{"product_id":"ligand-design-in-metal-chemistry-isbn-9781118839836","title":"Ligand Design in Metal Chemistry","description":"\u003cp\u003eThe design of ancillary ligands used to modify the structural and reactivity properties of metal complexes has evolved into a rapidly expanding sub-discipline in inorganic and organometallic chemistry. Ancillary ligand design has figured directly in the discovery of new bonding motifs and stoichiometric reactivity, as well as in the development of new catalytic protocols that have had widespread positive impact on chemical synthesis on benchtop and industrial scales.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eLigand Design in Metal Chemistry\u003c\/i\u003e presents a collection of cutting-edge contributions from leaders in the field of ligand design, encompassing a broad spectrum of ancillary ligand classes and reactivity applications. Topics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eKey concepts in ligand design\u003c\/li\u003e \u003cli\u003eRedox non-innocent ligands\u003c\/li\u003e \u003cli\u003eLigands for selective alkene metathesis\u003c\/li\u003e \u003cli\u003eLigands in cross-coupling\u003c\/li\u003e \u003cli\u003eLigand design in polymerization\u003c\/li\u003e \u003cli\u003eLigand design in modern lanthanide chemistry\u003c\/li\u003e \u003cli\u003eCooperative metal-ligand reactivity\u003c\/li\u003e \u003cli\u003eP,N Ligands for enantioselective hydrogenation\u003c\/li\u003e \u003cli\u003eSpiro-cyclic ligands in asymmetric catalysis\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThis book will be a valuable reference for academic researchers and industry practitioners working in the field of ligand design, as well as those who work in the many areas in which the impact of ancillary ligand design has proven significant, for example synthetic organic chemistry, catalysis, medicinal chemistry,  polymer science and materials chemistry.\u003c\/p\u003e \u003cp\u003eList of Contributors xii\u003c\/p\u003e \u003cp\u003eForeword by Stephen L. Buchwald xiv\u003c\/p\u003e \u003cp\u003eForeword by David Milstein xvi\u003c\/p\u003e \u003cp\u003e Preface xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Key Concepts in Ligand Design: An Introduction 1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRylan J. Lundgren and Mark Stradiotto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Covalent bond classification and elementary bonding concepts 2\u003c\/p\u003e \u003cp\u003e1.3 Reactive versus ancillary ligands 4\u003c\/p\u003e \u003cp\u003e1.4 Strong©\\ and weak©\\field ligands 4\u003c\/p\u003e \u003cp\u003e1.5 Trans effect 6\u003c\/p\u003e \u003cp\u003e1.6 Tolman electronic parameter 6\u003c\/p\u003e \u003cp\u003e1.7 Pearson acid base concept 8\u003c\/p\u003e \u003cp\u003e1.8 Multidenticity, ligand bite angle, and hemilability 8\u003c\/p\u003e \u003cp\u003e1.9 Quantifying ligand steric properties 10\u003c\/p\u003e \u003cp\u003e1.10 Cooperative and redox non©\\innocent ligands 12\u003c\/p\u003e \u003cp\u003e1.11 Conclusion 12\u003c\/p\u003e \u003cp\u003eReferences 13\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Catalyst Structure and Cis–Trans Selectivity in Ruthenium©\\based Olefin Metathesis 15\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBrendan L. Quigley and Robert H. Grubbs\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 15\u003c\/p\u003e \u003cp\u003e2.2 Metathesis reactions and mechanism 17\u003c\/p\u003e \u003cp\u003e2.2.1 Types of metathesis reactions 17\u003c\/p\u003e \u003cp\u003e2.2.2 Mechanism of Ru©\\catalyzed olefin metathesis 19\u003c\/p\u003e \u003cp\u003e2.2.3 Metallacycle geometry 19\u003c\/p\u003e \u003cp\u003e2.2.4 Influencing syn–anti preference of metallacycles 22\u003c\/p\u003e \u003cp\u003e2.3 Catalyst structure and E\/Z selectivity 24\u003c\/p\u003e \u003cp\u003e2.3.1 Trends in key catalysts 24\u003c\/p\u003e \u003cp\u003e2.3.2 Catalysts with unsymmetrical NHCs 26\u003c\/p\u003e \u003cp\u003e2.3.3 Catalysts with alternative NHC ligands 29\u003c\/p\u003e \u003cp\u003e2.3.4 Variation of the anionic ligands 31\u003c\/p\u003e \u003cp\u003e2.4 Z©\\selective Ru©\\based metathesis catalysts 33\u003c\/p\u003e \u003cp\u003e2.4.1 Thiophenolate©\\based Z©\\selective catalysts 33\u003c\/p\u003e \u003cp\u003e2.4.2 Dithiolate©\\based Z©\\selective catalysts 34\u003c\/p\u003e \u003cp\u003e2.5 Cyclometallated Z©\\selective metathesis catalysts 36\u003c\/p\u003e \u003cp\u003e2.5.1 Initial discovery 36\u003c\/p\u003e \u003cp\u003e2.5.2 Model for selectivity 37\u003c\/p\u003e \u003cp\u003e2.5.3 Variation of the anionic ligand 38\u003c\/p\u003e \u003cp\u003e2.5.4 Variation of the aryl group 40\u003c\/p\u003e \u003cp\u003e2.5.5 Variation of the cyclometallated NHC substituent 41\u003c\/p\u003e \u003cp\u003e2.5.6 Reactivity of cyclometallated Z©\\selective catalysts 42\u003c\/p\u003e \u003cp\u003e2.6 Conclusions and future outlook 42\u003c\/p\u003e \u003cp\u003eReferences 43\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Ligands for Iridium©\\catalyzed Asymmetric Hydrogenation of Challenging Substrates 46\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMarc©\\André Müller and Andreas Pfaltz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Asymmetric hydrogenation 46\u003c\/p\u003e \u003cp\u003e3.2 Iridium catalysts based on heterobidentate ligands 49\u003c\/p\u003e \u003cp\u003e3.3 Mechanistic studies and derivation of a model for the enantioselective step 57\u003c\/p\u003e \u003cp\u003e3.4 Conclusion 63\u003c\/p\u003e \u003cp\u003eReferences 64\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Spiro Ligands for Asymmetric Catalysis 66\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eShou©\\Fei Zhu and Qi©\\Lin Zhou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Development of chiral spiro ligands 66\u003c\/p\u003e \u003cp\u003e4.2 Asymmetric hydrogenation 73\u003c\/p\u003e \u003cp\u003e4.2.1 Rh©\\catalyzed hydrogenation of enamides 73\u003c\/p\u003e \u003cp\u003e4.2.2 Rh©\\ or Ir©\\catalyzed hydrogenation of enamines 73\u003c\/p\u003e \u003cp\u003e4.2.3 Ir©\\catalyzed hydrogenation of α,β©\\unsaturated carboxylic acids 75\u003c\/p\u003e \u003cp\u003e4.2.4 Ir©\\catalyzed hydrogenation of olefins directed by the carboxy group 78\u003c\/p\u003e \u003cp\u003e4.2.5 Ir©\\catalyzed hydrogenation of conjugate ketones 79\u003c\/p\u003e \u003cp\u003e4.2.6 Ir©\\catalyzed hydrogenation of ketones 80\u003c\/p\u003e \u003cp\u003e4.2.7 Ru©\\catalyzed hydrogenation of racemic 2©\\substituted aldehydes via dynamic kinetic resolution 81\u003c\/p\u003e \u003cp\u003e4.2.8 Ru©\\catalyzed hydrogenation of racemic 2©\\substituted ketones via DKR 82\u003c\/p\u003e \u003cp\u003e4.2.9 Ir©\\catalyzed hydrogenation of imines 84\u003c\/p\u003e \u003cp\u003e4.3 Carbon–carbon bond©\\forming reactions 85\u003c\/p\u003e \u003cp\u003e4.3.1 Ni©\\catalyzed hydrovinylation of olefins 85\u003c\/p\u003e \u003cp\u003e4.3.2 Rh©\\catalyzed hydroacylation 85\u003c\/p\u003e \u003cp\u003e4.3.3 Rh©\\catalyzed arylation of carbonyl compounds and imines 86\u003c\/p\u003e \u003cp\u003e4.3.4 Pd©\\catalyzed umpolung allylation reactions of aldehydes, ketones, and imines 87\u003c\/p\u003e \u003cp\u003e4.3.5 Ni©\\catalyzed three©\\component coupling reaction 87\u003c\/p\u003e \u003cp\u003e4.3.6 Au©\\catalyzed Mannich reactions of azlactones 89\u003c\/p\u003e \u003cp\u003e4.3.7 Rh©\\catalyzed hydrosilylation\/cyclization reaction 89\u003c\/p\u003e \u003cp\u003e4.3.8 Au©\\catalyzed [2 + 2] cycloaddition 90\u003c\/p\u003e \u003cp\u003e4.3.9 Au©\\catalyzed cyclopropanation 91\u003c\/p\u003e \u003cp\u003e4.3.10 Pd©\\catalyzed Heck reactions 91\u003c\/p\u003e \u003cp\u003e4.4 Carbon–heteroatom bond©\\forming reactions 91\u003c\/p\u003e \u003cp\u003e4.4.1 Cu©\\catalyzed N©¤H bond insertion reactions 91\u003c\/p\u003e \u003cp\u003e4.4.2 Cu©\\, Fe©\\, or Pd©\\catalzyed O©¤H insertion reactions 93\u003c\/p\u003e \u003cp\u003e4.4.3 Cu©\\catalyzed S©¤H, Si©¤H and B©¤H insertion reactions 95\u003c\/p\u003e \u003cp\u003e4.4.4 Pd©\\catalyzed allylic amination 95\u003c\/p\u003e \u003cp\u003e4.4.5 Pd©\\catalyzed allylic cyclization reactions with allenes 97\u003c\/p\u003e \u003cp\u003e4.4.6 Pd©\\catalyzed alkene carboamination reactions 98\u003c\/p\u003e \u003cp\u003e4.5 Conclusion 98\u003c\/p\u003e \u003cp\u003eReferences 98\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Application of Sterically Demanding Phosphine Ligands in Palladium©\\Catalyzed Cross©\\Coupling leading to C(sp2)©¤E Bond Formation (E = NH2 , OH, and F) 104\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMark Stradiotto and Rylan J. Lundgren\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 104\u003c\/p\u003e \u003cp\u003e5.1.1 General mechanistic overview and ancillary ligand design considerations 105\u003c\/p\u003e \u003cp\u003e5.1.2 Reactivity challenges 107\u003c\/p\u003e \u003cp\u003e5.2 Palladium©\\catalyzed selective monoarylation of ammonia 108\u003c\/p\u003e \u003cp\u003e5.2.1 Initial development 109\u003c\/p\u003e \u003cp\u003e5.2.2 Applications in heterocycle synthesis 110\u003c\/p\u003e \u003cp\u003e5.2.3 Application of Buchwald palladacycles and imidazole©\\derived monophosphines 112\u003c\/p\u003e \u003cp\u003e5.2.4 Heterobidentate κ2©\\P,N ligands: chemoselectivity and room temperature reactions 115\u003c\/p\u003e \u003cp\u003e5.2.5 Summary 117\u003c\/p\u003e \u003cp\u003e5.3 Palladium©\\catalyzed selective hydroxylation of (hetero)aryl halides 117\u003c\/p\u003e \u003cp\u003e5.3.1 Initial development 118\u003c\/p\u003e \u003cp\u003e5.3.2 Application of alternative ligand classes 120\u003c\/p\u003e \u003cp\u003e5.3.3 Summary 122\u003c\/p\u003e \u003cp\u003e5.4 Palladium©\\catalyzed nucleophilic fluorination of (hetero)aryl (pseudo)halides 123\u003c\/p\u003e \u003cp\u003e5.4.1 Development of palladium©\\catalyzed C(sp2)©¤F coupling employing (hetero)aryl triflates 124\u003c\/p\u003e \u003cp\u003e5.4.2 Discovery of biaryl monophosphine ancillary ligand modification 125\u003c\/p\u003e \u003cp\u003e5.4.3 Extending reactivity to (hetero)aryl bromides and iodides 127\u003c\/p\u003e \u003cp\u003e5.4.4 Summary 128\u003c\/p\u003e \u003cp\u003e5.5 Conclusions and outlook 129\u003c\/p\u003e \u003cp\u003eAcknowledgments 130\u003c\/p\u003e \u003cp\u003eReferences 131\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Pd©\\N©\\Heterocyclic Carbene Complexes in Cross©\\Coupling Applications 134\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJennifer Lyn Farmer, Matthew Pompeo, and Michael G. Organ\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 134\u003c\/p\u003e \u003cp\u003e6.2 N©\\heterocyclic carbenes as ligands for catalysis 135\u003c\/p\u003e \u003cp\u003e6.3 The relationship between N©\\heterocyclic carbene structure and reactivity 136\u003c\/p\u003e \u003cp\u003e6.3.1 Steric parameters of NHC ligands 136\u003c\/p\u003e \u003cp\u003e6.3.2 Electronic parameters of NHC ligands 138\u003c\/p\u003e \u003cp\u003e6.3.3 Tuning the electronic properties of NHC ligands 139\u003c\/p\u003e \u003cp\u003e6.4 Cross©\\coupling reactions leading to C©¤C bonds that proceed through transmetalation 140\u003c\/p\u003e \u003cp\u003e6.5 Kumada–Tamao–Corriu 141\u003c\/p\u003e \u003cp\u003e6.6 Suzuki–Miyaura 148\u003c\/p\u003e \u003cp\u003e6.6.1 The formation of tetra©\\ortho©\\substituted (hetero)biaryl compounds 149\u003c\/p\u003e \u003cp\u003e6.6.2 Enantioselective Suzuki–Miyaura coupling 153\u003c\/p\u003e \u003cp\u003e6.6.3 Formation of sp3©¤sp3 or sp2 ©¤sp3 bonds 156\u003c\/p\u003e \u003cp\u003e6.6.4 The formation of (poly)heteroaryl compounds 158\u003c\/p\u003e \u003cp\u003e6.7 Negishi coupling 163\u003c\/p\u003e \u003cp\u003e6.7.1 Mechanistic studies: investigating the role of additives and the nature of the active transmetalating species 166\u003c\/p\u003e \u003cp\u003e6.7.2 Selective cross©\\coupling of secondary organozinc reagents 168\u003c\/p\u003e \u003cp\u003e6.8 Conclusion 170\u003c\/p\u003e \u003cp\u003eReferences 171\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Redox Non©\\innocent Ligands: Reactivity and Catalysis 176\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBas de Bruin, Pauline Gualco, and Nanda D. Paul\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 176\u003c\/p\u003e \u003cp\u003e7.2 Strategy I. Redox non©\\innocent ligands used to modify the Lewis acid–base properties of the metal 179\u003c\/p\u003e \u003cp\u003e7.3 Strategy II. Redox non©\\innocent ligands as electron reservoirs 181\u003c\/p\u003e \u003cp\u003e7.4 Strategy III. Cooperative ligand©\\centered reactivity based on redox active ligands 192\u003c\/p\u003e \u003cp\u003e7.5 Strategy IV. Cooperative substrate©\\centered radical©\\type reactivity based on redox non©\\innocent substrates 195\u003c\/p\u003e \u003cp\u003e7.6 Conclusion 200\u003c\/p\u003e \u003cp\u003eReferences 201\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Ligands for Iron©\\based Homogeneous Catalysts for the Asymmetric Hydrogenation of Ketones and Imines 205\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDemyan E. Prokopchuk, Samantha A. M. Smith, and Robert H. Morris\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction: from ligands for ruthenium to ligands for iron 205\u003c\/p\u003e \u003cp\u003e8.1.1 Ligand design elements in precious metal homogeneous catalysts for asymmetric direct hydrogenation and asymmetric transfer hydrogenation 205\u003c\/p\u003e \u003cp\u003e8.1.2 Effective ligands for iron©\\catalyzed ketone and imine reduction 212\u003c\/p\u003e \u003cp\u003e8.1.3 Ligand design elements for iron catalysts 213\u003c\/p\u003e \u003cp\u003e8.2 First generation iron catalysts with symmetrical [6.5.6]©\\P©\\N©\\N©\\P ligands 216\u003c\/p\u003e \u003cp\u003e8.2.1 Synthetic routes to ADH and ATH iron catalysts 217\u003c\/p\u003e \u003cp\u003e8.2.2 Catalyst properties and mechanism of reaction 218\u003c\/p\u003e \u003cp\u003e8.3 Second generation iron catalysts with symmetrical [5.5.5]©\\P©\\N©\\N©\\P ligands 220\u003c\/p\u003e \u003cp\u003e8.3.1 Synthesis of second generation ATH catalysts 220\u003c\/p\u003e \u003cp\u003e8.3.2 Asymmetric transfer hydrogenation catalytic properties and mechanism 222\u003c\/p\u003e \u003cp\u003e8.3.3 Substrate scope 226\u003c\/p\u003e \u003cp\u003e8.4 Third generation iron catalysts with unsymmetrical [5.5.5]©\\P©\\NH©\\N©\\Pʹ ligands 227\u003c\/p\u003e \u003cp\u003e8.4.1 Synthesis of bis(tridentate)iron complexes and P©\\NH©\\NH2 ligands 227\u003c\/p\u003e \u003cp\u003e8.4.2 Template©\\assisted synthesis of iron P©\\NH©\\N©\\Pʹ complexes 228\u003c\/p\u003e \u003cp\u003e8.4.3 Selected catalytic properties 229\u003c\/p\u003e \u003cp\u003e8.4.4 Mechanism 230\u003c\/p\u003e \u003cp\u003e8.5 Conclusions 231\u003c\/p\u003e \u003cp\u003eAcknowledgments 232\u003c\/p\u003e \u003cp\u003eReferences 232\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Ambiphilic Ligands: Unusual Coordination and Reactivity Arising from Lewis Acid Moieties 237\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eGhenwa Bouhadir and Didier Bourissou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 237\u003c\/p\u003e \u003cp\u003e9.2 Design and structure of ambiphilic ligands 238\u003c\/p\u003e \u003cp\u003e9.3 Coordination of ambiphilic ligands 242\u003c\/p\u003e \u003cp\u003e9.3.1 Complexes featuring a pendant Lewis acid 242\u003c\/p\u003e \u003cp\u003e9.3.2 Bridging coordination involving M → Lewis acid interactions 243\u003c\/p\u003e \u003cp\u003e9.3.3 Bridging coordination of M©¤X bonds 248\u003c\/p\u003e \u003cp\u003e9.3.4 Ionization of M©¤X bonds 250\u003c\/p\u003e \u003cp\u003e9.4 Reactivity of metallic complexes deriving from ambiphilic ligands 251\u003c\/p\u003e \u003cp\u003e9.4.1 Lewis acid enhancement effect in Si©¤Si and C©¤C coupling reactions 251\u003c\/p\u003e \u003cp\u003e9.4.2 Hydrogenation, hydrogen transfer and hydrosilylation reactions assisted by boranes 255\u003c\/p\u003e \u003cp\u003e9.4.3 Activation\/functionalization of N2 and CO 262\u003c\/p\u003e \u003cp\u003e9.5 Conclusions and outlook 264\u003c\/p\u003e \u003cp\u003eReferences 266\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Ligand Design in Enantioselective Ring©\\opening Polymerization of Lactide 270\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKimberly M. Osten, Dinesh C. Aluthge, and Parisa Mehrkhodavandi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 270\u003c\/p\u003e \u003cp\u003e10.1.1 Tacticity in PLA 271\u003c\/p\u003e \u003cp\u003e10.1.2 Metal catalysts for the ROP of lactide 272\u003c\/p\u003e \u003cp\u003e10.1.3 Ligand design in the enantioselective polymerization of racemic lactide 274\u003c\/p\u003e \u003cp\u003e10.2 Indium and zinc complexes bearing chiral diaminophenolate ligands 292\u003c\/p\u003e \u003cp\u003e10.2.1 Zinc catalysts supported by chiral diaminophenolate ligands 292\u003c\/p\u003e \u003cp\u003e10.2.2 The first indium catalyst for lactide polymerization 294\u003c\/p\u003e \u003cp\u003e10.2.3 Polymerization of cyclic esters with first generation catalyst 295\u003c\/p\u003e \u003cp\u003e10.2.4 Ligand modifications 296\u003c\/p\u003e \u003cp\u003e10.3 Dinuclear indium complexes bearing chiral salen©\\type ligands 297\u003c\/p\u003e \u003cp\u003e10.3.1 Chiral indium salen complexes 297\u003c\/p\u003e \u003cp\u003e10.3.2 Polymerization studies 297\u003c\/p\u003e \u003cp\u003e10.4 Conclusions and future directions 301\u003c\/p\u003e \u003cp\u003eReferences 302\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Modern Applications of Trispyrazolylborate Ligands in Coinage Metal Catalysis 308\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAna Caballero, M. Mar Díaz©\\Requejo, Manuel R. Fructos, Juan Urbano, and Pedro J. Pérez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 308\u003c\/p\u003e \u003cp\u003e11.2 Trispyrazolylborate ligands: main features 310\u003c\/p\u003e \u003cp\u003e11.3 Catalytic Systems Based on TpXMl Complexes (M = Cu, Ag) 311\u003c\/p\u003e \u003cp\u003e11.3.1 Carbene addition reactions 312\u003c\/p\u003e \u003cp\u003e11.3.2 Carbene insertion reactions 314\u003c\/p\u003e \u003cp\u003e11.3.3 Nitrene addition reactions 319\u003c\/p\u003e \u003cp\u003e11.3.4 Nitrene insertion reactions 321\u003c\/p\u003e \u003cp\u003e11.3.5 Oxo transfer reactions 322\u003c\/p\u003e \u003cp\u003e11.3.6 Atom transfer radical reactions 324\u003c\/p\u003e \u003cp\u003e11.4 Conclusions 326\u003c\/p\u003e \u003cp\u003eAcknowledgments 326\u003c\/p\u003e \u003cp\u003eReferences 327\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Ligand Design in Modern Lanthanide Chemistry 330\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDavid P. Mills and Stephen T. Liddle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction and scope of the review 330\u003c\/p\u003e \u003cp\u003e12.2 C©\\donor ligands 333\u003c\/p\u003e \u003cp\u003e12.2.1 Silylalkyls 333\u003c\/p\u003e \u003cp\u003e12.2.2 Terphenyls 335\u003c\/p\u003e \u003cp\u003e12.2.3 Substituted cyclopentadienyls 336\u003c\/p\u003e \u003cp\u003e12.2.4 Constrained geometry cyclopentadienyls 338\u003c\/p\u003e \u003cp\u003e12.2.5 Benzene complexes 340\u003c\/p\u003e \u003cp\u003e12.2.6 Zerovalent arenes 342\u003c\/p\u003e \u003cp\u003e12.2.7 Tethered N©\\heterocyclic carbenes 343\u003c\/p\u003e \u003cp\u003e12.3 N©\\donor ligands 344\u003c\/p\u003e \u003cp\u003e12.3.1 Hexamethyldisilazide 344\u003c\/p\u003e \u003cp\u003e12.3.2 Substituted trispyrazolylborates 347\u003c\/p\u003e \u003cp\u003e12.3.3 Silyl©\\substituted triamidoamine, [N(CH2Ch2NSiMe2But)3]3– 348\u003c\/p\u003e \u003cp\u003e12.3.4 NacNac, {N(Dipp)C(Me)CHC(Me)N(Dipp)}− 349\u003c\/p\u003e \u003cp\u003e12.4 P©\\donor ligands 349\u003c\/p\u003e \u003cp\u003e12.4.1 Phospholides 349\u003c\/p\u003e \u003cp\u003e12.5 Multiple bonds 350\u003c\/p\u003e \u003cp\u003e12.5.1 Ln¨TCR2 350\u003cbr\u003e\u003cbr\u003e12.5.2 Ln ¨T NR 354\u003cbr\u003e\u003cbr\u003e12.5.3 Ln ¨T O 355\u003c\/p\u003e \u003cp\u003e12.6 Conclusions 356\u003c\/p\u003e \u003cp\u003eNotes 357\u003c\/p\u003e \u003cp\u003eReferences 357\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Tight Bite Angle N,O©\\Chelates. Amidates, Ureates and Beyond 364\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eScott A. Ryken, Philippa R. Payne, and Laurel L. Schafer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 364\u003cbr\u003e\u003cbr\u003e13.1.1 N,O©\\Proligands 366\u003cbr\u003e\u003cbr\u003e13.1.2 Preparing metal complexes 367\u003c\/p\u003e \u003cp\u003e13.2 Applications in reactivity and catalysis 377\u003cbr\u003e\u003cbr\u003e13.2.1 Polymerizations 377\u003cbr\u003e\u003cbr\u003e13.2.2 Hydrofunctionalization 385\u003c\/p\u003e \u003cp\u003e13.3 Conclusions 400\u003c\/p\u003e \u003cp\u003eReferences 401\u003cbr\u003e\u003cbr\u003eIndex 406\u003c\/p\u003e \"Catalysis underpins both modern industrial and academic chemistry, improving reaction sustainability, shaping reaction selectivity and facilitating fundamentally new reaction pathways. While the focus is often on the showpiece metals themselves, the ligands are the true shapers of this reactivity. Stradiotto and Lundgren have curated a collection that certainly celebrates ligands across a wide array of applications. At over 400 pages across 13 chapters written by world leaders in catalysis and ligand design, the book is a modern resource for those working in the area.  The book opens with a chapter detailing the underlying key concepts that feature throughout the rest of the book. This is likely the only chapter which would serve the undergraduate student – but as a stand-alone chapter would indeed provide a strong additional resource for final year students on a catalysis and\/or coordination chemistry course. From there, each chapter captures a specific vignette of relevance to the authors. The overall book is by no means comprehensive in coverage, but it neither intends to be or indeed should be. Instead, it permits the reader to learn about specific topics in the key authors voice, and from a unified perspective of the ligand design... The book, as a secondary impact, also helps to showcase the important contribution Canadian researchers have made to catalysis and ligand design, with 6 of the 13 chapters written by authors at Canadian universities.  In closing, the collection of articles found in Ligand Design in Metal Chemistry is certainly worthy of a book shelf spot for those working in the field of ligand design in catalysis. As the content of the book is necessarily focussed, this reviewer recommends a thorough read through the table of contents to ensure that chapters of particular interest are complemented by those that will introduce the reader to new areas.\" (AOC, Feb 2017) \u003cp\u003e\u003cb\u003eMark Stradiotto\u003c\/b\u003e, Department of Chemistry, Dalhousie University, Canada\u003cbr\u003e\u003cb\u003eRylan Lundgren\u003c\/b\u003e, Department of Chemistry, University of Alberta, Canada\u003cbr\u003e Both professors have a well-established track-record of working in the field of organometallic ligand design and catalysis, and have published extensively on the subjects of metal-catalyzed cross-coupling, novel transition-metal bond activation, and asymmetric catalysis. They are co-inventors of the now commercialized DalPhos ligand family and have broad experience of the  field of ligand design. Professor Stradiotto has worked in the field of organometallic chemistry for the past fourteen years. Professor Lundgren earned his PhD under the supervision of Prof Stradiotto at Dalhousie University in 2010. Following a PDF at MIT and Caltech with Prof. Greg Fu, Rylan accepted a faculty position at the University of Alberta (Canada).\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989529575653,"sku":"NP9781118839836","price":190.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118839836.jpg?v=1761784476","url":"https:\/\/k12savings.com\/products\/ligand-design-in-metal-chemistry-isbn-9781118839836","provider":"K12savings","version":"1.0","type":"link"}