{"product_id":"linker-strategies-in-solid-phase-organic-synthesis-isbn-9780470511169","title":"Linker Strategies in Solid-Phase Organic Synthesis","description":"Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis.  \u003cp\u003e\u003ci\u003eLinker Strategies in Solid-Phase Organic Synthesis\u003c\/i\u003e guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis.  Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003ethe principles of solid phase organic synthesis\u003c\/li\u003e \u003cli\u003eelectrophile and nucleophile cleavable linker units\u003c\/li\u003e \u003cli\u003ecyclative cleavage as a solid phase strategy\u003c\/li\u003e \u003cli\u003ephotocleavable linker units\u003c\/li\u003e \u003cli\u003esafety-catch linker units\u003c\/li\u003e \u003cli\u003eenzyme cleavable linker units\u003c\/li\u003e \u003cli\u003eT1 and T2 –versatile triazene linker groups\u003c\/li\u003e \u003cli\u003ehydrazone linker units\u003c\/li\u003e \u003cli\u003ebenzotriazole linker units\u003c\/li\u003e \u003cli\u003ephosphorus linker units\u003c\/li\u003e \u003cli\u003esulfur linker units\u003c\/li\u003e \u003cli\u003eselenium and tellurium linker units\u003c\/li\u003e \u003cli\u003esulfur, oxygen and selenium linker units cleaved by radical processes\u003c\/li\u003e \u003cli\u003esilicon and germanium linker units\u003c\/li\u003e \u003cli\u003eboron and stannane linker units\u003c\/li\u003e \u003cli\u003ebismuth linker units\u003c\/li\u003e \u003cli\u003etransition metal carbonyl linker units\u003c\/li\u003e \u003cli\u003elinkers releasing olefins or cycloolefins by ring-closing metathesis\u003c\/li\u003e \u003cli\u003efluorous linker units\u003c\/li\u003e \u003cli\u003esolid-phase radiochemistry\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eLinker Strategies in Solid-Phase Organic Synthesis\u003c\/i\u003e is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.\u003c\/p\u003e  \u003cb\u003eForeword.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003ePreface.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eList of Contributors.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAbout the Editor.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAbbreviations.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eI: INTRODUCTION.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1: General Introduction\u003c\/b\u003e \u003ci\u003e(Scott L. Dax).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction, Background and Pivotal Discoveries.\u003c\/p\u003e \u003cp\u003e1.2 Fundamentals of Conducting Solid-Phase Organic Chemistry.\u003c\/p\u003e \u003cp\u003e1.3 Concluding Comments.\u003c\/p\u003e \u003cp\u003e1.4 Personal Perspective and Testimony: Solid-phase Mannich Chemistry.\u003c\/p\u003e \u003cp\u003e1.5 References.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eII: TRADITIONAL LINKER UNITS FOR SOLID-PHASE ORGANIC SYNTHESIS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2: Electrophile Cleavable Linker Units\u003c\/b\u003e \u003ci\u003e(Michio Kuruso).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction.\u003c\/p\u003e \u003cp\u003e2.2 Resins for use with Electrophilic Linkers.\u003c\/p\u003e \u003cp\u003e2.3 Electrophile Cleavable Linkers.\u003c\/p\u003e \u003cp\u003e2.4 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3: Nucleophile Cleavable Linker Units\u003c\/b\u003e \u003ci\u003e(Andrea Porcheddu and Giampaolo\u003c\/i\u003e \u003ci\u003eGiacomelli).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction.\u003c\/p\u003e \u003cp\u003e3.2 Linker Units.\u003c\/p\u003e \u003cp\u003e3.3 Nucleophilic Labile Linker Units.\u003c\/p\u003e \u003cp\u003e3.4 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4: Cyclative Cleavage as a Solid-Phase Strategy\u003c\/b\u003e \u003ci\u003e(A. Ganesan).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction.\u003c\/p\u003e \u003cp\u003e4.2 C-N bond formation.\u003c\/p\u003e \u003cp\u003e4.3 C-O bond formation.\u003c\/p\u003e \u003cp\u003e4.4 C-C bond formation.\u003c\/p\u003e \u003cp\u003e4.5 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5: Photolabile Linker Units\u003c\/b\u003e \u003ci\u003e(Christian Bochet and Sébastien Mercier).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction.\u003c\/p\u003e \u003cp\u003e5.2 Linkers Based on the Ortho-Nitrobenzyloxy Function.\u003c\/p\u003e \u003cp\u003e5.3 Linkers Based on the Ortho-Nitrobenzylamino Function.\u003c\/p\u003e \u003cp\u003e5.4 Linkers Based on the α–Substituted Ortho-Nitrobenzyl Group.\u003c\/p\u003e \u003cp\u003e5.5 Linkers Based on the Ortho-Nitroveratryl Group.\u003c\/p\u003e \u003cp\u003e5.6 Linkers Based on the Phenacyl Group.\u003c\/p\u003e \u003cp\u003e5.7 Linkers Based on the Para-Methoxyphenacyl Group.\u003c\/p\u003e \u003cp\u003e5.8 Linkers Based on the Benzoin Group.\u003c\/p\u003e \u003cp\u003e5.9 Linkers Based on the Pivaloyl Group.\u003c\/p\u003e \u003cp\u003e5.10 Traceless Linkers.\u003c\/p\u003e \u003cp\u003e5.11 Other Types of Photolabile Linker Units.\u003c\/p\u003e \u003cp\u003e5.12 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6: Safety-Catch Linker Units\u003c\/b\u003e \u003ci\u003e(Sylvain Lebreton and Marcel Pátek).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction.\u003c\/p\u003e \u003cp\u003e6.2 Activation of a carbonyl group by the inductive effect (I-) of an adjacent substituent.\u003c\/p\u003e \u003cp\u003e6.3 Activation by the mesomeric effect (M-) of the X–Y=Z moiety adjacent to a carbonyl group.\u003c\/p\u003e \u003cp\u003e6.4 Activation by the positive mesomeric effect (M+) of the -X-Y=Z moiety adjacent to a \u003ci\u003eN\u003c\/i\u003e-acyl or \u003ci\u003eO\u003c\/i\u003e-alkyl group.\u003c\/p\u003e \u003cp\u003e6.5 Aromatic S\u003csub\u003eN\u003c\/sub\u003eAr substitution.\u003c\/p\u003e \u003cp\u003e6.6 Fragmentation by β-elimination.\u003c\/p\u003e \u003cp\u003e6.7 Safety-catch linker for release in aqueous buffers.\u003c\/p\u003e \u003cp\u003e6.8 Photochemical activation.\u003c\/p\u003e \u003cp\u003e6.9 Miscellaneous safety-catch linkers.\u003c\/p\u003e \u003cp\u003e6.10 Conclusion.\u003c\/p\u003e \u003cp\u003e6.11 References.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7: Enzyme Cleavable Linker Units\u003c\/b\u003e \u003ci\u003e(Mallesham Bejugam and Sabine L. Flitsch).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction.\u003c\/p\u003e \u003cp\u003e7.2 Enzyme Cleavable Linker Units.\u003c\/p\u003e \u003cp\u003e7.3 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIII: MULTIFUNCTIONAL LINKER UNITS FOR DIVERSITY-ORIENTED SYNTHESIS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8: An Introduction to Diversity-Oriented Synthesis\u003c\/b\u003e \u003ci\u003e(Richard J. Spandl, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 \u003ca id=\"_Toc218221686\" name=\"_Toc218221686\"\u003eIntroduction\u003c\/a\u003e.\u003c\/p\u003e \u003cp\u003e8.2 \u003ca id=\"_Toc218221687\" name=\"_Toc218221687\"\u003eExploring Chemical Space\u003c\/a\u003e.\u003c\/p\u003e \u003cp\u003e8.3 Sources of Skeletally Diverse Small Molecules.\u003c\/p\u003e \u003cp\u003e8.4 Enriching Chemical Space Using DOS.\u003c\/p\u003e \u003cp\u003e8.5 The Subjective Nature of ‘Diversity’.\u003c\/p\u003e \u003cp\u003e8.6 Differing Strategies Towards Similar Goals.\u003c\/p\u003e \u003cp\u003e8.7 Generating Skeletal Diversity.\u003c\/p\u003e \u003cp\u003e8.8 DOS and Solid-Phase Organic Synthesis.\u003c\/p\u003e \u003cp\u003e\u003ca id=\"_Toc218221700\" name=\"_Toc218221700\"\u003e8.9 Conclusion\u003c\/a\u003e.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 9:\u003c\/b\u003e \u003cb\u003eT1 and T2 – Versatile Triazene Linker Groups\u003c\/b\u003e \u003ci\u003e(Kerstin Knepper and Robert E. Ziegert).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction.\u003c\/p\u003e \u003cp\u003e9.2 The T1 Linker.\u003c\/p\u003e \u003cp\u003e9.3 The T2 Linker Units.\u003c\/p\u003e \u003cp\u003e9.4 \u003ca id=\"_Toc218222221\" name=\"_Toc218222221\"\u003eMiscellaneous Triazene Linker\u003c\/a\u003es.\u003c\/p\u003e \u003cp\u003e9.5 Conclusion.\u003c\/p\u003e \u003cp\u003e9.6 References.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 10: Hydrazone Linker Units\u003c\/b\u003e \u003ci\u003e(Ryszard Lazny).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction.\u003c\/p\u003e \u003cp\u003e10.2 Hydrazone Linker Units.\u003c\/p\u003e \u003cp\u003e10.3 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 11: Benzotriazole Linker Units\u003c\/b\u003e \u003ci\u003e(Daniel K. Whelligan).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction.\u003c\/p\u003e \u003cp\u003e11.2 Syntheses of Polymer-Supported Benzotriazoles.\u003c\/p\u003e \u003cp\u003e11.3 Polymer-Supported Benzotriazole Linked Reactions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 12:\u003c\/b\u003e \u003cb\u003eDiversity Cleavage Strategies from Phosphorus Linkers\u003c\/b\u003e \u003ci\u003e(Patrick G. Steel and Tom M. Woods).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction.\u003c\/p\u003e \u003cp\u003e12.2 Diversity Cleavage through olefination reactions.\u003c\/p\u003e \u003cp\u003e12.3 Diversity cleavage of enol phosphonates through palladium catalysed cross-coupling reactions.\u003c\/p\u003e \u003cp\u003e12.4 Oxidative diversity cleavage of cyanophosphoranes.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 13: Sulfur Linker Units\u003c\/b\u003e \u003ci\u003e(Peter J. H. Scott).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction.\u003c\/p\u003e \u003cp\u003e13.2 Sulfide Linker Units.\u003c\/p\u003e \u003cp\u003e13.3 Sulfonium Linker Units.\u003c\/p\u003e \u003cp\u003e13.4 Sulfoxide Linker Units.\u003c\/p\u003e \u003cp\u003e13.5 Sulfone Linker Units.\u003c\/p\u003e \u003cp\u003e13.6 Sulfonate Ester Linker Units.\u003c\/p\u003e \u003cp\u003e13.7 Sulfamate Linker Units.\u003c\/p\u003e \u003cp\u003e13.8 Thioester Linker Units.\u003c\/p\u003e \u003cp\u003e13.9 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 14:\u003c\/b\u003e \u003cb\u003eSelenium- and Tellurium-Based Linker Units\u003c\/b\u003e \u003ci\u003e(Tracy Yuen Sze But and Patrick H. Toy).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction.\u003c\/p\u003e \u003cp\u003e14.2 Selenium- and Tellurium-Based Linker Group Reagents and Their Syntheses.\u003c\/p\u003e \u003cp\u003e14.3 Selenium-Based Linker Group Attachment Methods.\u003c\/p\u003e \u003cp\u003e14.4 Selenium-Based Linker Group Cleavage Methods.\u003c\/p\u003e \u003cp\u003e14.5 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 15: Linker Units Cleaved by Radical Processes: Cleavage of Carbon-Sulfur, -Selenium, -Tellurium, -Oxygen, -Nitrogen and -Carbon Linkers\u003c\/b\u003e \u003ci\u003e(Giuditta Guazzelli, Marc Miller and David J. Procter).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction.\u003c\/p\u003e \u003cp\u003e15.2 Linkers cleaved using tin hydride, alkyltin and silicon hydride reagents.\u003c\/p\u003e \u003cp\u003e15.3 Linkers cleaved by oxidative electron-transfer.\u003c\/p\u003e \u003cp\u003e15.4 Linkers cleaved by reductive electron-transfer.\u003c\/p\u003e \u003cp\u003e15.5 Radical processes that indirectly trigger linker cleavage.\u003c\/p\u003e \u003cp\u003e15.6 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 16: Silicon and Germanium Linker Units\u003c\/b\u003e \u003ci\u003e(Alan C. Spivey and Christopher M. Diaper).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1Introduction.\u003c\/p\u003e \u003cp\u003e16.2 Silicon-based Linkers.\u003c\/p\u003e \u003cp\u003e16.3 Germanium-based Linkers.\u003c\/p\u003e \u003cp\u003e16.4 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 17: Boron and Stannane Linker Units\u003c\/b\u003e \u003ci\u003e(Peter J.H. Scott).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction.\u003c\/p\u003e \u003cp\u003e17.2 Organostannane Linker Units.\u003c\/p\u003e \u003cp\u003e17.3 Organoboron Linker Units.\u003c\/p\u003e \u003cp\u003e17.4 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 18: Bismuth Linker Units\u003c\/b\u003e \u003ci\u003e(Peter J.H Scott).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction.\u003c\/p\u003e \u003cp\u003e18.2 Bismuth Linker Units.\u003c\/p\u003e \u003cp\u003e18.3 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 19: Transition Metal Carbonyl Linker Units\u003c\/b\u003e \u003ci\u003e(Susan E. Gibson and Amol A. Walke).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction.\u003c\/p\u003e \u003cp\u003e19.2 Chromium carbonyl linker units.\u003c\/p\u003e \u003cp\u003e19.3 Cobalt carbonyl linker units.\u003c\/p\u003e \u003cp\u003e19.4 Manganese carbonyl linker units.\u003c\/p\u003e \u003cp\u003e19.5 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 20:\u003c\/b\u003e \u003cb\u003eLinkers Releasing Olefins or Cycloolefins by Ring Closing Metathesis\u003c\/b\u003e \u003ci\u003e(Jan H. van Maarseveen).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 Introduction.\u003c\/p\u003e \u003cp\u003e20.2 Cycloolefins via method I.\u003c\/p\u003e \u003cp\u003e20.3 Terminal olefins via route II.\u003c\/p\u003e \u003cp\u003e20.4 Terminal and internal olefins via route III.\u003c\/p\u003e \u003cp\u003e20.5 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 4: ALTERNATIVE LINKER STRATEGIES.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 21: Fluorous Linker Units\u003c\/b\u003e \u003ci\u003e(Wei Zhang).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21.1 Introduction.\u003c\/p\u003e \u003cp\u003e21.2 Fluorous linkers for synthesis of small molecules.\u003c\/p\u003e \u003cp\u003e21.3 Fluorous linkers for synthesis of biomolecules.\u003c\/p\u003e \u003cp\u003e21.4 Other applications of fluorous linkers.\u003c\/p\u003e \u003cp\u003e21.5 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 22: Solid-Phase Radiochemistry\u003c\/b\u003e \u003ci\u003e(Brian G. Hockley, Peter J. H. Scott and Michael R. Kilbourn).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22.1 Introduction.\u003c\/p\u003e \u003cp\u003e22.2 Solid-Phase Surrogates in Radiochemistry.\u003c\/p\u003e \u003cp\u003e22.3 Solid-Phase Radiochemistry.\u003c\/p\u003e \u003cp\u003e22.4 Conclusions and Perspectives.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 5: LINKER SELECTION TABLES.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 23: Linker Selection Tables\u003c\/b\u003e \u003ci\u003e(Peter J.H. Scott).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23.1 Introduction.\u003c\/p\u003e \u003cp\u003e23.2 Linkers for Alcohols, Phenols and Diols.\u003c\/p\u003e \u003cp\u003e23.3 Linkers for Carboxylic Acids, Esters and Related Compounds.\u003c\/p\u003e \u003cp\u003e23.4 Linkers for Aldehydes, Ketones and Related Carbonyl Compounds.\u003c\/p\u003e \u003cp\u003e23.5 Linkers for Amides, Ureas and Related Compounds.\u003c\/p\u003e \u003cp\u003e23.6 Linkers for Amines.\u003c\/p\u003e \u003cp\u003e23.7 Linkers Thiols, Thioethers and Disulfides.\u003c\/p\u003e \u003cp\u003e23.8 Linkers for Sugars.\u003c\/p\u003e \u003cp\u003e23.9 Linkers Liberating Alkyl Groups.\u003c\/p\u003e \u003cp\u003e23.10 Linkers for Alkenes, Alkynes and Related Compounds.\u003c\/p\u003e \u003cp\u003e23.11 Linkers for Aryl Compounds.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e  \"It is without a doubt an invaluable addition to any university or corporate library serving organic and biochemical researchers.\" (\u003ci\u003eCHOICE,\u003c\/i\u003e September 2010)\u003cbr\u003e \u003cbr\u003e  \"This book is a useful complement to literature reviews as well as other SPOS books. It will be a valuable resource for university libraries and an excellent first source for practitioners of solid-phase organic synthesis.\" (\u003ci\u003eJACS\u003c\/i\u003e, 2010)  \u003cp\u003e\u003cstrong\u003eDr Peter J. H. Scott, Department of Radiology, University of Michigan, Ann Arbor, USA\u003c\/strong\u003e\u003cbr\u003eDr. Peter Scott has worked at Siemens Molecular Imaging and Biomarker Research where he was head of radiochemistry at the LA Tech Center and involved in the design and synthesis of novel radiopharmaceuticals for use in PET imaging. In April 2009 Dr. Scott joined the University of Michigan in the Department of Radiology where his research interests are developing novel tracers and technology for PET imaging, including solid phase radiochemistry.   Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis.  \u003c\/p\u003e\u003cp\u003e\u003ci\u003e\u003cb\u003eLinker Strategies in Solid-Phase Organic Synthesis\u003c\/b\u003e\u003c\/i\u003e guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis.  Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports.\u003c\/p\u003e \u003cp\u003eTopics include:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003ethe principles of solid phase organic synthesis\u003c\/li\u003e \u003cli\u003eelectrophile and nucleophile cleavable linker units\u003c\/li\u003e \u003cli\u003ecyclative cleavage as a solid phase strategy\u003c\/li\u003e \u003cli\u003ephotocleavable linker units\u003c\/li\u003e \u003cli\u003esafety-catch linker units\u003c\/li\u003e \u003cli\u003eenzyme cleavable linker units\u003c\/li\u003e \u003cli\u003eT1 and T2 –versatile triazene linker groups\u003c\/li\u003e \u003cli\u003ehydrazone linker units\u003c\/li\u003e \u003cli\u003ebenzotriazole linker units\u003c\/li\u003e \u003cli\u003ephosphorus linker units\u003c\/li\u003e \u003cli\u003esulfur linker units\u003c\/li\u003e \u003cli\u003eselenium and tellurium linker units\u003c\/li\u003e \u003cli\u003esulfur, oxygen and selenium linker units cleaved by radical processes\u003c\/li\u003e \u003cli\u003esilicon and germanium linker units\u003c\/li\u003e \u003cli\u003eboron and stannane linker units\u003c\/li\u003e \u003cli\u003ebismuth linker units\u003c\/li\u003e \u003cli\u003etransition metal carbonyl linker units\u003c\/li\u003e \u003cli\u003elinkers releasing olefins or cycloolefins by ring-closing metathesis\u003c\/li\u003e \u003cli\u003efluorous linker units\u003c\/li\u003e \u003cli\u003esolid-phase radiochemistry\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis.\u003c\/p\u003e \u003cp\u003e\u003ci\u003e\u003cb\u003eLinker Strategies in Solid-Phase Organic Synthesis\u003c\/b\u003e\u003c\/i\u003e is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989533180133,"sku":"NP9780470511169","price":281.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470511169.jpg?v=1761784491","url":"https:\/\/k12savings.com\/products\/linker-strategies-in-solid-phase-organic-synthesis-isbn-9780470511169","provider":"K12savings","version":"1.0","type":"link"}