{"product_id":"fundamentals-of-biochemistry-isbn-9781118918432","title":"Fundamentals of Biochemistry","description":"\u003cp\u003eVoet, Voet and Pratt’s Fundamentals of Biochemistry, 5e addresses the enormous advances in biochemistry, particularly in the areas of structural biology and Bioinformatics, by providing a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future.  While continuing in its tradition of presenting complete and balanced coverage that is clearly written and relevant to human health and disease, Fundamentals of Biochemistry, 5e includes new pedagogy and enhanced visuals that provide a pathway for student learning.\u003c\/p\u003e \u003cp\u003eThe authors are careful to present new information such that it links it to existing content, ever mindful that students assimilate new information only in the proper context.\u003c\/p\u003e \u003cp\u003ePreface xii\u003c\/p\u003e \u003cp\u003eAcknowledgments xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I INTRODUCTION\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Life, Cell and Thermodynamics 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The Origin of Life 2\u003c\/p\u003e \u003cp\u003e2 Cellular Architecture 5\u003c\/p\u003e \u003cp\u003e3 Thermodynamics 11\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Physical and Chemical Properties of Water 23\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Physical Properties of Water 24\u003c\/p\u003e \u003cp\u003e2 Chemical Properties of Water 31\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I I BIOMOLECULES\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Overview of DNA Structure, Function, and Engineering 42\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Nucleotides 43\u003c\/p\u003e \u003cp\u003e2 Introduction to Nucleic Acid Structure 46\u003c\/p\u003e \u003cp\u003e3 Overview of Nucleic Acid Function 50\u003c\/p\u003e \u003cp\u003e4 Nucleic Acid Sequencing 53\u003c\/p\u003e \u003cp\u003e5 Manipulating DNA 66\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Amino Acids 80\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Amino Acid Structure 81\u003c\/p\u003e \u003cp\u003e2 Stereochemistry 88\u003c\/p\u003e \u003cp\u003e3 Amino Acid Derivatives 91\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Polypeptide Analysis, Sequencing and Evolution 97\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Polypeptide Diversity 98\u003c\/p\u003e \u003cp\u003e2 Protein Purifi cation and Analysis 99\u003c\/p\u003e \u003cp\u003e3 Protein Sequencing 110\u003c\/p\u003e \u003cp\u003e4 Protein Evolution 119\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Proteins: Structure and Folding 131\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Secondary Structure 132\u003c\/p\u003e \u003cp\u003e2 Tertiary Structure 145\u003c\/p\u003e \u003cp\u003e3 Quaternary Structure and Symmetry 158\u003c\/p\u003e \u003cp\u003e4 Protein Stability 160\u003c\/p\u003e \u003cp\u003e5 Protein Folding 165\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Physiological Activities of Proteins 180\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Oxygen Binding to Myoglobin and Hemoglobin 181\u003c\/p\u003e \u003cp\u003e2 Muscle Contraction 200\u003c\/p\u003e \u003cp\u003e3 Antibodies 212\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Saccharide Chemistry 221\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Monosaccharides 222\u003c\/p\u003e \u003cp\u003e2 Polysaccharides 228\u003c\/p\u003e \u003cp\u003e3 Glycoproteins 234\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Lipids, Bilayer and Membranes 245\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Lipid Classifi cation 246\u003c\/p\u003e \u003cp\u003e2 Lipid Bilayers 259\u003c\/p\u003e \u003cp\u003e3 Membrane Proteins 262\u003c\/p\u003e \u003cp\u003e4 Membrane Structure and Assembly 269\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Passive and Active Transport 293\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Thermodynamics of Transport 294\u003c\/p\u003e \u003cp\u003e2 Passive-Mediated Transport 295\u003c\/p\u003e \u003cp\u003e3 Active Transport 309\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I I I ENZYMES\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Mechanisms of Enzyme Action 322\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 General Properties of Enzymes 323\u003c\/p\u003e \u003cp\u003e2 Activation Energy and the Reaction Coordinate 327\u003c\/p\u003e \u003cp\u003e3 Catalytic Mechanisms 330\u003c\/p\u003e \u003cp\u003e4 Lysozyme 339\u003c\/p\u003e \u003cp\u003e5 Serine Proteases 345\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Properties of Enzymes 361\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Reaction Kinetics 362\u003c\/p\u003e \u003cp\u003e2 Enzyme Inhibition 374\u003c\/p\u003e \u003cp\u003e3 Control of Enzyme Activity 382\u003c\/p\u003e \u003cp\u003e4 Drug Design 391\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Hormones and Signal Transduction 402\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Hormones 403\u003c\/p\u003e \u003cp\u003e2 Receptor Tyrosine Kinases 408\u003c\/p\u003e \u003cp\u003e3 Heterotrimeric G Proteins 423\u003c\/p\u003e \u003cp\u003e4 The Phosphoinositide Pathway 432\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV METABOLISM\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14 Bioenergetics 442\u003c\/p\u003e \u003cp\u003e1 Overview of Metabolism 443\u003c\/p\u003e \u003cp\u003e2 “High-Energy” Compounds 452\u003c\/p\u003e \u003cp\u003e3 Oxidation–Reduction Reactions 462\u003c\/p\u003e \u003cp\u003e4 Experimental Approaches to the Study of Metabolism 468\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Glycolysis and the Pentose Phosphate Pathway 478\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Overview of Glycolysis 479\u003c\/p\u003e \u003cp\u003e2 The Reactions of Glycolysis 481\u003c\/p\u003e \u003cp\u003e3 Fermentation: The Anaerobic Fate of Pyruvate 497\u003c\/p\u003e \u003cp\u003e4 Regulation of Glycolysis 502\u003c\/p\u003e \u003cp\u003e5 Metabolism of Hexoses Other than Glucose 508\u003c\/p\u003e \u003cp\u003e6 The Pentose Phosphate Pathway 512\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Additional Pathways in Carbohydrate Metabolism 523\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Glycogen Breakdown 524\u003c\/p\u003e \u003cp\u003e2 Glycogen Synthesis 532\u003c\/p\u003e \u003cp\u003e3 Control of Glycogen Metabolism 536\u003c\/p\u003e \u003cp\u003e4 Gluconeogenesis 544\u003c\/p\u003e \u003cp\u003e5 Other Carbohydrate Biosynthetic Pathways 551\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 The Citric Acid Cycle 558\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Overview of the Citric Acid Cycle 559\u003c\/p\u003e \u003cp\u003e2 Synthesis of Acetyl-Coenzyme A 562\u003c\/p\u003e \u003cp\u003e3 Enzymes of the Citric Acid Cycle 568\u003c\/p\u003e \u003cp\u003e4 Regulation of the Citric Acid Cycle 575\u003c\/p\u003e \u003cp\u003e5 Reactions Related to the Citric Acid Cycle 579\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Mitochondrial ATP Synthesis 588\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The Mitochondrion 589\u003c\/p\u003e \u003cp\u003e2 Electron Transport 593\u003c\/p\u003e \u003cp\u003e3 Oxidative Phosphorylation 609\u003c\/p\u003e \u003cp\u003e4 Control of Oxidative Metabolism 620\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Photosynthesis 630\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Chloroplasts 631\u003c\/p\u003e \u003cp\u003e2 The Light Reactions 635\u003c\/p\u003e \u003cp\u003e3 The Dark Reactions 651\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Synthesis and Degradation of lipids 664\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Lipid Digestion, Absorption, and Transport 664\u003c\/p\u003e \u003cp\u003e2 Fatty Acid Oxidation 671\u003c\/p\u003e \u003cp\u003e3 Ketone Bodies 685\u003c\/p\u003e \u003cp\u003e4 Fatty Acid Biosynthesis 686\u003c\/p\u003e \u003cp\u003e5 Regulation of Fatty Acid Metabolism 697\u003c\/p\u003e \u003cp\u003e6 Synthesis of Other Lipids 700\u003c\/p\u003e \u003cp\u003e7 Cholesterol Metabolism 706\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Synthesis and Degradation of Amino Acids 718\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Protein Degradation 719\u003c\/p\u003e \u003cp\u003e2 Amino Acid Deamination 724\u003c\/p\u003e \u003cp\u003e3 The Urea Cycle 728\u003c\/p\u003e \u003cp\u003e4 Breakdown of Amino Acids 733\u003c\/p\u003e \u003cp\u003e5 Amino Acid Biosynthesis 746\u003c\/p\u003e \u003cp\u003e6 Other Products of Amino Acid Metabolism 758\u003c\/p\u003e \u003cp\u003e7 Nitrogen Fixation 764\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 Regulation of Fuel Metabolism 773\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Organ Specialization 774\u003c\/p\u003e \u003cp\u003e2 Hormonal Control of Fuel Metabolism 781\u003c\/p\u003e \u003cp\u003e3 Metabolic Homeostasis: The Regulation of Energy Metabolism, Appetite, and Body Weight 786\u003c\/p\u003e \u003cp\u003e4 Disturbances in Fuel Metabolism 790\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V GENE EXPRESSION AND REPLICATION\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23 Nucleotide Synthesis and Degradation 802\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Synthesis of Purine Ribonucleotides 802\u003c\/p\u003e \u003cp\u003e2 Synthesis of Pyrimidine Ribonucleotides 809\u003c\/p\u003e \u003cp\u003e3 Formation of Deoxyribonucleotides 812\u003c\/p\u003e \u003cp\u003e4 Nucleotide Degradation 820\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24 DNA structure and Interactions with Proteins 831\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The DNA Helix 832\u003c\/p\u003e \u003cp\u003e2 Forces Stabilizing Nucleic Acid Structures 848\u003c\/p\u003e \u003cp\u003e3 Fractionation of Nucleic Acids 856\u003c\/p\u003e \u003cp\u003e4 DNA–Protein Interactions 859\u003c\/p\u003e \u003cp\u003e5 Eukaryotic Chromosome Structure 868\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25 DNA Synthesis and Repair 879\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Overview of DNA Replication 880\u003c\/p\u003e \u003cp\u003e2 Prokaryotic DNA Replication 882\u003c\/p\u003e \u003cp\u003e3 Eukaryotic DNA Replication 898\u003c\/p\u003e \u003cp\u003e4 DNA Damage 904\u003c\/p\u003e \u003cp\u003e5 DNA Repair 909\u003c\/p\u003e \u003cp\u003e6 Recombination 916\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26 RNA Metabolism 938\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Prokaryotic RNA Transcription 939\u003c\/p\u003e \u003cp\u003e2 Transcription in Eukaryotes 948\u003c\/p\u003e \u003cp\u003e3 Posttranscriptional Processing 961\u003c\/p\u003e \u003cp\u003e\u003cb\u003e27 The Genetic Code and Translation 982\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The Genetic Code 983\u003c\/p\u003e \u003cp\u003e2 Transfer RNA and Its Aminoacylation 988\u003c\/p\u003e \u003cp\u003e3 Ribosomes 996\u003c\/p\u003e \u003cp\u003e4 Translation 1004\u003c\/p\u003e \u003cp\u003e5 Posttranslational Processing 1024\u003c\/p\u003e \u003cp\u003e\u003cb\u003e28 Gene Expression in Prokaryotes and Eukaryotes 1033\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Genome Organization 1034\u003c\/p\u003e \u003cp\u003e2 Regulation of Prokaryotic Gene Expression 1043\u003c\/p\u003e \u003cp\u003e3 Regulation of Eukaryotic Gene Expression 1052\u003c\/p\u003e \u003cp\u003e4 The Cell Cycle, Cancer, Apoptosis, and Development 1080\u003c\/p\u003e \u003cp\u003eGlossary G-1 Index I-1\u003c\/p\u003e \u003cp\u003eSOLUTIONS to Odd-Numbered Problems SP-1\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDonald Voet\u003c\/b\u003e received a Ph.D. in chemistry from Harvard University and did postdoctoral research in the Biology Department at MIT. Don took up a faculty position in the department of chemistry at the University of Pennsylvania, upon completing his postdoctoral work. He has been a visiting scholar at Oxford University, the University of California San Diego, and the Weismann Institute of Science in Israel.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJudith Voet\u003c\/b\u003e received her Ph.D. from Brandeis University and did postdoctoral research at the University of Pennsylvania, Haverford College and the Fox Chase Cancer Center. She taught at the University of Delaware before moving to Swarthmore College. Together with Don Voet, she is Co-Editor-in-Chief of the journal \u003ci\u003eBiochemistry and Molecular Biology Education\u003c\/i\u003e.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989256683749,"sku":"NP9781118918432","price":111.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118918432.jpg?v=1761783404","url":"https:\/\/k12savings.com\/products\/fundamentals-of-biochemistry-isbn-9781118918432","provider":"K12savings","version":"1.0","type":"link"}