{"product_id":"generation-and-effector-functions-of-regulatory-lymphocytes-isbn-9780470850749","title":"Generation and Effector Functions of Regulatory Lymphocytes","description":"Over the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions are diverse and can sometimes easily be lost, and it is not well understood how they interact with antigen-presenting cells. \u003cp\u003eThis book contains contributions from leading investigators from around the world, including lively discussion of the current state of the art in studies of regulatory lymphocytes. Topics featured are the physiological control of autoimmunity, the role of antigen-specific cells in various diseases and disease models and effector mechanisms. Therapeutic applications are considered, particularly for type 1 diabetes, tissue transplantation and the control of viral infection. This important and groundbreaking book should be of interest to all immunologists.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRelated\u003ci\u003e Novartis Foundation symposia:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e254 \u003ci\u003eImmunoinformatics: bioinformatic strategies for better understanding of immune function\u003c\/i\u003e\u003cbr\u003eChair: Hans-Georg Rammensee\u003c\/p\u003e \u003cp\u003e256 \u003ci\u003eCancer and inflammation\u003c\/i\u003e\u003cbr\u003eChair: Siamon Gordon\u003c\/p\u003e  Chair's Introduction (J. Bach).  \u003cp\u003eThymic generation and selection of  CD25\u003csup\u003e+\u003c\/sup\u003eCD4\u003csup\u003e+\u003c\/sup\u003e regulatory T cells; implicaitons of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance (S. Sakaguchi, \u003ci\u003eet al.\u003c\/i\u003e ).\u003c\/p\u003e \u003cp\u003eControl of Tcell activation by CD4\u003csup\u003e+\u003c\/sup\u003eCD25\u003csup\u003e+\u003c\/sup\u003e suppressor T cells (E.M. Shevach, \u003cb\u003eet al.\u003c\/b\u003e).\u003c\/p\u003e \u003cp\u003eRegulaton of experimental autoimmune encephalomyelitis (EAE) by CD4\u003csup\u003e+\u003c\/sup\u003eCD25\u003csup\u003e+\u003c\/sup\u003e regulatroy T cells (A.P. Kohm, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eThe role of CD28 and CTLA4 in the function of homeostasis of CD4\u003csup\u003e+\u003c\/sup\u003eCD25\u003csup\u003e+\u003c\/sup\u003e regulatory T cells (E. Boden, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eCD4\u003csup\u003e+\u003c\/sup\u003eCD25\u003csup\u003e+\u003c\/sup\u003e regulatory cells from human peripheral blood express very high levels of CD25 \u003ci\u003eex vivo\u003c\/i\u003e (C. Baecher-Allan, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eControl of immune pathology by regulatory Tcells (F. Powrie, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eGeneral discussion I TGFß.\u003c\/p\u003e \u003cp\u003eType 1 T regulatory cells and their relationship with CD4\u003csup\u003e+\u003c\/sup\u003eCD2 5\u003csup\u003e+ \u003c\/sup\u003e T regulatory cells (M.G. Roncarolo, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e(PRO)insulin-specific regulatory T cells (L.C. Harrison, et al.).\u003c\/p\u003e \u003cp\u003eCD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into mechanism of protection against Type 1 diabetes (Q. Mi, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eSeven surprises in the TCR-centred regulation of immune responsiveness in an autoimmmune system (E. Sercarz, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eRegulatory cells in transplantation (K.J. Wood, et al.).\u003c\/p\u003e \u003cp\u003eCD4\u003csup\u003e+\u003c\/sup\u003e regulatory T cells in chronic viral infection (K.J. Hasenkrug).\u003c\/p\u003e \u003cp\u003eGeneral discussion II.\u003c\/p\u003e \u003cp\u003eModulation of T cell responses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship (M.H.M. Wauben, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eDendritic cells: controller of the immune system and a new promise for immunotherapy (J. Banchereau, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eRegulation of viral and autoimmune responses (C. Asseman, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eGeneral discussion III Active immune regulation.\u003c\/p\u003e \u003cp\u003eNotch signalling in the peripheral immune system (M.J. Dallman, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eCD3 antibody treament stimulates the functional capability of regulatory T cells (L. Chatenoud).\u003c\/p\u003e \u003cp\u003eThe role of dendritic cells in regulating mucosal immunity and tolerance (A. Mowat, \u003ci\u003eet al.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eIndex of Contributors.\u003c\/p\u003e \u003cp\u003eSubject Index. \u003c\/p\u003e  The \u003cstrong\u003eNovartis Foundation\u003c\/strong\u003e is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.   Over the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions are diverse and can sometimes easily be lost, and it is not well understood how they interact with antigen-presenting cells.  \u003cp\u003eThis book contains contributions from leading investigators from around the world, including lively discussion of the current state of the art in studies of regulatory lymphocytes. Topics featured are the physiological control of autoimmunity, the role of antigen-specific cells in various diseases and disease models and effector mechanisms. Therapeutic applications are considered, particularly for type 1 diabetes, tissue transp lantation and the control of viral infection. This important and groundbreaking book should be of interest to all immunologists.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e\u003ci\u003eRelated Novartis Foundation symposia:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e254 Immunoinformatics: bioinformatic strategies for better understanding of immune function\u003c\/p\u003e \u003cp\u003eChair: Hans-Georg Rammensee\u003c\/p\u003e \u003cp\u003e256 Cancer and inflammation\u003c\/p\u003e \u003cp\u003eChair: Simon Gordon\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989277262053,"sku":"NP9780470850749","price":253.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470850749.jpg?v=1761783486","url":"https:\/\/k12savings.com\/products\/generation-and-effector-functions-of-regulatory-lymphocytes-isbn-9780470850749","provider":"K12savings","version":"1.0","type":"link"}