{"product_id":"introduction-to-strategies-for-organic-synthesis-isbn-9781119347248","title":"Introduction to Strategies for Organic Synthesis","description":"\u003cp\u003e\u003cb\u003eBridging the Gap Between Organic Chemistry Fundamentals and Advanced Synthesis Problems\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIntroduction to Strategies of Organic Synthesis\u003c\/i\u003e bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist’s point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule.  \u003c\/p\u003e \u003cp\u003eSuccess in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity.  This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule.\u003c\/p\u003e \u003cp\u003eThis new Second Edition of \u003ci\u003eIntroduction to Strategies for Organic Synthesis\u003c\/i\u003e:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eReviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms\u003c\/li\u003e \u003cli\u003eExplores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions\u003c\/li\u003e \u003cli\u003eHelps students envision forward reactions and backwards disconnections as a matter of routine\u003c\/li\u003e \u003cli\u003eGives students confidence in performing retrosynthetic analyses of target molecules Includes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions\u003c\/li\u003e \u003cli\u003eProvides clear explanations in easy-to-follow, student-friendly language\u003c\/li\u003e \u003cli\u003eFocuses on the \u003ci\u003estrategies\u003c\/i\u003e of organic synthesis rather than a catalogue of reactions and modern reagents\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike.\u003c\/p\u003e \u003cp\u003ePreface xix\u003c\/p\u003e \u003cp\u003eAcknowlegments xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 1 Synthetic Toolbox 1: Retrosynthesis and Protective Groups 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Retrosynthetic Analysis 3\u003c\/p\u003e \u003cp\u003e1.2 Protective Groups 11\u003c\/p\u003e \u003cp\u003eCHAPTER 1 Problems Protective Groups 19\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 2 Synthetic Toolbox 2: Overview of Organic Transformations 21\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Nucleophiles and Electrophiles 23\u003c\/p\u003e \u003cp\u003e2.2 Oxidation and Reduction Reactions 27\u003c\/p\u003e \u003cp\u003eCHAPTER 2 Problems Nucleophiles, Electrophiles, and Redox 41\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 3 Synthesis of Monofunctional Target Molecules (1-FG TMs) 45\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Synthesis of Alcohols (ROH) and Phenols (ArOH) 47\u003c\/p\u003e \u003cp\u003e3.2 Synthesis of Alkyl (RX) and Aryl Halides (ArX) 61\u003c\/p\u003e \u003cp\u003e3.3 Synthesis of Ethers (ROR′) 67\u003c\/p\u003e \u003cp\u003e3.4 Synthesis of Thiols (RSH) and Thioethers (RSR´) 73\u003c\/p\u003e \u003cp\u003e3.5 Synthesis of Amines (RNH2) and Anilines (ArNH2) 77\u003c\/p\u003e \u003cp\u003e3.6 Synthesis of Alkenes (R2C¨TCR2) 85\u003c\/p\u003e \u003cp\u003e3.7 Synthesis of Alkynes (RC≡CR′) 93\u003c\/p\u003e \u003cp\u003e3.8 Synthesis of Alkanes (RH) 97\u003c\/p\u003e \u003cp\u003e3.9 Synthesis of Aldehydes and Ketones (RCHO, R2C¨TO) 105\u003c\/p\u003e \u003cp\u003e3.10 Synthesis of Carboxylic Acids (RCO2H) 117\u003c\/p\u003e \u003cp\u003e3.11 Synthesis of Carboxylic Acid Derivatives 125\u003c\/p\u003e \u003cp\u003eCHAPTER 3 Problems 1-FG TMs 139\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 4 Synthesis of Target Molecules with Two Functional Groups (2-FG TMs) 143\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Synthesis of β©\\Hydroxy Carbonyls and α,β©\\Unsaturated Carbonyls 145\u003c\/p\u003e \u003cp\u003e4.2 More Enolate Reactions: Synthesis of 1,3©\\Dicarbonyls, 1,5©\\Dicarbonyls, and Cyclohexenones 157\u003c\/p\u003e \u003cp\u003e4.3 “Illogical” 2©\\Group Disconnections: Umpolung (Polarity Reversal) 171\u003c\/p\u003e \u003cp\u003eCHAPTER 4 Problems 2-FG TMs 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 5 Synthesis of Aromatic Target Molecules 187\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Electrophilic Aromatic Substitution (ArH + E+ → ArE) 189\u003c\/p\u003e \u003cp\u003e5.2 Synthesis of Aromatic TMs via Diazonium Salts (ArN2 + + Nu: → ArNu) 201\u003c\/p\u003e \u003cp\u003e5.3 Nucleophilic Aromatic Substitution (ArX + Nu: → ArNu) 205\u003c\/p\u003e \u003cp\u003eCHAPTER 5 Problems Aromatic TMs 209\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 6 Synthesis of Compounds Containing Rings 211\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Synthesis of Cyclopropanes 213\u003c\/p\u003e \u003cp\u003e6.2 Synthesis of Cyclobutanes 215\u003c\/p\u003e \u003cp\u003e6.3 Synthesis of Five©\\Membered Rings (Radical Cyclization Reactions) 217\u003c\/p\u003e \u003cp\u003e6.4 Synthesis of Six©\\Membered Rings (Diels–Alder Reaction) 221\u003c\/p\u003e \u003cp\u003eCHAPTER 6 Problems Cyclic TMs 231\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 7 Predicting and Controlling Stereochemistry 235\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Reactions that Form Racemates 237\u003c\/p\u003e \u003cp\u003e7.2 SN2 Mechanism: Backside Attack 243\u003c\/p\u003e \u003cp\u003e7.3 Elimination Mechanisms 245\u003c\/p\u003e \u003cp\u003e7.4 Additions to Alkenes and Alkynes 247\u003c\/p\u003e \u003cp\u003e7.5 Additions to Carbonyls 251\u003c\/p\u003e \u003cp\u003e7.6 Additions to Enolates: Aldol Stereochemistry 257\u003c\/p\u003e \u003cp\u003e7.7 Enantioselectivity and Asymmetric Syntheses 261\u003c\/p\u003e \u003cp\u003eCHAPTER 7 Problems Stereochemistry 269\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 8 Transition Metal-Mediated Carbon–Carbon Bond Formation 273\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Transition Metal Coordination Complexes 275\u003c\/p\u003e \u003cp\u003e8.2 Organometallic Reaction Mechanisms 283\u003c\/p\u003e \u003cp\u003e8.3 Carbonylation and Decarbonylation 291\u003c\/p\u003e \u003cp\u003e8.4 (ArX + Alkene → Ar©\\Alkene) 295\u003c\/p\u003e \u003cp\u003e8.5 Palladium©\\Catalyzed Cross©\\Coupling Reactions (RX + R′M → R©\\R′) 297\u003c\/p\u003e \u003cp\u003e8.6 Olefin Metathesis Reactions 303\u003c\/p\u003e \u003cp\u003e8.7 Retrosynthesis: Disconnections Based on Metal-Mediated Reactions 307\u003c\/p\u003e \u003cp\u003eCHAPTER 8 Problems Transition Metal-Mediated Synthesis 309\u003c\/p\u003e \u003cp\u003eSOLUTIONS TO PROBLEMS 313\u003c\/p\u003e \u003cp\u003eIndex 389\u003c\/p\u003e   \u003cp\u003e\u003cb\u003eLAURIE S. STARKEY, P\u003csmall\u003eH\u003c\/small\u003eD,\u003c\/b\u003e is a Professor of Organic Chemistry at California State Polytechnic University, Pomona, where she has been teaching organic chemistry and organic synthesis since 1996. Her research focuses on chemical education, including the development and assessment of online learning tools and the creation of educational videos and animations. Dr. Starkey was awarded the Cal Poly Pomona College of Science's Distinguished Teaching Award in 2000, and the Provost's Award in Teaching Excellence in 2013.     \u003c\/p\u003e\u003cp\u003e\u003cb\u003eBRIDGING THE GAP BETWEEN ORGANIC CHEMISTRY FUNDAMENTALS AND ADVANCED SYNTHESIS PROBLEMS\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003eIntroduction to Strategies for Organic Synthesis\u003c\/i\u003e bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist's point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule.  \u003c\/p\u003e\u003cp\u003eSuccess in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity. This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule.  \u003c\/p\u003e\u003cp\u003eThis new Second Edition of \u003ci\u003eIntroduction to Strategies for Organic Synthesis\u003c\/i\u003e: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eReviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms\u003c\/li\u003e \u003cli\u003eExplores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions\u003c\/li\u003e \u003cli\u003eHelps students envision forward reactions and backwards disconnections as a matter of routine\u003c\/li\u003e \u003cli\u003eGives students confidence in performing retrosynthetic analyses of target molecules\u003c\/li\u003e \u003cli\u003eIncludes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions\u003c\/li\u003e \u003cli\u003eProvides clear explanations in easy-to-follow, student-friendly language\u003c\/li\u003e \u003cli\u003eFocuses on the \u003ci\u003estrategies\u003c\/i\u003e of organic synthesis rather than a catalog of reactions and modern reagents\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989467316453,"sku":"NP9781119347248","price":58.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119347248.jpg?v=1761784216","url":"https:\/\/k12savings.com\/products\/introduction-to-strategies-for-organic-synthesis-isbn-9781119347248","provider":"K12savings","version":"1.0","type":"link"}