{"product_id":"ligand-receptor-energetics-isbn-9780471176268","title":"Ligand-Receptor Energetics","description":"A foundation for quantitative perspectives and a framework for interpreting experimental observations.\u003cbr\u003e \u003cbr\u003e Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena. This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and meanings of energetic quantities for ligand-receptor complexes.\u003cbr\u003e \u003cbr\u003e Ligand-Receptor Energetics is the only book on this topic that is both accessible to beginners and extremely useful for experienced investigators. It features numerous specific examples; tables of literature results; extensive, up-to-date thermodynamic data; graphical representations of ligand bonding concepts; and four helpful appendices. Topics covered include:\u003cbr\u003e * Affinities -from site, stoichiometric, and ghost-site perspectives\u003cbr\u003e * Facts and fantasies from graphical analyses\u003cbr\u003e * Numerical evaluation of stoichiometric binding constants\u003cbr\u003e * Affinity profiles\u003cbr\u003e * Thermodynamic perspectives\u003cbr\u003e * Forces of interaction\u003cbr\u003e * Molecular scenarios.\u003cbr\u003e \u003cbr\u003e This valuable supplementary text for students in all areas of the basic life sciences is also an excellent professional reference for researchers in biochemistry, molecular biology, physiology, biophysics, microbiology, neurobiology, immunology, pharmacology, endocrinology, and toxicology.Energetische Wechselbeziehungen zwischen Ligand und Rezeptor sind besonders bei der Wechselwirkung kleiner Moleküle mit größeren unter Bildung komplexer Makromoleküle von Bedeutung, welche eine essentielle Rolle in Chemie, Biochemie, Biophysik, Pharmakologie und vielen anderen Gebieten spielen. Hier werden die thermodynamischen Ansätze experimentell und theoretisch erläutert - mit vielen Illustrationen zur Erklärung der Ligand-Bindungskonzepte. Number of Liganded Molecules.\u003cbr\u003e \u003cbr\u003e Affinities: From a Site Perspective.\u003cbr\u003e \u003cbr\u003e Affinities: From a Stoichiometric Perspective.\u003cbr\u003e \u003cbr\u003e Affinities: From a Ghost-Site Perspective.\u003cbr\u003e \u003cbr\u003e Facts and Fantasies from Graphical Analyses.\u003cbr\u003e \u003cbr\u003e Numerical Evaluations of Stoichiometric Binding Constants.\u003cbr\u003e \u003cbr\u003e Affinity Profiles.\u003cbr\u003e \u003cbr\u003e Thermodynamic Perspectives.\u003cbr\u003e \u003cbr\u003e Forces of Interaction.\u003cbr\u003e \u003cbr\u003e Molecular Scenarios.\u003cbr\u003e \u003cbr\u003e Appendices.\u003cbr\u003e \u003cbr\u003e Index. IRVING M. KLOTZ, PhD, is Morrison Professor Emeritus in the Departments of Chemistry and of Biochemistry, Molecular Biology, and Cell Biology at Northwestern University. He has published books on thermodynamics and biochemical energetics, as well as many research papers on ligand-receptor interactions and the structure and function of proteins. A foundation for quantitative perspectives and a framework for interpreting experimental observations.\u003cbr\u003e \u003cbr\u003e Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena. This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and meanings of energetic quantities for ligand-receptor complexes.\u003cbr\u003e \u003cbr\u003e Ligand-Receptor Energetics is the only book on this topic that is both accessible to beginners and extremely useful for experienced investigators. It features numerous specific examples; tables of literature results; extensive, up-to-date thermodynamic data; graphical representations of ligand bonding concepts; and four helpful appendices. Topics covered include:\u003cbr\u003e * Affinities -from site, stoichiometric, and ghost-site perspectives\u003cbr\u003e * Facts and fantasies from graphical analyses\u003cbr\u003e * Numerical evaluation of stoichiometric binding constants\u003cbr\u003e * Affinity profiles\u003cbr\u003e * Thermodynamic perspectives\u003cbr\u003e * Forces of interaction\u003cbr\u003e * Molecular scenarios.\u003cbr\u003e \u003cbr\u003e This valuable supplementary text for students in all areas of the basic life sciences is also an excellent professional reference for researchers in biochemistry, molecular biology, physiology, biophysics, microbiology, neurobiology, immunology, pharmacology, endocrinology, and toxicology.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989529641189,"sku":"NP9780471176268","price":143.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471176268.jpg?v=1761784475","url":"https:\/\/k12savings.com\/products\/ligand-receptor-energetics-isbn-9780471176268","provider":"K12savings","version":"1.0","type":"link"}