{"product_id":"equilibria-and-kinetics-of-biological-macromolecules-isbn-9781118479704","title":"Equilibria and Kinetics of Biological Macromolecules","description":"\u003cp\u003eProgressively builds a deep understanding of macromolecular behavior\u003c\/p\u003e \u003cp\u003eBased on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models.\u003c\/p\u003e \u003cp\u003eWith its strong emphasis on molecular interactions, \u003ci\u003eEquilibria and Kinetics of Biological Macromolecules\u003c\/i\u003e offers new insights and perspectives on proteins and other macromolecules. The text features coverage of:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eBasic theory, applications, and new research findings\u003c\/li\u003e \u003cli\u003eRelated topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulations\u003c\/li\u003e \u003cli\u003ePrinciples and applications of molecular simulations in a dedicated chapter and interspersed throughout the text\u003c\/li\u003e \u003cli\u003eMacromolecular binding equilibria from the perspective of statistical mechanics\u003c\/li\u003e \u003cli\u003eStochastic processes related to macromolecules\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eSuggested readings at the end of each chapter include original research papers, reviews and monographs, enabling readers to explore individual topics in greater depth. At the end of the text, ten appendices offer refreshers on mathematical treatments, including probability, computational methods, Poisson equations, and defining molecular boundaries.\u003c\/p\u003e \u003cp\u003eWith its classroom-tested pedagogical approach, \u003ci\u003eEquilibria and Kinetics of Biological Macromolecules\u003c\/i\u003e is recommended as a graduate-level textbook for biophysics courses and as a reference for researchers who want to strengthen their understanding of macromolecular behavior.\u003c\/p\u003e  \u003cp\u003ePreface xix\u003c\/p\u003e \u003cp\u003eAcknowledgments xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 1 BASIC PRINCIPLES 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1. Thermodynamics 3\u003c\/p\u003e \u003cp\u003e2. Four Basic Quantum Mechanical Models of Nuclear and Electronic Motion: A Synopsis 35\u003c\/p\u003e \u003cp\u003e3. Molecular Structure and Interactions 51\u003c\/p\u003e \u003cp\u003e4. Water and the Hydrophobic Effect 77\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 2 STATISTICAL MECHANICS: THE MOLECULAR BASIS OF THERMODYNAMICS 91\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5. The Molecular Partition Function 93\u003c\/p\u003e \u003cp\u003e6. System Ensembles and Partition Functions 111\u003c\/p\u003e \u003cp\u003e7. Sampling Molecular Systems with Simulations 137\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 3 BINDING TO MACROMOLECULES 161\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8. Binding Equilibria 163\u003c\/p\u003e \u003cp\u003e9. Thermodynamics of Molecular Interactions 185\u003c\/p\u003e \u003cp\u003e10. Elements of Statistical Mechanics of Liquids and Solutions 197\u003c\/p\u003e \u003cp\u003e11. Analysis of Binding Equilibria in Terms of Partition Functions 213\u003c\/p\u003e \u003cp\u003e12. Coupled Equilibria 223\u003c\/p\u003e \u003cp\u003e13. Allosteric Function 239\u003c\/p\u003e \u003cp\u003e14. Charged Groups: Binding of Hydrogen Ions, Solvation, and Charge–Charge Interactions 255\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 4 CONFORMATIONAL STABILITY AND CONFORMATION CHANGE 277\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15. Some Elements of Polymer Physics 279\u003c\/p\u003e \u003cp\u003e16. Helix-Coil Equilibria 291\u003c\/p\u003e \u003cp\u003e17. Protein Unfolding Equilibria 311\u003c\/p\u003e \u003cp\u003e18. Elasticity of Biological Materials 347\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 5 KINETICS AND IRREVERSIBLE PROCESSES 357\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19. Kinetics 359\u003c\/p\u003e \u003cp\u003e20. Kinetics of Protein Folding 389\u003c\/p\u003e \u003cp\u003e21. Irreversible and Stochastic Processes 415\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDICES 437\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIndex 491\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eJAN HERMANS, PhD,\u003c\/b\u003e is Emeritus Professor in the Department of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill. He is the author of over 130 papers in the field of protein and macromolecular biophysics.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eBARRY LENTZ, PhD,\u003c\/b\u003e is Professor in the Department of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill and Director of the UNC Molecular \u0026amp; Cellular Biophysics Program. He has authored roughly 130 original research publications in the field of biophysics, focusing on biomembrane microstructure and cell function.\u003c\/p\u003e  \u003cp\u003eProgressively builds a deep understanding of macromolecular behavior\u003c\/p\u003e \u003cp\u003eBased on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models.\u003c\/p\u003e \u003cp\u003eWith its strong emphasis on molecular interactions, \u003ci\u003eEquilibria and Kinetics of Biological Macromolecules\u003c\/i\u003e offers new insights and perspectives on proteins and other macromolecules. The text features coverage of:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eBasic theory, applications, and new research findings\u003c\/li\u003e \u003cli\u003eRelated topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulations\u003c\/li\u003e \u003cli\u003ePrinciples and applications of molecular simulations in a dedicated chapter and interspersed throughout the text\u003c\/li\u003e \u003cli\u003eMacromolecular binding equilibria from the perspective of statistical mechanics\u003c\/li\u003e \u003cli\u003eStochastic processes related to macromolecules\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eSuggested readings at the end of each chapter include original research papers, reviews and monographs, enabling readers to explore individual topics in greater depth. At the end of the text, ten appendices offer refreshers on mathematical treatments, including probability, computational methods, Poisson equations, and defining molecular boundaries.\u003c\/p\u003e \u003cp\u003eWith its classroom-tested pedagogical approach, \u003ci\u003eEquilibria and Kinetics of Biological Macromolecules\u003c\/i\u003e is recommended as a graduate-level textbook for biophysics courses and as a reference for researchers who want to strengthen their understanding of macromolecular behavior.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989151367397,"sku":"NP9781118479704","price":173.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118479704.jpg?v=1761783005","url":"https:\/\/k12savings.com\/products\/equilibria-and-kinetics-of-biological-macromolecules-isbn-9781118479704","provider":"K12savings","version":"1.0","type":"link"}