{"product_id":"exploring-and-exploiting-genetic-risk-for-psychiatric-disorders-isbn-9780262547383","title":"Exploring and Exploiting Genetic Risk for Psychiatric Disorders","description":"\u003cb\u003eAn edited volume that looks at the state of psychiatric genetics and how to chart a path forward.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eIn this edited collection, experts from psychiatric and statistical genetics, neurobiology, and clinical psychiatry investigate whether and how to pursue the discovery of additional genetic risk factors for mental illnesses. Using the existing knowledge and frameworks of genetic risk factors, they look at how a better understanding of the biology that underlies mental illnesses can improve and enhance the care that patients receive.List of Contributors vii\u003cbr\u003ePreface xi\u003cbr\u003e1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1\u003cbr\u003eGene Discovery \u003cbr\u003e2 Delineating Additional Risk Factors 13\u003cbr\u003e3 Data Collection: Next Steps in Psychiatric Genetics 39\u003cbr\u003e4 Environmental Risk and Gene-Environment Relationships in Psychiatric Disorders 51\u003cbr\u003eUnderstanding Rare Variation \u003cbr\u003e5 Rare Variants: Shared Paths for Therapeutic Development and Neurobiological Investigation 69\u003cbr\u003e6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental Disorders 103\u003cbr\u003e7 Experimental Model Systems for Rare and Common Variants 117\u003cbr\u003eUnderstanding Common Variation\u003cbr\u003e8 Common Alleles: Next Steps in the Study of Common Variants 131\u003cbr\u003e9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders 155\u003cbr\u003e10 From Common Variant to Function: State-of-the-Art Approaches 167\u003cbr\u003e11 Contextualizing Convergent Common Variant Mechanisms through Systems Biology 179\u003cbr\u003eClinical Considerations \u003cbr\u003e12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201\u003cbr\u003e13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities and Obstacles 219\u003cbr\u003e14 Ethical Challenges Associated with Advances in Genetic Prediction of Neuropsychiatric Disorders 237\u003cbr\u003e15 Psychiatric Genetic Counseling: Next Steps 249\u003cbr\u003e16 Concluding Summary 261\u003cbr\u003eBibliography 267\u003cbr\u003eSubject Index 319\u003cbr\u003eStrungmann Forum Report Series 325Joshua A. Gordon is Director of the National Institute of Mental Health (NIMH) and Chief of the Integrative Neuroscience Section at the National Institute of Neurologic Disorders and Stroke (NINDS).\u003cbr\u003e\u003cbr\u003eElisabeth B. Binder is a director and scientific member at the Max Planck Institute of Psychiatry.","brand":"The MIT Press","offers":[{"title":"Default Title","offer_id":46303376408805,"sku":"NP9780262547383","price":50.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780262547383.jpg?v=1767726553","url":"https:\/\/k12savings.com\/products\/exploring-and-exploiting-genetic-risk-for-psychiatric-disorders-isbn-9780262547383","provider":"K12savings","version":"1.0","type":"link"}