{"product_id":"iron-in-clinical-practice-isbn-9781394210886","title":"Iron in Clinical Practice","description":"\u003cp\u003e\u003cb\u003eLearn the tools for addressing a widespread public health issue with this practical guide\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eIron deficiency and iron overload are among the most common health conditions encountered in the course of clinical practice, with the potential to produce a range of morbidities and increase overall mortality. However, these conditions are often under-recognized, resulting in unnecessary disease and loss of well-being. There is an urgent need to raise awareness among clinicians of the causes, effects and management of iron imbalance. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eIron in Clinical Practice\u003c\/i\u003e meets this need with a brisk, practical guide to recognizing and treating both iron deficiency and iron overload in clinical settings. Edited by two Oxford haematologists and leading specialists in iron management, it covers major areas of medicine and surgery impacted by these disorders. The result is an essential resource for both beginning and experienced clinicians. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eIron in Clinical Practice\u003c\/i\u003e readers will find: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eIntroductory chapters outlining the role of iron in the body, its utilization and mechanisms of trafficking and distribution, and how these are impacted by disease.\u003c\/li\u003e\n\u003cli\u003eCoverage of a range of clinical settings across medicine, surgery and primary care.\u003c\/li\u003e\n\u003cli\u003eIllustrations, tables, and graphs throughout.\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eIron in Clinical Practice\u003c\/i\u003e is ideal for all health care practitioners of any specialty. \u003c\/p\u003e\u003cp\u003eList of Contributors xiii\u003c\/p\u003e \u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Introduction to Iron 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 An Introduction to Iron in the Body 3\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSue Pavord and Noemi Roy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 3\u003c\/p\u003e \u003cp\u003eIron in the Body 3\u003c\/p\u003e \u003cp\u003eEssential Functions of Iron in the Body 6\u003c\/p\u003e \u003cp\u003eIron Deficiency 6\u003c\/p\u003e \u003cp\u003eIron Overload 6\u003c\/p\u003e \u003cp\u003eBibliography 9\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Regulation of Iron Trafficking in the Body 11\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMegan Teh and Hal Drakesmith\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 11\u003c\/p\u003e \u003cp\u003eHepcidin and Systemic Iron Homeostasis 11\u003c\/p\u003e \u003cp\u003eRegulation of Hepcidin 12\u003c\/p\u003e \u003cp\u003eSensing Iron Concentrations 12\u003c\/p\u003e \u003cp\u003eErythropoietic Demand 14\u003c\/p\u003e \u003cp\u003eInflammation 14\u003c\/p\u003e \u003cp\u003eCellular Iron Homeostasis: Ferritin and Transferrin Receptor 14\u003c\/p\u003e \u003cp\u003eAssessing Iron Status – How the Markers Used Relate to Underlying Biology 15\u003c\/p\u003e \u003cp\u003eBibliography 16\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Iron and Immunity 17\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eFabiana Busti and Domenico Girelli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 17\u003c\/p\u003e \u003cp\u003eThe Battle for Iron and the Concept of ‘Nutritional Immunity’ 17\u003c\/p\u003e \u003cp\u003eTherapeutic Interventions Harnessing Nutritional Immunity 18\u003c\/p\u003e \u003cp\u003eIron Status and Susceptibility to Infections 19\u003c\/p\u003e \u003cp\u003eIron Deficiency and Health of Populations 19\u003c\/p\u003e \u003cp\u003eIron Overload and Risk of Infection 20\u003c\/p\u003e \u003cp\u003eIron Status and Response to Vaccines 20\u003c\/p\u003e \u003cp\u003eBibliography 22\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Iron Deficiency 23\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2a Assessment and Management of Iron Deficiency 25\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Impact of Iron Deficiency on the Individual 27\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePatrick Kyei-Mensah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 27\u003c\/p\u003e \u003cp\u003eSymptoms and Signs of Iron Deficiency 28\u003c\/p\u003e \u003cp\u003eImpact of Iron Deficiency on Specific At-risk Groups 28\u003c\/p\u003e \u003cp\u003ePregnancy, Parturition and Lactation 30\u003c\/p\u003e \u003cp\u003ePaediatric Population 30\u003c\/p\u003e \u003cp\u003eNon-pregnant Premenopausal Women 31\u003c\/p\u003e \u003cp\u003eIndividuals from Resource-poor Settings 31\u003c\/p\u003e \u003cp\u003eOther Clinical Situations Associated with Iron Deficiency 31\u003c\/p\u003e \u003cp\u003eGastrointestinal Bleeding 31\u003c\/p\u003e \u003cp\u003eHeart Failure 31\u003c\/p\u003e \u003cp\u003eChronic Obstructive Airway Disease 32\u003c\/p\u003e \u003cp\u003eRenal Disease 32\u003c\/p\u003e \u003cp\u003eConclusion 32\u003c\/p\u003e \u003cp\u003eBibliography 32\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Assessment of Iron Deficiency 33\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHanke L. Matlung and Dorine W. Swinkels\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 33\u003c\/p\u003e \u003cp\u003eDefinitions 33\u003c\/p\u003e \u003cp\u003eFerritin Thresholds 33\u003c\/p\u003e \u003cp\u003eInflammation and Liver Disease 36\u003c\/p\u003e \u003cp\u003eAdditional Biomarkers 36\u003c\/p\u003e \u003cp\u003eRed Cell Indices 36\u003c\/p\u003e \u003cp\u003eHepcidin Levels 37\u003c\/p\u003e \u003cp\u003eConclusion 38\u003c\/p\u003e \u003cp\u003eBibliography 38\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Available Treatments for Iron Deficiency 39\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePaolo Polzella\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 39\u003c\/p\u003e \u003cp\u003eOral Iron Supplementation 39\u003c\/p\u003e \u003cp\u003eAdministration of Oral Iron 39\u003c\/p\u003e \u003cp\u003eIntravenous Iron Therapy 40\u003c\/p\u003e \u003cp\u003ePotential Adverse Effects of Intravenous Iron 41\u003c\/p\u003e \u003cp\u003eIndividualising Treatment 42\u003c\/p\u003e \u003cp\u003eBibliography 43\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2b Causes, Impact, Management and Prevention of Iron Deficiency in Clinical Specialties 45\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Iron Deficiency in Primary Care 47\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDavid McCartney\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 47\u003c\/p\u003e \u003cp\u003ePresentation of Iron Deficiency in Primary Care 47\u003c\/p\u003e \u003cp\u003eThe Main Causes of Iron Deficiency in Primary Care 48\u003c\/p\u003e \u003cp\u003ePre-menopausal Women 48\u003c\/p\u003e \u003cp\u003ePost-menopausal Women and Men 49\u003c\/p\u003e \u003cp\u003eOlder Adults 49\u003c\/p\u003e \u003cp\u003eThe Diagnosis of Iron Deficiency in Primary Care 49\u003c\/p\u003e \u003cp\u003eHaemoglobin 49\u003c\/p\u003e \u003cp\u003eIron Studies 49\u003c\/p\u003e \u003cp\u003eFurther Investigations 50\u003c\/p\u003e \u003cp\u003eTreatment of Iron Deficiency in Primary Care 50\u003c\/p\u003e \u003cp\u003eDietary Advice and Prevention of Future Iron Deficiency 51\u003c\/p\u003e \u003cp\u003eBibliography 51\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Iron Deficiency in the Preoperative Patient 53\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eCaroline R. Evans\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 53\u003c\/p\u003e \u003cp\u003eHaemoglobin Thresholds 53\u003c\/p\u003e \u003cp\u003eCauses of Iron Deficiency in the Surgical Setting 54\u003c\/p\u003e \u003cp\u003eLaboratory Tests 54\u003c\/p\u003e \u003cp\u003eManagement of Preoperative Iron Deficiency 55\u003c\/p\u003e \u003cp\u003eIron Treatment 55\u003c\/p\u003e \u003cp\u003ePostoperative Management 56\u003c\/p\u003e \u003cp\u003eConclusion 56\u003c\/p\u003e \u003cp\u003eBibliography 56\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Iron Deficiency in Gastroenterology 57\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMohmmed Tauseef Sharip and Nurulamin M. Noor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 57\u003c\/p\u003e \u003cp\u003eGastrointestinal Causes of Iron Deficiency 57\u003c\/p\u003e \u003cp\u003eAssessment of Iron Deficiency in Patients with Gastrointestinal Disease 59\u003c\/p\u003e \u003cp\u003eSpecific Gastrointestinal Investigations 59\u003c\/p\u003e \u003cp\u003eAngiodysplasia 62\u003c\/p\u003e \u003cp\u003eTreatment of Iron Deficiency in Patients with Gastrointestinal Disease 62\u003c\/p\u003e \u003cp\u003eBibliography 64\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Iron Deficiency in Renal Medicine 65\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePhilip A. Kalra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 65\u003c\/p\u003e \u003cp\u003eTypes of Iron Used in Nephrology and Safety Considerations 65\u003c\/p\u003e \u003cp\u003eIron Use in Haemodialysis Patients 66\u003c\/p\u003e \u003cp\u003eIron Use in Non-Dialysis-Dependent Chronic Kidney Disease 68\u003c\/p\u003e \u003cp\u003eIron Use in Peritoneal Dialysis 68\u003c\/p\u003e \u003cp\u003eBibliography 69\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Iron Deficiency in Cardiology 71\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSamira Lakhal-Littleton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 71\u003c\/p\u003e \u003cp\u003eCauses of Iron Deficiency in Heart Failure 71\u003c\/p\u003e \u003cp\u003eImpact of Iron Deficiency in Heart Failure 72\u003c\/p\u003e \u003cp\u003eManagement of Iron Deficiency in Heart Failure 72\u003c\/p\u003e \u003cp\u003eDiagnostic and Management Uncertainties in Individuals with Cardiac Disease 73\u003c\/p\u003e \u003cp\u003eCurrent Definitions of Iron Deficiency 73\u003c\/p\u003e \u003cp\u003eCurrent Iron Replacement Therapies 74\u003c\/p\u003e \u003cp\u003eBibliography 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Iron Deficiency in Neurology 77\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eCarmen Jacob and Ian Galea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 77\u003c\/p\u003e \u003cp\u003eIron Utilisation in the Central Nervous System 77\u003c\/p\u003e \u003cp\u003eIron and Neurocognitive Development 79\u003c\/p\u003e \u003cp\u003eNeurological Associations in Iron Deficiency 79\u003c\/p\u003e \u003cp\u003eRecommendations for Management of Iron Deficiency with Neurological Symptoms 80\u003c\/p\u003e \u003cp\u003eConclusion 80\u003c\/p\u003e \u003cp\u003eBibliography 80\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Iron Deficiency in Obstetrics 83\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSue Pavord\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 83\u003c\/p\u003e \u003cp\u003eThe Maternal Effects of Iron Deficiency 83\u003c\/p\u003e \u003cp\u003eFetal Effects of Iron Deficiency 85\u003c\/p\u003e \u003cp\u003eDefining Anaemia in Pregnancy 85\u003c\/p\u003e \u003cp\u003eHow Is Iron Deficiency Diagnosed in Pregnancy? 86\u003c\/p\u003e \u003cp\u003eIndications for Intravenous Iron 86\u003c\/p\u003e \u003cp\u003eManagement of Postpartum Anaemia 87\u003c\/p\u003e \u003cp\u003eBibliography 87\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Iron Deficiency in Gynaecology 89\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eImo J. Akpan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 89\u003c\/p\u003e \u003cp\u003eCauses of Heavy Menstrual Bleeding 89\u003c\/p\u003e \u003cp\u003eDefinition of Heavy Menstrual Bleeding 89\u003c\/p\u003e \u003cp\u003ePrevention of Iron Deficiency in Gynaecology 89\u003c\/p\u003e \u003cp\u003eInvestigation of Heavy Menstrual Bleeding 90\u003c\/p\u003e \u003cp\u003eManagement of Heavy Menstrual Bleeding 91\u003c\/p\u003e \u003cp\u003eHormonal Preparations 91\u003c\/p\u003e \u003cp\u003eAnticoagulation Modification 91\u003c\/p\u003e \u003cp\u003eHaemostatic Agents 92\u003c\/p\u003e \u003cp\u003eSurgical Management 92\u003c\/p\u003e \u003cp\u003eIron Deficiency and Iron Deficiency Anaemia in Gynaecology 92\u003c\/p\u003e \u003cp\u003eImpact of Iron Deficiency in Gynaecology 92\u003c\/p\u003e \u003cp\u003eManagement of Iron Deficiency in Women with Gynaecological Bleeding 94\u003c\/p\u003e \u003cp\u003eOral Iron Supplementation 94\u003c\/p\u003e \u003cp\u003eParenteral Iron Supplementation 95\u003c\/p\u003e \u003cp\u003eBlood Transfusion 95\u003c\/p\u003e \u003cp\u003eBibliography 95\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Iron Deficiency in Orthopaedics 97\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAntony Palmer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 97\u003c\/p\u003e \u003cp\u003eDiagnosis 97\u003c\/p\u003e \u003cp\u003eAetiology of Iron Deficiency 98\u003c\/p\u003e \u003cp\u003ePreoperative Treatment of Iron Deficiency Anaemia 98\u003c\/p\u003e \u003cp\u003ePatient Outcomes 98\u003c\/p\u003e \u003cp\u003eIron Deficiency Without Anaemia 100\u003c\/p\u003e \u003cp\u003eBibliography 100\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Iron Deficiency in Intensive Care 101\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAkshay Shah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 101\u003c\/p\u003e \u003cp\u003eIron Homeostasis in Critical Illness 101\u003c\/p\u003e \u003cp\u003eDiagnosing Iron Deficiency in Critical Illness 103\u003c\/p\u003e \u003cp\u003eClinical Implications of Iron Deficiency in Intensive Care Unit 103\u003c\/p\u003e \u003cp\u003ePatient Blood Management in Intensive Care 104\u003c\/p\u003e \u003cp\u003eIntravenous Iron in Intensive Care 104\u003c\/p\u003e \u003cp\u003eConcomitant Therapies for Anaemia Management in Intensive Care 104\u003c\/p\u003e \u003cp\u003eBibliography 105\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Iron Deficiency in Medical Oncology 107\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSue Pavord\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 107\u003c\/p\u003e \u003cp\u003eCauses of Anaemia in Patients with Cancer 107\u003c\/p\u003e \u003cp\u003eDiagnosis of Iron Deficiency in Patients with Cancer 108\u003c\/p\u003e \u003cp\u003eManagement of Anaemia in Patients with Cancer 108\u003c\/p\u003e \u003cp\u003eErythropoiesis Stimulating Agents 108\u003c\/p\u003e \u003cp\u003eBlood Transfusion in Oncology 109\u003c\/p\u003e \u003cp\u003ePrevention of Anaemia in Patients with Cancer 109\u003c\/p\u003e \u003cp\u003eImplementation of Local Policy 109\u003c\/p\u003e \u003cp\u003eNovel Anti-anaemia Agents 110\u003c\/p\u003e \u003cp\u003eConclusion 110\u003c\/p\u003e \u003cp\u003eBibliography 111\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Iron Overload 113\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3a Causes of Iron Overload 115\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Transfusional Iron Overload 117\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSamah Babiker and John Porter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 117\u003c\/p\u003e \u003cp\u003eThe Causes of Iron Overload and Influencing Factors 117\u003c\/p\u003e \u003cp\u003ePathophysiology and Effects of Transfusional Iron Loading on Body Iron Distribution 117\u003c\/p\u003e \u003cp\u003eRates of Transfusional Iron Overloading and Distribution in Different Diseases 119\u003c\/p\u003e \u003cp\u003eConsequences of Transfusional Iron Overload 119\u003c\/p\u003e \u003cp\u003ePrevention of Transfusional Iron Overload 121\u003c\/p\u003e \u003cp\u003eBibliography 121\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Haemochromatosis 123\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGraca Porto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 123\u003c\/p\u003e \u003cp\u003ePathogenesis 123\u003c\/p\u003e \u003cp\u003eFrequency and Penetrance of HFE-Related Haemochromatosis 124\u003c\/p\u003e \u003cp\u003eDiagnosis 125\u003c\/p\u003e \u003cp\u003eTreatment and Prevention 127\u003c\/p\u003e \u003cp\u003eBibliography 127\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Ineffective Erythropoiesis 129\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eNoémi Roy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 129\u003c\/p\u003e \u003cp\u003eErythropoiesis 129\u003c\/p\u003e \u003cp\u003eThe Role of Erythropoietin and Iron 130\u003c\/p\u003e \u003cp\u003eFerrokinetic Studies 131\u003c\/p\u003e \u003cp\u003eErythroferrone 131\u003c\/p\u003e \u003cp\u003eBibliography 132\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3b Effects of Iron Overload on Body Organs 133\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Iron Overload in the Heart 135\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMalcolm Walker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIron and the Heart 135\u003c\/p\u003e \u003cp\u003eCardiac Iron Regulation 135\u003c\/p\u003e \u003cp\u003eIron Overload 135\u003c\/p\u003e \u003cp\u003eClinical Presentations and Their Management 136\u003c\/p\u003e \u003cp\u003eVentricular Dysfunction and Heart Failure 136\u003c\/p\u003e \u003cp\u003eArrhythmia 137\u003c\/p\u003e \u003cp\u003eAssessment of Cardiac Iron 137\u003c\/p\u003e \u003cp\u003eMagnetic Resonance Imaging 137\u003c\/p\u003e \u003cp\u003eOther Heart Tests 138\u003c\/p\u003e \u003cp\u003eLong-Term Management and Prevention 138\u003c\/p\u003e \u003cp\u003eBibliography 140\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 Iron Overload and the Liver 141\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eEmma Saunsbury and Jeremy Cobbold\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 141\u003c\/p\u003e \u003cp\u003eHistological Patterns of Hepatic Iron Overload 141\u003c\/p\u003e \u003cp\u003ePathophysiology of Hepatic Damage Secondary to Iron Overload 141\u003c\/p\u003e \u003cp\u003eAssessment of Hepatic Iron Overload 143\u003c\/p\u003e \u003cp\u003eBibliography 144\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23 Impact of Iron Overload on the Endocrine System 147\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAmy Morrison and Miles Levy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 147\u003c\/p\u003e \u003cp\u003eDiabetes Mellitus 147\u003c\/p\u003e \u003cp\u003eReproductive Endocrinology 148\u003c\/p\u003e \u003cp\u003eGrowth and Bone Health 150\u003c\/p\u003e \u003cp\u003eAdrenal Function 150\u003c\/p\u003e \u003cp\u003eSummary 151\u003c\/p\u003e \u003cp\u003eBibliography 152\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24 Iron Overload and the Musculoskeletal System 153\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eKassim Javaid\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 153\u003c\/p\u003e \u003cp\u003eOsteoporosis and Fracture Risk 153\u003c\/p\u003e \u003cp\u003eOsteoarthritis 154\u003c\/p\u003e \u003cp\u003eCalcium Pyrophosphate Deposition Disease 155\u003c\/p\u003e \u003cp\u003eManagement of Iron Overload in the Joints 155\u003c\/p\u003e \u003cp\u003eBibliography 156\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3c Assessment and Management of Iron Overload 157\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25 Assessment of Iron Overload 159\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSubarna Chakravorty\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 159\u003c\/p\u003e \u003cp\u003eAwareness of Potential Causes 159\u003c\/p\u003e \u003cp\u003eAssessment of Transfusional Iron Overload 159\u003c\/p\u003e \u003cp\u003eRole of Serum Ferritin and Iron Studies in Assessing Iron Overload 160\u003c\/p\u003e \u003cp\u003eImaging in Iron Overload 161\u003c\/p\u003e \u003cp\u003eMonitoring Requirements for At-risk Patients 162\u003c\/p\u003e \u003cp\u003eBibliography 163\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26 Management of Iron Overload 165\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eNandini Sadasivam\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 165\u003c\/p\u003e \u003cp\u003eIron Chelation Therapy 165\u003c\/p\u003e \u003cp\u003eIndications for Iron Chelation Therapy 165\u003c\/p\u003e \u003cp\u003eAdministration of Iron Chelation Therapy 166\u003c\/p\u003e \u003cp\u003eCombination Chelation Therapy 166\u003c\/p\u003e \u003cp\u003eWhen to Start Iron Chelation Therapy 168\u003c\/p\u003e \u003cp\u003ePractical Tips for Clinicians 168\u003c\/p\u003e \u003cp\u003eDesferrioxamine 168\u003c\/p\u003e \u003cp\u003eDeferasirox 169\u003c\/p\u003e \u003cp\u003eDeferiprone 169\u003c\/p\u003e \u003cp\u003eCalculation of ROIL Adults 169\u003c\/p\u003e \u003cp\u003eCalculation of ROIL in Paediatric 169\u003c\/p\u003e \u003cp\u003ePractical Prescribing Tips 170\u003c\/p\u003e \u003cp\u003eDose Adjustments for Comorbidities 171\u003c\/p\u003e \u003cp\u003eRenal Disease 171\u003c\/p\u003e \u003cp\u003eDesferrioxamine 171\u003c\/p\u003e \u003cp\u003eDeferasirox 171\u003c\/p\u003e \u003cp\u003eEstablished Dialysis 171\u003c\/p\u003e \u003cp\u003eLiver Disease 171\u003c\/p\u003e \u003cp\u003eDeferasirox 171\u003c\/p\u003e \u003cp\u003ePregnancy 171\u003c\/p\u003e \u003cp\u003eEmerging Novel Therapies 171\u003c\/p\u003e \u003cp\u003eBibliography 172\u003c\/p\u003e \u003cp\u003eIndex 173\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eSue Pavord, MD,\u003c\/b\u003e is a Consultant Haematologist at Oxford University Hospitals NHS FT, UK, and Associate Senior Lecturer in Medicine at the University of Oxford. She specialises in all aspects of medical haematology and has established services for iron deficiency management in different clinical settings, and has led national guidelines in this area. She is President of the British Society for Haematology 2024-2026. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eNoemi Roy, MD,\u003c\/b\u003e is Consultant Haematologist at Oxford University Hospitals NHS FT, UK, and an Honorary Senior Clinical Lecturer at the University of Oxford. She specialises in red cell disorders and iron overload. She has been a key player in patient and public engagement in the field and is co-founder of the Congenital Anaemia Network.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eLearn the tools for addressing a widespread public health issue with this practical guide\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eIron deficiency and iron overload are among the most common health conditions encountered in the course of clinical practice, with the potential to produce a range of morbidities and increase overall mortality. However, these conditions are often under-recognized, resulting in unnecessary disease and loss of well-being. There is an urgent need to raise awareness among clinicians of the causes, effects and management of iron imbalance. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eIron in Clinical Practice\u003c\/i\u003e meets this need with a brisk, practical guide to recognizing and treating both iron deficiency and iron overload in clinical settings. Edited by two Oxford haematologists and leading specialists in iron management, it covers major areas of medicine and surgery impacted by these disorders. The result is an essential resource for both beginning and experienced clinicians. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eIron in Clinical Practice\u003c\/i\u003e readers will find: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eIntroductory chapters outlining the role of iron in the body, its utilization and mechanisms of trafficking and distribution, and how these are impacted by disease.\u003c\/li\u003e\n\u003cli\u003eCoverage of a range of clinical settings across medicine, surgery and primary care.\u003c\/li\u003e\n\u003cli\u003eIllustrations, tables, and graphs throughout.\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eIron in Clinical Practice\u003c\/i\u003e is ideal for all health care practitioners of any specialty.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989478785253,"sku":"NP9781394210886","price":65.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781394210886.jpg?v=1761784265","url":"https:\/\/k12savings.com\/products\/iron-in-clinical-practice-isbn-9781394210886","provider":"K12savings","version":"1.0","type":"link"}