{"product_id":"genomes-evolution-and-culture-isbn-9781118876404","title":"Genomes, Evolution, and Culture","description":"This book combines recent information and discoveries in the field of human molecular biology and human molecular evolution. It provides an interdisciplinary approach drawing together data from various diverse disciplines to address both the more classical anthropological content and the current more contemporary molecular focus of courses. Chapters include a history of human evolutionary genetics; the human genome structure and function; population structure and variability; gene and genomic dynamics; culture; health and disease; bioethics; future. \u003cp\u003ePreface, ix\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The history of human evolutionary genetics, 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWorld views, 1\u003c\/p\u003e \u003cp\u003eScience and philosophy, 1\u003c\/p\u003e \u003cp\u003eThe biology of mankind: anatomy and physiology in a historical context (up to the 16th century), 3\u003c\/p\u003e \u003cp\u003eBeginnings of the present scientific model, 4\u003c\/p\u003e \u003cp\u003eBiological evolution and genetic foundations: the brilliant quartet, 5\u003c\/p\u003e \u003cp\u003eNineteenth century: cytology, embryology, and reproduction, 9\u003c\/p\u003e \u003cp\u003eTwentieth century, the century of genetics, 10\u003c\/p\u003e \u003cp\u003eThe synthetic theory of evolution, 11\u003c\/p\u003e \u003cp\u003eBacterial and molecular genetics, 11\u003c\/p\u003e \u003cp\u003eParallel developments: paleoanthropology, 12\u003c\/p\u003e \u003cp\u003eTechnical and methodological developments, 13\u003c\/p\u003e \u003cp\u003eConclusions, 14\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 14\u003c\/p\u003e \u003cp\u003eReferences, 14\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 The human genome: structure, function, and variation, 16\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eScience, politics, and ethics, 16\u003c\/p\u003e \u003cp\u003eStructural aspects, 17\u003c\/p\u003e \u003cp\u003eNormal and abnormal phenotype distribution, 19\u003c\/p\u003e \u003cp\u003eFunction, 21\u003c\/p\u003e \u003cp\u003eSex chromosomes, 23\u003c\/p\u003e \u003cp\u003ePaleogenomics, 25\u003c\/p\u003e \u003cp\u003eVariability: mtDNA, 28\u003c\/p\u003e \u003cp\u003eNuclear variability, 28\u003c\/p\u003e \u003cp\u003eExomes and proteomes, 30\u003c\/p\u003e \u003cp\u003eSelection or drift? History, 31\u003c\/p\u003e \u003cp\u003eSelection or drift? Methods, 32\u003c\/p\u003e \u003cp\u003eSelection or drift? Analyses, 34\u003c\/p\u003e \u003cp\u003eNervous system and culture, 37\u003c\/p\u003e \u003cp\u003eConclusions, 37\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 37\u003c\/p\u003e \u003cp\u003eReferences, 38\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Population structure, 42\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDNA-based marker systems, 42\u003c\/p\u003e \u003cp\u003eSNPs, STRs, and Indels as DNA markers, 45\u003c\/p\u003e \u003cp\u003ePopulation genetic tools for analyzing population structure, 49\u003c\/p\u003e \u003cp\u003eForces affecting population dynamics, structure, and evolution, 55\u003c\/p\u003e \u003cp\u003eApplications of population genetics, 60\u003c\/p\u003e \u003cp\u003eFrom populations to races and species, 62\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 64\u003c\/p\u003e \u003cp\u003eReferences, 65\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Genetic variability, 68\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eOn the nature of variability, 68\u003c\/p\u003e \u003cp\u003eMechanisms responsible for generating genetic variability, 69\u003c\/p\u003e \u003cp\u003eRandomness of mutations, 71\u003c\/p\u003e \u003cp\u003eInheritance and environment, 75\u003c\/p\u003e \u003cp\u003eSelection works on the phenotype, 76\u003c\/p\u003e \u003cp\u003eThe impact of selection, 77\u003c\/p\u003e \u003cp\u003eCultural expressions as markers of ancestry, 79\u003c\/p\u003e \u003cp\u003eCongruency among marker systems, 80\u003c\/p\u003e \u003cp\u003eDoes junk DNA exist?, 80\u003c\/p\u003e \u003cp\u003eHow genetic diversity is studied?, 82\u003c\/p\u003e \u003cp\u003eEpigenetic diversity, 84\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 85\u003c\/p\u003e \u003cp\u003eReferences, 86\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Gene and genomic dynamics, 87\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMolecular evidence for punctuated equilibrium and gradualism, 88\u003c\/p\u003e \u003cp\u003eNext-generation sequencing, 90\u003c\/p\u003e \u003cp\u003eGenetic variation, 92\u003c\/p\u003e \u003cp\u003eVariation, population structure, and effective population size, 94\u003c\/p\u003e \u003cp\u003eRecombination and its effect on variation, 94\u003c\/p\u003e \u003cp\u003eLinkage equilibrium and disequilibrium, 95\u003c\/p\u003e \u003cp\u003eForces leading to linkage disequilibrium, 98\u003c\/p\u003e \u003cp\u003eLinkage disequilibrium and SNP haplotypes, 99\u003c\/p\u003e \u003cp\u003eLinkage disequilibrium in humans, 100\u003c\/p\u003e \u003cp\u003eGenome structural variations, 102\u003c\/p\u003e \u003cp\u003eCNV classifications and formation mechanisms, 102\u003c\/p\u003e \u003cp\u003eMethods used to detect CNVs, 103\u003c\/p\u003e \u003cp\u003eCNVs associated with human phenotypes, 105\u003c\/p\u003e \u003cp\u003eCNVs and evolution, 106\u003c\/p\u003e \u003cp\u003eCNV in primates, 107\u003c\/p\u003e \u003cp\u003eChromosome rearrangements and selfish genetic elements, 108\u003c\/p\u003e \u003cp\u003eTransposable elements, 109\u003c\/p\u003e \u003cp\u003ePopulation dynamics of transposable elements, 110\u003c\/p\u003e \u003cp\u003eTransposons in human evolution, 111\u003c\/p\u003e \u003cp\u003eSelfish genetic elements in evolution, 113\u003c\/p\u003e \u003cp\u003eGenome-wide association studies, 113\u003c\/p\u003e \u003cp\u003eConcerns over the effective use of GWAS, 117\u003c\/p\u003e \u003cp\u003eConclusions, 117\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 118\u003c\/p\u003e \u003cp\u003eReferences, 119\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Human origins and early diasporas, 124\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe on switch to humanity, 124\u003c\/p\u003e \u003cp\u003eEarly hominins, 128\u003c\/p\u003e \u003cp\u003eEmerging themes and variations in hominin evolution, 130\u003c\/p\u003e \u003cp\u003eThe first hominin migrants, 134\u003c\/p\u003e \u003cp\u003eThe emergence of modern humans, 135\u003c\/p\u003e \u003cp\u003eThe Saharan pump, 135\u003c\/p\u003e \u003cp\u003eEarly migrations, 136\u003c\/p\u003e \u003cp\u003eNeanderthals prevailed, 136\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 138\u003c\/p\u003e \u003cp\u003eReferences, 139\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Culture, 141\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eConcept, 141\u003c\/p\u003e \u003cp\u003eOrigin and development, 141\u003c\/p\u003e \u003cp\u003eFactors that could condition cultural evolution, 142\u003c\/p\u003e \u003cp\u003eBiology–culture interaction, 145\u003c\/p\u003e \u003cp\u003eLanguage, 146\u003c\/p\u003e \u003cp\u003eDomestication, 148\u003c\/p\u003e \u003cp\u003eArt, 151\u003c\/p\u003e \u003cp\u003eFree will, morality, and religion, 153\u003c\/p\u003e \u003cp\u003eConclusions, 155\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 155\u003c\/p\u003e \u003cp\u003eReferences, 155\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Health and disease, 158\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eHopes and reality, 158\u003c\/p\u003e \u003cp\u003eConcept of health and methods of study, 158\u003c\/p\u003e \u003cp\u003eDarwinian medicine, 160\u003c\/p\u003e \u003cp\u003eParent–offspring conflict, 161\u003c\/p\u003e \u003cp\u003ePathogen history, 161\u003c\/p\u003e \u003cp\u003eEvolution of infectious diseases, 162\u003c\/p\u003e \u003cp\u003eDNA damage, mutagenesis, and teratogenesis, 163\u003c\/p\u003e \u003cp\u003eWhat is better, more or less gene product?, 165\u003c\/p\u003e \u003cp\u003eGenetic manipulation of animals to study health and disease, 166\u003c\/p\u003e \u003cp\u003eReproductive fitness and health, 167\u003c\/p\u003e \u003cp\u003eConsanguinity, 168\u003c\/p\u003e \u003cp\u003eViolence, 168\u003c\/p\u003e \u003cp\u003eCancer, 171\u003c\/p\u003e \u003cp\u003eDegenerative diseases, 172\u003c\/p\u003e \u003cp\u003eEcogenetics, pharmacogenetics, and pharmacogenomics, 174\u003c\/p\u003e \u003cp\u003eDetection of genetic diseases, 176\u003c\/p\u003e \u003cp\u003eGenetic counseling, 176\u003c\/p\u003e \u003cp\u003eTreatment, 178\u003c\/p\u003e \u003cp\u003eConclusions, 179\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 179\u003c\/p\u003e \u003cp\u003eReferences, 180\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Recent human evolution: an integrative approach, 182\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRecent human evolution, 182\u003c\/p\u003e \u003cp\u003eOut of Africa, 184\u003c\/p\u003e \u003cp\u003eBack to Africa, 188\u003c\/p\u003e \u003cp\u003eBeyond Arabia, 190\u003c\/p\u003e \u003cp\u003eThe Asian agricultural revolution and the Austronesian expansion, 194\u003c\/p\u003e \u003cp\u003eEvidence from plants and animals, 198\u003c\/p\u003e \u003cp\u003eContacts between South America and Polynesia, 200\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 202\u003c\/p\u003e \u003cp\u003eReferences, 203\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Bioethics: consequences and implications of genetic technology on human evolution, 206\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSocial and biological evolution, 207\u003c\/p\u003e \u003cp\u003eOverview of ethics and philosophical influences on Western ethics, 207\u003c\/p\u003e \u003cp\u003eEvolution of ethics and morality, 212\u003c\/p\u003e \u003cp\u003eThe history and beginning of modern-day bioethics, 213\u003c\/p\u003e \u003cp\u003eReproductive technologies and the new eugenics: unnatural selection?, 216\u003c\/p\u003e \u003cp\u003eEnhancement through IVF, PGD, and CRISPR, 219\u003c\/p\u003e \u003cp\u003eEthical issues associated with medical technology, 220\u003c\/p\u003e \u003cp\u003eGene therapy, 220\u003c\/p\u003e \u003cp\u003eStem cell therapy, 222\u003c\/p\u003e \u003cp\u003eBiosimilars, 222\u003c\/p\u003e \u003cp\u003eGenetic privacy, 222\u003c\/p\u003e \u003cp\u003eGenetic testing, 223\u003c\/p\u003e \u003cp\u003eDNA profiling, 224\u003c\/p\u003e \u003cp\u003eConclusions, 227\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 227\u003c\/p\u003e \u003cp\u003eReferences, 228\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Future of human evolution, 230\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGene and culture coevolution, 231\u003c\/p\u003e \u003cp\u003eLife expectancy and population growth: past, present, and future, 231\u003c\/p\u003e \u003cp\u003eMutation rates and future evolution, 232\u003c\/p\u003e \u003cp\u003eThe evolution of new genes, 234\u003c\/p\u003e \u003cp\u003eClimate change, 234\u003c\/p\u003e \u003cp\u003eDiet, 235\u003c\/p\u003e \u003cp\u003eSex selection, 236\u003c\/p\u003e \u003cp\u003eArtificial selection, 236\u003c\/p\u003e \u003cp\u003eTranshumanism and artificial intelligence, 237\u003c\/p\u003e \u003cp\u003eConclusions, 238\u003c\/p\u003e \u003cp\u003eReview questions and exercises, 239\u003c\/p\u003e \u003cp\u003eReferences, 239\u003c\/p\u003e \u003cp\u003eAppendix, 241\u003c\/p\u003e \u003cp\u003eIndex, 249\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRene Herrera\u003c\/b\u003e Emeritus, Department of Molecular and Human Genetics, College of Medicine, Florida International University, USA\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRalph Bertrand\u003c\/b\u003e Department of Biology, Colorado College, USA\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFrancisco Salzano \u003c\/b\u003eDepartamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Brazil\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989279391973,"sku":"NP9781118876404","price":74.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118876404.jpg?v=1761783494","url":"https:\/\/k12savings.com\/products\/genomes-evolution-and-culture-isbn-9781118876404","provider":"K12savings","version":"1.0","type":"link"}