{"product_id":"genomics-proteomics-and-vaccines-isbn-9780470856161","title":"Genomics, Proteomics and Vaccines","description":"While the sequence of the human genome sequence has hit the headlines, extensive exploitation of this for practical applications is still to come. Genomic and post-genomic technologies applied to viral and bacterial pathogens, which are almost equally important from a scientific perspective, have the potential to be translated into useful products and processes much more rapidly.\u003cbr\u003e \u003cbr\u003e Genomics, Proteomics and Vaccines introduces the history of vaccinology and discusses how vaccines are expected to evolve in the future. It describes the relevant technologies, including genome sequencing and analysis, DNA microarrays, 2D electrophoresis and 2D chromatography, mass spectrometry and high-throughput protein expression and purification. The book also features examples of the exploitation of genomics and post-genomics in vaccine discovery, and contains useful descriptions of the biology and pathogenesis of clinically important bacterial pathogens.\u003cbr\u003e \u003cbr\u003e This book should be of interest to all those working in vaccine discovery and development in pharmaceutical and biotechnology companies as well as in academic institutions\"Genomics, Proteomics and Vaccines\" erläutert die Auswirkungen der neuen Disziplin der Genomik auf den traditionellen Bereich der Impfstoffentwicklung.\u003cbr\u003e \u003cbr\u003e Mit Beispielen für den Einsatz der Genomik bei der Entwicklung von Impfstoffen gegen wichtige Krankheitserreger.\u003cbr\u003e \u003cbr\u003e Das Buch beschreibt einen der vielversprechendsten Bereiche für den Einfluss der Genomik auf die Medizintechnologie.  Preface.  \u003cp\u003eList of Contributors.\u003c\/p\u003e \u003cp\u003ePART 1: INTRODUCTION.\u003c\/p\u003e \u003cp\u003e1. Vaccination: Past, Present and Future (Maria Lattanzi and Rino Rappuoli).\u003c\/p\u003e \u003cp\u003e2. Bioinformatics, DNA Microarrays and Proteomics in Vaccine Discovery: Competing or Complementary Technologies? (Guido Grandi).\u003c\/p\u003e \u003cp\u003ePART 2: TECHNOLOGIES.\u003c\/p\u003e \u003cp\u003e3. Genome Sequencing and Analysis (Hervé Tettelin and Tamara Feldblyum).\u003c\/p\u003e \u003cp\u003e4. Understanding DNA Microarrays: Sources and Magnitudes of Variances in DNA Microarray Data Sets (She-pin Hung, G. Wesley Hatfield, Suman Sundaresh and Pierre F. Baldi).\u003c\/p\u003e \u003cp\u003e5. The proteome, \u003ci\u003eAnno Domini\u003c\/i\u003e Two Zero Zero Three (Pier Giorgio Righetti, Mahmoud Hamdan, Frederic Reymond and Joël S. Rossier).\u003c\/p\u003e \u003cp\u003e6. Mass Spectrometry in Proteomics (Pierre-Alain Binz).\u003c\/p\u003e \u003cp\u003e7. High Throughput Cloning, Expression and Purification Technologies (Andreas Kreusch and Scott A. Lesley).\u003c\/p\u003e \u003cp\u003ePART 3: APPLICATIONS.\u003c\/p\u003e \u003cp\u003e8. Meningococcus B: from Genome to Vaccine (Davide Serruto, Rino Rappuoli and Mariagrazia Pizza).\u003c\/p\u003e \u003cp\u003e9. Vaccines Against Pathogenic Streptococci (John L. Telford, Immaculada Margarit y Ros, Domenico Maione, Vega Masignani, Hervé Tettelin, Giuliano Bensi and Guido Grandi).\u003c\/p\u003e \u003cp\u003e10. Identification of the 'Antigenome'–a Novel Tools for Design and Development of Subunit Vaccines Against Bacterial Pathogens (Eszter Nagy, Tamás Henics, Alexander von Gabain and Andreas Meinke).\u003c\/p\u003e \u003cp\u003e11. Searching the Chlamydia Genomes for New Vaccine Candidates (Giulio Ratti, Oretta Finco and Guido Grandi).\u003c\/p\u003e \u003cp\u003e12. Proteomics and Anti-Chlamydia Vaccine Discovery (Gunna Christiansen, Svend Birkelund, Brian B. Vandahl and Allan C Shaw).\u003c\/p\u003e \u003cp\u003e13. Proteome Analysis of Other Membrane and Extracelular Proteins from \u003ci\u003ePseudomonas aeruginosa\u003c\/i\u003e for vaccine Discovery (Stuart J. Cordwell and Amanda S. Nouwens).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e  \"...this book kept me fascinated for many hours...it is an excellent book...\" (\u003ci\u003eJournal of Chemical Technology \u0026amp; Biotechnology\u003c\/i\u003e, Vol 80 (11), November 2005)  \u003cp\u003e\"…an excellent book on a topical issue that will appeal to research scientists looking to find new and alternative means of designing and developing vaccines.\" (\u003ci\u003eASM News\u003c\/i\u003e, March 2005)\u003c\/p\u003e \u003cp\u003e\"...chapters are written by experts in the field...new data is provided as well as descriptions of their biology...\" (\u003ci\u003eCAB Publishing\u003c\/i\u003e, 2004)\u003c\/p\u003e \u003cp\u003e\"...should be of interest to all those working in vaccine discovery and development in pharmaceutical and biotechnology companies as well as in academic institutions.\" (\u003ci\u003eThe Biotech Journal\u003c\/i\u003e, November\/December 2003)\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eGuido Grandi\u003c\/strong\u003e is the editor of \u003cem\u003eGenomics, Proteomics and Vaccines\u003c\/em\u003e, published by Wiley.   The field of vaccine development is one of the first to benefit from the new technologies of genomics, proteomics and bioinformatics. The complete genome sequences of many bacteria are available and comparisons of pathogenic strains with non-pathogenic relatives are becoming common. Vaccines can now be targeted towards specific gene products that traditional vaccine research failed to discover. This book describes the current status of this field and summarizes the various strategies that are delivering results.  \u003c\/p\u003e\u003cp\u003eThe introductory section provides an overview of vaccine research and looks at how genomics can complement traditional approaches. The second section focuses on advanced technologies, such as genome sequence analysis, microarrays, proteomics and high-throughput cloning.\u003c\/p\u003e \u003cp\u003eThe third section constitutes the unique part of this book, with six chapters that describe the application of genomic and proteomic techniques in the search for new antibacterial vaccines. The target pathogens include meningococcus B, streptococci, chlamydia and \u003ci\u003ePseudomonas\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003eInfectious diseases are once again threatening the health of human populations, even in countries where they were thought to have been controlled. With the spread of antibiotic resistance, the concept of prevention rather than cure becomes ever more important. The new genomic approaches described in this book will help to accelerate vaccine development and benefit the health of millions of people worldwide.\u003c\/p\u003e \u003cp\u003eThis book should be of interest to all those working in vaccine discovery and development in pharmaceutical and biotechnology companies as well as in academic institutions.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989279457509,"sku":"NP9780470856161","price":246.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470856161.jpg?v=1761783495","url":"https:\/\/k12savings.com\/products\/genomics-proteomics-and-vaccines-isbn-9780470856161","provider":"K12savings","version":"1.0","type":"link"}