{"product_id":"iron-metabolism-isbn-9781118925614","title":"Iron Metabolism","description":"\u003cp\u003eIron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems  a natural target for  pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is  associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health.\u003c\/p\u003e \u003cp\u003eThe 4th edition of \u003ci\u003eIron Metabolism \u003c\/i\u003eis written in a lively style by one of the leaders in the field, presented in colour  and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism\/homeostasis.\u003c\/p\u003e \u003cp\u003ePreface xii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Solution Chemistry of Iron 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Iron Chemistry 1\u003c\/p\u003e \u003cp\u003e1.2 Interactions of Iron with Dioxygen and Chemistry of Oxygen Free Radicals 2\u003c\/p\u003e \u003cp\u003e1.3 Hydrolysis of Iron Salts 5\u003c\/p\u003e \u003cp\u003e1.4 Formation and Characterisation of Ferrihydrite 7\u003c\/p\u003e \u003cp\u003e1.5 Ageing of Amorphous Ferrihydrite to more Crystalline Products 10\u003c\/p\u003e \u003cp\u003e1.6 Biomineralisation 11\u003c\/p\u003e \u003cp\u003e1.7 Magnetite Biomineralisation by Magnetotactic Bacteria 13\u003c\/p\u003e \u003cp\u003e1.7.1 Biogenesis of the Magnetosome Membrane 15\u003c\/p\u003e \u003cp\u003e1.7.2 Protein Sorting 15\u003c\/p\u003e \u003cp\u003e1.7.3 Chain Formation 16\u003c\/p\u003e \u003cp\u003e1.7.4 Biomineralisation 16\u003c\/p\u003e \u003cp\u003e1.7.5 A Model for Magnetosome Formation 17\u003c\/p\u003e \u003cp\u003eReferences 18\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 The Essential Role of Iron in Biology 22\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction: Iron an Essential Element in Biology 22\u003c\/p\u003e \u003cp\u003e2.2 Physical Techniques for the Study of Iron in Biological Systems 25\u003c\/p\u003e \u003cp\u003e2.3 Classes of Iron Proteins 29\u003c\/p\u003e \u003cp\u003e2.4 Haemoproteins 29\u003c\/p\u003e \u003cp\u003e2.4.1 Oxygen Carriers 30\u003c\/p\u003e \u003cp\u003e2.4.2 Activators of Molecular Oxygen 34\u003c\/p\u003e \u003cp\u003e2.4.3 Electron Transport Proteins 38\u003c\/p\u003e \u003cp\u003e2.5 Iron–Sulphur Proteins 41\u003c\/p\u003e \u003cp\u003e2.6 Non‐haem, Non‐Fe–S Proteins 48\u003c\/p\u003e \u003cp\u003e2.6.1 Mononuclear Non‐haem Iron Enzymes 48\u003c\/p\u003e \u003cp\u003e2.6.2 Dinuclear Non‐haem Iron Proteins 55\u003c\/p\u003e \u003cp\u003e2.6.3 Proteins of Iron Storage, Transport and Metabolism 61\u003c\/p\u003e \u003cp\u003e2.7 The Dark Side of Iron: ROS, RNS and NTBI 62\u003c\/p\u003e \u003cp\u003e2.7.1 ROS and RNS 63\u003c\/p\u003e \u003cp\u003e2.7.2 NTBI and LPI 64\u003c\/p\u003e \u003cp\u003eReferences 64\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Microbial Iron Uptake 71\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 71\u003c\/p\u003e \u003cp\u003e3.2 Iron Uptake from Siderophores 74\u003c\/p\u003e \u003cp\u003e3.2.1 Siderophores 74\u003c\/p\u003e \u003cp\u003e3.2.2 Iron Transport across the Outer Membrane in Gram‐negative Bacteria 78\u003c\/p\u003e \u003cp\u003e3.2.3 Transport across the Periplasm and Cytoplasmic Membrane in Gram‐negative Bacteria 86\u003c\/p\u003e \u003cp\u003e3.2.4 Iron Uptake by Gram‐positive Bacteria 92\u003c\/p\u003e \u003cp\u003e3.3 Fe\u003csup\u003e2+\u003c\/sup\u003e Transport Systems 93\u003c\/p\u003e \u003cp\u003e3.4 Iron Release from Siderophores in the Cytoplasm 97\u003c\/p\u003e \u003cp\u003e3.5 Intracellular Iron Metabolism 98\u003c\/p\u003e \u003cp\u003e3.6 Control of Gene Expression by Iron 101\u003c\/p\u003e \u003cp\u003eReferences 108\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Iron Acquisition by Pathogens 120\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 120\u003c\/p\u003e \u003cp\u003e4.2 Host Defence Mechanisms, Nutritional Immunity 121\u003c\/p\u003e \u003cp\u003e4.3 Pathogenicity and PAIs 123\u003c\/p\u003e \u003cp\u003e4.4 Pathogen‐specific Iron Uptake Systems 125\u003c\/p\u003e \u003cp\u003e4.4.1 Siderophores Associated with Virulence 125\u003c\/p\u003e \u003cp\u003e4.4.2 Transferrin\/lactoferrin Iron Uptake 126\u003c\/p\u003e \u003cp\u003e4.4.3 Haem Iron Uptake 133\u003c\/p\u003e \u003cp\u003e4.4.4 Ferrous Iron Uptake 138\u003c\/p\u003e \u003cp\u003e4.4.5 Ferric Citrate Uptake by Bacillus cereus 141\u003c\/p\u003e \u003cp\u003e4.5 Role of Fur and Fur Homologues in Virulence 141\u003c\/p\u003e \u003cp\u003e4.6 Role of Pathogen ECF Sigma Factors 141\u003c\/p\u003e \u003cp\u003e4.7 Fungal Pathogens 143\u003c\/p\u003e \u003cp\u003eReferences 146\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Iron Uptake by Plants and Fungi 155\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Iron Uptake by Plants 155\u003c\/p\u003e \u003cp\u003e5.1.1 Introduction 155\u003c\/p\u003e \u003cp\u003e5.1.2 Genome Sequencing 157\u003c\/p\u003e \u003cp\u003e5.1.3 Iron Acquisition by the Roots of Plants 160\u003c\/p\u003e \u003cp\u003e5.1.4 Long‐distance Iron Transport 166\u003c\/p\u003e \u003cp\u003e5.2 Iron Metabolism and Homeostasis in Plants 169\u003c\/p\u003e \u003cp\u003e5.2.1 New Tools in Plant Research 169\u003c\/p\u003e \u003cp\u003e5.2.2 Intracellular Iron Metabolism 170\u003c\/p\u003e \u003cp\u003e5.2.3 Plant Iron Homeostasis 171\u003c\/p\u003e \u003cp\u003e5.2.4 Diurnal Regulation of Iron Homeostasis 176\u003c\/p\u003e \u003cp\u003e5.3 Iron Uptake, Metabolism and Homeostasis in Fungi 178\u003c\/p\u003e \u003cp\u003e5.3.1 Introduction 178\u003c\/p\u003e \u003cp\u003e5.3.2 High‐ and Low‐affinity Iron Uptake Pathways 179\u003c\/p\u003e \u003cp\u003e5.3.3 Siderophore‐mediated Iron Uptake 184\u003c\/p\u003e \u003cp\u003e5.3.4 Intracellular Iron Metabolism 185\u003c\/p\u003e \u003cp\u003e5.3.5 Iron Homeostasis 186\u003c\/p\u003e \u003cp\u003eReferences 190\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Cellular Iron Uptake and Export in Mammals 205\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 The Transferrins 205\u003c\/p\u003e \u003cp\u003e6.1.1 Introduction 205\u003c\/p\u003e \u003cp\u003e6.1.2 The Transferrin Family 206\u003c\/p\u003e \u003cp\u003e6.1.3 Structure of Transferrins 211\u003c\/p\u003e \u003cp\u003e6.1.4 Transferrin iron Binding 215\u003c\/p\u003e \u003cp\u003e6.1.5 Binding of other Metals by Transferrin 218\u003c\/p\u003e \u003cp\u003e6.2 Cellular Iron Uptake 219\u003c\/p\u003e \u003cp\u003e6.2.1 The Transferrin Receptors 219\u003c\/p\u003e \u003cp\u003e6.2.2 The Transferrin to Cell Cycle and Iron Release 222\u003c\/p\u003e \u003cp\u003e6.2.3 Iron Uptake from other Sources 228\u003c\/p\u003e \u003cp\u003e6.3 Cellular Iron Export 230\u003c\/p\u003e \u003cp\u003eReferences 236\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Mammalian Iron Metabolism and Dietary Iron Absorption 247\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 An overview of Mammalian Iron Metabolism 247\u003c\/p\u003e \u003cp\u003e7.1.1 Introduction 247\u003c\/p\u003e \u003cp\u003e7.1.2 The Way Different Cells Handle Iron 249\u003c\/p\u003e \u003cp\u003e7.2 Mammalian Iron Absorption 251\u003c\/p\u003e \u003cp\u003e7.2.1 Introduction 251\u003c\/p\u003e \u003cp\u003e7.2.2 The Intestinal Mucosa 252\u003c\/p\u003e \u003cp\u003e7.2.3 Sources of Dietary Iron 253\u003c\/p\u003e \u003cp\u003e7.2.4 Iron Loss and Effects on Uptake 255\u003c\/p\u003e \u003cp\u003e7.3 Molecular Mechanisms of Mucosal Iron Absorption 256\u003c\/p\u003e \u003cp\u003e7.3.1 Iron Uptake at the Apical Pole 256\u003c\/p\u003e \u003cp\u003e7.3.2 Iron Transit through and Storage in Enterocytes 259\u003c\/p\u003e \u003cp\u003e7.3.3 Iron Efflux across the Basolateral Membrane 259\u003c\/p\u003e \u003cp\u003e7.3.4 Regulation of Iron Uptake by the Enterocyte 261\u003c\/p\u003e \u003cp\u003eReferences 261\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Intracellular Iron Utilisation 265\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Intracellular Iron Pools 265\u003c\/p\u003e \u003cp\u003e8.1.1 Introduction 265\u003c\/p\u003e \u003cp\u003e8.1.2 The Cytosolic Labile Iron Pool (LIP) 266\u003c\/p\u003e \u003cp\u003e8.1.3 Distribution of Iron in the Cytosol 268\u003c\/p\u003e \u003cp\u003e8.1.4 Other Intracellular Iron Pools 269\u003c\/p\u003e \u003cp\u003e8.2 Mitochondrial Iron Metabolism 271\u003c\/p\u003e \u003cp\u003e8.2.1 Mitochondrial Iron Uptake and Storage 271\u003c\/p\u003e \u003cp\u003e8.2.2 Mitochondrial Fe–S Protein Biogenesis 271\u003c\/p\u003e \u003cp\u003e8.2.3 Maturation of Cytosolic and Nuclear Fe–S Proteins 275\u003c\/p\u003e \u003cp\u003e8.2.4 Haem Biosynthesis 283\u003c\/p\u003e \u003cp\u003e8.3 Haem Oxygenase 287\u003c\/p\u003e \u003cp\u003e8.3.1 Structure and Catalytic Cycle 287\u003c\/p\u003e \u003cp\u003e8.3.2 Activation of Haem Oxygenase 1 (HO‐1) 292\u003c\/p\u003e \u003cp\u003eReferences 292\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Iron Storage Proteins 300\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 300\u003c\/p\u003e \u003cp\u003e9.2 The Ferritin Superfamily and Haemosiderins 301\u003c\/p\u003e \u003cp\u003e9.2.1 The Ferritin Superfamily 301\u003c\/p\u003e \u003cp\u003e9.2.2 Structure of Vertebrate and Invertebrate Ferritins 304\u003c\/p\u003e \u003cp\u003e9.2.3 Plant and Bacterial Ferritins 308\u003c\/p\u003e \u003cp\u003e9.2.4 Dps Proteins and Rubrerythrins 313\u003c\/p\u003e \u003cp\u003e9.2.5 The Mineral Core 319\u003c\/p\u003e \u003cp\u003e9.2.6 Haemosiderins 319\u003c\/p\u003e \u003cp\u003e9.3 Iron Uptake and Release from Ferritin 320\u003c\/p\u003e \u003cp\u003e9.3.1 Iron Uptake in Ferritins 320\u003c\/p\u003e \u003cp\u003e9.3.2 Iron Uptake in Dps Proteins 333\u003c\/p\u003e \u003cp\u003e9.3.3 Iron Release from Ferritin 333\u003c\/p\u003e \u003cp\u003e9.4 Biotechnological Applications of Ferritins 335\u003c\/p\u003e \u003cp\u003eReferences 336\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Cellular and Systemic Iron Homeostasis 346\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Cellular Iron Homeostasis 346\u003c\/p\u003e \u003cp\u003e10.1.1 Translational Control of Protein Synthesis 346\u003c\/p\u003e \u003cp\u003e10.1.2 The IRE\/IRP System 347\u003c\/p\u003e \u003cp\u003e10.1.3 The IREs – distribution and Structure 348\u003c\/p\u003e \u003cp\u003e10.1.4 Structural Features of IRP1 and 2 351\u003c\/p\u003e \u003cp\u003e10.1.5 The IRE\/IRP System Revisited – Iron Controls Iron 353\u003c\/p\u003e \u003cp\u003e10.1.6 Metabolic Consequences of Mutations in IREs 357\u003c\/p\u003e \u003cp\u003e10.2 Systemic Iron Homeostasis 357\u003c\/p\u003e \u003cp\u003e10.2.1 Introduction 357\u003c\/p\u003e \u003cp\u003e10.2.2 Hepcidin, the Key Player 358\u003c\/p\u003e \u003cp\u003e10.2.3 Factors which Regulate Hepcidin Synthesis 360\u003c\/p\u003e \u003cp\u003e10.3 Integration of Iron Homeostatic Systems 367\u003c\/p\u003e \u003cp\u003eReferences 367\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Iron Deficiency, Iron Overload and Therapy 376\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Iron‐deficiency Anaemia (IDA) 376\u003c\/p\u003e \u003cp\u003e11.1.1 Introduction – The Size of the Problem 376\u003c\/p\u003e \u003cp\u003e11.1.2 Causes of IDA 378\u003c\/p\u003e \u003cp\u003e11.1.3 Clinical Stages and Diagnosis of IDA 380\u003c\/p\u003e \u003cp\u003e11.1.4 Therapeutic Approaches 383\u003c\/p\u003e \u003cp\u003e11.1.5 Anaemia of Chronic Disease (ACD), Iron Refractory IDA (IRIDA) and Anaemia of Chronic Kidney Disease (CKD) 384\u003c\/p\u003e \u003cp\u003e11.2 Hereditary Iron Overload 386\u003c\/p\u003e \u003cp\u003e11.2.1 Introduction 386\u003c\/p\u003e \u003cp\u003e11.2.2 Hereditary Haemochromatosis (HH) 386\u003c\/p\u003e \u003cp\u003e11.2.3 Causes of HH 387\u003c\/p\u003e \u003cp\u003e11.2.4 Types of Haemochromatosis 388\u003c\/p\u003e \u003cp\u003e11.2.5 Therapy of Hereditary Haemochromatosis 391\u003c\/p\u003e \u003cp\u003e11.3 Acquired Iron Overload 395\u003c\/p\u003e \u003cp\u003e11.3.1 Introduction – Causes of Acquired Iron Overload 395\u003c\/p\u003e \u003cp\u003e11.3.2 Mechanisms of Iron Toxicity 397\u003c\/p\u003e \u003cp\u003e11.3.3 Evaluation of Iron Overload 398\u003c\/p\u003e \u003cp\u003e11.3.4 Chelation Therapy for Acquired Iron Overload 400\u003c\/p\u003e \u003cp\u003e11.3.5 Other Therapeutic Approaches 405\u003c\/p\u003e \u003cp\u003eReferences 406\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Iron and Immunity 418\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 418\u003c\/p\u003e \u003cp\u003e12.1.1 Innate Immunity 419\u003c\/p\u003e \u003cp\u003e12.2 The Key Role of Macrophages 422\u003c\/p\u003e \u003cp\u003e12.2.1 Overview 422\u003c\/p\u003e \u003cp\u003e12.2.2 Macrophage Phenotypes 425\u003c\/p\u003e \u003cp\u003e12.2.3 Microglia 426\u003c\/p\u003e \u003cp\u003e12.3 Effect of Iron Status on Phagocytic Cell Function 429\u003c\/p\u003e \u003cp\u003e12.3.1 Iron Deficiency 429\u003c\/p\u003e \u003cp\u003e12.3.2 Iron Overload 430\u003c\/p\u003e \u003cp\u003e12.4 Effect of Phagocytic Cell Function on Iron Metabolism 431\u003c\/p\u003e \u003cp\u003e12.4.1 The IRE–Iron Regulatory Protein (IRP) System 431\u003c\/p\u003e \u003cp\u003e12.5 Effector Molecules of the Innate Immune System 433\u003c\/p\u003e \u003cp\u003e12.5.1 Toll‐like Receptors 433\u003c\/p\u003e \u003cp\u003e12.5.2 NF‐κB 433\u003c\/p\u003e \u003cp\u003e12.5.3 Hypoxia‐Inducible Factor 1 (HIF 1) 434\u003c\/p\u003e \u003cp\u003e12.5.4 Haem Oxygenase 435\u003c\/p\u003e \u003cp\u003e12.5.5 DMT1, Nramp1 437\u003c\/p\u003e \u003cp\u003e12.6 Adaptive Immunity 437\u003c\/p\u003e \u003cp\u003e12.6.1 Cd8\u003csup\u003e+\u003c\/sup\u003e Lymphocytes and Cytotoxicity 438\u003c\/p\u003e \u003cp\u003e12.6.2 CD4\u003csup\u003e+\u003c\/sup\u003e lymphocytes 438\u003c\/p\u003e \u003cp\u003e12.7 Immune Function and other Factors 438\u003c\/p\u003e \u003cp\u003e12.7.1 Iron Supplementation and Immune Function 438\u003c\/p\u003e \u003cp\u003e12.7.2 Immune Function in the Elderly Population 439\u003c\/p\u003e \u003cp\u003e12.7.3 Iron Overload and Immune Function 439\u003c\/p\u003e \u003cp\u003e12.7.4 Thalassaemia 440\u003c\/p\u003e \u003cp\u003e12.8 Concluding Remarks 440\u003c\/p\u003e \u003cp\u003eReferences 440\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Iron and Oxidative Stress 444\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Oxidative stress 444\u003c\/p\u003e \u003cp\u003e13.1.1 Introduction – Milestones in the History of Life 444\u003c\/p\u003e \u003cp\u003e13.1.2 Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) 447\u003c\/p\u003e \u003cp\u003e13.1.3 Cellular Defence Mechanisms Against Oxidative Stress 450\u003c\/p\u003e \u003cp\u003e13.1.4 Role of ROS and RNS in Cell Signalling 460\u003c\/p\u003e \u003cp\u003e13.1.5 ROS, RNS and Oxidative Damage 466\u003c\/p\u003e \u003cp\u003eReferences 476\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Interactions between Iron and other Metals 482\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 482\u003c\/p\u003e \u003cp\u003e14.2 Iron Interactions with Essential Metals 483\u003c\/p\u003e \u003cp\u003e14.2.1 Copper 483\u003c\/p\u003e \u003cp\u003e14.2.2 Zinc 494\u003c\/p\u003e \u003cp\u003e14.2.3 Cobalt 497\u003c\/p\u003e \u003cp\u003e14.2.4 Manganese 500\u003c\/p\u003e \u003cp\u003e14.2.5 Calcium 501\u003c\/p\u003e \u003cp\u003e14.3 Iron Interactions with Toxic Metals 502\u003c\/p\u003e \u003cp\u003e14.3.1 Lead 502\u003c\/p\u003e \u003cp\u003e14.3.2 Cadmium 503\u003c\/p\u003e \u003cp\u003e14.3.3 Aluminium 505\u003c\/p\u003e \u003cp\u003eReferences 507\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Iron Homeostasis and Neurodegeneration 516\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 516\u003c\/p\u003e \u003cp\u003e15.2 Brain iron 517\u003c\/p\u003e \u003cp\u003e15.2.1 Brain Iron Homeostasis 517\u003c\/p\u003e \u003cp\u003e15.2.2 Aging and Brain Iron Content 518\u003c\/p\u003e \u003cp\u003e15.3 Iron and Neurodegeneration 522\u003c\/p\u003e \u003cp\u003e15.3.1 Introduction 522\u003c\/p\u003e \u003cp\u003e15.3.2 Adverse Effects of Iron in Neurodegeneration 522\u003c\/p\u003e \u003cp\u003e15.4 Neurodegeneration with Brain Iron Accumulation 524\u003c\/p\u003e \u003cp\u003e15.4.1 Aceruloplasminaemia 524\u003c\/p\u003e \u003cp\u003e15.4.2 Neuroferritinopathy 526\u003c\/p\u003e \u003cp\u003e15.4.3 Other NBIAs 528\u003c\/p\u003e \u003cp\u003e15.5 Other Monogenic Neurodegenerative Diseases 530\u003c\/p\u003e \u003cp\u003e15.5.1 Huntington’s Disease 530\u003c\/p\u003e \u003cp\u003e15.5.2 Friedreich’s Ataxia 532\u003c\/p\u003e \u003cp\u003e15.6 Neurodegeneration Involving Multiple Genes 533\u003c\/p\u003e \u003cp\u003e15.6.1 Parkinson’s Disease (PD) 533\u003c\/p\u003e \u003cp\u003e15.6.2 Alzheimer’s Disease (AD) 535\u003c\/p\u003e \u003cp\u003e15.6.3 Multiple Sclerosis (MS) 537\u003c\/p\u003e \u003cp\u003e15.7 Intracerebral Haemorrhage 538\u003c\/p\u003e \u003cp\u003eReferences 539\u003c\/p\u003e \u003cp\u003eConcluding Remarks 544\u003c\/p\u003e \u003cp\u003eIndex 547\u003c\/p\u003e 'This textbook is clearly a milestone which should be to hand for every researcher and scholar working on or interested in the biochemistry and clinical aspects of iron. Those needing to go further in depth on some specific aspects will find not only an excellent starting point but also their pathway through the impressive list of references at the end of each chapter.' \u003cb\u003eActa Cryst (International Union of Crystallography), November 2017\u003c\/b\u003e  \u003cstrong\u003eProfessor Robert Crichton, Department of Biochemistry, Université Catholique de Louvain, Belgium\u003c\/strong\u003e\u003cbr\u003eProfessor Crichton has worked on cytochrome c in Glasgow, insect haemoglobins in Munich, ferritins and transferrins in Glasgow and Berlin, and on all these areas plus new developments in the understanding of iron-protein interactions in Louvain-la-Neuve. He is the author of \u003cem\u003eMetal-Based Neurodegeneration\u003c\/em\u003e.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989478850789,"sku":"NP9781118925614","price":213.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118925614.jpg?v=1761784265","url":"https:\/\/k12savings.com\/products\/iron-metabolism-isbn-9781118925614","provider":"K12savings","version":"1.0","type":"link"}