{"product_id":"how-not-to-study-a-disease-isbn-9780262045902","title":"How Not to Study a Disease","description":"\u003cb\u003eAn authority on Alzheimer's disease offers a history of past failures and a roadmap that points us in a new direction in our journey to a cure.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eFor decades, some of our best and brightest medical scientists have dedicated themselves to finding a cure for Alzheimer's disease. What happened? Where is the cure? The biggest breakthroughs occurred twenty-five years ago, with little progress since. In \u003ci\u003eHow Not to Study a Disease\u003c\/i\u003e, neurobiologist Karl Herrup explains why the Alzheimer's discoveries of the 1990s didn't bear fruit and maps a direction for future research. Herrup describes the research, explains what's taking so long, and offers an approach for resetting future research.\u003cbr\u003e\u003cbr\u003eHerrup offers a unique insider's perspective, describing the red flags that science ignored in the rush to find a cure. He is unsparing in calling out the stubbornness, greed, and bad advice that has hamstrung the field, but his final message is a largely optimistic one. Herrup presents a new and sweeping vision of the field that includes a redefinition of the disease and a fresh conceptualization of aging and dementia that asks us to imagine the brain as a series of interconnected \"neighborhoods.\" He calls for changes in virtually every aspect of the Alzheimer's disease research effort, from the drug development process, to the mechanisms of support for basic research, to the often-overlooked role of the scientific media, and more. With \u003ci\u003eHow Not to Study a Disease\u003c\/i\u003e, Herrup provides a roadmap that points us in a new direction in our journey to a cure for Alzheimer's.Prologue ix\u003cbr\u003eI In the Beginning 1\u003cbr\u003e1 A Layperson's History of Alzheimer's Disease 3\u003cbr\u003e2 A Physician's History of Alzheimer's Disease 23\u003cbr\u003e3 A Scientist's History of Alzheimer's Disease 33\u003cbr\u003e4 Mystery Solved! How Four Discoveries Transformed an Entire Field 53\u003cbr\u003eII What Happened to our Cure? 71\u003cbr\u003e5 Building a Model of Alzheimer's Disease 73\u003cbr\u003eIII Double-Edged Swords 97\u003cbr\u003e6 Federal Support of Basic Biomedical Research 99\u003cbr\u003e7 The Pharmaceutical and Biotech Industry 115\u003cbr\u003e8 Testing Our Models: Breaking Bad 131\u003cbr\u003e9 What is Alzheimer's Disease? 149\u003cbr\u003eIV Where Shall We Go From Here? 169\u003cbr\u003e10 A Layperson's Guide to the Biology of Aging 171\u003cbr\u003e11 Building a New Model of Alzheimer's Disease 187\u003cbr\u003e12 Rebalancing our Research Portfolio 207\u003cbr\u003e13 Rebalancing our Institutions 227\u003cbr\u003e14 Final Thoughts 243\u003cbr\u003eAcknowledgments 247\u003cbr\u003eNotes 249\u003cbr\u003eIndex 255“In \u003ci\u003eHow Not to Study a Disease\u003c\/i\u003e, a lucid, knowledgeable, but not entirely objective critique of the field of Alzheimer’s research, Karl Herrup, a professor of neurobiology at the University of Pittsburgh School of Medicine, analyzes this challenge. He describes the complexity of even defining the disease; tells of the excitement of Alzheimer’s research in the 1990s, when its cause was thought to be understood and treatments seemed imminent; and charts the long and expensive trickle of disappointment in the decades since, as it has become clear that the disease is much more complicated than was initially thought. As his title signals, Herrup criticizes the field for its adherence to a causal theory of Alzheimer’s that he argues does not hold up.”\u003cbr\u003e\u003cb\u003e—\u003ci\u003eNew York Review of Books\u003c\/i\u003e\u003c\/b\u003e\"...[an] important, accessible study...\" \u003ci\u003e\u003cb\u003e—\u003c\/b\u003e \u003cb\u003eNature\u003c\/b\u003e\u003c\/i\u003eKarl Herrup is Professor of Neurobiology and an Investigator in the Alzheimer's Disease Research Center at the University of Pittsburgh School of Medicine. He is also Adjunct Professor of Life Science at the Hong Kong University of Science and Technology, where he was formerly Head of Life Sciences.","brand":"The MIT Press","offers":[{"title":"Default Title","offer_id":46299731624165,"sku":"NP9780262045902","price":27.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780262045902.jpg?v=1767729334","url":"https:\/\/k12savings.com\/products\/how-not-to-study-a-disease-isbn-9780262045902","provider":"K12savings","version":"1.0","type":"link"}