{"product_id":"mass-spectrometry-handbook-isbn-9780470536735","title":"Mass Spectrometry Handbook","description":"Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.  \u003cp\u003eFOREWORD xi\u003c\/p\u003e \u003cp\u003ePREFACE xiii\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION I BIOTECHNOLOGY\/PROTEINS 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Targeted Proteomics Using Immunoaffi nity Purifi cation 3\u003cbr\u003e \u003ci\u003eKaren R. Jonscher, Lei Jin, John C. Cambier, Shaikh M. Rahman, and Jacob E. Friedman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifi cations by Lipid Peroxidation Products 23\u003cbr\u003e \u003ci\u003eNavin Rauniyar and Laszlo Prokai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Imaging Mass Spectrometry (IMS) for Biological Application 41\u003cbr\u003e \u003ci\u003eYuki Sugiura, Ikuko Yao, and Mitsutoshi Setou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs 85\u003cbr\u003e \u003ci\u003eGeorge W. Jackson, Rafal Drabek, Mithil Soni, Roger McNichols, Richard C. Willson, and George E. Fox\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION II PHARMACEUTICAL 107\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5 Preclinical Pharmacokinetics: Industrial Perspective 109\u003cbr\u003e \u003ci\u003eAyman El-Kattan and Manthena Varma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective 119\u003cbr\u003e \u003ci\u003eWenying Jian, Wilson Shou, Richard W. Edom, Naidong Weng, and Mingshe Zhu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies 171\u003cbr\u003e \u003ci\u003eXiaoying Xu, Wenkui Li, and Francis L.S. Tse\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Determination of Pharmacokinetic Parameters by HPLC-MS\/MS and UPLC-MS\/MS 191\u003cbr\u003e \u003ci\u003eMargrét Thorsteinsdóttir, Baldur Bragi Sigurðsson, and Gísli Bragason\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS 209\u003cbr\u003e \u003ci\u003eKevin A. Schug\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Hydrogen\/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture, Dynamics, and Interactions of Biopharmaceutical Products 227\u003cbr\u003e \u003ci\u003eIgor A. Kaltashov, Cedric E. Bobst, and Rinat R. Abzalimov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods 243\u003cbr\u003e \u003ci\u003eSatoka Aoyagi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Accelerator Mass Spectrometry in Pharmaceutical Development 259\u003cbr\u003e \u003ci\u003eBenjamin J. Stewart, Graham Bench, Bruce A. Buchholz, Kurt W. Haack, Michael A. Malfatti, Ted J. Ognibene, and Kenneth W. Turteltaub\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION III CLINICAL ANALYSIS 271\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism 273\u003cbr\u003e \u003ci\u003eDonald H. Chace\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Mass Spectrometry for Steroid Analysis 297\u003cbr\u003e \u003ci\u003eWilliam J. Griffi ths, Michael Ogundare, Anna Meljon, and Yuqin Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION IV FORENSICS 339\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15 Forensic Applications of Isotope Ratio Mass Spectrometry 341\u003cbr\u003e \u003ci\u003eSarah J. Benson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry 373\u003cbr\u003e \u003ci\u003eMichael E. Sigman and C. Douglas Clark\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION V SPACE EXPLORATION 389\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17 Mass Spectrometry in Solar System Exploration 391\u003cbr\u003e \u003ci\u003ePaul V. Johnson, Luther W. Beegle, and Isik Kanik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Application of GC × GC–TOFMS to the Characterization of Extraterrestrial Organic Matter 407\u003cbr\u003e \u003ci\u003eJonathan S. Watson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION VI HOMELAND SECURITY 417\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19 Methods of Mass Spectrometry in Homeland Security Applications 419\u003cbr\u003e \u003ci\u003eÜnige A. Laskay, Erin J. Kaleta, and Vicki H. Wysocki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Homeland Security 441\u003cbr\u003e \u003ci\u003eChristina L. Crawford and Herbert H. Hill, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Mass Spectrometry in Homeland Security 477\u003cbr\u003e \u003ci\u003eYasuaki Takada\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer 491\u003cbr\u003e \u003ci\u003eGary S. Groenewold, Anthony D. Appelhans, Garold L. Gresham, and John E. Olson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235\/238 Isotope Ratios 509\u003cbr\u003e \u003ci\u003eR. Steven Pappas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION VII FOOD ANALYSIS 529\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e24 Mass Spectrometry in Agriculture, Food, and Flavors: Selected Applications 531\u003cbr\u003e \u003ci\u003eMaciej Stobiecki, Piotr Kachlicki, and Henryk Jeleñ\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Top-Down Proteomic Identifi cation of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS\/MS 559\u003cbr\u003e \u003ci\u003eClifton K. Fagerquist and Omar Sultan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION VIII ENVIRONMENTAL 575\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e26 Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography\/Mass Spectrometry 577\u003cbr\u003e \u003ci\u003eWolfgang Schwack\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry 593\u003cbr\u003e \u003ci\u003eChongzheng Na and Terese M. Olson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 Proton Transfer Reaction Mass Spectrometry (PTR-MS) 605\u003cbr\u003e \u003ci\u003eYujie Wang, Chengyin Shen, Jianquan Li, Haihe Jiang, and Yannan Chu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Determination of Chlorinated Compounds in Dialysis Water and in Biological Fluids\/Matrices 631\u003cbr\u003e \u003ci\u003eDiana Poli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION IX GEOLOGICAL 645\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e30 Mass Spectrometry Techniques for Analysis of Oil and Gas Trapped in Fluid Inclusions 647\u003cbr\u003e \u003ci\u003eSimon C. George, Herbert Volk, and Adriana Dutkiewicz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 LA-MC-ICP-MS Applied to U-Pb Zircon Geochronology 675\u003cbr\u003e \u003ci\u003eAlain Cocherie and Michèle Robert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e32 Hydrocarbon Processing 707\u003cbr\u003e \u003ci\u003eMaoqi Feng, Thomas Andrews, and Eloy Flores III\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33 Hydrocarbon Processing: MALDI-MS of Polydisperse Hydrocarbon Samples 725\u003cbr\u003e \u003ci\u003eAlan A. Herod\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e34 Renewable Energy: Mass Spectrometry in Biofuel Research 749\u003cbr\u003e \u003ci\u003eIngvar Eide and Kolbjørn Zahlsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION X ARCHAEOLOGY 763\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e35 Mass Spectrometry in Archaeology 765\u003cbr\u003e \u003ci\u003eRobert Hedges and James McCullagh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e36 Archaeometric Data from Mass Spectrometric Analysis of Organic Materials: Proteins, Lipids, Terpenoid Resins, Lignocellulosic Polymers, and Dyestuff 797\u003cbr\u003e \u003ci\u003eMaria Perla Colombini, Francesca Modugno, and Erika Ribechini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e37 Laser Ablation ICP-MS in Archaeology 829\u003cbr\u003e \u003ci\u003eHector Neff\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e38 Spatially Resolved MS in the Study of Art and Archaeological Objects 845\u003cbr\u003e \u003ci\u003eGiuseppe Spoto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e39 Laser Ablation–Inductively Coupled Plasma Mass Spectrometry for the Investigation of Archaeological Samples 859\u003cbr\u003e \u003ci\u003eMartín Resano, Esperanza García-Ruiz, and Frank Vanhaecke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION XI SURFACE ANALYSIS 885\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e40 Mass Spectrometry in Semiconductor Research 887\u003cbr\u003e \u003ci\u003eStefan Flege and Wolfgang Ensinger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e41 Analysis of Thin and Thick Films 943\u003cbr\u003e \u003ci\u003ePhilippe Le Coustumer, Patrick Chapon, Agnès Tempez, Yuriy Popov, George Thompson, Igor Molchan, Nicolas Trigoulet, Peter Skeldon, Antonino Licciardello, Nunzio Tuccitto, Ivan Delfanti, Katrin Fuhrer, Marc Gonin, James Whitby, Markus Hohl, Christian Tanner, Nerea Bordel Garcia, Lara Lobo Revilla, Jorge Pisonero, Rosario Pereiro, Cristina Gonzalez Gago, Alfredo Sanz Medel, Mihai Ganciu Petcu, Ani Surmeian, Constantin Diplasu, Andreea Groza, Norbert Jakubowski, Roland Dorka, Stela Canulescu, Johann Michler, Philippe Belenguer, Thomas Nelis, Abdellatif Zahri, Philippe Guillot, Laurent Thérèse, Arnaud Littner, Richard Vaux, Julien Malherbe, Frédéric Huneau, Fred Stevie, and Hugues François-Saint-Cyr\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e42 SIMS for Organic Film Analysis 961\u003cbr\u003e \u003ci\u003eTaoufi q Mouhib and Arnaud Delcorte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e43 Ceramics: Contribution of Secondary Ion Mass\u003cbr\u003e Spectrometry (SIMS) to the Study of Crystal Chemistry of Mica Minerals 1017\u003cbr\u003e \u003ci\u003eLuisa Ottolini, Emanuela Schingaro, and Fernando Scordari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION XII POLYMERS 1061\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e44 ETV-ICPMS for Analysis of Polymers 1063\u003cbr\u003e \u003ci\u003eMaite Aramendía Marzo, Martín Resano, and Frank Vanhaecke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e45 Polymers 1079\u003cbr\u003e \u003ci\u003eMaurizio S. Montaudo and Salvatore Battiato\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e46 Mass Spectroscopy in Polymer Research 1107\u003cbr\u003e \u003ci\u003eJale Hacaloglu and Talat Yalcin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e47 Laser Mass Spectrometry Applied to the Analysis of Polymers 1135\u003cbr\u003e \u003ci\u003eJérôme Bour and David Ruch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION XIII ANALYTICAL TECHNIQUES 1143\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e48 Measuring Thermodynamic Properties of Metals and Alloys 1145\u003cbr\u003e \u003ci\u003eEvan H. Copland and Nathan S. Jacobson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e49 High-Performance Thin-Layer Chromatography–Mass Spectrometry for Analysis of Small Molecules 1181\u003cbr\u003e \u003ci\u003eGertrud E. Morlock\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e50 Laser Ionization Mass Spectrometry of Inorganic Ions 1207\u003cbr\u003e \u003ci\u003eJulius Pavlov and Athula B. Attygalle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e51 Mass Spectrometry in the SSITKA Studies 1229\u003cbr\u003e \u003ci\u003eL.G. Pinaeva, E.M. Sadovskaya, A.P. Suknev, V.B. Goncharov, and B.S. Bal’zhinimaev\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e52 Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences 1257\u003cbr\u003e \u003ci\u003eElena Crespo, Marco M.L. Steeghs, Simona M. Cristescu, and Frans J.M. Harren\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 1283\u003c\/p\u003e  \u003cp\u003e“In summary, this handbook presents research from a variety of areas tied together by the common thread of mass spectrometry. The authors present their works in a manner that is accessible to beginning researchers and include sufficient references to allow in depth exploration of the topic. More seasoned scientists could also benefit from this book as they venture into new areas of research.”  (\u003ci\u003eJournal of American Society for Mass Spectrometry\u003c\/i\u003e, 6 October 2012)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMike S. Lee\u003c\/b\u003e is President of Milestone Development Services where he consults and develops workshops and symposia to support industry with innovative technologies and solutions. His research interests include the application of mass spectrometry for the analysis of proteins, natural products, drug metabolites, impurities, and degradants. Recently, he has been involved in the development of automated orthogonal control systems for electrospray ionization and the development of digital separation devices for sampling, separation, and enrichment.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eEnables readers to select and implement the most effective mass spectrometry methods\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eFor decades, mass spectrometry has been the dominant force in analytical chemistry, offering unparalleled levels of sensitivity and selectivity for trace analysis and an impressive range of applications across numerous research disciplines. Now in one expertly written, edited, and organized reference, the Mass Spectrometry Handbook brings together the best tested and proven mass spectrometry methods available.\u003c\/p\u003e \u003cp\u003eThe \u003ci\u003eHandbook\u003c\/i\u003e provides a unique reference that allows for easy access to a variety of real-world applications that involve mass spectrometry. Each chapter in the Handbook provides essential background and history, detailed analytical methodology, and valuable references. Readers will obtain a step-by-step guide through the most popular and effective methods for each application. The exciting applications—starting with life sciences and culminating with specialized analytical techniques—are featured:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eBiotechnology\/Proteins\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eEnvironmental\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePharmaceutical\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eGeological\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eClinical Analysis\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eArchaeology\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eForensics\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eSurface Analysis\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eSpace Exploration\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePolymers\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eHomeland Security\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eAnalytical Techniques\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eFood Analysis\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEach chapter has been written by one or more leading international experts in the field of mass spectrometry. These authors have thoroughly examined the current literature in order to present the state of the technology. Moreover, based on their own firsthand laboratory experience, they explain why particular methods work or don't work for particular research objectives. References at the end of each chapter serve as a gateway to the most important studies in the field.\u003c\/p\u003e \u003cp\u003eWith its tremendous breadth and depth of coverage, the Mass Spectrometry Handbook is an excellent resource for practicing mass spectrometrists as well as for novices who want to quickly master the many applications and methods of mass spectrometry.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989578825957,"sku":"NP9780470536735","price":246.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470536735.jpg?v=1761784673","url":"https:\/\/k12savings.com\/products\/mass-spectrometry-handbook-isbn-9780470536735","provider":"K12savings","version":"1.0","type":"link"}