{"product_id":"introduction-to-veterinary-genetics-isbn-9781405168328","title":"Introduction to Veterinary Genetics","description":"The concepts of veterinary genetics are crucial to understanding and controlling many diseases and disorders in animals.  They are also crucial to enhancing animal production. Accessible and clearly presented, \u003ci\u003eIntroduction to Veterinary Genetics\u003c\/i\u003e provides a succinct introduction to the aspects of genetics relevant to animal diseases and production. Now in its third edition, this is the only introductory level textbook on genetics that has been written specifically for veterinary and animal science students.  \u003cp\u003eCoverage includes: basic genetics, molecular biology, genomics, cytogenetics, immunogenetics, population genetics, quantitative genetics, biotechnology, and the use of molecular tools in the control of inherited disorders. \u003c\/p\u003e \u003cp\u003eThis book describes in detail how genetics is being applied to artificial selection in animal production.   It also covers the conservation of genetic diversity in both domesticated and wild animals.\u003c\/p\u003e \u003cp\u003eNew for the Third Edition:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003eEnd-of-chapter summaries provide quick recaps.\u003c\/li\u003e \u003cli\u003eCovers new topics: epigenetics, genomics and bioinformatics.\u003c\/li\u003e \u003cli\u003eThoroughly revised according to recent advances in genetics.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eIntroduction to Veterinary Genetics\u003c\/i\u003e is still the only introductory genetics textbook for students of veterinary and animal science and will continue to be an indispensable reference tool for veterinary students and practitioners alike.\u003c\/p\u003e \u003cp\u003ePreface x\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Basic genetics 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChromosomes 1\u003c\/p\u003e \u003cp\u003eMeiosis and mitosis 4\u003c\/p\u003e \u003cp\u003eThe biochemistry of inheritance 11\u003c\/p\u003e \u003cp\u003eWhat is a gene? 18\u003c\/p\u003e \u003cp\u003eGene regulation 22\u003c\/p\u003e \u003cp\u003eMutation 23\u003c\/p\u003e \u003cp\u003eGenes, alleles, and loci 24\u003c\/p\u003e \u003cp\u003eSimple or Mendelian inheritance 25\u003c\/p\u003e \u003cp\u003eLinkage 27\u003c\/p\u003e \u003cp\u003eInactivation 32\u003c\/p\u003e \u003cp\u003eTypes of DNA 35\u003c\/p\u003e \u003cp\u003eFurther reading 38\u003c\/p\u003e \u003cp\u003eAppendix 1.1 Banded karyotypes of domestic species 39\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Molecular biology 46\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRestriction enzymes 46\u003c\/p\u003e \u003cp\u003eRecombinant DNA and DNA cloning 49\u003c\/p\u003e \u003cp\u003eComplementary DNA 51\u003c\/p\u003e \u003cp\u003eDNA sequencing 53\u003c\/p\u003e \u003cp\u003ePolymerase chain reaction 55\u003c\/p\u003e \u003cp\u003eSouthern analysis and related technologies 58\u003c\/p\u003e \u003cp\u003eDNA expression microarrays 58\u003c\/p\u003e \u003cp\u003eThe detection of variation in base sequence 60\u003c\/p\u003e \u003cp\u003eVeterinary diagnosis 63\u003c\/p\u003e \u003cp\u003eVariable number of tandem repeats (VNTR), DNA fingerprints, and microsatellites 64\u003c\/p\u003e \u003cp\u003eSingle nucleotide polymorphisms (SNPs) 68\u003c\/p\u003e \u003cp\u003eCopy number variation (CNV) 69\u003c\/p\u003e \u003cp\u003eGene mapping 70\u003c\/p\u003e \u003cp\u003eWhole-genome sequence assembly 74\u003c\/p\u003e \u003cp\u003eProduction of polypeptide from cloned DNA 76\u003c\/p\u003e \u003cp\u003eTransgenesis 77\u003c\/p\u003e \u003cp\u003eAntisense technology 80\u003c\/p\u003e \u003cp\u003eRNA interference 81\u003c\/p\u003e \u003cp\u003eFurther reading 84\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Single-gene disorders 85\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eInborn errors of metabolism 85\u003c\/p\u003e \u003cp\u003eSex-limited inheritance 87\u003c\/p\u003e \u003cp\u003eGenetic heterogeneity of disease 88\u003c\/p\u003e \u003cp\u003eType of gene action and type of disease 90\u003c\/p\u003e \u003cp\u003ePhenocopies 91\u003c\/p\u003e \u003cp\u003eA sample of single-gene disorders 92\u003c\/p\u003e \u003cp\u003eA revolution in mapping and identifying the causal mutation of single-gene disorders 96\u003c\/p\u003e \u003cp\u003eFurther reading 98\u003c\/p\u003e \u003cp\u003eAppendix 3.1 A sample of single-gene traits that have been characterized at the molecular level 98\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Chromosomal aberrations 103\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAbnormal chromosome number 103\u003c\/p\u003e \u003cp\u003eAbnormal chromosome structure 107\u003c\/p\u003e \u003cp\u003eChromosomal aberrations in cancer 112\u003c\/p\u003e \u003cp\u003eEvolution of karyotypes 113\u003c\/p\u003e \u003cp\u003eInterspecific hybridization 113\u003c\/p\u003e \u003cp\u003eFreemartins 114\u003c\/p\u003e \u003cp\u003eBiological basis of sex 115\u003c\/p\u003e \u003cp\u003eClassification of intersex 116\u003c\/p\u003e \u003cp\u003eA sample of chromosomal aberrations 117\u003c\/p\u003e \u003cp\u003eFurther reading 119\u003c\/p\u003e \u003cp\u003eAppendix 4.1 A sample of chromosomal aberrations in animals 119\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Single genes in populations 121\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGene and genotype frequencies 121\u003c\/p\u003e \u003cp\u003eRandom mating 122\u003c\/p\u003e \u003cp\u003eThe Hardy–Weinberg law 123\u003c\/p\u003e \u003cp\u003eExtensions to the Hardy–Weinberg law 125\u003c\/p\u003e \u003cp\u003eSelection and mutation 127\u003c\/p\u003e \u003cp\u003eGenetic drift and the founder effect 133\u003c\/p\u003e \u003cp\u003eExtending population genetics to more than one locus 134\u003c\/p\u003e \u003cp\u003eFurther reading 137\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Familial disorders not due to a single gene 139\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eLiability and threshold 139\u003c\/p\u003e \u003cp\u003eThe multifactorial model 139\u003c\/p\u003e \u003cp\u003eMore than one threshold 141\u003c\/p\u003e \u003cp\u003eSome final points 143\u003c\/p\u003e \u003cp\u003eFurther reading 149\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Is it inherited? 150\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGeneral evidence for a genetic aetiology 150\u003c\/p\u003e \u003cp\u003eThe four types of simple, Mendelian inheritance 151\u003c\/p\u003e \u003cp\u003eStudying and analysing the data 153\u003c\/p\u003e \u003cp\u003eFurther reading 157\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Immunogenetics 158\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAntibodies 159\u003c\/p\u003e \u003cp\u003eRed-cell antigens 160\u003c\/p\u003e \u003cp\u003eThe major histocompatibility complex (MHC) 163\u003c\/p\u003e \u003cp\u003eFurther reading 171\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Pharmacogenetics 172\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenetic polymorphisms affecting drug metabolism 172\u003c\/p\u003e \u003cp\u003eGenetics and anaesthesia 173\u003c\/p\u003e \u003cp\u003eWarfarin resistance 174\u003c\/p\u003e \u003cp\u003eMultifactorial pharmacogenetics 175\u003c\/p\u003e \u003cp\u003eFurther reading 178\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Hosts, parasites, and pathogens 179\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eHost–pathogen interactions 179\u003c\/p\u003e \u003cp\u003eResistance in hosts 183\u003c\/p\u003e \u003cp\u003eResistance in parasites and pathogens 184\u003c\/p\u003e \u003cp\u003eControl of parasites and pathogens 188\u003c\/p\u003e \u003cp\u003eIncreasing the level of resistance in hosts 190\u003c\/p\u003e \u003cp\u003eFurther reading 193\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Single genes in animal breeding 195\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCoat colour 195\u003c\/p\u003e \u003cp\u003eExamples of coat-colour genes 195\u003c\/p\u003e \u003cp\u003eCarpet wool 200\u003c\/p\u003e \u003cp\u003eProlificacy in sheep 200\u003c\/p\u003e \u003cp\u003ePolledness 201\u003c\/p\u003e \u003cp\u003eMuscular hypertrophy in cattle and sheep 201\u003c\/p\u003e \u003cp\u003eDwarf poultry 202\u003c\/p\u003e \u003cp\u003eGenes for sexing chickens 202\u003c\/p\u003e \u003cp\u003ePedigree checking 204\u003c\/p\u003e \u003cp\u003eFurther reading 206\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Relationship and inbreeding 207\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe inbreeding coefficient 207\u003c\/p\u003e \u003cp\u003eRelationship 208\u003c\/p\u003e \u003cp\u003eThe inbreeding coefficient revisited 209\u003c\/p\u003e \u003cp\u003eA general expression for relationship and inbreeding 210\u003c\/p\u003e \u003cp\u003eThe base population 211\u003c\/p\u003e \u003cp\u003eInbreeding in populations 212\u003c\/p\u003e \u003cp\u003eInbreeding depression 212\u003c\/p\u003e \u003cp\u003eFurther reading 215\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Quantitative variation 216\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eQuantitative traits 216\u003c\/p\u003e \u003cp\u003eThe performance of an individual animal 218\u003c\/p\u003e \u003cp\u003eThe differences between animals 220\u003c\/p\u003e \u003cp\u003eHeritability 221\u003c\/p\u003e \u003cp\u003eCorrelations between traits 224\u003c\/p\u003e \u003cp\u003eQuantitative trait loci (QTL) 224\u003c\/p\u003e \u003cp\u003eFurther reading 228\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Selection between populations 230\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eComparison between populations 230\u003c\/p\u003e \u003cp\u003eGenotype–environment interaction 232\u003c\/p\u003e \u003cp\u003eFurther reading 234\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Selection within populations 235\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEstimated breeding values and accuracy of selection 235\u003c\/p\u003e \u003cp\u003eClues to a candidate’s breeding value for a trait 236\u003c\/p\u003e \u003cp\u003eCombining clues from more than one source 236\u003c\/p\u003e \u003cp\u003eBest linear unbiased prediction (BLUP) 238\u003c\/p\u003e \u003cp\u003eCorrelated traits 239\u003c\/p\u003e \u003cp\u003eSelection for more than one trait 240\u003c\/p\u003e \u003cp\u003eThe importance of inbreeding and genetic drift 242\u003c\/p\u003e \u003cp\u003eSire-reference schemes 243\u003c\/p\u003e \u003cp\u003eMarker-assisted selection (MAS) and genome-wide selection (GWS) 244\u003c\/p\u003e \u003cp\u003eFurther reading 247\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Breed structure 249\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe traditional pyramid 249\u003c\/p\u003e \u003cp\u003eClosed-nucleus breeding schemes 249\u003c\/p\u003e \u003cp\u003eOpen-nucleus breeding schemes 250\u003c\/p\u003e \u003cp\u003eInformation nucleus 252\u003c\/p\u003e \u003cp\u003eFurther reading 253\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Crossing 254\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRegular crossing 254\u003c\/p\u003e \u003cp\u003eCrossing to produce a synthetic 260\u003c\/p\u003e \u003cp\u003eGrading-up 261\u003c\/p\u003e \u003cp\u003eFurther reading 265\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Selection and regular crossing 267\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSelection 267\u003c\/p\u003e \u003cp\u003eSelection and regular crossing 267\u003c\/p\u003e \u003cp\u003eFurther reading 269\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Biotechnology and the future 270\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eArtificial insemination (AI) 270\u003c\/p\u003e \u003cp\u003eMultiple ovulation and embryo transfer (MOET) 271\u003cbr\u003e In vitro maturation (IVM) and in vitro fertilization (IVF) of ova 272\u003c\/p\u003e \u003cp\u003eControl of sex ratio 273\u003c\/p\u003e \u003cp\u003eRecombinant proteins 273\u003c\/p\u003e \u003cp\u003eTransgenesis 274\u003c\/p\u003e \u003cp\u003eAnimal cloning 275\u003c\/p\u003e \u003cp\u003eFurther reading 279\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Conservation genetics 280\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMeasurement of genetic diversity within populations 280\u003c\/p\u003e \u003cp\u003eMeasurement of genetic diversity among populations 282\u003c\/p\u003e \u003cp\u003eImportance of genetic diversity 283\u003c\/p\u003e \u003cp\u003eLoss of genetic diversity 284\u003c\/p\u003e \u003cp\u003eConservation of genetic diversity 286\u003c\/p\u003e \u003cp\u003eFurther reading 289\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Genetic and environmental control of inherited disorders 291\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEnvironmental control of inherited disorders 291\u003c\/p\u003e \u003cp\u003eGenetic control of single-gene disorders 294\u003c\/p\u003e \u003cp\u003eGene therapy 300\u003c\/p\u003e \u003cp\u003eGenetic control of multifactorial disorders 300\u003c\/p\u003e \u003cp\u003eGenetic control – some final points 302\u003c\/p\u003e \u003cp\u003eCrossing: thinking outside the square 304\u003c\/p\u003e \u003cp\u003eFurther reading 306\u003c\/p\u003e \u003cp\u003eGlossary 307\u003c\/p\u003e \u003cp\u003eIndex 310\u003c\/p\u003e Frank Nicholas is Emeritus Professor of Animal Genetics in the Faculty of Veterinary Science at the \u003cst1:place w:st=\"on\"\u003e\u003cst1:placetype w:st=\"on\"\u003eUniversity\u003c\/st1:placetype\u003e of \u003cst1:placename w:st=\"on\"\u003eSydney\u003c\/st1:placename\u003e\u003c\/st1:place\u003e.  He has edited and co-authored several books about genetics and one about Charles Darwin, and he created and maintains Online Mendelian Inheritance of Animals (OMIA; omia.angis.org.au), a comparative knowledge-base of genetic disorders and other familial traits in non-laboratory animals.    The concepts of veterinary genetics are crucial to understanding and controlling many diseases and disorders in animals.  They are also crucial to enhancing animal production. Accessible and clearly presented, \u003ci\u003eIntroduction to Veterinary Genetics\u003c\/i\u003e provides a succinct introduction to the aspects of genetics relevant to animal diseases and production. Now in its third edition, this is the only introductory level textbook on genetics that has been written specifically for veterinary and animal science students.  \u003cp\u003eCoverage includes: basic genetics, molecular biology, genomics, cytogenetics, immunogenetics, population genetics, quantitative genetics, biotechnology, and the use of molecular tools in the control of inherited disorders. \u003c\/p\u003e \u003cp\u003eThis book describes in detail how genetics is being applied to artificial selection in animal production.   It also covers the conservation of genetic diversity in both domesticated and wild animals.\u003c\/p\u003e \u003cp\u003eNew for the Third Edition:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003eEnd-of-chapter summaries provide quick recaps.\u003c\/li\u003e \u003cli\u003eCovers new topics: epigenetics, genomics and bioinformatics.\u003c\/li\u003e \u003cli\u003eThoroughly revised according to recent advances in genetics.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eIntroduction to Veterinary Genetics\u003c\/i\u003e is still the only introductory genetics textbook for students of veterinary and animal science and will continue to be an indispensable reference tool for veterinary students and practitioners alike.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989469216997,"sku":"NP9781405168328","price":71.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781405168328.jpg?v=1761784225","url":"https:\/\/k12savings.com\/products\/introduction-to-veterinary-genetics-isbn-9781405168328","provider":"K12savings","version":"1.0","type":"link"}