Introduction to Medicinal Chemistry

This work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities of today's pharmacist have dictated a restructuring of the pharmacy curriculum, including individual course content. This book reflects and addresses these developments. This is a well-written work that covers most major areas of pharmaceutical research. The text is presented in a logical and concise fashion being divided into chapters based upon therapeutic topic. This makes the work very useful for teaching a course in medicinal chemistry since therapeutic areas can be separately covered without having to make use of the entire book which overall contains a tremendous amount of information. This book is a significant contribution to understanding what medicinal chemistry is and how this science is used to develop new therapeutic agents.Was ist medizinische Chemie? Wie kann man ihre Erkenntnisse nutzen, um neue therapeutische Wirkstoffe zu entwickeln und zu vervollkommnen? Dieses Buch stellt das Zusammenspiel von Grundlagenfachern - organischer Chemie, Biochemie und Biologie - und klinischer Praxis in den Vordergrund - ein Ansatz, der die gestiegene Verantwortung des Pharmazeuten in unserer Zeit reflektiert. Der Leser verfolgt, wie sich Therapiestrategien fur bestimmte Krankheitsbilder historisch entwickelt haben - so werden auch Schwierigkeiten nachvollziehbar, mit denen man bei der Prognose von Wirkung und Einsatzmoglichkeiten neuartiger Pharmazeutika zu kampfen haben kann. Gut verstandlich geschrieben, mit brillianten Graphiken versehen und ubersichtlich gegliedert - in Anlehnung an moderne Studienplane der Pharmazie: Zu jedem Krankheitsbild bzw. Organsystem werden die Wirkstoffe, eingeteilt nach Strukturklassen, abgehandelt. Insbesondere fur Studenten der hoheren Semester und den Nachwuchs der industriellen Forschung geeignet. Basic Considerations of Drug Activity.

Mechanisms of Drug Action.

Drug Metabolism and Inactivation.

Anticancer Drugs and Their Mechanism of Action.

Analgetics and Nonsteroidal Antiinflammatory Agents.

Antimicrobial Drugs I. Antimicrobial Drugs II.

Drugs Affecting Cholinergic Mechanisms.

Drugs Affecting Adrenergic Mechanisms.

Drugs and the Cardiovascular Diseases.

Drugs and the Cardiovascular Diseases II.

Psychoactive Drugs--Chemotherapy of the Mind.

Histamine Antagonists and Local Anesthetics.

Steroids.

New Developments and New Problems.

Index. Aus dem Inhalt:
Basic Considerations of Drug Activity/
Mechanisms of Drug Action/
Drug Metabolism and Inactivation/
Anticancer Drugs and Their Mechanism of Action/
Analgetics and Nonsteroidal Antiinflammatory Agents/
Antimicrobial Drugs/
Drugs Affecting Cholinergic Mechanisms/
Drugs Affecting Adrenegic Mechanisms/
Drugs and the Cardiovascular Diseases/
Psychoactive Drugs -
Chemotherapy of the Mind/
Histamine Antagonists and Local Anesthetics/
Steroids. Alex Gringauz, Lithuanian, American chemistry educator, pharmacist, researcher, writer. Member American Chemical Society, American Pharmaceutical Association, Sigma Xi. Gringauz, Alex was born on May 18, 1934 in Klaipeda, Lithuania. Came to the United States, 1947.

Bachelor of Science in Pharmacy cum laude, Brooklyn College of Pharmacy, 1956. Master of Science, Purdue University, 1958. Doctor of Philosophy, Purdue University, 1960.