Essential Endocrinology and Diabetes

The Essentials are an international, best-selling series of textbooks, all of which are designed to support lecture series or themes on core topics within the health sciences. See www.wiley.com for further details.

Essential Endocrinology and Diabetes provides the accurate and up-to-date knowledge required for treating all areas of endocrinology and diabetes, covering the latest research, clinical guidelines, investigational methods, and therapies. This classic text explains the vital aspects of endocrine physiology in a succinct and easy-to-use format, with full-colour illustrations, clinical images, and case studies to assist readers in applying theory to practice.

The text covers the principles of endocrinology, clinical endocrinology, and clinical diabetes and obesity, and has been revised throughout to present the most recent developments in the field. The seventh edition includes new and updated material on the latest molecular techniques, approaches to clinical investigation and diagnostics, next generation sequencing technology, and positron emission tomography (PET). The treatment of type 1 diabetes and type 2 diabetes has been updated with clinical algorithms and reflects significant advances such as incretin-based therapies, SGLT2 inhibitors, the development of better insulins, and technologies that support self-management.

• Provides students and practitioners with comprehensive and authoritative information on all major aspects of endocrine physiology
• Covers diagnosis, management, and complications of clinical disorders such as endocrine neoplasia, and type 1 diabetes and type 2 diabetes
• Explains the core principle of feedback regulation, which is vital for the correct interpretation of many clinical tests
• Features case histories, learning objectives, ‘recap’ links to chapter content, cross-referencing guides, key information boxes, and chapter summaries

Essential Endocrinology and Diabetes, Seventh Edition is the ideal textbook for medical and biomedical students, junior doctors, and clinicians looking to refresh their knowledge of endocrine science.

For more information on the complete range of Wiley medical student and junior doctor publishing, please visit: www.wiley.com

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All content reviewed by students for students

Wiley Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind.

If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more.

This title is also available as an e-book. For more details, please see www.wiley.com/buy/9781118763964

Essential Endocrinology and Diabetes vermittelt den aktuellen Wissenstand zu allen Behandlungsbereichen der Endokrinologie und Diabetes: klinische Leitlinien, Untersuchungsmethoden und Therapien. Dieses Standardlehrwerk erläutert prägnant und leicht verständlich die wesentlichen physiologischen Aspekte des endokrinen Systems und bietet darüber hinaus Illustrationen und klinische Aufnahmen in Farbe sowie Fallstudien, anhand derer der Transfer in die Praxis gelingt.

Diese Publikation beschäftigt sich mit den Prinzipien der Endokrinologie, klinischen Endokrinologie, klinischen Diabetes und Adipositas. Die 7. Auflage wurde vollständig überarbeitet und spiegelt die jüngsten Entwicklungen des Fachgebiets wider. Hinzu kommen neue und aktualisierte Inhalte zu den jüngsten molekularen Verfahren, Ansätzen der klinischen Untersuchung und Diagnostik, Next-Generation-Technologien zur Sequenzierung sowie zur Positronen-Emissions-Tomographie (PET). Die Behandlungsverfahren von Diabetes Typ 1 und Typ 2 wurden um klinische Algorithmen ergänzt und beleuchten wegweisende Fortschritte, u. a. inkretinbasierte Therapien, SGLT-2-Inhibitoren, die Entwicklungen bessere Insuline und Verfahren zur Unterstützung des Selbstmanagements.
- Stellt Studenten und Ärzten umfassend die relevanten Informationen zu allen wichtigen physiologischen Aspekten des endokrinen Systems zur Verfügung.
- Beschäftigt sich mit Diagnose, Management und Komplikationen klinischer Erkrankungen wie endokrine Neoplasie, Typ-1- und Typ-2-Diabetes.
- Erklärt die Kernprinzipien der Feedback-Regulation als wichtiges Instrument für die korrekte Interpretation einer Vielzahl klinischer Tests.
- Bietet Fallbeispiele, Lernziele, Verweise auf Zusammenfassungen der Kapitelinhalte, Querverweise, Textkästchen mit wichtigen Informationen und Kapitelzusammenfassungen.

Die 7.Auflage von Essential Endocrinology and Diabetes ist das ideale Lehrbuch für Studenten der Medizin und Biomedizin, Assistenzärzte und Kliniker, die ihre Kenntnisse des Fachgebiets auffrischen möchten.

Preface vii

List of abbreviations ix

Part 1: Foundations of Endocrinology 1

1 Overview of endocrinology 3

2 Basic cell biology and hormone synthesis 12

3 Molecular basis of hormone action 22

4 Investigations in endocrinology and diabetes 39

Part 2: Endocrinology – Biology to Clinical Practice 51

5 The hypothalamus and pituitary gland 53

6 The adrenal gland 80

7 Reproductive endocrinology 103

8 The thyroid gland 134

9 Calcium and metabolic bone disorders 155

10 Pancreatic and gastrointestinal endocrinology and endocrine neoplasia 175

Part 3: Diabetes and Obesity 193

11 Overview of diabetes 195

12 Type 1 diabetes 213

13 Type 2 diabetes 239

14 Complications of diabetes 265

15 Obesity 293

Index 311

Richard I.G. Holt, Professor in Diabetes and Endocrinology, Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

Neil A. Hanley, Professor of Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

ESSENTIAL ENDOCRINOLOGY AND DIABETES

The Essentials are an international, best-selling series of textbooks, all of which are designed to support lecture series or themes on core topics within the health sciences. See www.wiley.com for further details.

Essential Endocrinology and Diabetes provides the accurate and up-to-date knowledge required for treating all areas of endocrinology and diabetes, covering the latest research, clinical guidelines, investigational methods, and therapies. This classic text explains the vital aspects of endocrine physiology in a succinct and easy-to-use format, with full-colour illustrations, clinical images, and case studies to assist readers in applying theory to practice.

The text covers the principles of endocrinology, clinical endocrinology, and clinical diabetes and obesity, and has been revised throughout to present the most recent developments in the field. The seventh edition includes new and updated material on the latest molecular techniques, approaches to clinical investigation and diagnostics, next generation sequencing technology, and positron emission tomography (PET). The treatment of type 1 diabetes and type 2 diabetes has been updated with clinical algorithms and reflects significant advances such as incretin-based therapies, SGLT2 inhibitors, the development of better insulins, and technologies that support self-management.

• Provides students and practitioners with comprehensive and authoritative information on all major aspects of endocrine physiology
• Covers diagnosis, management, and complications of clinical disorders such as endocrine neoplasia, and type 1 diabetes and type 2 diabetes
• Explains the core principle of feedback regulation, which is vital for the correct interpretation of many clinical tests
• Features case histories, learning objectives, ‘recap’ links to chapter content, cross-referencing guides, key information boxes, and chapter summaries

Essential Endocrinology and Diabetes, Seventh Edition is the ideal textbook for medical and biomedical students, junior doctors, and clinicians looking to refresh their knowledge of endocrine science.

For more information on the complete range of Wiley medical student and junior doctor publishing, please visit: www.wiley.com

To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email

All content reviewed by students for students

Wiley Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind.

If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more.

This title is also available as an e-book. For more details, please see www.wiley.com/buy/9781118763964