{"product_id":"formulating-pharma-nutra-and-cosmeceutical-products-from-herbal-substances-isbn-9781119769477","title":"Formulating Pharma-, Nutra-, and Cosmeceutical Products from Herbal Substances","description":"\u003cp\u003e\u003cb\u003eA practical and up-to-date discussion of the formulation and design of dosage forms and delivery systems containing herbal ingredients\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eIn \u003ci\u003eFormulating Pharma-, Nutra-, and Cosmeceutical Products from Herbal Substances: Dosage Forms and Delivery Systems\u003c\/i\u003e, a team of distinguished researchers delivers a step-by-step approach to preparing and manufacturing dosage forms and delivery systems. Intuitively organized with comprehensive coverage of the fundamentals, functional materials, manufacturing, and marketing of pharmaceutical, nutraceutical, and cosmeceutical products, the book also examines regulatory issues of quality, safety, and efficacy. \u003c\/p\u003e\u003cp\u003eThe authors discuss essential formulation development and delivery information for novel and controlled delivery systems of herbal ingredients. Readers will also find: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eA thorough introduction to the basic principles of developing modern pharma-, nutra-, and cosmeceutical products from herbal substances\u003c\/li\u003e\n\u003cli\u003eComprehensive explorations of conventional formulations, including issues of stability\u003c\/li\u003e\n\u003cli\u003ePractical discussions of advanced formulations, including chronotherapeutic delivery systems, liposome-based delivery of phytoconstituents, and nanoparticle mediated delivery of herbal actives\u003c\/li\u003e\n\u003cli\u003eComplete treatments of regulatory challenges, including nonclinical characterization and documentation for marketing authorizations of herbal formulations\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003ePerfect for professionals working in the herbal drug, natural product, and dietary supplement industries, \u003ci\u003eFormulating Pharma-, Nutra-, and Cosmeceutical Products from Herbal Substances\u003c\/i\u003e will also benefit academic researchers and graduate students studying herbal research, cosmetics, and pharmaceutical sciences. \u003c\/p\u003e\u003cp\u003eList of Contributors xxxi\u003c\/p\u003e \u003cp\u003eForeword by Prof. J.M.S. Rana xxxix\u003c\/p\u003e \u003cp\u003eForeword by Prof. Anil Bhandari xli\u003c\/p\u003e \u003cp\u003eAbout the Editors xliii\u003c\/p\u003e \u003cp\u003ePreface xlv\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I Introduction and Basic Principles 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 From Traditional to Modern Medicine: The Role of Herbs and Phytoconstituents in Pharmaceuticals, Nutraceuticals, and Cosmetics 3\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePooja Shah, Surojit Banerjee, Anupama Singh, Hitesh Kulhari, and Vikas Anand Saharan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 3\u003c\/p\u003e \u003cp\u003e1.2 Traditional Uses of Herbs in Pharmaceuticals, Nutraceuticals, and Cosmeceuticals 5\u003c\/p\u003e \u003cp\u003e1.3 Herbs as a Source of Modern Medicine 17\u003c\/p\u003e \u003cp\u003e1.4 Herbs as a Source of Nutraceuticals\/Dietary Supplements 18\u003c\/p\u003e \u003cp\u003e1.5 Herbs as a Source of Cosmeceuticals 18\u003c\/p\u003e \u003cp\u003e1.6 Advantages of Herbal Formulations 24\u003c\/p\u003e \u003cp\u003e1.7 Challenges of Herbal Formulations 33\u003c\/p\u003e \u003cp\u003e1.8 Regulatory Scenario for Herbal Products in Modern Medicine 45\u003c\/p\u003e \u003cp\u003e1.9 Approved Herbal Products 47\u003c\/p\u003e \u003cp\u003e1.10 Conclusion 48\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Preparation of Extracts and Their Standardization 75\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eNeeraj K. Sethiya, Garima Agarwal, Samir Bhargava, Vijay S. Rana, Bhavna Kumar, Manmohan Singhal, Dheeraj Bisht, and Umesh K. Patil\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 75\u003c\/p\u003e \u003cp\u003e2.2 Major Parameters 76\u003c\/p\u003e \u003cp\u003e2.3 Minor Parameters 76\u003c\/p\u003e \u003cp\u003e2.4 Important Terminology Used for the Preparation of Extracts and Standardization 76\u003c\/p\u003e \u003cp\u003e2.5 Preparation of Extracts 77\u003c\/p\u003e \u003cp\u003e2.6 Extraction of Plant Material 77\u003c\/p\u003e \u003cp\u003e2.7 Extraction Methods 77\u003c\/p\u003e \u003cp\u003e2.8 Types of Extractions 82\u003c\/p\u003e \u003cp\u003e2.9 Methods of Fractionation and Separation of Phytoconstituents 83\u003c\/p\u003e \u003cp\u003e2.10 Factors Affecting Selection of Extraction Method 83\u003c\/p\u003e \u003cp\u003e2.11 Standardization 83\u003c\/p\u003e \u003cp\u003e2.12 Conclusion 85\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Isolation and Purification of Phytoconstituents 91\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eShreya Sen Sarma, Biswajit Singh, Sushil K. Chaudhary, and Deepak Kumar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 91\u003c\/p\u003e \u003cp\u003e3.2 Isolation and Purification 92\u003c\/p\u003e \u003cp\u003e3.3 Hyphenated Techniques and Metabolomics 104\u003c\/p\u003e \u003cp\u003e3.4 Chemical Fingerprinting 107\u003c\/p\u003e \u003cp\u003e3.5 Bio-Assay-Guided Isolation 107\u003c\/p\u003e \u003cp\u003e3.6 Conclusion 108\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Natural Polysaccharides for Designing Herbal Formulations 119\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSaumyadeep Bora, Shuchi Patel, Shreyansh Sharma, Deep Pooja, and Hitesh Kulhari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 119\u003c\/p\u003e \u003cp\u003e4.2 Classification of Natural Polysaccharides 120\u003c\/p\u003e \u003cp\u003e4.3 General Properties and Applications of Important Natural Polysaccharides 122\u003c\/p\u003e \u003cp\u003e4.4 Conclusion and Future Perspectives 127\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Principles of Sustained, Controlled, and Targeted Delivery of Herbal Actives 139\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAseem Setia, Abhishesh K. Mehata, Chandrashekar Singh, Paresh Badgujar, and Madaswamy S. Muthu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 139\u003c\/p\u003e \u003cp\u003e5.2 Need for a Drug Delivery System 140\u003c\/p\u003e \u003cp\u003e5.3 Solubility and Dissolution-Enhanced Drug Delivery Systems 140\u003c\/p\u003e \u003cp\u003e5.4 Modified-Release Drug Delivery System 141\u003c\/p\u003e \u003cp\u003e5.5 Types of Modified Drug Delivery Systems 141\u003c\/p\u003e \u003cp\u003e5.6 Plant Actives and Extracts as a NDDS 148\u003c\/p\u003e \u003cp\u003e5.7 Drug Delivery Systems of Herbal Actives 150\u003c\/p\u003e \u003cp\u003e5.8 Targeted Drug Delivery Systems 154\u003c\/p\u003e \u003cp\u003e5.9 Clinical Trials of Herbal Actives 155\u003c\/p\u003e \u003cp\u003e5.10 Commercially Available Herbal Actives Drug Delivery System 156\u003c\/p\u003e \u003cp\u003e5.11 Conclusion and Future Perspective 156\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Formulation and Delivery Issues for Active Ingredients of Herbal Medicines, Nutraceuticals, and Cosmetics: Comparisons to Small-Molecule Drugs 163\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMonika Ola, Rajveer Bhaskar, Pradeep S. Patil, Sangita V. Badgujar, and Nitin G. Haswani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 163\u003c\/p\u003e \u003cp\u003e6.2 Incompatibility Within Formulation 164\u003c\/p\u003e \u003cp\u003e6.3 Challenges Associated with Herbal Formulations 167\u003c\/p\u003e \u003cp\u003e6.4 Stability Issues 169\u003c\/p\u003e \u003cp\u003e6.5 Solubility Issues 170\u003c\/p\u003e \u003cp\u003e6.6 Permeability Issues 172\u003c\/p\u003e \u003cp\u003e6.7 Bioavailability and Pharmacokinetics 172\u003c\/p\u003e \u003cp\u003e6.8 Factors Affecting Bioavailability of Natural Actives 173\u003c\/p\u003e \u003cp\u003e6.9 Factors Affecting the Pharmacokinetics of Herbal Formulation 174\u003c\/p\u003e \u003cp\u003e6.10 Modification of Herbal Actives Half-Life 175\u003c\/p\u003e \u003cp\u003e6.11 Strategies for Modifying the Half-Life of Herbal Actives 176\u003c\/p\u003e \u003cp\u003e6.12 Enhancement of Bioavailability of Herbal Actives 177\u003c\/p\u003e \u003cp\u003e6.13 Small Molecules (Synthetic Drugs) Versus Herbal Actives 180\u003c\/p\u003e \u003cp\u003e6.14 Conclusion 182\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II Conventional Formulations 193\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Stability of Herbal Formulations: Emerging Trends and Techniques 195\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDimple S. Lalchandani, Laltanpuii Chenkual, and Pawan K. Porwal\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 195\u003c\/p\u003e \u003cp\u003e7.2 Importance of Analytical Methods in the Stability Study of Herbal Formulations 196\u003c\/p\u003e \u003cp\u003e7.3 Challenges Encountered in the Stability Study of Herbal Formulations 196\u003c\/p\u003e \u003cp\u003e7.4 Analytical Techniques for Estimating the Stability of Herbal Formulations 197\u003c\/p\u003e \u003cp\u003e7.5 Emerging Trends in Analytical Methods of Herbal Medicine 207\u003c\/p\u003e \u003cp\u003e7.6 Quality Control and Assurance of Herbal Products 212\u003c\/p\u003e \u003cp\u003e7.7 Challenges in Quality Assurance of Herbal Medicine 212\u003c\/p\u003e \u003cp\u003e7.8 Regulatory Basis of Herbal Drug and Stability Testing 213\u003c\/p\u003e \u003cp\u003e7.9 Conclusion 214\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Fast-Dissolving\/-Disintegrating Herbal Dosage Forms 219\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDebadri Banerjee, Vikas Anand Saharan, and Anupama Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 219\u003c\/p\u003e \u003cp\u003e8.2 Principles of Disintegration 220\u003c\/p\u003e \u003cp\u003e8.3 Natural and Synthetic Disintegrants 221\u003c\/p\u003e \u003cp\u003e8.4 Orally Disintegrating Tablets (ODTs) 221\u003c\/p\u003e \u003cp\u003e8.5 Orally Disintegrating Films (ODFs) 229\u003c\/p\u003e \u003cp\u003e8.6 Fast-Disintegrating Pellets 232\u003c\/p\u003e \u003cp\u003e8.7 Fast-Dissolving\/-Disintegrating Dosage Forms of Phytoconstituents 233\u003c\/p\u003e \u003cp\u003e8.8 Challenges 234\u003c\/p\u003e \u003cp\u003e8.9 Clinical Trials 235\u003c\/p\u003e \u003cp\u003e8.10 Marketed Formulation 236\u003c\/p\u003e \u003cp\u003e8.11 Conclusion 236\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Herbal Formulations for Transmucosal Drug Delivery 243\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDebadri Banerjee, Vikas Anand Saharan, and Anupama Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 243\u003c\/p\u003e \u003cp\u003e9.2 Mucoadhesion 243\u003c\/p\u003e \u003cp\u003e9.3 Transcellular and Paracellular Permeation 246\u003c\/p\u003e \u003cp\u003e9.4 Various Transmucosal Routes: Drug Delivery Aspects 247\u003c\/p\u003e \u003cp\u003e9.5 Phytochemical Delivery Through Transmucosal Route 257\u003c\/p\u003e \u003cp\u003e9.6 Challenges 258\u003c\/p\u003e \u003cp\u003e9.7 Clinical Trials 261\u003c\/p\u003e \u003cp\u003e9.8 Marketed Herbal Mucoadhesive Products 261\u003c\/p\u003e \u003cp\u003e9.9 Conclusion 261\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Solid Dispersions 271\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKirti Shirsath, Indrani Maji, Srushti Mahajan, Mayur Aalhate, Ujala Gupta, and Pankaj K. Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 271\u003c\/p\u003e \u003cp\u003e10.2 Components for Solid Dispersion-Based Formulations 273\u003c\/p\u003e \u003cp\u003e10.3 Physiological Principle Behind Drug Absorption 276\u003c\/p\u003e \u003cp\u003e10.4 Methods of Preparation 277\u003c\/p\u003e \u003cp\u003e10.5 Characterization of Solid Dispersion 281\u003c\/p\u003e \u003cp\u003e10.6 Drug Delivery Applications 283\u003c\/p\u003e \u003cp\u003e10.7 Challenges in the Extraction of Phytoconstituent 286\u003c\/p\u003e \u003cp\u003e10.8 Conclusion 287\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Formulating Pharma-, Nutra-, and Cosmeceutical Products from Herbal Substances 299\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePooja Khairnar, Tejaswini Kolipaka, Giriraj Pandey, Vivek Phatale, Aachal Hedaoo, and Saurabh Srivastava\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 299\u003c\/p\u003e \u003cp\u003e11.2 Challenges for the Delivery of Herbal Actives 300\u003c\/p\u003e \u003cp\u003e11.3 Rationale for Pelletization 300\u003c\/p\u003e \u003cp\u003e11.4 Ideal Characteristics and Advantages of Pelletization of Herbal Actives 301\u003c\/p\u003e \u003cp\u003e11.5 Phenomenon of Pelletization 302\u003c\/p\u003e \u003cp\u003e11.6 Pelletization Techniques 303\u003c\/p\u003e \u003cp\u003e11.7 Characterization of Pellets 306\u003c\/p\u003e \u003cp\u003e11.8 Delivery Aspects of Pellets for Herbal Actives 309\u003c\/p\u003e \u003cp\u003e11.9 Regulatory Considerations Toward Clinical Translation 314\u003c\/p\u003e \u003cp\u003e11.10 Marketed Products 316\u003c\/p\u003e \u003cp\u003e11.11 Conclusion and Future Perspective 316\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Hydrogels as Delivery Systems in Herbal Medicine 323\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKhushi Rode, Nandkishor Rajankar, Mayur Aalhate, Srushti Mahajan, Indrani Maji, Ujala Gupta, and Pankaj K. Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 323\u003c\/p\u003e \u003cp\u003e12.2 Application of Hydrogels 324\u003c\/p\u003e \u003cp\u003e12.3 Benefits of Hydrogels in Delivering Herbal Medicine 326\u003c\/p\u003e \u003cp\u003e12.4 Hydrogels as an Effective Delivery of Nanocarrier System 330\u003c\/p\u003e \u003cp\u003e12.5 Modification in Hydrogel Properties to Effectively Deliver Herbal Medicine 335\u003c\/p\u003e \u003cp\u003e12.6 Formulation of Hydrogels to Precisely Deliver Herbal Medicine 342\u003c\/p\u003e \u003cp\u003e12.7 Challenges Associated with the Delivery of Hydrogels 343\u003c\/p\u003e \u003cp\u003e12.8 Conclusion and Future Prospects 344\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Emulsions and Self-Emulsifying Delivery Systems for Herbal Actives 355\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePuja Tripathy, Raju Barman, Rinku Baishya, and Deepak Kumar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 355\u003c\/p\u003e \u003cp\u003e13.2 Emulsions 356\u003c\/p\u003e \u003cp\u003e13.3 Composition of Emulsion 357\u003c\/p\u003e \u003cp\u003e13.4 Thermodynamics of EMs 358\u003c\/p\u003e \u003cp\u003e13.5 Preparation Methods 359\u003c\/p\u003e \u003cp\u003e13.6 Characterization of Emulsions 362\u003c\/p\u003e \u003cp\u003e13.7 Optimization of Emulsions 363\u003c\/p\u003e \u003cp\u003e13.8 Herbal-Active Loaded Emulsions 364\u003c\/p\u003e \u003cp\u003e13.9 Clinical Studies 364\u003c\/p\u003e \u003cp\u003e13.10 Conclusion and Future Perspectives 371\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III Advanced Formulations 379\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Chronotherapeutic Delivery Systems 381\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAkanksha Chaturvedi, Priyanka Arora, and Rahul Shukla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 381\u003c\/p\u003e \u003cp\u003e14.2 Principles of Biological Clock 382\u003c\/p\u003e \u003cp\u003e14.3 Need for a Chronotherapeutic Drug Delivery System 383\u003c\/p\u003e \u003cp\u003e14.4 Mechanisms of Chronotherapeutic Drug Delivery Systems 384\u003c\/p\u003e \u003cp\u003e14.5 Development of Chronotherapeutic Delivery Systems 384\u003c\/p\u003e \u003cp\u003e14.6 Technological Advancement in Chronotherapeutic Drug Delivery Systems 386\u003c\/p\u003e \u003cp\u003e14.7 Phytomedicine-Loaded Chronotherapeutic Drug Delivery Systems in Therapeutic Intervention 388\u003c\/p\u003e \u003cp\u003e14.8 Chinese Herbal Medicines-Incorporated Chronotherapeutic Drug Delivery Systems 391\u003c\/p\u003e \u003cp\u003e14.9 Herbal Excipients Modulating Chronotherapeutic Drug Delivery Systems 391\u003c\/p\u003e \u003cp\u003e14.10 Clinical Translation and Patented Chronotherapeutic Drug Delivery Systems-Based Formulations 392\u003c\/p\u003e \u003cp\u003e14.11 Challenges\/Hurdles in Chonopharmaceutical Drug Research and Development 393\u003c\/p\u003e \u003cp\u003e14.12 Conclusion and Future Perspectives 395\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Liposomes-Based Delivery of Phytoconstituents 399\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eShuchi Patel, Mahima Jadav, Deepali Sammal, Hitesh Kulhari, and Deep Pooja\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 399\u003c\/p\u003e \u003cp\u003e15.2 Types of Liposomes 399\u003c\/p\u003e \u003cp\u003e15.3 Preparation of Liposomes by Different Methods 401\u003c\/p\u003e \u003cp\u003e15.4 Delivery of Phytoconstituents Using Liposomes 403\u003c\/p\u003e \u003cp\u003e15.5 Conclusion 412\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Nanoparticles-Mediated Delivery of Herbal Actives 419\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePriyanka Dubey, Shivangi Bharadwaj, Shruti Richa, Kajal Kumari, Payal Khesarwani, and Swapnil Sharma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 419\u003c\/p\u003e \u003cp\u003e16.2 General Principles of Nanoparticle-Mediated Herbal Actives 420\u003c\/p\u003e \u003cp\u003e16.3 Types of Herbal Nanoformulations 422\u003c\/p\u003e \u003cp\u003e16.4 Methods of Preparation for Herbal Active Nanoformulations 432\u003c\/p\u003e \u003cp\u003e16.5 NPs Mediated Delivery of Herbal Actives to Treat Different Diseases 435\u003c\/p\u003e \u003cp\u003e16.6 New Approaches, Challenges, and Limitations of Herbal-Mediated Nanoformulation 439\u003c\/p\u003e \u003cp\u003e16.7 Clinical Trials and US Food and Drug Administration-Approved Herbal Active Nanoformulations 442\u003c\/p\u003e \u003cp\u003e16.8 Conclusion and Future Prospective 442\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Herbal Extracts and Phytoconstituents-Loaded Transferosomes, Ethosomes, and Transdermal Patches in Drug Delivery 453\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eNirmal Morya, Keshav Hirave, Debadri Banerjee, Anupama Singh, and Vikas Anand Saharan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 453\u003c\/p\u003e \u003cp\u003e17.2 Delivery Aspects 454\u003c\/p\u003e \u003cp\u003e17.3 Transferosomes 456\u003c\/p\u003e \u003cp\u003e17.4 Ethosomes 466\u003c\/p\u003e \u003cp\u003e17.5 Transdermal Patches 476\u003c\/p\u003e \u003cp\u003e17.6 Challenges in Herbal Active Delivery 486\u003c\/p\u003e \u003cp\u003e17.7 Conclusion 486\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Dendrimers as Nanocarriers for Phytoceuticals 495\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSurojit Banerjee, Keshav Hirave, Deep Pooja, Hitesh Kulhari, Anupama Singh, and Vikas Anand Saharan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction 495\u003c\/p\u003e \u003cp\u003e18.2 Principles of Dendrimers 496\u003c\/p\u003e \u003cp\u003e18.3 Types of Dendrimers 499\u003c\/p\u003e \u003cp\u003e18.4 Dendrimer Formulations 504\u003c\/p\u003e \u003cp\u003e18.5 Preparation Process 508\u003c\/p\u003e \u003cp\u003e18.6 Toxicity of Dendrimers 511\u003c\/p\u003e \u003cp\u003e18.7 Challenges for Herbal Actives 514\u003c\/p\u003e \u003cp\u003e18.8 Examples of Dendrimer-Based Delivery of Phytoconstituents 517\u003c\/p\u003e \u003cp\u003e18.9 Preclinical Studies 517\u003c\/p\u003e \u003cp\u003e18.10 Conclusion 523\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Applications of Carbon-Based Nanomaterials for the Delivery of Herbal Molecules 533\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSaumyadeep Bora, Deep Pooja, Brahmaji R. Mutyala, and Hitesh Kulhari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 533\u003c\/p\u003e \u003cp\u003e19.2 Properties of Herbal Molecules 534\u003c\/p\u003e \u003cp\u003e19.3 Challenges Associated with the Delivery of Herbal Molecules 535\u003c\/p\u003e \u003cp\u003e19.4 Role of Nanocarriers in Herbal Molecule Delivery 536\u003c\/p\u003e \u003cp\u003e19.5 Characteristics of Carbon-Based Nanomaterials for Herbal Molecule Delivery 537\u003c\/p\u003e \u003cp\u003e19.6 Classification of Carbon-Based Nanomaterials 537\u003c\/p\u003e \u003cp\u003e19.7 Applications of Carbon-Based Nanomaterials in Herbal Molecule Delivery 539\u003c\/p\u003e \u003cp\u003e19.8 Conclusion and Future Perspectives 542\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Phytoconstituents and Plant Extract-Based Formulations for Wound Healing 549\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKeshav Hirave, Nirmal Morya, Surojit Banerjee, Anupama Singh, and Vikas Anand Saharan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 Introduction 549\u003c\/p\u003e \u003cp\u003e20.2 Mechanism of Wound Healing 550\u003c\/p\u003e \u003cp\u003e20.3 Wound Classification 553\u003c\/p\u003e \u003cp\u003e20.4 Factors Affecting Wound Healing 554\u003c\/p\u003e \u003cp\u003e20.5 Nanocarrier in Wound Dressing 556\u003c\/p\u003e \u003cp\u003e20.6 Medicinal Plants in Wound Healing\/Plant Extracts, Extract Fractions and Phytoconstituent and Plant Extract Used in Wound Healing 556\u003c\/p\u003e \u003cp\u003e20.7 Plant-Derived Phytoconstituent and Extract-Based Formulation for Wound Healing 567\u003c\/p\u003e \u003cp\u003e20.8 Clinical Trials 573\u003c\/p\u003e \u003cp\u003e20.9 Role of Different Plants in Wound Healing 573\u003c\/p\u003e \u003cp\u003e20.10 Marketed Formulations\/Commercial Products 584\u003c\/p\u003e \u003cp\u003e20.11 Some Patented Innovations in Wound Healing 585\u003c\/p\u003e \u003cp\u003e20.12 Future Directions and Challenges 585\u003c\/p\u003e \u003cp\u003e20.13 Conclusion 589\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Chemo-Herbal Combination Drug Delivery for Cancer Management 599\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eShivangi Bharadwaj, Priyanka Dubey, Shruti Richa, Kajal Kumari, Payal Kesarwani, Kanika Verma, and Swapnil Sharma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21.1 Introduction 599\u003c\/p\u003e \u003cp\u003e21.2 Challenges in Targeting Chemo-Herbal Drugs: Overcoming Physicochemical, Biological, and Physiological Barriers for Effective Drug Delivery 601\u003c\/p\u003e \u003cp\u003e21.3 Optimizing Drug Delivery Strategies for Chemo-herbal Drugs: Overcoming Barriers and Enhancing Therapeutic Efficacy with Effective Targeting 602\u003c\/p\u003e \u003cp\u003e21.4 Delivery Aspects of Chemo-Herbal Formulation in Cancer Therapy 614\u003c\/p\u003e \u003cp\u003e21.5 Clinical Trials of Chemo-Herbal Formulations 621\u003c\/p\u003e \u003cp\u003e21.6 Conclusion and Future Perspective 624\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 Protein Nanocarriers for the Delivery of Phytoconstituents 633\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eNgangom Bidyarani, Kulandaivelu Velmourougane, Umesh Kumar, and Radha Prasanna\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22.1 Introduction 633\u003c\/p\u003e \u003cp\u003e22.2 Protein Nanocarriers 633\u003c\/p\u003e \u003cp\u003e22.3 Methods of Preparation of Protein-Based Nanocarriers 634\u003c\/p\u003e \u003cp\u003e22.4 Protein Nanocarriers for Phytoconstituents Delivery 635\u003c\/p\u003e \u003cp\u003e22.5 Prospects of Nanotechnology for Delivery Purposes 637\u003c\/p\u003e \u003cp\u003e22.6 Current Scenario and the Path Ahead 638\u003c\/p\u003e \u003cp\u003e22.7 Conclusions 638\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV Regulatory Challenges 643\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23 Nonclinical Characterization and Documentation for Marketing Authorizations of Herbal Formulations 645\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSwati Dobhal, Nitish S. Jangwan, Shradha Bisht, Vikas Anand Saharan, and Mamta F. Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23.1 Introduction 645\u003c\/p\u003e \u003cp\u003e23.2 Nonclinical Characterization of Herbal Formulations: Pharmacodynamics, Toxicology and Pharmacokinetic Studies 646\u003c\/p\u003e \u003cp\u003e23.3 Regulatory Approvals for Marketing Herbal Formulations: A Global Overview of Documentation Requirements 652\u003c\/p\u003e \u003cp\u003e23.4 Challenges 668\u003c\/p\u003e \u003cp\u003e23.5 Conclusion 669\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24 Quality Challenge in Regulatory Approval of Medicinal Products Containing Combinations of Herbal Substances 677\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSiddheshwar Kisan Chauthe, Soham Rajyaguru, Aditi Puranik, Nishi Yadao, and Kajal Rathod\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24.1 Introduction to Phytomedicines 677\u003c\/p\u003e \u003cp\u003e24.2 Classification of Herbal Medicines Based on Regulatory Frameworks and Standards 678\u003c\/p\u003e \u003cp\u003e24.3 Quality Challenges Related to Herbal Medicines 679\u003c\/p\u003e \u003cp\u003e24.4 Global Regulatory Landscape of Herbal Medicines 684\u003c\/p\u003e \u003cp\u003e24.5 WHO Regulatory Guidelines on GMP, GACP and Quality Control of Herbal Medicines 690\u003c\/p\u003e \u003cp\u003e24.6 Development and Standardization of Herbal Medicines 695\u003c\/p\u003e \u003cp\u003e24.7 Challenges in the Development of Herbal Medicines 696\u003c\/p\u003e \u003cp\u003e24.8 Conclusion 697\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25 Evidence-Based Clinical Assessment of Herbal Formulations: Traditional and Modern Insights 703\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDebadri Banerjee, Surojit Banerjee, Pooja Shah, Anupama Singh, and Vikas Anand Saharan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25.1 Introduction 703\u003c\/p\u003e \u003cp\u003e25.2 Indian Traditional Medicine 704\u003c\/p\u003e \u003cp\u003e25.3 Modern Herbal Medicine 706\u003c\/p\u003e \u003cp\u003e25.4 Regulatory Guidelines 708\u003c\/p\u003e \u003cp\u003e25.5 Validation Approaches and Clinical Assessments 713\u003c\/p\u003e \u003cp\u003e25.6 Obstacles to Clinical Assessment of Herbal Formulations 716\u003c\/p\u003e \u003cp\u003e25.7 Conclusion 732\u003c\/p\u003e \u003cp\u003eReferences 733\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26 Patient Safety Issues with Herbal Substances and Formulations 743\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDeepali Sammal, Saumyadeep Bora, Hitesh Kulhari, and Deep Pooja\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eObjectives 743\u003c\/p\u003e \u003cp\u003e26.1 Introduction 743\u003c\/p\u003e \u003cp\u003e26.2 World Health Organization Regulatory Guidelines for Safety of Herbal Medicines 744\u003c\/p\u003e \u003cp\u003e26.3 European Guidelines for the Herbal Medicines 745\u003c\/p\u003e \u003cp\u003e26.4 Indian Regulations for Herbal Medicines 746\u003c\/p\u003e \u003cp\u003e26.5 USFDA Guidelines for Herbal Medicines 746\u003c\/p\u003e \u003cp\u003e26.6 Safety of Herbal Medicinal Products 747\u003c\/p\u003e \u003cp\u003e26.7 Hepatotoxicity Caused by Herbal Medicines 748\u003c\/p\u003e \u003cp\u003e26.8 Nephrotoxicity Induced by Herbal Drug Medicines 749\u003c\/p\u003e \u003cp\u003e26.9 Genotoxicity Induced by Herbal Drug Medicines 749\u003c\/p\u003e \u003cp\u003e26.10 Other Toxicities Induced by Herbal Drug Medicines 750\u003c\/p\u003e \u003cp\u003e26.11 Conclusion 750\u003c\/p\u003e \u003cp\u003eAcknowledgment 750\u003c\/p\u003e \u003cp\u003eReferences 750\u003c\/p\u003e \u003cp\u003eIndex 753\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eAnupama Singh, PhD,\u003c\/b\u003e is Professor and Head of the Department of Pharmacognosy at Sardar Bhagwan Singh University. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eHitesh Kulhari, PhD,\u003c\/b\u003e is an Assistant Professor in the School of Nano Sciences at the Central University of Gujarat. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eVikas Anand Saharan, PhD,\u003c\/b\u003e is Associate Professor and In-charge of the Department of Pharmaceutical Technology (Formulations) at National Institute of Pharmaceutical Education and Research Guwahati (NIPER-G).   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eA practical and up-to-date discussion of the formulation and design of dosage forms and delivery systems containing herbal ingredients\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eIn \u003ci\u003eFormulating Pharma-, Nutra-, and Cosmeceutical Products from Herbal Substances: Dosage Forms and Delivery Systems\u003c\/i\u003e, a team of distinguished researchers delivers a step-by-step approach to preparing and manufacturing dosage forms and delivery systems. Intuitively organized with comprehensive coverage of the fundamentals, functional materials, manufacturing, and marketing of pharmaceutical, nutraceutical, and cosmeceutical products, the book also examines regulatory issues of quality, safety, and efficacy. \u003c\/p\u003e\u003cp\u003eThe authors discuss essential formulation development and delivery information for novel and controlled delivery systems of herbal ingredients. Readers will also find: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eA thorough introduction to the basic principles of developing modern pharma-, nutra-, and cosmeceutical products from herbal substances\u003c\/li\u003e\n\u003cli\u003eComprehensive explorations of conventional formulations, including issues of stability\u003c\/li\u003e\n\u003cli\u003ePractical discussions of advanced formulations, including chronotherapeutic delivery systems, liposome-based delivery of phytoconstituents, and nanoparticle mediated delivery of herbal actives\u003c\/li\u003e\n\u003cli\u003eComplete treatments of regulatory challenges, including nonclinical characterization and documentation for marketing authorizations of herbal formulations\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003ePerfect for professionals working in the herbal drug, natural product, and dietary supplement industries, \u003ci\u003eFormulating Pharma-, Nutra-, and Cosmeceutical Products from Herbal Substances\u003c\/i\u003e will also benefit academic researchers and graduate students studying herbal research, cosmetics, and pharmaceutical sciences.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989235581157,"sku":"NP9781119769477","price":299.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119769477.jpg?v=1761783318","url":"https:\/\/k12savings.com\/products\/formulating-pharma-nutra-and-cosmeceutical-products-from-herbal-substances-isbn-9781119769477","provider":"K12savings","version":"1.0","type":"link"}