{"product_id":"functional-biochemistry-in-health-and-disease-isbn-9780471931652","title":"Functional Biochemistry in Health and Disease","description":"Functional Biochemistry in Health and Disease provides a clear and straightforward account of the biochemistry that is necessary to understand the physiological functions of tissues or organs essential to the life of human beings. Focusing on the dynamic aspects of biochemistry and its application to the basic functions of the body, the book bridges the gap between biochemistry and medical practice.\u003cbr\u003e \u003cbr\u003e Carefully structured within five sections, each biochemical, physiological or medical subject that is covered in the book is presented in one complete chapter. Consequently, each subject can be read and studied in isolation although cross-sectional links between the subjects are included where necessary. Background material, both biochemical and medical, that is necessary for an understanding of the subject, is included at the start of each chapter and clear, relevant diagrams enhance students' understanding.\u003cbr\u003e * Focuses on medically relevant aspects of biochemistry written from a physiological rather than a chemical perspective.\u003cbr\u003e * Clear presentation that minimises the use of jargon.\u003cbr\u003e * Each chapter contains boxes on related topics, relevant diagrams and a brief glossary.\u003cbr\u003e * Coverage includes athletic performance, apoptosis and the immune system.\u003cbr\u003e * Key historical developments are included to show how modern biochemistry has evolved.\u003cbr\u003e \u003cbr\u003e By linking biochemistry, medical education and clinical practice this book will prove invaluable to students in medical and health sciences, biomedical science and human biology taking an introductory biochemistry course. In addition it will appeal to biochemistry and biology students interested in clinical applications of biochemistry.Dieses Grundlagenwerk nähert sich seinem Stoff über die übergeordneten Fragestellungen. So werden biochemische Reaktionen und Stoffwechselvorgänge nicht anhand einzelner Moleküle, sondern hinsichtlich der physiologischen Zusammenhänge und ihrer klinischen Bedeutung erklärt. Abbreviations.\u003cbr\u003e \u003cbr\u003e I INTRODUCTION.\u003cbr\u003e \u003cbr\u003e 1 The Structural and Biochemical Hierarchy of a Cell and a Human.\u003cbr\u003e \u003cbr\u003e Cell structure.\u003cbr\u003e \u003cbr\u003e Tissues.\u003cbr\u003e \u003cbr\u003e The whole human.\u003cbr\u003e \u003cbr\u003e The biochemical hierarchy.\u003cbr\u003e \u003cbr\u003e II ESSENTIAL TOPICS IN DYNAMIC BIOCHEMISTRY.\u003cbr\u003e \u003cbr\u003e 2 Energy: In the Body, Tissues and Biochemical Processes.\u003cbr\u003e \u003cbr\u003e Energy transformations in the whole body.\u003cbr\u003e \u003cbr\u003e Energy transformations in tissues and organs.\u003cbr\u003e \u003cbr\u003e Energy transformation in biochemical reactions and pathways.\u003cbr\u003e \u003cbr\u003e Adenosine triphosphate: its role in the cell.\u003cbr\u003e \u003cbr\u003e 3 Enzymes: Activities, Properties, Regulation and Physiology.\u003cbr\u003e \u003cbr\u003e Nomenclature and classifi cation.\u003cbr\u003e \u003cbr\u003e Basic facts.\u003cbr\u003e \u003cbr\u003e Mechanisms by which an enzyme enhances the rate of a reaction.\u003cbr\u003e \u003cbr\u003e Cofactors and prosthetic groups.\u003cbr\u003e \u003cbr\u003e Factors that change the activity of an enzyme.\u003cbr\u003e \u003cbr\u003e Allosteric inhibition.\u003cbr\u003e \u003cbr\u003e The physiological signifi cance of Km and Vmax values.\u003cbr\u003e \u003cbr\u003e Enzymes as tools.\u003cbr\u003e \u003cbr\u003e Enzymes in diagnosis.\u003cbr\u003e \u003cbr\u003e Enzymes as therapeutic agents.\u003cbr\u003e \u003cbr\u003e Enzymes as targets for therapy.\u003cbr\u003e \u003cbr\u003e Kinetic structure of a biochemical pathway.\u003cbr\u003e \u003cbr\u003e Regulation of enzyme activity.\u003cbr\u003e \u003cbr\u003e 4 Transport into the Body: The Gastrointestinal Tract, Digestion and Absorption.\u003cbr\u003e \u003cbr\u003e Gross structure of the gastrointestinal tract.\u003cbr\u003e \u003cbr\u003e Biochemistry of cooking and food preparation.\u003cbr\u003e \u003cbr\u003e Digestion and absorption.\u003cbr\u003e \u003cbr\u003e The gastrointestinal tract and disease.\u003cbr\u003e \u003cbr\u003e 5 Transport into the Cell: Particles, Molecules and Ions.\u003cbr\u003e \u003cbr\u003e Structure of the plasma membrane.\u003cbr\u003e \u003cbr\u003e Diffusion through membranes.\u003cbr\u003e \u003cbr\u003e Active transport.\u003cbr\u003e \u003cbr\u003e Endocytosis and exocytosis.\u003cbr\u003e \u003cbr\u003e Physiological importance of some transport systems.\u003cbr\u003e \u003cbr\u003e III ESSENTIAL METABOLISM.\u003cbr\u003e \u003cbr\u003e 6 Carbohydrate Metabolism.\u003cbr\u003e \u003cbr\u003e Glycolysis.\u003cbr\u003e \u003cbr\u003e The biochemical and physiological importance of anaerobic glycolysis.\u003cbr\u003e \u003cbr\u003e Regulation of the flux through glycolysis.\u003cbr\u003e \u003cbr\u003e Glycogen synthesis.\u003cbr\u003e \u003cbr\u003e Synthesis of Fructose and lactose.\u003cbr\u003e \u003cbr\u003e The pentose phosphate pathway.\u003cbr\u003e \u003cbr\u003e Gluconeogenesis: glucose formation from non-carbohydrate sources.\u003cbr\u003e \u003cbr\u003e Role of the liver in the regulation of the blood glucose concentration.\u003cbr\u003e \u003cbr\u003e Hormones and control of gluconeogenesis.\u003cbr\u003e \u003cbr\u003e Regulation of glycolysis and gluconeogenesis by ATP\/ADP concentration ratio in the liver.\u003cbr\u003e \u003cbr\u003e Hypoglycaemia.\u003cbr\u003e \u003cbr\u003e Hyperglycaemia.\u003cbr\u003e \u003cbr\u003e 7 Fat Metabolism.\u003cbr\u003e \u003cbr\u003e Fats in nutrition.\u003cbr\u003e \u003cbr\u003e Fat fuels.\u003cbr\u003e \u003cbr\u003e Physiological importance of fat fuels.\u003cbr\u003e \u003cbr\u003e Limitations or drawbacks of fats as a fuel.\u003cbr\u003e \u003cbr\u003e Genetic defects in fatty acid oxidation.\u003cbr\u003e \u003cbr\u003e Pathological concentrations of fat fuels.\u003cbr\u003e \u003cbr\u003e 8 Amino Acid and Protein Metabolism.\u003cbr\u003e \u003cbr\u003e Introduction.\u003cbr\u003e \u003cbr\u003e Sources of amino acids.\u003cbr\u003e \u003cbr\u003e Protein and amino acid requirements.\u003cbr\u003e \u003cbr\u003e Fate of amino acids.\u003cbr\u003e \u003cbr\u003e Central role of transdeamination.\u003cbr\u003e \u003cbr\u003e Amino acid metabolism in different tissues.\u003cbr\u003e \u003cbr\u003e Glutamine: an amino acid of central importance.\u003cbr\u003e \u003cbr\u003e Urea 'salvage'.\u003cbr\u003e \u003cbr\u003e 9 Oxidation of Fuels and ATP Generation: Physiological and Clinical Importance.\u003cbr\u003e \u003cbr\u003e The Krebs cycle.\u003cbr\u003e \u003cbr\u003e The electron transfer chain.\u003cbr\u003e \u003cbr\u003e Oxidative phosphorylation.\u003cbr\u003e \u003cbr\u003e Coupling of electron transfer with oxidative phosphorylation.\u003cbr\u003e \u003cbr\u003e Transport into and out of mitochondria.\u003cbr\u003e \u003cbr\u003e 'Energy' transport in the cytosol: the creatine\/phosphocreatine shuttle.\u003cbr\u003e \u003cbr\u003e Regulation of fl uxes.\u003cbr\u003e \u003cbr\u003e The physiological importance of mitochondrial ATP generation.\u003cbr\u003e \u003cbr\u003e The effect of ageing on ATP generation.\u003cbr\u003e \u003cbr\u003e 10 Metabolism of Ammonia and Nucleic Acids.\u003cbr\u003e \u003cbr\u003e Roles of ammonia.\u003cbr\u003e \u003cbr\u003e Urea synthesis.\u003cbr\u003e \u003cbr\u003e Degradation of nucleic acids, nucleotides, nucleosides and bases: the generation of ammonia.\u003cbr\u003e \u003cbr\u003e Ammonia toxicity.\u003cbr\u003e \u003cbr\u003e Defi ciencies of urea cycle enzymes.\u003cbr\u003e \u003cbr\u003e 11 Synthesis of Fatty Acids, Triacylglycerol, Phospholipids and Fatty Messengers: The Roles of Polyunsaturated Fatty Acids.\u003cbr\u003e \u003cbr\u003e Synthesis of long-chain fatty acids.\u003cbr\u003e \u003cbr\u003e Unsaturated fatty acids.\u003cbr\u003e \u003cbr\u003e Essential fatty acids.\u003cbr\u003e \u003cbr\u003e Phospholipids.\u003cbr\u003e \u003cbr\u003e Fatty messenger molecules.\u003cbr\u003e \u003cbr\u003e Fatty acids in neurological and behavioural disorders.\u003cbr\u003e \u003cbr\u003e 12 Hormones: From Action in the Cell to Function in the Body.\u003cbr\u003e \u003cbr\u003e Endocrine hormones: traditional and novel.\u003cbr\u003e \u003cbr\u003e The action, effects and functions of a hormone.\u003cbr\u003e \u003cbr\u003e Action of hormones.\u003cbr\u003e \u003cbr\u003e The biochemical and physiological effects of a hormone.\u003cbr\u003e \u003cbr\u003e Pheromones.\u003cbr\u003e \u003cbr\u003e Kinetic principles that apply to hormone action.\u003cbr\u003e \u003cbr\u003e IV ESSENTIAL PROCESSES OF LIFE.\u003cbr\u003e \u003cbr\u003e 13 Physical Activity: In Non-Athletes, Athletes and Patients.\u003cbr\u003e \u003cbr\u003e The mechanical basis of movement by skeletal muscle.\u003cbr\u003e \u003cbr\u003e Structure of muscle.\u003cbr\u003e \u003cbr\u003e Proteins involved in muscle action.\u003cbr\u003e \u003cbr\u003e Mechanism of contraction: the cross-bridge cycle.\u003cbr\u003e \u003cbr\u003e Regulation of contraction.\u003cbr\u003e \u003cbr\u003e Fuels for muscle.\u003cbr\u003e \u003cbr\u003e Fuels for various athletic events and games.\u003cbr\u003e \u003cbr\u003e Fatigue.\u003cbr\u003e \u003cbr\u003e Fatigue in patients.\u003cbr\u003e \u003cbr\u003e Physical training.\u003cbr\u003e \u003cbr\u003e Development of muscle.\u003cbr\u003e \u003cbr\u003e Health benefi ts of physical activity.\u003cbr\u003e \u003cbr\u003e Health hazards of physical activity.\u003cbr\u003e \u003cbr\u003e Skeletal muscle diseases.\u003cbr\u003e \u003cbr\u003e 14 Mental Activity and Mental Illness.\u003cbr\u003e \u003cbr\u003e Mental activity.\u003cbr\u003e \u003cbr\u003e Cells in the brain.\u003cbr\u003e \u003cbr\u003e Electrical communication.\u003cbr\u003e \u003cbr\u003e Chemical communication.\u003cbr\u003e \u003cbr\u003e Fuels and energy metabolism in the brain.\u003cbr\u003e \u003cbr\u003e Mental illnesses: biochemical causes.\u003cbr\u003e \u003cbr\u003e Recreational drugs.\u003cbr\u003e \u003cbr\u003e 15 Nutrition: Biochemistry, Physiology and Pathology.\u003cbr\u003e \u003cbr\u003e Basic information required for discussion of some biochemical aspects of nutrition.\u003cbr\u003e \u003cbr\u003e Vitamins.\u003cbr\u003e \u003cbr\u003e Minerals.\u003cbr\u003e \u003cbr\u003e A healthy diet.\u003cbr\u003e \u003cbr\u003e Nutrition for specifi c activities or conditions.\u003cbr\u003e \u003cbr\u003e Overnutrition.\u003cbr\u003e \u003cbr\u003e Malnutrition.\u003cbr\u003e \u003cbr\u003e Functional foods and nutraceuticals.\u003cbr\u003e \u003cbr\u003e Nutrition for patients with genetic disorders.\u003cbr\u003e \u003cbr\u003e Vegetarian diets.\u003cbr\u003e \u003cbr\u003e Eating disorders.\u003cbr\u003e \u003cbr\u003e 16 Starvation: Metabolic Changes, Survival and Death.\u003cbr\u003e \u003cbr\u003e Mechanisms for the regulation of the blood glucose concentration.\u003cbr\u003e \u003cbr\u003e Metabolic responses to starvation.\u003cbr\u003e \u003cbr\u003e Sequence of metabolic changes from intermediate starvation to death.\u003cbr\u003e \u003cbr\u003e Progressive decrease in protein degradation in starvation.\u003cbr\u003e \u003cbr\u003e 17 Defence Against Pathogens: Barriers, Enzymes and the Immune System.\u003cbr\u003e \u003cbr\u003e When the physical barrier is breached.\u003cbr\u003e \u003cbr\u003e The immune system.\u003cbr\u003e \u003cbr\u003e Adaptive immunity.\u003cbr\u003e \u003cbr\u003e Cytokines.\u003cbr\u003e \u003cbr\u003e Mechanisms for killing pathogens.\u003cbr\u003e \u003cbr\u003e Killing of intracellular bacteria and large parasites in the extracellular fluid.\u003cbr\u003e \u003cbr\u003e Allergy.\u003cbr\u003e \u003cbr\u003e Fuels and generation of ATP in immune cells: consequences for a patient.\u003cbr\u003e \u003cbr\u003e Essential fatty acids and proliferation.\u003cbr\u003e \u003cbr\u003e The lymph nodes.\u003cbr\u003e \u003cbr\u003e Tolerance.\u003cbr\u003e \u003cbr\u003e Chronic infl ammation and autoimmunity.\u003cbr\u003e \u003cbr\u003e Immunosuppressive agents.\u003cbr\u003e \u003cbr\u003e Conditions that reduce the effectiveness of the immune system.\u003cbr\u003e \u003cbr\u003e Factors that increase the effectiveness of the immune system.\u003cbr\u003e \u003cbr\u003e Return of the 'old' infectious diseases.\u003cbr\u003e \u003cbr\u003e New infectious diseases.\u003cbr\u003e \u003cbr\u003e Defence in the intestine.\u003cbr\u003e \u003cbr\u003e 18 Survival after Trauma: Metabolic Changes and Response of the Immune System.\u003cbr\u003e \u003cbr\u003e Physiological and metabolie responses the ebb \u0026amp; fl ow phases.\u003cbr\u003e \u003cbr\u003e Nutrition.\u003cbr\u003e \u003cbr\u003e Mobilisation of triacylglycerol and protein in trauma.\u003cbr\u003e \u003cbr\u003e Metabolic changes in trauma and in starvation.\u003cbr\u003e \u003cbr\u003e Fever.\u003cbr\u003e \u003cbr\u003e Summary of the effects of trauma on the immune system and the whole body.\u003cbr\u003e \u003cbr\u003e 19 Sexual Reproduction.\u003cbr\u003e \u003cbr\u003e Male reproductive system.\u003cbr\u003e \u003cbr\u003e Female reproductive system.\u003cbr\u003e \u003cbr\u003e The menstrual cycle.\u003cbr\u003e \u003cbr\u003e Ovulation.\u003cbr\u003e \u003cbr\u003e Chemical communication in male and female reproduction.\u003cbr\u003e \u003cbr\u003e Coitus and the sexual response in the male and female.\u003cbr\u003e \u003cbr\u003e Fertilisation.\u003cbr\u003e \u003cbr\u003e Pregnancy.\u003cbr\u003e \u003cbr\u003e Parturition.\u003cbr\u003e \u003cbr\u003e Contraception.\u003cbr\u003e \u003cbr\u003e The menopause.\u003cbr\u003e \u003cbr\u003e Sexually transmitted diseases.\u003cbr\u003e \u003cbr\u003e 20 Growth and Death of Cells and Humans: The Cell Cycle, Apoptosis and Necrosis.\u003cbr\u003e \u003cbr\u003e Introduction to cell proliferation.\u003cbr\u003e \u003cbr\u003e The cell cycle.\u003cbr\u003e \u003cbr\u003e Death.\u003cbr\u003e \u003cbr\u003e V SERIOUS DISEASES.\u003cbr\u003e \u003cbr\u003e 21 Cancer: Genes, Cachexia and Death.\u003cbr\u003e \u003cbr\u003e Basic information.\u003cbr\u003e \u003cbr\u003e Oncogenes and proto-oncogenes.\u003cbr\u003e \u003cbr\u003e Proteins expressed by oncogenes.\u003cbr\u003e \u003cbr\u003e Processes by which proto-oncogenes can be activated or converted to oncogenes.\u003cbr\u003e \u003cbr\u003e Tumour suppressor genes.\u003cbr\u003e \u003cbr\u003e Telomeres and telomerase in tumour cells.\u003cbr\u003e \u003cbr\u003e Metastasis.\u003cbr\u003e \u003cbr\u003e Metabolic changes in cancer patients.\u003cbr\u003e \u003cbr\u003e Overview of cancer.\u003cbr\u003e \u003cbr\u003e Cancer-causing agents or conditions.\u003cbr\u003e \u003cbr\u003e Chemotherapy.\u003cbr\u003e \u003cbr\u003e Radiotherapy.\u003cbr\u003e \u003cbr\u003e 22 Atherosclerosis, Hypertension and Heart Attack.\u003cbr\u003e \u003cbr\u003e Atherosclerosis.\u003cbr\u003e \u003cbr\u003e Hypertension.\u003cbr\u003e \u003cbr\u003e Heart attack (myocardial infarction).\u003cbr\u003e \u003cbr\u003e Index.  \"This text and resource will appeal to biochemists looking to better translate their knowledge and undersatnding into real situations. It will particularly appeal to physiologists and medical students hoping to unravel the biochemical processes that underpin the physiology of life.\" (ChemBioChem, 11 April 2011)\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e\"\u003ci\u003eFunctional Biochemistry in Health and Disease\u003c\/i\u003e provides a clear and straightforward account of the biochemistry that is necessary to understand the physiological functions of tissues or organs essential to the life of human beings'. The book makes a strong connection between biochemistry and medical practice.\" (\u003ci\u003eAustralian Biochemist\u003c\/i\u003e, December 2010)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eEric Newsholme\u003c\/b\u003e, Merton College and Department of Biochemistry, University of Oxford, UK.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eTony Leech\u003c\/b\u003e, Gresham's School, Norfolk, UK.\u003c\/p\u003e Functional Biochemistry in Health and Disease provides a clear and straightforward account of the biochemistry that is necessary to understand the physiological functions of tissues or organs essential to the life of human beings. Focusing on the dynamic aspects of biochemistry and its application to the basic functions of the body, the book bridges the gap between biochemistry and medical practice.\u003cbr\u003e \u003cbr\u003e Carefully structured within five sections, each biochemical, physiological or medical subject that is covered in the book is presented in one complete chapter. Consequently, each subject can be read and studied in isolation although cross-sectional links between the subjects are included where necessary. Background material, both biochemical and medical, that is necessary for an understanding of the subject, is included at the start of each chapter and clear, relevant diagrams enhance students' understanding.\u003cbr\u003e * Focuses on medically relevant aspects of biochemistry written from a physiological rather than a chemical perspective.\u003cbr\u003e * Clear presentation that minimises the use of jargon.\u003cbr\u003e * Each chapter contains boxes on related topics, relevant diagrams and a brief glossary.\u003cbr\u003e * Coverage includes athletic performance, apoptosis and the immune system.\u003cbr\u003e * Key historical developments are included to show how modern biochemistry has evolved.\u003cbr\u003e \u003cbr\u003e \u003cbr\u003e \u003cbr\u003e By linking biochemistry, medical education and clinical practice this book will prove invaluable to students in medical and health sciences, biomedical science and human biology taking an introductory biochemistry course. In addition it will appeal to biochemistry and biology students interested in clinical applications of biochemistry.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989252817125,"sku":"NP9780471931652","price":82.5,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471931652.jpg?v=1761783389","url":"https:\/\/k12savings.com\/products\/functional-biochemistry-in-health-and-disease-isbn-9780471931652","provider":"K12savings","version":"1.0","type":"link"}