{"product_id":"micrornas-in-medicine-isbn-9781118300398","title":"MicroRNAs in Medicine","description":"\u003cp\u003e\u003ci\u003eMicroRNAs in Medicine\u003c\/i\u003e provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics.\u003c\/p\u003e \u003cp\u003eIncluding background information on the field as well as reviews of the latest research breakthroughs, \u003ci\u003eMicroRNAs in Medicine\u003c\/i\u003e is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.\u003c\/p\u003e  Foreword ix\u003cbr\u003e \u003ci\u003eSir David Baulcombe\u003c\/i\u003e  \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eContributors xiii\u003c\/p\u003e \u003cp\u003e1 MICRORNAS: A BRIEF INTRODUCTION 1\u003cbr\u003e \u003ci\u003eCharles H. Lawrie\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I: MICRORNAS AS PHYSIOLOGICAL REGULATORS 25\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27\u003cbr\u003e \u003ci\u003eErika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 MICRORNAS AS REGULATORS OF IMMUNITY 41\u003cbr\u003e \u003ci\u003eDonald T. Gracias and Peter D. Katsikis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 REGULATION OF SENESCENCE BY MICRORNAS 59\u003cbr\u003e \u003ci\u003eIoannis Grammatikakis and Myriam Gorospe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS IMPLICATED IN AGING 77\u003cbr\u003e \u003ci\u003eAlejandro P. Ugalde, Agnieszka Kwarciak, Xurde M. Caravia, Carlos López-Otín, and Andrew J. Ramsay\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 MICRORNAS AND HEMATOPOIESIS 91\u003cbr\u003e \u003ci\u003eSukhinder K. Sandhu and Ramiro Garzon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 MICRORNAS IN PLATELET PRODUCTION AND ACTIVATION 101\u003cbr\u003e \u003ci\u003eLeonard C. Edelstein, Srikanth Nagalla, and Paul F. Bray\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II: MICRORNAS IN INFECTIOUS DISEASE: HOST–PATHOGEN INTERACTIONS 117\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS INTERACTIONS 119\u003cbr\u003e \u003ci\u003eAurélie Fender and Sébastien Pfeffer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 MICRORNA EXPRESSION IN AVIAN HERPESVIRUSES 137\u003cbr\u003e \u003ci\u003eYongxiu Yao and Venugopal Nair\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 FUNCTION OF HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153\u003cbr\u003e \u003ci\u003eNatalie L. Reynolds, Jon A. Pavelin, and Finn E. Grey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 INVOLVEMENT OF SMALL NON-CODING RNA IN HIV-1 INFECTION 165\u003cbr\u003e \u003ci\u003eGuihua Sun, John J. Rossi, and Daniela Castanotto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 MICRORNA IN MALARIA 183\u003cbr\u003e \u003ci\u003ePanote Prapansilp and Gareth D.H. Turner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III: CANCER 199\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 THE MICRORNA DECALOGUE OF CANCER INVOLVEMENT 201\u003cbr\u003e \u003ci\u003eTanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and George A. Calin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223\u003cbr\u003e \u003ci\u003eEva E. Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and Pedro P. Medina\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245\u003cbr\u003e \u003ci\u003eYolanda Sánchez and Maite Huarte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 REGULATION OF HYPOXIA RESPONSES BY MICRORNA EXPRESSION 267\u003cbr\u003e \u003ci\u003eCarme Camps, Adrian L. Harris, and Jiannis Ragoussis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287\u003cbr\u003e \u003ci\u003eClaudia Piovan and Marilena V. Iorio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 MICRORNAS IN HUMAN PROSTATE CANCER: FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311\u003cbr\u003e \u003ci\u003eMustafa Ozen and Omer Faruk Karatas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329\u003cbr\u003e \u003ci\u003eKatrin Pfütze, Xiaoya Luo, and Barbara Burwinkel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 GENETIC VARIATIONS IN MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER SUSCEPTIBILITY AND SURVIVAL 343\u003cbr\u003e \u003ci\u003eMing Yang and Dongxin Lin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 MICRORNA IN MYELOPOIESIS AND MYELOID DISORDERS 353\u003cbr\u003e \u003ci\u003eSara E. Meyer and H. Leighton Grimes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC LEUKEMIA 371\u003cbr\u003e \u003ci\u003eXabier Agirre and Felipe Prósper\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 ROLE OF MIRNAS IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383\u003cbr\u003e \u003ci\u003eVeronica Balatti, Yuri Pekarsky, Lara Rizzotto, and Carlo M. Croce\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 MICRORNA IN B-CELL NON-HODGKIN’S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403\u003cbr\u003e \u003ci\u003eNerea Martínez, Lorena Di Lisio, and Miguel Angel Piris\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 MICRORNAS IN DIFFUSE LARGE B-CELL LYMPHOMA 419\u003cbr\u003e \u003ci\u003eIzidore S. Lossos and Alvaro J. Alencar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 THE ROLE OF MICRORNAS IN HODGKIN’S LYMPHOMA 435\u003cbr\u003e \u003ci\u003eWouter Plattel, Joost Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 MICRORNA EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449\u003cbr\u003e \u003ci\u003eCornelis P. Tensen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV: HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e28 MICRORNAS AND HEREDITARY DISORDERS 465\u003cbr\u003e \u003ci\u003eMatías Morín and Miguel A. Moreno-Pelayo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 MICRORNAS AND CARDIOVASCULAR DISEASES 477\u003cbr\u003e \u003ci\u003eKoh Ono\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 MICRORNAS AND DIABETES 495\u003cbr\u003e \u003ci\u003eRomano Regazzi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 MICRORNAS IN LIVER DISEASES 509\u003cbr\u003e \u003cb\u003ePatricia Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M. Banales\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523\u003cbr\u003e \u003ci\u003eAndreas Junker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33 THE ROLE OF MICRORNAS IN ALZHEIMER’S DISEASE 539\u003cbr\u003e \u003ci\u003eShahar Barbash and Hermona Soreq\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553\u003cbr\u003e \u003ci\u003eAoife Kearney, Javier A. Bravo, and Timothy G. Dinan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V: CIRCULATING MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e35 CIRCULATING MICRORNAS AS NON-INVASIVE BIOMARKERS 569\u003cbr\u003e \u003ci\u003eHeidi Schwarzenbach and Klaus Pantel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589\u003cbr\u003e \u003ci\u003eKasey C. Vickers\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND METASTASIS IN RENAL CARCINOMA 607\u003cbr\u003e \u003ci\u003eFederica Collino, Cristina Grange, and Giovanni Camussi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT PERSPECTIVES AND FUTURE DIRECTIONS 623\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e38 MICRORNA REGULATION OF CANCER STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625\u003cbr\u003e \u003ci\u003eCan Liu and Dean G. Tang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e39 THERAPEUTIC MODULATION OF MICRORNAS 639\u003cbr\u003e \u003ci\u003eAchim Aigner and Hannelore Dassow\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e40 LOCKED NUCLEIC ACIDS AS MICRORNA THERAPEUTICS 663\u003cbr\u003e \u003ci\u003eHenrik Ørum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 673\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eDr. Charles Lawrie\u003c\/strong\u003e is Director of Oncology at the Biodonostia Institute in San Sebastián, Spain. The author of numerous research papers and book chapters, Dr. Lawrie is an Associate Editor for the \u003cem\u003eJournal of Cancer Research\u003c\/em\u003e, and serves on the editorial boards of a number of other prestigious journals including \u003cem\u003eCancers\u003c\/em\u003e, \u003cem\u003eJournal of RNAi and Gene Silencing\u003c\/em\u003e, \u003cem\u003eAmerican Journal of Blood\u003c\/em\u003e, and \u003cem\u003eISRN Hematology\u003c\/em\u003e.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eA comprehensive review of the role and function of microRNAs in human health, and their potential as novel therapeutics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSince their first formal recognition just over ten years ago, microRNAs (or miRNAs) have become one of the hottest subjects in science and medicine. MiRNAs are key players in practically every biological process examined to date—especially in the area of biomedicine, where miRNAs are recognized as essential physiological regulators and play crucial roles in a wide range of diseases including infectious diseases, hereditary disorders, immunological and heart disease, neurological and psychological disorders, and cancer.\u003c\/p\u003e \u003cp\u003eWritten by an international team of renowned experts in the field, \u003ci\u003eMicroRNAs in Medicine\u003c\/i\u003e provides an easy access point into the current literature on miRNAs for both scientists and clinicians, with particular focus on their relevance to medicine. Beginning with an introduction to basic miRNA role and function, this text goes on to cover the importance of miRNAs in normal physiology, infectious and non-infectious diseases, cancer, circulating miRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics.\u003c\/p\u003e \u003cp\u003eStarting with a Foreword by Sir David Baulcombe, one of the pioneers of miRNA discovery, \u003ci\u003eMicroRNAs in Medicine\u003c\/i\u003e provides in-depth and easily accessible coverage of the function of miRNAs in major aspects of medical science, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eStem cell fate and reprogramming\u003c\/li\u003e \u003cli\u003eAdaptive and innate immunity\u003c\/li\u003e \u003cli\u003eAging and senescence\u003c\/li\u003e \u003cli\u003eHematopoiesis\u003c\/li\u003e \u003cli\u003eViruses including HIV\u003c\/li\u003e \u003cli\u003eMalaria\u003c\/li\u003e \u003cli\u003eCancer\u003c\/li\u003e \u003cli\u003eHereditary disorders\u003c\/li\u003e \u003cli\u003eCardiovascular diseases\u003c\/li\u003e \u003cli\u003eDiabetes\u003c\/li\u003e \u003cli\u003eLiver disease\u003c\/li\u003e \u003cli\u003eNeurological and psychological disorders\u003c\/li\u003e \u003cli\u003eCirculating miRNAs as cellular messengers and novel biomarkers\u003c\/li\u003e \u003cli\u003eTherapeutic use of miRNAs\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAccessible to both the experienced researcher and those newer to the field, this one-stop source of information is ideal for students, researchers, and clinicians.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989621653733,"sku":"NP9781118300398","price":226.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118300398.jpg?v=1761784845","url":"https:\/\/k12savings.com\/products\/micrornas-in-medicine-isbn-9781118300398","provider":"K12savings","version":"1.0","type":"link"}