{"product_id":"flavonoid-pharmacokinetics-isbn-9780470578711","title":"Flavonoid Pharmacokinetics","description":"\u003cp\u003e\u003cb\u003eSETS FORTH A FRAMEWORK FOR THE ANALYSIS AND STUDY OF FLAVONOIDS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMore and more dietary supplements contain flavonoids. These products are typically viewed as food rather than drug products by regulatory agencies and therefore not subjected to rigorous clinical trials before they are marketed to the general public. As a result, the use of flavonoid-containing supplements presents a potential public health risk. From discovery to therapeutic application, this book is a comprehensive guide to both achiral and chiral flavonoids, enabling researchers to perform essential preclinical and clinical pharmacokinetics studies in order to ensure the efficacy of flavonoids marketed for therapeutic use. Moreover, the book examines the safety and toxicology of flavonoids as well as flavonoid-drug interactions.\u003c\/p\u003e \u003cp\u003eWith contributions from a multidisciplinary team of leading researchers, \u003ci\u003eFlavonoids Pharmacokinetics\u003c\/i\u003e reviews and synthesizes the most recent research findings and results from preclinical and clinical studies. The book begins with a comprehensive overview of polyphenols and flavonoids. Next, the book covers:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eMethods of analysis of achiral flavonoids\u003c\/li\u003e \u003cli\u003ePreclinical pharmacokinetic of flavonoids\u003c\/li\u003e \u003cli\u003eToxicology and safety of flavonoids\u003c\/li\u003e \u003cli\u003eMethods of analysis for chiral flavonoids\u003c\/li\u003e \u003cli\u003eClinical pharmacokinetics of flavonoids\u003c\/li\u003e \u003cli\u003eFlavonoids and drug interactions\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThroughout the book, the authors provide examples that demonstrate the use of pharmacokinetics concepts during the preclinical and clinical drug development process.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eFlavonoid Pharmacokinetics \u003c\/i\u003eis written for pharmaceutical, food, and nutritional scientists and students, offering the tools they need to thoroughly analyze and test flavonoids and flavonoid-containing supplements to ensure their safety and efficacy.\u003c\/p\u003e \u003cp\u003eForeword ix\u003c\/p\u003e \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003eContributors xv\u003c\/p\u003e \u003cp\u003e1 Polyphenols and Flavonoids: An Overview 1\u003cbr\u003e\u003ci\u003eJaime A. Yáñez, Connie M. Remsberg, Jody K. Takemoto, Karina R. Vega-Villa, Preston K. Andrews, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Analysis of Flavonoids through Chromatography 71\u003cbr\u003e\u003ci\u003eJody K. Takemoto, Stephanie E. Martinez, and Neal M. Davies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Chiral Methods of Flavonoid Analysis 117\u003cbr\u003e\u003ci\u003eJaime A. Yáñez, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Preclinical Pharmacokinetics of Flavonoids 161\u003cbr\u003e\u003ci\u003eJaime A. Yáñez, Casey L. Sayre, and Neal M. Davies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Clinical Pharmacokinetics of Flavonoids 195\u003cbr\u003e\u003ci\u003eCasey L. Sayre, Karen D. Gerde, Jaime A. Yáñez, and Neal M. Davies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Toxicology and Safety of Flavonoids 249\u003cbr\u003e\u003ci\u003eStephanie E. Martinez, Neal M. Davies, and Jonathan K. Reynolds\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Flavonoids and Drug Interactions 281\u003cbr\u003e\u003ci\u003eJaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre, and Neal M. Davies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 321\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eNeal M. Davies, PhD\u003c\/b\u003e. is Dean of Professor in the Faculty of Pharmacy at the University of Manitoba. He has also held faculty positions at the University of Sydney and Washington State University. Dr. Davies’s research focuses on pharmaceutics and the pharmacokinetics and pharmacodynamics of natural products. He is a graduate of the University of Alberta.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJaime A. Yáñez, PhD\u003c\/b\u003e. is Senior Study Director in Drug Metabolism and Pharmacokinetics at Alcon Research, Ltd., a Novartis Company. Previously, he worked at Schering-Plough Research Institute and Merck Research Laboratories. He also serves as Adjunct Faculty and Research Consultant at Universities and research organizations in Peru, Mexico, Spain and the United States. Dr. Yáñez’s expertise spans preclinical and clinical pharmacokinetics, pharmacodynamics, pharmaceutics, and predictive computer modeling and simulation, all with an emphasis on natural products.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSETS FORTH A FRAMEWORK FOR THE ANALYSIS AND STUDY OF FLAVONOIDS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMore and more dietary supplements contain flavonoids. These products are typically viewed as food rather than drug products by regulatory agencies and therefore not subjected to rigorous clinical trials before they are marketed to the general public. As a result, the use of flavonoid-containing supplements presents a potential public health risk. From discovery to therapeutic application, this book is a comprehensive guide to both achiral and chiral flavonoids, enabling researchers to perform essential preclinical and clinical pharmacokinetics studies in order to ensure the efficacy of flavonoids marketed for therapeutic use. Moreover, the book examines the safety and toxicology of flavonoids as well as flavonoid-drug interactions.\u003c\/p\u003e \u003cp\u003eWith contributions from a multidisciplinary team of leading researchers, \u003ci\u003eFlavonoids Pharmacokinetics\u003c\/i\u003e reviews and synthesizes the most recent research findings and results from preclinical and clinical studies. The book begins with a comprehensive overview of polyphenols and flavonoids. Next, the book covers:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eMethods of analysis of achiral flavonoids\u003c\/li\u003e \u003cli\u003ePreclinical pharmacokinetic of flavonoids\u003c\/li\u003e \u003cli\u003eToxicology and safety of flavonoids\u003c\/li\u003e \u003cli\u003eMethods of analysis for chiral flavonoids\u003c\/li\u003e \u003cli\u003eClinical pharmacokinetics of flavonoids\u003c\/li\u003e \u003cli\u003eFlavonoids and drug interactions\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThroughout the book, the authors provide examples that demonstrate the use of pharmacokinetics concepts during the preclinical and clinical drug development process.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eFlavonoid Pharmacokinetics \u003c\/i\u003eis written for pharmaceutical, food, and nutritional scientists and students, offering the tools they need to thoroughly analyze and test flavonoids and flavonoid-containing supplements to ensure their safety and efficacy.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989220278501,"sku":"NP9780470578711","price":142.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470578711.jpg?v=1761783258","url":"https:\/\/k12savings.com\/products\/flavonoid-pharmacokinetics-isbn-9780470578711","provider":"K12savings","version":"1.0","type":"link"}