u003e provides an overview of the importance and effects of asymmetry from the atomic and molecular world of physics and chemistry to the organisms and structures that we see and use in our everyday life. The reader will develop a broad appreciation of three-dimensional asymmetry from the microscopic molecular world to the macroscopic world of handedness, automobile driving, windmills, sports, and similar phenomena. The book features:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eAn introduction to basic definitions and the nomenclature of asymmetric and dissymmetric molecules\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eUp-to-date examples of the importance and consequences of asymmetry in modern drug applications, current theories of the origin of asymmetry in nature, and examples of molecular asymmetry in smell, taste, and insect communication\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eMany illustrations, chemical structures, and photographs that enable the reader to connect the actual asymmetrical structures to the different phenomena that depend on structural asymmetry\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eIn the 150 years since Louis Pasteur discovered asymmetry in molecular structures, scientists have made great progress in understanding how interactions between chiral molecules influence biochemical processes. This knowledge is leading to very sophisticated asymmetric synthetic techniques that have greatly benefitted many research groups especially those in the pharmaceutical industry. This guide to the role of molecular and macroscopic chirality will inspire students and scientists in chemistry, biology, physics, and drug discovery.\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eList of Figures and Biographic Photographs xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The Mirror Image 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eHandedness 2\u003c\/p\u003e \u003cp\u003eThe Symmetry of Nonsuperimposable Mirror Images 5\u003c\/p\u003e \u003cp\u003eNomenclature for Chiral Molecules 11\u003c\/p\u003e \u003cp\u003eNomenclature for Dissymmetric and Other Chiral Molecules 19\u003c\/p\u003e \u003cp\u003eSummary 24\u003c\/p\u003e \u003cp\u003eSuggestions for Further Reading 24\u003c\/p\u003e \u003cp\u003eReferences 25\u003c\/p\u003e \u003cp\u003eList of Biographic Photographs, Sidebars, and Figures 25\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Molecular Chirality in Living Systems 27\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eOptical Rotation 30\u003c\/p\u003e \u003cp\u003eFrom Biot to Pasteur 36\u003c\/p\u003e \u003cp\u003eBiochemical Homochirality 44\u003c\/p\u003e \u003cp\u003eDetermination of Absolute Structures of Chiral Molecules 52\u003c\/p\u003e \u003cp\u003eSummary 54\u003c\/p\u003e \u003cp\u003eSuggestions for Further Reading 55\u003c\/p\u003e \u003cp\u003eReferences 55\u003c\/p\u003e \u003cp\u003eList of Biographic Photographs, Sidebars, and Figures 56\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The Origin of Chirality in Living Systems 59\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMust Life be Chiral? 60\u003c\/p\u003e \u003cp\u003eMirror-image life? 62\u003c\/p\u003e \u003cp\u003eThe Origin of Homochirality in Living Systems 63\u003c\/p\u003e \u003cp\u003eExtraterrestrial Chirality 65\u003c\/p\u003e \u003cp\u003eNuclear Chirality 70\u003c\/p\u003e \u003cp\u003eOther Extraterrestrial Sources 72\u003c\/p\u003e \u003cp\u003eThe Beginning of Life on Earth: Biochemistry 73\u003c\/p\u003e \u003cp\u003eGetting Started in the Right (or Left) Direction 76\u003c\/p\u003e \u003cp\u003eSummary 78\u003c\/p\u003e \u003cp\u003eSuggestions for Further Reading 78\u003c\/p\u003e \u003cp\u003eReferences 79\u003c\/p\u003e \u003cp\u003eList of Sidebars and Figures 80\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Chiral Chemistry, Recognition, and Control in Living Systems 81\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChiral Chemical Evolution 81\u003c\/p\u003e \u003cp\u003eChiral Recognition at the Molecular Level 83\u003c\/p\u003e \u003cp\u003eExamples of Chiral Recognition and Discrimination 87\u003c\/p\u003e \u003cp\u003eSmell 87\u003c\/p\u003e \u003cp\u003eTaste 91\u003c\/p\u003e \u003cp\u003eCommunication 93\u003c\/p\u003e \u003cp\u003eChirality as a Control Mechanism in Biochemistry 104\u003c\/p\u003e \u003cp\u003eSummary 108\u003c\/p\u003e \u003cp\u003eSuggestions for Further Reading 108\u003c\/p\u003e \u003cp\u003eReferences 108\u003c\/p\u003e \u003cp\u003eList of Biographic Photographs, Sidebars, and Figures 110\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Chirality and Drugs 111\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChirality in Natural Remedies and Folk Medicines 112\u003c\/p\u003e \u003cp\u003eEnantiomeric Differences in Natural Products 114\u003c\/p\u003e \u003cp\u003eThalidomide and Regulation of Chiral Drugs 118\u003c\/p\u003e \u003cp\u003eChirality and Drug Activity 121\u003c\/p\u003e \u003cp\u003eIbuprofen 121\u003c\/p\u003e \u003cp\u003eProzac 122\u003c\/p\u003e \u003cp\u003eCialis 123\u003c\/p\u003e \u003cp\u003eNexium 125\u003c\/p\u003e \u003cp\u003eLipitor 128\u003c\/p\u003e \u003cp\u003eChiral Switching 129\u003c\/p\u003e \u003cp\u003eEphedrine, Pseudoephedrine, and Methamphetamine 131\u003c\/p\u003e \u003cp\u003ePreparation of Pure Enantiomers 135\u003c\/p\u003e \u003cp\u003eSummary 143\u003c\/p\u003e \u003cp\u003eSuggestions for Further Reading 143\u003c\/p\u003e \u003cp\u003eReferences 143\u003c\/p\u003e \u003cp\u003eList of Biographic Photographs, Sidebars, and Figures 145\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 The Chirality of Living Systems 147\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePreliminary Cautions 148\u003c\/p\u003e \u003cp\u003eChirality in Nature 153\u003c\/p\u003e \u003cp\u003eClassification of Plant and Animal Chirality (Asymmetry) 159\u003c\/p\u003e \u003cp\u003eSymmetric Life 160\u003c\/p\u003e \u003cp\u003eRacemic Life 160\u003c\/p\u003e \u003cp\u003eAsymmetric Life 162\u003c\/p\u003e \u003cp\u003eHomo sapiens Asymmetry 170\u003c\/p\u003e \u003cp\u003eSummary 171\u003c\/p\u003e \u003cp\u003eSuggestions for Further Reading 171\u003c\/p\u003e \u003cp\u003eReferences 172\u003c\/p\u003e \u003cp\u003eList of Sidebars and Figures 173\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 The Handedness of Homo sapiens 175\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAre You Right-Handed or Left-Handed? 176\u003c\/p\u003e \u003cp\u003eThe Statistics of Handedness 178\u003c\/p\u003e \u003cp\u003eThe Origin of Left-Handedness 183\u003c\/p\u003e \u003cp\u003eThe Human Genetics of Handedness 186\u003c\/p\u003e \u003cp\u003eSummary 192\u003c\/p\u003e \u003cp\u003eSuggestions for Further Reading 193\u003c\/p\u003e \u003cp\u003eReferences 194\u003c\/p\u003e \u003cp\u003eList of Sidebars and Figures 195\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Living in a Right-Hander’s World 197\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eClockwise and Counterclockwise (or Anticlockwise) Rotation 198\u003c\/p\u003e \u003cp\u003eHelical Stairways 201\u003c\/p\u003e \u003cp\u003eAround the House 204\u003c\/p\u003e \u003cp\u003eMaking Music Left-Handed 205\u003c\/p\u003e \u003cp\u003eThe Chirality of Writing 207\u003c\/p\u003e \u003cp\u003eSports and the Left-Hander 210\u003c\/p\u003e \u003cp\u003eAmerican Baseball: The Chiral Sport 216\u003c\/p\u003e \u003cp\u003eDriving on the Left or Right Side 221\u003c\/p\u003e \u003cp\u003eWindmills 224\u003c\/p\u003e \u003cp\u003eSummary 227\u003c\/p\u003e \u003cp\u003eSuggestions for Further Reading 228\u003c\/p\u003e \u003cp\u003eReferences 228\u003c\/p\u003e \u003cp\u003eList of Sidebars and Figures 228\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 The Asymmetric Universe 231\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eList of Figures 234\u003c\/p\u003e \u003cp\u003eAppendix 235\u003c\/p\u003e \u003cp\u003eBiography 239\u003c\/p\u003e \u003cp\u003eIndex 241\u003c\/p\u003e \"Riehl should be commended for presenting an understable introduction to chirality to such a wide audience.\" (Choice, October 2010). \u003cb\u003eJAMES P. RIEHL\u003c\/b\u003e received a BS degree in chemistry from Villanova University in 1970 and a PhD in physical chemistry from Purdue University in 1975. He is currently Dean of the Swenson College of Science and Engineering and Professor of Chemistry at the University of Minnesota Duluth, a position he has held since 2000. Dr. Riehl is a frequent invited speaker nationally and internationally on the topic of molecular chirality, and is the author of numerous research publications in the applications of optical spectroscopy to the study of chiral structures. He was the recipient of the St. Louis Award of the American Chemical Society for his outstanding contributions to the chemistry profession, and currently holds a University of Minnesota McKnight Presidential Leadership Chair.  \u003cb\u003eAn overview of the importance and consequences of asymmetry from molecules to the macroscopic world\u003c\/b\u003e  \u003cp\u003eAs scientists have become more capable of probing the structure of three-dimensional objects at the molecular level, the need to understand the concept and the consequences of mirror-image asymmetry—chirality—has increased enormously. Written at an introductory level, \u003ci\u003eMirror-Image Asymmetry\u003c\/i\u003e provides an overview of the importance and effects of asymmetry from the atomic and molecular world of physics and chemistry to the organisms and structures that we see and use in our everyday life. The reader will develop a broad appreciation of three-dimensional asymmetry from the microscopic molecular world to the macroscopic world of handedness, automobile driving, windmills, sports, and similar phenomena. The book features:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eAn introduction to basic definitions and the nomenclature of asymmetric and dissymmetric molecules\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eUp-to-date examples of the importance and consequences of asymmetry in modern drug applications, current theories of the origin of asymmetry in nature, and examples of molecular asymmetry in smell, taste, and insect communication\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eMany illustrations, chemical structures, and photographs that enable the reader to connect the actual asymmetrical structures to the different phenomena that depend on structural asymmetry\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eIn the 150 years since Louis Pasteur discovered asymmetry in molecular structures, scientists have made great progress in understanding how interactions between chiral molecules influence biochemical processes. This knowledge is leading to very sophisticated asymmetric synthetic techniques that have greatly benefitted many research groups especially those in the pharmaceutical industry. This guide to the role of molecular and macroscopic chirality will inspire students and scientists in chemistry, biology, physics, and drug discovery.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989631811813,"sku":"NP9780470387597","price":69.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470387597.jpg?v=1761784884","url":"https:\/\/k12savings.com\/products\/mirror-image-asymmetry-isbn-9780470387597","provider":"K12savings","version":"1.0","type":"link"}