{"product_id":"genomics-isbn-9781405108195","title":"Genomics","description":"Written by the successful author team of Sandy Primrose and Richard Twyman, \u003ci\u003eGenomics: Applications in Human Biology\u003c\/i\u003e is a topical book showing how the new science of genomics is adding impetus to the advances in human health provided by biotechnology. \u003cbr\u003e \u003cul\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eWritten to provide the necessary overview of the subject, covering technological developments, applications and (where necessary) the ethical implications.\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eDivided into three sections, the first section introduces the role of biotechnology and genomics in medicine and sets out some of the technological advances that have been the basis of recent medical breakthroughs.\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eThe second section takes a closer look at how biotechnology and genomics are influencing the prevention and treatment of different categories of disease.\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eFinally the contribution of biotechnology and genomics to the development of different types of therapy is described, including conventional drugs, recombinant proteins and gene\/cell therapies.\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eReferences to appropriate sections in other two popular books, authored by Sandy Primrose and Richard Twyman, are included - Principles of Gene Manipulation and Principles of Gene Analysis and Genomics.\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eFeatures several categories of boxed text, including history boxes (describing the origins and development of particular technologies or treatments), molecular boxes (featuring the molecular basis of diseases or treatments in more detail) and ethic boxes (which discusses the ethical implications of technology development and new therapies).\u003c\/li\u003e \u003c\/ul\u003e  \u003cb\u003eChapter One: Biotechnology And Genomics In Medicine.\u003c\/b\u003e \u003cp\u003eIntroduction.\u003c\/p\u003e \u003cp\u003eRecombinant DNA Technology.\u003c\/p\u003e \u003cp\u003eFrom Recombinant DNA To Molecular Medicine.\u003c\/p\u003e \u003cp\u003eGene Medicine.\u003c\/p\u003e \u003cp\u003eDisease Models.\u003c\/p\u003e \u003cp\u003eThe Impact Of Genomics On Medicine.\u003c\/p\u003e \u003cp\u003eThe New Molecular Medicine.\u003c\/p\u003e \u003cp\u003eOutline Of This Book.\u003c\/p\u003e \u003cp\u003eFurther Reading.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter Two: An Overview Of Genomics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction.\u003c\/p\u003e \u003cp\u003eA Review Of Progress: The Human Genome Project.\u003c\/p\u003e \u003cp\u003eThe Future: Functional Genomics.\u003c\/p\u003e \u003cp\u003eMutational Genomics.\u003c\/p\u003e \u003cp\u003eFurther Reading.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter Three: Genomics And The Challenge Of Infectious Disease.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMicroorganisms Causing Disease.\u003c\/p\u003e \u003cp\u003eWhere Do New Diseases Come From?.\u003c\/p\u003e \u003cp\u003eIdentifying The Causative Agent Of A Disease.\u003c\/p\u003e \u003cp\u003eMolecular Epidemiology.\u003c\/p\u003e \u003cp\u003eHost Resistance To Infection.\u003c\/p\u003e \u003cp\u003eUnderstanding Bacterial Pathogenicity.\u003c\/p\u003e \u003cp\u003eComparative Genomics And Genome Plasticity.\u003c\/p\u003e \u003cp\u003eCombating Infectious Disease.\u003c\/p\u003e \u003cp\u003eFurther Reading.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter Four: Analyzing And Treating Genetic Diseases.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenetic Disease In Context.\u003c\/p\u003e \u003cp\u003eDetecting Single Gene Disorders.\u003c\/p\u003e \u003cp\u003eTreating Single Gene Disorders.\u003c\/p\u003e \u003cp\u003eFinding Genes For Monogenic Diseases And Determining Gene Function.\u003c\/p\u003e \u003cp\u003eAnalysis Of Polygenic Disorders.\u003c\/p\u003e \u003cp\u003eHaplotypes.\u003c\/p\u003e \u003cp\u003eThe Major Histocompatibility Complex (MHC).\u003c\/p\u003e \u003cp\u003eIndividual Responses To Drugs (Pharmacogenomics).\u003c\/p\u003e \u003cp\u003eFurther Reading.\u003c\/p\u003e \u003cp\u003eChapter Five: Diagnosis And Treatment Of Cancer.\u003c\/p\u003e \u003cp\u003eIntroduction.\u003c\/p\u003e \u003cp\u003eThe Impact Of Genomics On Cancer Research.\u003c\/p\u003e \u003cp\u003eNew Methods For The Diagnosis Of Cancer.\u003c\/p\u003e \u003cp\u003eNew Approaches To Cancer Therapy.\u003c\/p\u003e \u003cp\u003eFurther Reading.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter Six: The Large Scale Production Of Biopharmaceuticals.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eOverview.\u003c\/p\u003e \u003cp\u003eThe Generation Of Monoclonal Antibodies.\u003c\/p\u003e \u003cp\u003eThe Large Scale Culture Of Microorganisms.\u003c\/p\u003e \u003cp\u003eThe Large Scale Culture Of Animal Cells.\u003c\/p\u003e \u003cp\u003eExpression Systems.\u003c\/p\u003e \u003cp\u003eDownstream Processing.\u003c\/p\u003e \u003cp\u003eUsing Gene Manipulation To Facilitate Downstream Processing. Of Biopharmaceuticals.\u003c\/p\u003e \u003cp\u003eThe Quality Of Biopharmaceuticals.\u003c\/p\u003e \u003cp\u003eGood Manufacturing Practice.\u003c\/p\u003e \u003cp\u003eAlternative Production Systems.\u003c\/p\u003e \u003cp\u003eFurther Reading.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter Seven: Genomics And The Development Of New Chemical Entities.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction. How Drugs Are Developed.\u003c\/p\u003e \u003cp\u003eHigh-Throughput Screening.\u003c\/p\u003e \u003cp\u003eTarget Validation And Animal Models.\u003c\/p\u003e \u003cp\u003eCombinatorial Chemistry.\u003c\/p\u003e \u003cp\u003eDynamic Combinatorial Libraries.\u003c\/p\u003e \u003cp\u003eVirtual Screening.\u003c\/p\u003e \u003cp\u003eCombinatorial Biosynthesis And Chemobiosynthesis.\u003c\/p\u003e \u003cp\u003eDrug Metabolism.\u003c\/p\u003e \u003cp\u003eToxicogenomics.\u003c\/p\u003e \u003cp\u003eFurther Reading.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter Eight: Gene And Cell Therapies.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction.\u003c\/p\u003e \u003cp\u003eGene Therapy.\u003c\/p\u003e \u003cp\u003eNucleic Acids As Drugs.\u003c\/p\u003e \u003cp\u003eDNA Vaccines.\u003c\/p\u003e \u003cp\u003eDisease Models.\u003c\/p\u003e \u003cp\u003eCell Therapy.\u003c\/p\u003e \u003cp\u003eFurther Reading.\u003c\/p\u003e \"Genomics is the more specialised...but still manages to cover an impressive array of topics relevant to human biology, including infectious disease, cancer and biopharmaceuticals. Wherever possible, the authors have gone out of their way to link technology and biological application.\" \u003ci\u003ePaul B. Rainey, Times Higher Education Supplement, March 2004\u003c\/i\u003e \u003c!--end--\u003e  \u003cb\u003eSandy Primrose\u003c\/b\u003e was an academic for 10 years and a senior manager in the biotechnology industry for 20 years. He now manages a consultancy practice focused on technology management. He is also Visiting Professor at the Universities of Warwick and Liverpool, and sits on the board of a number of biotechnology companies.\u003cbr\u003e \u003cp\u003e\u003cb\u003eRichard Twyman\u003c\/b\u003e worked as a research scientist at the University of Warwick and the MRC Laboratory of Molecular Biology in Cambridge before taking up scientific writing as a full-time occupation in 1998. He is currently a Visiting Fellow at the Department of Biology, University of York, and manages a company that provides scientific writing services.\u003c\/p\u003e  Written by the successful author team of Sandy Primrose and Richard Twyman, \u003ci\u003eGenomics: Applications in Human Biology\u003c\/i\u003e is a topical book showing how the new science of genomics is adding impetus to the advances in human health provided by biotechnology. \u003cbr\u003e \u003cp\u003eAimed at advanced undergraduates, it assumes a basic knowledge of the principles of recombinant DNA technology and will form an excellent basis for further study into human disease, cancer, and new therapies.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cul\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eWritten to provide the necessary overview of the subject, covering technological developments, applications and (where necessary) their ethical implications\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eDivided into three sections, the first section introduces the role of biotechnology and genomics in medicine and sets out some of the technological advances that have been the basis of recent medical breakthroughs\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eThe second section takes a closer look at how biotechnology and genomics are influencing the prevention and treatment of different categories of disease\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eFinally the contribution of biotechnology and genomics to the development of different types of therapy is described, including conventional drugs, recombinant proteins and gene\/cell therapies\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eReferences to appropriate sections in two other popular books, authored by Sandy Primrose and Richard Twyman, are included - Principles of Gene Manipulation and Principles of Gene Analysis and Genomics\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eFeatures several categories of boxed text, including history boxes (describing the origins and development of particular technologies or treatments), molecular boxes (featuring the molecular basis of diseases or treatments in more detail) and ethics boxes (which discusses the ethical implications of technology development and new therapies)\u003c\/li\u003e \u003c\/ul\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989279883493,"sku":"NP9781405108195","price":109.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781405108195.jpg?v=1761783496","url":"https:\/\/k12savings.com\/products\/genomics-isbn-9781405108195","provider":"K12savings","version":"1.0","type":"link"}