{"product_id":"introductory-biostatistics-isbn-9780470905401","title":"Introductory Biostatistics","description":"\u003cp\u003eMaintaining the same accessible and hands-on presentation, \u003ci\u003eIntroductory Biostatistics, Second Edition \u003c\/i\u003econtinues to provide an organized introduction to basic statistical concepts commonly applied in research across the health sciences. With plenty of real-world examples, the new edition provides a practical, modern approach to the statistical topics found in the biomedical and public health fields.\u003c\/p\u003e \u003cp\u003eBeginning with an overview of descriptive statistics in the health sciences, the book delivers topical coverage of probability models, parameter estimation, and hypothesis testing. Subsequently, the book focuses on more advanced topics with coverage of regression analysis, logistic regression, methods for count data, analysis of survival data, and designs for clinical trials. This extensive update of \u003ci\u003eIntroductory Biostatistics, Second Edition \u003c\/i\u003eincludes:\u003c\/p\u003e \u003cp\u003e• A new chapter on the use of higher order Analysis of Variance (ANOVA) in factorial and block designs\u003c\/p\u003e \u003cp\u003e• A new chapter on testing and inference methods for repeatedly measured outcomes including continuous, binary, and count outcomes\u003c\/p\u003e \u003cp\u003e• R incorporated throughout along with SAS®, allowing readers to replicate results from presented examples with either software\u003c\/p\u003e \u003cp\u003e• Multiple additional exercises, with partial solutions available to aid comprehension of crucial concepts\u003c\/p\u003e \u003cp\u003e• Notes on Computations sections to provide further guidance on the use of software\u003c\/p\u003e \u003cp\u003e• A related website that hosts the large data sets presented throughout the book\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIntroductory Biostatistics, Second Edition \u003c\/i\u003eis an excellent textbook for upper-undergraduate and graduate students in introductory biostatistics courses. The book is also an ideal reference for applied statisticians working in the fields of public health, nursing, dentistry, and medicine.\u003c\/p\u003e \u003cp\u003ePreface to the Second Edition xiii\u003c\/p\u003e \u003cp\u003ePreface to the First Edition xv\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Descriptive Methods for Categorical Data 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Proportions 1\u003c\/p\u003e \u003cp\u003e1.1.1 Comparative Studies 2\u003c\/p\u003e \u003cp\u003e1.1.2 Screening Tests 5\u003c\/p\u003e \u003cp\u003e1.1.3 Displaying Proportions 7\u003c\/p\u003e \u003cp\u003e1.2 Rates 10\u003c\/p\u003e \u003cp\u003e1.2.1 Changes 11\u003c\/p\u003e \u003cp\u003e1.2.2 Measures of Morbidity and Mortality 13\u003c\/p\u003e \u003cp\u003e1.2.3 Standardization of Rates 15\u003c\/p\u003e \u003cp\u003e1.3 Ratios 18\u003c\/p\u003e \u003cp\u003e1.3.1 Relative Risk 18\u003c\/p\u003e \u003cp\u003e1.3.2 Odds and Odds Ratio 18\u003c\/p\u003e \u003cp\u003e1.3.3 Generalized Odds for Ordered 2 × \u003cb\u003e\u003ci\u003ek \u003c\/i\u003e\u003c\/b\u003eTables 21\u003c\/p\u003e \u003cp\u003e1.3.4 Mantel–Haenszel Method 25\u003c\/p\u003e \u003cp\u003e1.3.5 Standardized Mortality Ratio 28\u003c\/p\u003e \u003cp\u003e1.4 Notes on Computations 30\u003c\/p\u003e \u003cp\u003eExercises 32\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Descriptive Methods for Continuous Data 55\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Tabular and Graphical Methods 55\u003c\/p\u003e \u003cp\u003e2.1.1 One‐Way Scatter Plots 55\u003c\/p\u003e \u003cp\u003e2.1.2 Frequency Distribution 56\u003c\/p\u003e \u003cp\u003e2.1.3 Histogram and Frequency Polygon 60\u003c\/p\u003e \u003cp\u003e2.1.4 Cumulative Frequency Graph and Percentiles 64\u003c\/p\u003e \u003cp\u003e2.1.5 Stem and Leaf Diagrams 68\u003c\/p\u003e \u003cp\u003e2.2 Numerical Methods 69\u003c\/p\u003e \u003cp\u003e2.2.1 Mean 69\u003c\/p\u003e \u003cp\u003e2.2.2 Other Measures of Location 72\u003c\/p\u003e \u003cp\u003e2.2.3 Measures of Dispersion 73\u003c\/p\u003e \u003cp\u003e2.2.4 Box Plots 76\u003c\/p\u003e \u003cp\u003e2.3 Special Case of Binary Data 77\u003c\/p\u003e \u003cp\u003e2.4 Coefficients of Correlation 78\u003c\/p\u003e \u003cp\u003e2.4.1 Pearson’s Correlation Coefficient 80\u003c\/p\u003e \u003cp\u003e2.4.2 Nonparametric Correlation Coefficients 83\u003c\/p\u003e \u003cp\u003e2.5 Notes on Computations 85\u003c\/p\u003e \u003cp\u003eExercises 87\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Probability and Probability Models 103\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Probability 103\u003c\/p\u003e \u003cp\u003e3.1.1 Certainty of Uncertainty 104\u003c\/p\u003e \u003cp\u003e3.1.2 Probability 104\u003c\/p\u003e \u003cp\u003e3.1.3 Statistical Relationship 106\u003c\/p\u003e \u003cp\u003e3.1.4 Using Screening Tests 109\u003c\/p\u003e \u003cp\u003e3.1.5 Measuring Agreement 112\u003c\/p\u003e \u003cp\u003e3.2 Normal Distribution 114\u003c\/p\u003e \u003cp\u003e3.2.1 Shape of the Normal Curve 114\u003c\/p\u003e \u003cp\u003e3.2.2 Areas Under the Standard Normal Curve 116\u003c\/p\u003e \u003cp\u003e3.2.3 Normal Distribution as a Probability Model 122\u003c\/p\u003e \u003cp\u003e3.3 Probability Models for Continuous Data 124\u003c\/p\u003e \u003cp\u003e3.4 Probability Models for Discrete Data 125\u003c\/p\u003e \u003cp\u003e3.4.1 Binomial Distribution 126\u003c\/p\u003e \u003cp\u003e3.4.2 Poisson Distribution 128\u003c\/p\u003e \u003cp\u003e3.5 Brief Notes on the Fundamentals 130\u003c\/p\u003e \u003cp\u003e3.5.1 Mean and Variance 130\u003c\/p\u003e \u003cp\u003e3.5.2 Pair‐Matched Case–Control Study 130\u003c\/p\u003e \u003cp\u003e3.6 Notes on Computations 132\u003c\/p\u003e \u003cp\u003eExercises 134\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Estimation of Parameters 141\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Basic Concepts 142\u003c\/p\u003e \u003cp\u003e4.1.1 Statistics as Variables 143\u003c\/p\u003e \u003cp\u003e4.1.2 Sampling Distributions 143\u003c\/p\u003e \u003cp\u003e4.1.3 Introduction to Confidence Estimation 145\u003c\/p\u003e \u003cp\u003e4.2 Estimation of Means 146\u003c\/p\u003e \u003cp\u003e4.2.1 Confidence Intervals for a Mean 147\u003c\/p\u003e \u003cp\u003e4.2.2 Uses of Small Samples 149\u003c\/p\u003e \u003cp\u003e4.2.3 Evaluation of Interventions 151\u003c\/p\u003e \u003cp\u003e4.3 Estimation of Proportions 153\u003c\/p\u003e \u003cp\u003e4.4 Estimation of Odds Ratios 157\u003c\/p\u003e \u003cp\u003e4.5 Estimation of Correlation Coefficients 160\u003c\/p\u003e \u003cp\u003e4.6 Brief Notes on the Fundamentals 163\u003c\/p\u003e \u003cp\u003e4.7 Notes on Computations 165\u003c\/p\u003e \u003cp\u003eExercises 166\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Introduction to Statistical Tests of Significance 179\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Basic Concepts 180\u003c\/p\u003e \u003cp\u003e5.1.1 Hypothesis Tests 181\u003c\/p\u003e \u003cp\u003e5.1.2 Statistical Evidence 182\u003c\/p\u003e \u003cp\u003e5.1.3 Errors 182\u003c\/p\u003e \u003cp\u003e5.2 Analogies 185\u003c\/p\u003e \u003cp\u003e5.2.1 Trials by Jury 185\u003c\/p\u003e \u003cp\u003e5.2.2 Medical Screening Tests 186\u003c\/p\u003e \u003cp\u003e5.2.3 Common Expectations 186\u003c\/p\u003e \u003cp\u003e5.3 Summaries and Conclusions 187\u003c\/p\u003e \u003cp\u003e5.3.1 Rejection Region 187\u003c\/p\u003e \u003cp\u003e5.3.2 \u003ci\u003ep \u003c\/i\u003eValues 189\u003c\/p\u003e \u003cp\u003e5.3.3 Relationship to Confidence Intervals 191\u003c\/p\u003e \u003cp\u003e5.4 Brief Notes on the Fundamentals 193\u003c\/p\u003e \u003cp\u003e5.4.1 Type I and Type II Errors 193\u003c\/p\u003e \u003cp\u003e5.4.2 More about Errors and \u003ci\u003ep \u003c\/i\u003eValues 194\u003c\/p\u003e \u003cp\u003eExercises 194\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Comparison of Population Proportions 197\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 One‐Sample Problem with Binary Data 197\u003c\/p\u003e \u003cp\u003e6.2 Analysis of Pair‐Matched Data 199\u003c\/p\u003e \u003cp\u003e6.3 Comparison of Two Proportions 202\u003c\/p\u003e \u003cp\u003e6.4 Mantel–Haenszel Method 206\u003c\/p\u003e \u003cp\u003e6.5 Inferences for General Two‐Way Tables 211\u003c\/p\u003e \u003cp\u003e6.6 Fisher’s Exact Test 217\u003c\/p\u003e \u003cp\u003e6.7 Ordered 2 × \u003ci\u003eK \u003c\/i\u003eContingency Tables 219\u003c\/p\u003e \u003cp\u003e6.8 Notes on Computations 222\u003c\/p\u003e \u003cp\u003eExercises 222\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Comparison of Population Means 235\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 One‐Sample Problem with Continuous Data 235\u003c\/p\u003e \u003cp\u003e7.2 Analysis of Pair‐Matched Data 237\u003c\/p\u003e \u003cp\u003e7.3 Comparison of Two Means 242\u003c\/p\u003e \u003cp\u003e7.4 Nonparametric Methods 246\u003c\/p\u003e \u003cp\u003e7.4.1 Wilcoxon Rank‐Sum Test 246\u003c\/p\u003e \u003cp\u003e7.4.2 Wilcoxon Signed‐Rank Test 250\u003c\/p\u003e \u003cp\u003e7.5 One‐Way Analysis of Variance 252\u003c\/p\u003e \u003cp\u003e7.5.1 One‐Way Analysis of Variance Model 253\u003c\/p\u003e \u003cp\u003e7.5.2 Group Comparisons 258\u003c\/p\u003e \u003cp\u003e7.6 Brief Notes on the Fundamentals 259\u003c\/p\u003e \u003cp\u003e7.7 Notes on Computations 260\u003c\/p\u003e \u003cp\u003eExercises 260\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Analysis of Variance 273\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Factorial Studies 273\u003c\/p\u003e \u003cp\u003e8.1.1 Two Crossed Factors 273\u003c\/p\u003e \u003cp\u003e8.1.2 Extensions to More Than Two Factors 278\u003c\/p\u003e \u003cp\u003e8.2 Block Designs 280\u003c\/p\u003e \u003cp\u003e8.2.1 Purpose 280\u003c\/p\u003e \u003cp\u003e8.2.2 Fixed Block Designs 281\u003c\/p\u003e \u003cp\u003e8.2.3 Random Block Designs 284\u003c\/p\u003e \u003cp\u003e8.3 Diagnostics 287\u003c\/p\u003e \u003cp\u003eExercises 291\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Regression Analysis 297\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Simple Regression Analysis 298\u003c\/p\u003e \u003cp\u003e9.1.1 Correlation and Regression 298\u003c\/p\u003e \u003cp\u003e9.1.2 Simple Linear Regression Model 301\u003c\/p\u003e \u003cp\u003e9.1.3 Scatter Diagram 302\u003c\/p\u003e \u003cp\u003e9.1.4 Meaning of Regression Parameters 302\u003c\/p\u003e \u003cp\u003e9.1.5 Estimation of Parameters and Prediction 303\u003c\/p\u003e \u003cp\u003e9.1.6 Testing for Independence 307\u003c\/p\u003e \u003cp\u003e9.1.7 Analysis of Variance Approach 309\u003c\/p\u003e \u003cp\u003e9.1.8 Some Biomedical Applications 311\u003c\/p\u003e \u003cp\u003e9.2 Multiple Regression Analysis 317\u003c\/p\u003e \u003cp\u003e9.2.1 Regression Model with Several Independent Variables 318\u003c\/p\u003e \u003cp\u003e9.2.2 Meaning of Regression Parameters 318\u003c\/p\u003e \u003cp\u003e9.2.3 Effect Modifications 319\u003c\/p\u003e \u003cp\u003e9.2.4 Polynomial Regression 319\u003c\/p\u003e \u003cp\u003e9.2.5 Estimation of Parameters and Prediction 320\u003c\/p\u003e \u003cp\u003e9.2.6 Analysis of Variance Approach 321\u003c\/p\u003e \u003cp\u003e9.2.7 Testing Hypotheses in Multiple Linear Regression 322\u003c\/p\u003e \u003cp\u003e9.2.8 Some Biomedical Applications 330\u003c\/p\u003e \u003cp\u003e9.3 Graphical and Computational Aids 334\u003c\/p\u003e \u003cp\u003eExercises 336\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Logistic Regression 351\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Simple Regression Analysis 353\u003c\/p\u003e \u003cp\u003e10.1.1 Simple Logistic Regression Model 353\u003c\/p\u003e \u003cp\u003e10.1.2 Measure of Association 355\u003c\/p\u003e \u003cp\u003e10.1.3 Effect of Measurement Scale 356\u003c\/p\u003e \u003cp\u003e10.1.4 Tests of Association 358\u003c\/p\u003e \u003cp\u003e10.1.5 Use of the Logistic Model for Different Designs 358\u003c\/p\u003e \u003cp\u003e10.1.6 Overdispersion 359\u003c\/p\u003e \u003cp\u003e10.2 Multiple Regression Analysis 362\u003c\/p\u003e \u003cp\u003e10.2.1 Logistic Regression Model with Several Covariates 363\u003c\/p\u003e \u003cp\u003e10.2.2 Effect Modifications 364\u003c\/p\u003e \u003cp\u003e10.2.3 Polynomial Regression 365\u003c\/p\u003e \u003cp\u003e10.2.4 Testing Hypotheses in Multiple Logistic Regression 365\u003c\/p\u003e \u003cp\u003e10.2.5 Receiver Operating Characteristic Curve 372\u003c\/p\u003e \u003cp\u003e10.2.6 ROC Curve and Logistic Regression 374\u003c\/p\u003e \u003cp\u003e10.3 Brief Notes on the Fundamentals 375\u003c\/p\u003e \u003cp\u003e10.4 Notes on Computing 377\u003c\/p\u003e \u003cp\u003eExercises 377\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Methods for Count Data 383\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Poisson Distribution 383\u003c\/p\u003e \u003cp\u003e11.2 Testing Goodness of Fit 387\u003c\/p\u003e \u003cp\u003e11.3 Poisson Regression Model 389\u003c\/p\u003e \u003cp\u003e11.3.1 Simple Regression Analysis 389\u003c\/p\u003e \u003cp\u003e11.3.2 Multiple Regression Analysis 393\u003c\/p\u003e \u003cp\u003e11.3.3 Overdispersion 402\u003c\/p\u003e \u003cp\u003e11.3.4 Stepwise Regression 404\u003c\/p\u003e \u003cp\u003eExercises 406\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Methods for Repeatedly Measured Responses 409\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Extending Regression Methods Beyond Independent Data 409\u003c\/p\u003e \u003cp\u003e12.2 Continuous Responses 410\u003c\/p\u003e \u003cp\u003e12.2.1 Extending Regression using the Linear Mixed Model 410\u003c\/p\u003e \u003cp\u003e12.2.2 Testing and Inference 414\u003c\/p\u003e \u003cp\u003e12.2.3 Comparing Models 417\u003c\/p\u003e \u003cp\u003e12.2.4 Special Cases: Random Block Designs and Multi‐level Sampling 418\u003c\/p\u003e \u003cp\u003e12.3 Binary Responses 423\u003c\/p\u003e \u003cp\u003e12.3.1 Extending Logistic Regression using Generalized Estimating Equations 423\u003c\/p\u003e \u003cp\u003e12.3.2 Testing and Inference 425\u003c\/p\u003e \u003cp\u003e12.4 Count Responses 427\u003c\/p\u003e \u003cp\u003e12.4.1 Extending Poisson Regression using Generalized Estimating Equations 427\u003c\/p\u003e \u003cp\u003e12.4.2 Testing and Inference 428\u003c\/p\u003e \u003cp\u003e12.5 Computational Notes 431\u003c\/p\u003e \u003cp\u003eExercises 432\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Analysis of Survival Data and Data from Matched Studies 439\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Survival Data 440\u003c\/p\u003e \u003cp\u003e13.2 Introductory Survival Analyses 443\u003c\/p\u003e \u003cp\u003e13.2.1 Kaplan–Meier Curve 444\u003c\/p\u003e \u003cp\u003e13.2.2 Comparison of Survival Distributions 446\u003c\/p\u003e \u003cp\u003e13.3 Simple Regression and Correlation 450\u003c\/p\u003e \u003cp\u003e13.3.1 Model and Approach 451\u003c\/p\u003e \u003cp\u003e13.3.2 Measures of Association 452\u003c\/p\u003e \u003cp\u003e13.3.3 Tests of Association 455\u003c\/p\u003e \u003cp\u003e13.4 Multiple Regression and Correlation 456\u003c\/p\u003e \u003cp\u003e13.4.1 Proportional Hazards Model with Several Covariates 456\u003c\/p\u003e \u003cp\u003e13.4.2 Testing Hypotheses in Multiple Regression 457\u003c\/p\u003e \u003cp\u003e13.4.3 Time‐Dependent Covariates and Applications 461\u003c\/p\u003e \u003cp\u003e13.5 Pair‐Matched Case–Control Studies 464\u003c\/p\u003e \u003cp\u003e13.5.1 Model 465\u003c\/p\u003e \u003cp\u003e13.5.2 Analysis 466\u003c\/p\u003e \u003cp\u003e13.6 Multiple Matching 468\u003c\/p\u003e \u003cp\u003e13.6.1 Conditional Approach 469\u003c\/p\u003e \u003cp\u003e13.6.2 Estimation of the Odds Ratio 469\u003c\/p\u003e \u003cp\u003e13.6.3 Testing for Exposure Effect 470\u003c\/p\u003e \u003cp\u003e13.7 Conditional Logistic Regression 472\u003c\/p\u003e \u003cp\u003e13.7.1 Simple Regression Analysis 473\u003c\/p\u003e \u003cp\u003e13.7.2 Multiple Regression Analysis 478\u003c\/p\u003e \u003cp\u003eExercises 484\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Study Designs 493\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Types of Study Designs 494\u003c\/p\u003e \u003cp\u003e14.2 Classification of Clinical Trials 495\u003c\/p\u003e \u003cp\u003e14.3 Designing Phase I Cancer Trials 497\u003c\/p\u003e \u003cp\u003e14.4 Sample Size Determination for Phase II Trials and Surveys 499\u003c\/p\u003e \u003cp\u003e14.5 Sample Sizes for Other Phase II Trials 501\u003c\/p\u003e \u003cp\u003e14.5.1 Continuous Endpoints 501\u003c\/p\u003e \u003cp\u003e14.5.2 Correlation Endpoints 502\u003c\/p\u003e \u003cp\u003e14.6 About Simon’s Two‐Stage Phase II Design 503\u003c\/p\u003e \u003cp\u003e14.7 Phase II Designs for Selection 504\u003c\/p\u003e \u003cp\u003e14.7.1 Continuous Endpoints 505\u003c\/p\u003e \u003cp\u003e14.7.2 Binary Endpoints 505\u003c\/p\u003e \u003cp\u003e14.8 Toxicity Monitoring in Phase II Trials 506\u003c\/p\u003e \u003cp\u003e14.9 Sample Size Determination for Phase III Trials 508\u003c\/p\u003e \u003cp\u003e14.9.1 Comparison of Two Means 509\u003c\/p\u003e \u003cp\u003e14.9.2 Comparison of Two Proportions 511\u003c\/p\u003e \u003cp\u003e14.9.3 Survival Time as the Endpoint 513\u003c\/p\u003e \u003cp\u003e14.10 Sample Size Determination for Case–Control Studies 515\u003c\/p\u003e \u003cp\u003e14.10.1 Unmatched Designs for a Binary Exposure 516\u003c\/p\u003e \u003cp\u003e14.10.2 Matched Designs for a Binary Exposure 518\u003c\/p\u003e \u003cp\u003e14.10.3 Unmatched Designs for a Continuous Exposure 520\u003c\/p\u003e \u003cp\u003eExercises 522\u003c\/p\u003e \u003cp\u003eReferences 529\u003c\/p\u003e \u003cp\u003eAppendices 535\u003c\/p\u003e \u003cp\u003eAnswers to Selected Exercises 541\u003c\/p\u003e \u003cp\u003eIndex 585\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eChap T. Le, PhD,\u003c\/b\u003e is Distinguished Professor of Biostatistics and Director of Biostatistics and Bioinformatics at the University of Minnesota Masonic Cancer Center. He has provided statistical consulting for a variety of biomedical research projects, and he has worked on collaborations focusing on the analyses of survival and categorical data and, currently, in the areas of cancer and tobacco research. Dr. Le is the author of \u003ci\u003eHealth and Numbers: A Problems-Based Introduction to Biostatistics, Third Edition; Applied Categorical Data Analysis and Translational Research, Second Edition; and Applied Survival Analysis\u003c\/i\u003e, all published by Wiley.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eLynn E. Eberly, PhD,\u003c\/b\u003e is Associate Professor in the Division of Biostatistics at the University of Minnesota. The author of more than 100 journal articles, Dr. Eberly has been a statistical collaborator in biomedical and public health research for more than 18 years. Her current research interests include methods for and applications to correlated data in neurodegenerative conditions, endocrinology, psychiatry\/psychology, and cancer research.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003e\"Students from health, medical, pharmacy, and nursing will find...Introductory Biostatistics extremely useful.Difficult biostatistical concepts are made easier by simple and careful explanations...\"\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eJournal of Statistical Computation and Simulation\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMaintaining the same accessible and hands-on presentation, \u003ci\u003eIntroductory Biostatistics, Second Edition\u003c\/i\u003e continues to provide an organized introduction to basic statistical concepts commonly applied in research across the health sciences. With plenty of real-world examples, the new edition provides a practical, modern approach to the statistical topics found in the biomedical and public health fields.\u003c\/p\u003e \u003cp\u003eBeginning with an overview of descriptive statistics in the health sciences, the book delivers topical coverage of probability models, parameter estimation, and hypothesis testing. Subsequently, the book focuses on more advanced topics with coverage of regression analysis, logistic regression, methods for count data, analysis of survival data, and designs for clinical trials. This extensive update of \u003ci\u003eIntroductory Biostatistics, Second Edition\u003c\/i\u003e includes:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eA new chapter on the use of higher order Analysis of Variance (ANOVA) in factorial and blockdesigns\u003c\/li\u003e \u003cli\u003eA new chapter on testing and inference methods for repeatedly measured outcomes includingcontinuous, binary, and count outcomes\u003c\/li\u003e \u003cli\u003eR incorporated throughout along with SAS®, allowing readers to replicate results from presented examples with either software\u003c\/li\u003e \u003cli\u003eMultiple additional exercises, with partial solutions available to aid comprehension of crucialconcepts\u003c\/li\u003e \u003cli\u003eNotes on Computations sections to provide further guidance on the use of software\u003c\/li\u003e \u003cli\u003eA related website that hosts the large data sets presented throughout the book\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eIntroductory Biostatistics, Second Edition\u003c\/i\u003e is an excellent textbook for upper-undergraduate and graduate students in introductory biostatistics courses. The book is also an ideal reference for applied statisticians working in the fields of public health, nursing, dentistry, and medicine.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989469970661,"sku":"NP9780470905401","price":118.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470905401.jpg?v=1761784227","url":"https:\/\/k12savings.com\/products\/introductory-biostatistics-isbn-9780470905401","provider":"K12savings","version":"1.0","type":"link"}