{"product_id":"medicinal-chemistry-of-bioactive-natural-products-isbn-9780471660071","title":"Medicinal Chemistry of Bioactive Natural Products","description":"Current discoveries and research into bioactive natural products\u003cbr\u003e \u003cbr\u003e Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.\u003cbr\u003e \u003cbr\u003e Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.\u003cbr\u003e \u003cbr\u003e Enhanced by examples with updated research results, the discussion covers such topics as:\u003cbr\u003e * The chemistry and biology of epothilones\u003cbr\u003e * Vancomycin and other glycopeptide antibiotic derivates\u003cbr\u003e * Antitumor and other related activities of Taxol and its analogs\u003cbr\u003e * The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)\u003cbr\u003e * Huperzine A: A natural drug for the treatment of Alzheimer's disease\u003cbr\u003e * The medicinal chemistry of ginkgolides from Ginkgo biloba\u003cbr\u003e * Recent progress in Calophyllum coumarins as potent anti-HIV agents\u003cbr\u003e * Plant-derived anti-HIV agents and analogs\u003cbr\u003e * Chemical synthesis of annonaceous acetogenins and their structurally modified mimics  \u003cb\u003ePreface.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eContributors.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The Chemistry and Biology of Epothilones—Lead Structures for the Discovery of Improved Microtubule Inhibitors\u003c\/b\u003e (\u003ci\u003eKarl-Heinz Altmann\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e1.1. Introduction.\u003c\/p\u003e \u003cp\u003e1.2. Biological Effects of Epo B.\u003c\/p\u003e \u003cp\u003e1.3. Epothilone Analogs and SAR Studies.\u003c\/p\u003e \u003cp\u003e1.4. Pharmacophore Modeling and Conformational Studies.\u003c\/p\u003e \u003cp\u003e1.5. Epothilone Analogs in Clinical Development.\u003c\/p\u003e \u003cp\u003e1.6. Conclusions.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives\u003c\/b\u003e (\u003ci\u003eRoderich D. Su¨ssmuth\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2.1. Introduction.\u003c\/p\u003e \u003cp\u003e2.2. Classification of Glycopeptide Antibiotics.\u003c\/p\u003e \u003cp\u003e2.3. Mode of Action.\u003c\/p\u003e \u003cp\u003e2.4. Glycopeptide Resistance.\u003c\/p\u003e \u003cp\u003e2.5. Biosynthesis.\u003c\/p\u003e \u003cp\u003e2.6. Total Synthesis.\u003c\/p\u003e \u003cp\u003e2.7. Glycopeptides as Chiral Selectors in Chromatography and Capillary Electrophoresis.\u003c\/p\u003e \u003cp\u003e2.8. Structural Modifications of Glycopeptide Antibiotics and Structure Activity Relationship (SAR) Studies.\u003c\/p\u003e \u003cp\u003eAcknowledgment.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs\u003c\/b\u003e (\u003ci\u003eWei-Shuo Fang, Qi-Cheng Fang, and Xiao-Tian Liang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3.1. Discovery and Research and Development of Taxol.\u003c\/p\u003e \u003cp\u003e3.2. Paclitaxel Analogs Active Against Normal Tumor Cells.\u003c\/p\u003e \u003cp\u003e3.3. Exploration on Mechanism of Paclitaxel Related to Tubulin Binding and Quest for Its Pharmacophore.\u003c\/p\u003e \u003cp\u003e3.4. Natural and Semisynthetic Taxoids Overcoming Multidrug Resistance (MDR).\u003c\/p\u003e \u003cp\u003e3.5 Design, Synthesis and Pharmacological Activity of Prodrugs of Paclitaxel.\u003c\/p\u003e \u003cp\u003e3.6 Other Biological Actions of Paclitaxel.\u003c\/p\u003e \u003cp\u003e3.7 New Antimicrotubule Molecules Mimicking Action of Paclitaxel.\u003c\/p\u003e \u003cp\u003e3.8 Conclusion.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer\u003c\/b\u003e\u003cb\u003e’\u003c\/b\u003e\u003cb\u003es Disease\u003c\/b\u003e (\u003ci\u003eDa-Yuan Zhu, Chang-Heng Tan, and Yi-Ming Li\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4.1 Introduction.\u003c\/p\u003e \u003cp\u003e4.2. Profiles of HA.\u003c\/p\u003e \u003cp\u003e4.3. Plant Resources.\u003c\/p\u003e \u003cp\u003e4.4. Pharmacology.\u003c\/p\u003e \u003cp\u003e4.5. Clinical Trials.\u003c\/p\u003e \u003cp\u003e4.6. Synthesis of HA and Its Analogs.\u003c\/p\u003e \u003cp\u003e4.7. Structural Biology.\u003c\/p\u003e \u003cp\u003e4.8. ZT-1: New Generation of HA AChE.\u003c\/p\u003e \u003cp\u003eAbbreviations.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Qinghaosu (Artemisinin)\u003c\/b\u003e\u003cb\u003e—\u003c\/b\u003e\u003cb\u003eA Fantastic Antimalarial Drug from a Traditional Chinese Medicine\u003c\/b\u003e (\u003ci\u003eYing Li, Hao Huang, and Yu-Lin Wu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5.1. Introduction.\u003c\/p\u003e \u003cp\u003e5.2. Qinghaosu and Qinghao (Artemisia annua L. Composites).\u003c\/p\u003e \u003cp\u003e5.3. Reaction of Qinghaosu.\u003c\/p\u003e \u003cp\u003e5.4. Chemical Synthesis and Biosynthesis of Qinghaosu.\u003c\/p\u003e \u003cp\u003e5.5. Derivatives and Antimalarial Activity.\u003c\/p\u003e \u003cp\u003e5.6. Pharmacology and Chemical Biology of Qinghaosu and Its Derivatives.\u003c\/p\u003e \u003cp\u003e5.7 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Progress of Studies on the Natural Cembranoids from the Soft Coral Species of\u003c\/b\u003e \u003cb\u003eSarcophyton\u003c\/b\u003e \u003cb\u003eGenus\u003c\/b\u003e (\u003ci\u003eYulin Li, Lizeng Peng, and Tao Zhang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6.1. Introduction.\u003c\/p\u003e \u003cp\u003e6.2. Cembrane-Type Constituents from the Sarcophyton Genus.\u003c\/p\u003e \u003cp\u003e6.3. Physiological Action of Sarcophytol A and Sarcophytol B.\u003c\/p\u003e \u003cp\u003e6.4. Total Synthesis of the Natural Cembranoids.\u003c\/p\u003e \u003cp\u003e6.5. Studies on Novel Macrocyclization Methods of Cembrane-Type Diterpenoids.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Medicinal Chemistry of Ginkgolides from\u003c\/b\u003e \u003cb\u003eGinkgo biloba\u003c\/b\u003e (\u003ci\u003eKristian Strø\u003c\/i\u003e\u003ci\u003emgaard\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7.1. Introduction.\u003c\/p\u003e \u003cp\u003e7.2. Ginkgolides and the PAF Receptor.\u003c\/p\u003e \u003cp\u003e7.3. Ginkgolides and Glycine Receptors.\u003c\/p\u003e \u003cp\u003e7.4. Various Effects of Ginkgolides.\u003c\/p\u003e \u003cp\u003e7.5. Conclusions and Outlook.\u003c\/p\u003e \u003cp\u003eAcknowledgment.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Recent Progress in\u003c\/b\u003e \u003cb\u003eCalophyllum\u003c\/b\u003e \u003cb\u003eCoumarins as Potent Anti-HIV Agents\u003c\/b\u003e (\u003ci\u003eLin Wang, Tao Ma, and Gang Liu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8.1. Introduction.\u003c\/p\u003e \u003cp\u003e8.2. Anti-HIV-1 Activity of Calophyllum Coumarins.\u003c\/p\u003e \u003cp\u003e8.3. Pharmacology of Calanolides.\u003c\/p\u003e \u003cp\u003e8.4. Preparation of Calophyllum Coumarins.\u003c\/p\u003e \u003cp\u003e8.5. Structure Modification of Calanolides.\u003c\/p\u003e \u003cp\u003e8.6. Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Recent Progress and Prospects on Plant-Derived Anti-HIV Agents and Analogs\u003c\/b\u003e (\u003ci\u003eDonglei Yu and Kuo-Hsiung Lee\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9.1. Introduction.\u003c\/p\u003e \u003cp\u003e9.2. Khellactone Coumarin Analogs as Anti-HIV Agents.\u003c\/p\u003e \u003cp\u003e9.3. Biphenyl Derivatives as Anti-HIV Agents.\u003c\/p\u003e \u003cp\u003e9.4. Triterpene Betulinic Acid Derivatives as Anti-HIV Agents.\u003c\/p\u003e \u003cp\u003e9.5. Conclusions.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Recent Progress on the Chemical Synthesis of Annonaceous Acetogenins and Their Structurally Modi\u003c\/b\u003e\u003cb\u003efi\u003c\/b\u003e\u003cb\u003eed Mimics\u003c\/b\u003e (\u003ci\u003eTai-Shan Hu, Yu-Lin Wu, and Zhu-Jun Yao\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10.1. Introduction.\u003c\/p\u003e \u003cp\u003e10.2. Total Synthesis of Mono-THF Acetogenins.\u003c\/p\u003e \u003cp\u003e10.3. Total Synthesis of Bis-THF Acetogenins.\u003c\/p\u003e \u003cp\u003e10.4. Total Synthesis of THP-Containing Acetogenins.\u003c\/p\u003e \u003cp\u003e10.5. Design and Synthesis of Mimics of Acetogenins.\u003c\/p\u003e \u003cp\u003e10.6. Summary.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e  \"…an in-depth resource for anyone concerned about natural products and their application in medicine...it provides concise information that is difficult to find in a compact format elsewhere.\" (\u003ci\u003eClinical Chemistry\u003c\/i\u003e, January 2007)  \u003cp\u003e\"…I can imagine this book being used in an interdisciplinary graduate course…[or] as a reference text.\" (\u003ci\u003eJournal of the American Chemical Society\u003c\/i\u003e, September 13, 2006)\u003c\/p\u003e \u003cp\u003e\"The authors are to be commended on the excellent blending of chemical, biological, and pharmacologic data…highly recommended to all with an interest in medicinal natural products chemistry.\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, June 1, 2006)\u003c\/p\u003e  \u003cb\u003eXIAO-TIAN LIANG\u003c\/b\u003e received his BS degree from the National Central University (China) in 1946 and his PhD degree from the University of Washington at Seattle (USA) in 1951. After postdoctoral work at Harvard University, he joined the faculty of the Institute of Materia Medica, Chinese Academy of Medical Sciences. In 1980, he was elected as an Academician of Academia Sinica (Chinese Academy of Sciences) and has served on the advisory editorial boards of Tetrahedron and Tetrahedron Letters, among other scientific journals. He coauthored more than 300 scientific papers and reviews, and has written or edited more than ten books.  \u003cp\u003e\u003cb\u003eWEI-SHUO FANG\u003c\/b\u003e graduated from Beijing Medical University, and obtained his PhD degree from Peking Union Medical College (PUMC) in 1997. After postdoctoral training in the US, he joined the faculty of the Institute of Materia Medica, Chinese Academy of Medical Sciences \u0026amp; PUMC. He has conducted visiting study in the University of Illinois at Urbana-Champaign and coauthored more than thirty articles in peer-reviewed journals.\u003c\/p\u003e  \u003cb\u003eCurrent discoveries and research into bioactive natural products\u003c\/b\u003e  \u003cp\u003e\u003ci\u003eMedicinal Chemistry of Bioactive Natural Products\u003c\/i\u003e provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies—developed for natural products—with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.\u003c\/p\u003e \u003cp\u003eRather than attempting to be a comprehensive encyclopedia of bioactive natural products, \u003ci\u003eMedicinal Chemistry of Bioactive Natural Products\u003c\/i\u003e guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.\u003c\/p\u003e \u003cp\u003eEnhanced by examples with updated research results, the discussion covers such topics as:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eThe chemistry and biology of epothilones\u003c\/li\u003e \u003cli\u003eVancomycin and other glycopeptide antibiotic derivates\u003c\/li\u003e \u003cli\u003eAntitumor and other related activities of Taxol and its analogs\u003c\/li\u003e \u003cli\u003eThe antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)\u003c\/li\u003e \u003cli\u003eHuperzine A: A natural drug for the treatment of Alzheimer's disease\u003c\/li\u003e \u003cli\u003eThe medicinal chemistry of ginkgolides from Ginkgo biloba\u003c\/li\u003e \u003cli\u003eRecent progress in Calophyllum coumarins as potent anti-HIV agents\u003c\/li\u003e \u003cli\u003ePlant-derived anti-HIV agents and analogs\u003c\/li\u003e \u003cli\u003eChemical synthesis of annonaceous acetogenins and their structurally modified mimics\u003c\/li\u003e \u003c\/ul\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989603598565,"sku":"NP9780471660071","price":166.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471660071.jpg?v=1761784773","url":"https:\/\/k12savings.com\/products\/medicinal-chemistry-of-bioactive-natural-products-isbn-9780471660071","provider":"K12savings","version":"1.0","type":"link"}