{"product_id":"glial-neurobiology-isbn-9780470015643","title":"Glial Neurobiology","description":"\u003cp\u003e\"This volume is a very valuable and much needed contribution.\"\u003cbr\u003e—\u003ci\u003e\u003cb\u003eQuarterly Review of Biology\u003c\/b\u003e\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAT LAST - A comprehensive, accessible textbook on glial neurobiology!\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGlial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead, on neurones and neuronal networks because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn’t exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFeatures of this book:\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003ean accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain function and nervous system pathology\u003c\/li\u003e \u003cli\u003ean exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the ACNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels\u003c\/li\u003e \u003cli\u003ean investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more\u003c\/li\u003e \u003cli\u003ea wealth of illustrations, including unique images from the authors' own libraries of images, describing the main features of glial cells\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten by two leading experts in the field, \u003ci\u003eGlial Neurobiology\u003c\/i\u003e provides a concise, authoritative introduction to glial physiology and pathology for undergraduate\/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, and neurology, neurosurgery and physiology students. It is also an invaluable resource for researchers in neuroscience, physiology, pharmacology and pharmaceutics.\u003c\/p\u003e  \u003cb\u003ePreface.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eList of abbreviations.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I Physiology of Glia.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction to Glia.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Founders of glial research: from Gabriel Valentin to Karl-Ludwig Schleich.\u003c\/p\u003e \u003cp\u003e1.2 Beginning of the modern era.\u003c\/p\u003e \u003cp\u003e1.3 Changing concepts: Glia express molecules of excitation.\u003c\/p\u003e \u003cp\u003e1.4 Glia and neurones in dialogue.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 General Overview of Signalling in the Nervous System.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Intercellular signalling: Wiring and volume modes of transmission.\u003c\/p\u003e \u003cp\u003e2.2 Intracellular signalling.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Morphology of Glial Cells.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Astrocytes.\u003c\/p\u003e \u003cp\u003e3.2 Oligodendrocytes.\u003c\/p\u003e \u003cp\u003e3.3 NG2 expressing glia.\u003c\/p\u003e \u003cp\u003e3.4 Schwann cells.\u003c\/p\u003e \u003cp\u003e3.5 Microglia.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Glial Development.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Phylogeny of glia and evolutionary specificity of glial cells in human brain.\u003c\/p\u003e \u003cp\u003e4.2 Macroglial cells.\u003c\/p\u003e \u003cp\u003e4.3 Astroglial cells are brain stem cells.\u003c\/p\u003e \u003cp\u003e4.4 Schwann cell lineage.\u003c\/p\u003e \u003cp\u003e4.5 Microglial cell lineage.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 General Physiology of Glial Cells.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Membrane potential and ion distribution.\u003c\/p\u003e \u003cp\u003e5.2 Ion channels.\u003c\/p\u003e \u003cp\u003e5.3 Receptors to neurotransmitters and neuromodulators.\u003c\/p\u003e \u003cp\u003e5.4 Glial syncytium – gap junctions.\u003c\/p\u003e \u003cp\u003e5.5 Glial calcium signalling.\u003c\/p\u003e \u003cp\u003e5.6 Neurotransmitter release from astroglial cells.\u003c\/p\u003e \u003cp\u003e5.7 Glial neurotransmitter transporters.\u003c\/p\u003e \u003cp\u003e5.8 Glial cells produce and release neuropeptides.\u003c\/p\u003e \u003cp\u003e5.9 Glial cell derived growth factors.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Neuronal–Glial Interactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Close apposition of neurones and astroglia: the tripartite synapse.\u003c\/p\u003e \u003cp\u003e6.2 Neuronal–glial synapses.\u003c\/p\u003e \u003cp\u003e6.3 Signalling from neurones to astrocytes.\u003c\/p\u003e \u003cp\u003e6.4 Signalling from astrocytes to neurones.\u003c\/p\u003e \u003cp\u003e6.5 Signalling between oligodendrocytes and neurones.\u003c\/p\u003e \u003cp\u003e6.6 Signalling between Schwann cells and peripheral nerves and nerve endings.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II Glial Cells and Nervous System Function.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Astrocytes.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Developmental function – producing new neural cells.\u003c\/p\u003e \u003cp\u003e7.2 Developmental function – neuronal guidance.\u003c\/p\u003e \u003cp\u003e7.3 Regulation of synaptogenesis and control of synaptic maintenance and elimination.\u003c\/p\u003e \u003cp\u003e7.4 Structural function – creation of the functional microarchitecture of the brain.\u003c\/p\u003e \u003cp\u003e7.5 Vascular function – creation of glial–vascular interface (blood–brain barrier) and glia–neurone–vascular units.\u003c\/p\u003e \u003cp\u003e7.6 Regulation of brain microcirculation.\u003c\/p\u003e \u003cp\u003e7.7 Ion homeostasis in the extracellular space.\u003c\/p\u003e \u003cp\u003e7.8 Regulation of extracellular glutamate concentration.\u003c\/p\u003e \u003cp\u003e7.9 Water homeostasis and regulation of the extracellular space volume.\u003c\/p\u003e \u003cp\u003e7.10 Neuronal metabolic support.\u003c\/p\u003e \u003cp\u003e7.11 Astroglia regulate synaptic transmission.\u003c\/p\u003e \u003cp\u003e7.12 Integration in neuronal–glial networks.\u003c\/p\u003e \u003cp\u003e7.13 Astrocytes as cellular substrate of memory and consciousness?\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Oligodendrocytes, Schwann Cells and Myelination.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 The myelin sheath.\u003c\/p\u003e \u003cp\u003e8.2 Myelination.\u003c\/p\u003e \u003cp\u003e8.3 Myelin and propagation of the action potential.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III Glia and Nervous System Pathology.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 General Pathophysiology of Glia.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Reactive astrogliosis.\u003c\/p\u003e \u003cp\u003e9.2 Wallerian degeneration.\u003c\/p\u003e \u003cp\u003e9.3 Activation of microglia.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Glia and Diseases of the Nervous System.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Alexander’s disease.\u003c\/p\u003e \u003cp\u003e10.2 Spreading depression.\u003c\/p\u003e \u003cp\u003e10.3 Stroke and ischaemia.\u003c\/p\u003e \u003cp\u003e10.4 Cytotoxic brain oedema.\u003c\/p\u003e \u003cp\u003e10.5 Neurodegenerative diseases.\u003c\/p\u003e \u003cp\u003e10.6 Neuropathic pain.\u003c\/p\u003e \u003cp\u003e10.7 Demyelinating diseases.\u003c\/p\u003e \u003cp\u003e10.8 Infectious diseases.\u003c\/p\u003e \u003cp\u003e10.9 Peripheral neuropathies.\u003c\/p\u003e \u003cp\u003e10.10 Psychiatric diseases.\u003c\/p\u003e \u003cp\u003e10.11 Gliomas.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eConclusions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRecommended literature.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAuthor Index.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSubject Index.\u003c\/b\u003e\u003c\/p\u003e \"This volume is a very valuable and much needed contribution.\" (\u003ci\u003eQuarterly Review of Biology\u003c\/i\u003e, December 2008)  \u003cb\u003eAlexei Verkhratsky\u003c\/b\u003e is Professor of Neurophysiology and Chairman of the Division of Neuroscience at the University of Manchester, UK  \u003cp\u003e\u003cb\u003eArthur Butt\u003c\/b\u003e is Professor of Cellular Neurophysiology, Department of Pharmacy and Biomedical Sciences, University of Portsmouth, UK.\u003c\/p\u003e \u003cp\u003eGlial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead on neurones and neuronal networks, because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn't exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFeatures of this book:\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003ean accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain fusion and nervous system pathology\u003c\/li\u003e \u003cli\u003ean exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the CNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels\u003c\/li\u003e \u003cli\u003ean investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more\u003c\/li\u003e \u003cli\u003ea wealth of illustrations, including unique images from the authors' own libraries of images describing the main features of glial cells\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten by two leading experts in the field, \u003ci\u003eGlial Neurobiology\u003c\/i\u003e provides a concise, authoritative introduction to glial physiology and pathology for undergraduate\/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, and neurology, neurosurgery and physiology students. It will also appeal to researchers in neuroscience, physiology, pharmacology and pharmaceutics.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989291974885,"sku":"NP9780470015643","price":258.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470015643.jpg?v=1761783545","url":"https:\/\/k12savings.com\/products\/glial-neurobiology-isbn-9780470015643","provider":"K12savings","version":"1.0","type":"link"}