{"product_id":"glial-physiology-and-pathophysiology-isbn-9780470978528","title":"Glial Physiology and Pathophysiology","description":"\u003cb\u003eGlial Physiology and Pathophysiology\u003c\/b\u003e provides a comprehensive, advanced text on the biology and pathology of glial cells.\u003cbr\u003e\u003cbr\u003eCoverage includes:\u003cbr\u003e \u003cul\u003e \u003cli\u003ethe morphology and interrelationships between glial cells and neurones in different parts of the nervous systems\u003c\/li\u003e \u003cli\u003ethe cellular physiology of the different kinds of glial cells\u003c\/li\u003e \u003cli\u003ethe mechanisms of intra- and inter-cellular signalling in glial networks\u003c\/li\u003e \u003cli\u003ethe mechanisms of glial-neuronal communications\u003c\/li\u003e \u003cli\u003ethe role of glial cells in synaptic plasticity, neuronal survival and development of nervous system\u003c\/li\u003e \u003cli\u003ethe cellular and molecular mechanisms of metabolic neuronal-glial interactions\u003c\/li\u003e \u003cli\u003ethe role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's\u003c\/li\u003e \u003c\/ul\u003e Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it.\u003cbr\u003e \u003cul\u003e \u003cli\u003eAn up-to-date and fully referenced text on the most numerous cells in the human brain\u003c\/li\u003e \u003cli\u003eDetailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system\u003c\/li\u003e \u003cli\u003eDescribes the role of glial cells in neuropathology\u003c\/li\u003e \u003cli\u003eFocus boxes highlight key points and summarise important facts\u003c\/li\u003e \u003cli\u003eCompanion website with downloadable figures and slides\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003eAbout the Authors xxi\u003c\/p\u003e \u003cp\u003eAbbreviations xxv\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xxxii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 History of Neuroscience and the Dawn of Research in Neuroglia 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 The miraculous human brain: localising the brain functions 1\u003c\/p\u003e \u003cp\u003e1.2 Cellular organisation of the brain 10\u003c\/p\u003e \u003cp\u003e1.3 Mechanisms of communications in neural networks 14\u003c\/p\u003e \u003cp\u003e1.4 The concept of neuroglia 27\u003c\/p\u003e \u003cp\u003e1.5 Beginning of the modern era 47\u003c\/p\u003e \u003cp\u003e1.6 Concluding remarks 49\u003c\/p\u003e \u003cp\u003eReferences 49\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 General Overview of Signalling in the Nervous System 59\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Intercellular signalling: wiring and volume modes of transmission 59\u003c\/p\u003e \u003cp\u003e2.2 Cellular signalling: receptors 62\u003c\/p\u003e \u003cp\u003e2.3 Intracellular signalling: second messengers 67\u003c\/p\u003e \u003cp\u003e2.4 Calcium signalling 67\u003c\/p\u003e \u003cp\u003e2.5 Concluding remarks 72\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Neuroglia: Definition, Classification, Evolution, Numbers, Development 73\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Definition of neuroglia as homeostatic cells of the nervous system 74\u003c\/p\u003e \u003cp\u003e3.2 Classification 75\u003c\/p\u003e \u003cp\u003e3.3 Evolution of neuroglia 76\u003c\/p\u003e \u003cp\u003e3.4 Numbers: how many glial cells are in the brain? 93\u003c\/p\u003e \u003cp\u003e3.5 Embryogenesis and development of neuroglia in mammals 96\u003c\/p\u003e \u003cp\u003e3.6 Concluding remarks 99\u003c\/p\u003e \u003cp\u003eReferences 100\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Astroglia 105\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Definition and heterogeneity 107\u003c\/p\u003e \u003cp\u003e4.2 Morphology of the main types of astroglia 113\u003c\/p\u003e \u003cp\u003e4.3 How to identify astrocytes in the nervous tissue 119\u003c\/p\u003e \u003cp\u003e4.4 Astroglial syncytial networks 120\u003c\/p\u003e \u003cp\u003e4.5 Physiology of astroglia 125\u003c\/p\u003e \u003cp\u003e4.6 Functions of astroglia 175\u003c\/p\u003e \u003cp\u003e4.7 Concluding remarks 231\u003c\/p\u003e \u003cp\u003eReferences 231\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Oligodendrocytes 245\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Oligodendrocyte anatomy 247\u003c\/p\u003e \u003cp\u003e5.2 Myelin structure and function 252\u003c\/p\u003e \u003cp\u003e5.3 Physiology of oligodendrocytes 266\u003c\/p\u003e \u003cp\u003e5.4 Oligodendrocyte development 283\u003c\/p\u003e \u003cp\u003e5.5 Concluding remarks 299\u003c\/p\u003e \u003cp\u003eReferences 299\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 NG2-glial Cells 321\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Definition of NG2-glia 321\u003c\/p\u003e \u003cp\u003e6.2 Structure of NG2-glia 324\u003c\/p\u003e \u003cp\u003e6.3 Physiology of NG2-glia 327\u003c\/p\u003e \u003cp\u003e6.4 Proliferation of NG2-glia and generation of oligodendrocytes 332\u003c\/p\u003e \u003cp\u003e6.5 Relationship between NG2-glia and CNS pericytes 333\u003c\/p\u003e \u003cp\u003e6.6 Evolution of NG2-glia 336\u003c\/p\u003e \u003cp\u003e6.7 Concluding remarks 337\u003c\/p\u003e \u003cp\u003eReferences 337\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Microglia 343\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Definition of microglia 344\u003c\/p\u003e \u003cp\u003e7.2 Microglial origin and development 345\u003c\/p\u003e \u003cp\u003e7.3 Morphology of microglia 345\u003c\/p\u003e \u003cp\u003e7.4 General physiology of microglia 351\u003c\/p\u003e \u003cp\u003e7.5 Microglial migration and motility 372\u003c\/p\u003e \u003cp\u003e7.6 Physiological functions of microglia: role in synaptic transmission and plasticity 373\u003c\/p\u003e \u003cp\u003e7.7 Microglia in ageing 375\u003c\/p\u003e \u003cp\u003e7.8 Concluding remarks 375\u003c\/p\u003e \u003cp\u003eReferences 376\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Peripheral Glial Cells 381\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Peripheral nervous system 382\u003c\/p\u003e \u003cp\u003e8.2 Schwann cells 390\u003c\/p\u003e \u003cp\u003e8.3 Satellite glial cells 407\u003c\/p\u003e \u003cp\u003e8.4 Enteric glia 412\u003c\/p\u003e \u003cp\u003e8.5 Olfactory ensheathing cells (OECs) 418\u003c\/p\u003e \u003cp\u003e8.6 Concluding remarks 422\u003c\/p\u003e \u003cp\u003eReferences 423\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 General Pathophysiology of Neuroglia 431\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Neurological disorders as gliopathologies 431\u003c\/p\u003e \u003cp\u003e9.2 Reactive astrogliosis 433\u003c\/p\u003e \u003cp\u003e9.3 Wallerian degeneration 439\u003c\/p\u003e \u003cp\u003e9.4 Excitotoxic vulnerability of oligodendrocytes: the death of white matter 442\u003c\/p\u003e \u003cp\u003e9.5 Activation of microglia 444\u003c\/p\u003e \u003cp\u003e9.6 Concluding remarks 449\u003c\/p\u003e \u003cp\u003eReferences 450\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Neuroglia in Neurological Diseases 453\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 454\u003c\/p\u003e \u003cp\u003e10.2 Genetic astrogliopathology: Alexander disease 456\u003c\/p\u003e \u003cp\u003e10.3 Stroke and ischaemia 458\u003c\/p\u003e \u003cp\u003e10.4 Migraine and spreading depression 467\u003c\/p\u003e \u003cp\u003e10.5 CNS oedema 469\u003c\/p\u003e \u003cp\u003e10.6 Metabolic disorders 471\u003c\/p\u003e \u003cp\u003e10.7 Toxic encephalopathies 473\u003c\/p\u003e \u003cp\u003e10.8 Neurodegenerative diseases 474\u003c\/p\u003e \u003cp\u003e10.9 Leukodystrophies 487\u003c\/p\u003e \u003cp\u003e10.10 Epilepsy 488\u003c\/p\u003e \u003cp\u003e10.11 Psychiatric diseases 490\u003c\/p\u003e \u003cp\u003e10.12 Autistic disorders 491\u003c\/p\u003e \u003cp\u003e10.13 Neuropathic pain 492\u003c\/p\u003e \u003cp\u003e10.14 Demyelinating diseases 494\u003c\/p\u003e \u003cp\u003e10.15 Infectious diseases 496\u003c\/p\u003e \u003cp\u003e10.16 Peripheral neuropathies 499\u003c\/p\u003e \u003cp\u003e10.17 Gliomas 501\u003c\/p\u003e \u003cp\u003e10.18 Concluding remarks 504\u003c\/p\u003e \u003cp\u003eReferences 504\u003c\/p\u003e \u003cp\u003eAuthor Index 513\u003c\/p\u003e \u003cp\u003eSubject Index 517\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAlexei Verkhratsky\u003c\/b\u003e is Professor of Neurophysiology and Chairman of the Division of Neuroscience at the University of Manchester, UK.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eArthur Butt\u003c\/b\u003e is Professor of Cellular Neurophysiology, Department of Pharmacy and Biomedical Sciences, University of Portsmouth, UK.\u003c\/p\u003e \u003cb\u003eGlial Physiology and Pathophysiology\u003c\/b\u003e provides a comprehensive, advanced text on the biology and pathology of glial cells.\u003cbr\u003e\u003cbr\u003eCoverage includes:\u003cbr\u003e \u003cul\u003e \u003cli\u003ethe morphology and interrelationships between glial cells and neurones in different parts of the nervous systems\u003c\/li\u003e \u003cli\u003ethe cellular physiology of the different kinds of glial cells\u003c\/li\u003e \u003cli\u003ethe mechanisms of intra- and inter-cellular signalling in glial networks\u003c\/li\u003e \u003cli\u003ethe mechanisms of glial-neuronal communications\u003c\/li\u003e \u003cli\u003ethe role of glial cells in synaptic plasticity, neuronal survival and development of nervous system\u003c\/li\u003e \u003cli\u003ethe cellular and molecular mechanisms of metabolic neuronal-glial interactions\u003c\/li\u003e \u003cli\u003ethe role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's\u003c\/li\u003e \u003c\/ul\u003e Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it.\u003cbr\u003e \u003cul\u003e \u003cli\u003eAn up-to-date and fully referenced text on the most numerous cells in the human brain\u003c\/li\u003e \u003cli\u003eDetailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system\u003c\/li\u003e \u003cli\u003eDescribes the role of glial cells in neuropathology\u003c\/li\u003e \u003cli\u003eFocus boxes highlight key points and summarise important facts\u003c\/li\u003e \u003cli\u003eCompanion website with downloadable figures and slides\u003c\/li\u003e \u003c\/ul\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989292105957,"sku":"NP9780470978528","price":153.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470978528.jpg?v=1761783544","url":"https:\/\/k12savings.com\/products\/glial-physiology-and-pathophysiology-isbn-9780470978528","provider":"K12savings","version":"1.0","type":"link"}