{"product_id":"enzyme-regulation-in-metabolic-pathways-isbn-9781119155386","title":"Enzyme Regulation in Metabolic Pathways","description":"\u003cp\u003e\u003ci\u003eEnzyme Regulation in Metabolic Pathways \u003c\/i\u003eshows the reader how to understand the roles of enzymes and their kinetic constants in intermediary metabolism. It provides a means of correlating data obtained in experimental studies to multiple possible mechanisms through which some enzyme may catalyze the conversion of a substrate to a product. Although not the most appropriate means of determining some potential kinetic mechanism, quasi-equilibrium assumptions are used throughout the book, keeping the rate equation derivations simple. Actual metabolic pathways with known (presumed) positive and negative regulation events are linked to these potential kinetic mechanisms using both rate equation derivations and data plots illustrating how the rate equation derivations can be used to explain the data plots. \u003c\/p\u003e \u003cbr\u003eThis book will be a valuable reference for students in biological sciences and biochemistry majors required to take a core course in enzymology. \u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eAuthor’s Review ix\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I 1 Characteristics of Enzymes 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2 Self-Assembly of Polymers 17\u003c\/p\u003e \u003cp\u003e3 Beginnings of Equations 27\u003c\/p\u003e \u003cp\u003e4 Metabolite Distribution Systems 37\u003c\/p\u003e \u003cp\u003e5 Modification of Enzymatic Activity 51\u003c\/p\u003e \u003cp\u003e6 Modification of Metabolite Flow Through Metabolic Pathways 67\u003c\/p\u003e \u003cp\u003e7 Which is the Real Substrate? 75\u003c\/p\u003e \u003cp\u003e8 Non-Quasi-Equilibrium Assumptions 79\u003c\/p\u003e \u003cp\u003e9 Underlying Attributes of Assessing Enzymatic Activities 85\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II 10 Breakdown of the Michaelis–Menten Equation (or Complex Enzyme Mechanisms) 97\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11 Rate Equation Derivation by the King–Altman Method: Two Substrates and Two Products 117\u003c\/p\u003e \u003cp\u003e12 Modification of Enzyme Mechanisms: The Next Generation 141\u003c\/p\u003e \u003cp\u003e13 What Are These “Rate Constants” We Have Been Dealing With? 151\u003c\/p\u003e \u003cp\u003eIndex 165\u003c\/p\u003e \u003cb\u003eLloyd Wolfinbarger, Jr.\u003c\/b\u003e Professor Emeritus at Old Dominion University in Norfolk, Virginia, USA \u003cp\u003eEnzymology is the study of enzymes as protein molecules, with specific folding patterns of the amino acid polymer and unique binding sites wherein intra- and inter-molecular distances define the specificity of the molecule to attract, bind to, and change some substrate molecule.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eEnzyme Regulation in Metabolic Pathways show\u003c\/i\u003es the reader how to understand the roles of enzymes and their kinetic constants in intermediary metabolism. It provides a means of correlating data obtained in experimental studies to multiple possible mechanisms through which some enzyme may catalyze the conversion of a substrate to a product. Quasi-equilibrium assumptions are used throughout the book, keeping the rate equation derivations simple. Actual metabolic pathways with known (presumed) positive and negative regulation events are linked to these potential kinetic mechanisms using both rate equation derivations and data plots illustrating how the rate equation derivations can be used to explain the data plots.\u003c\/p\u003e \u003cp\u003eThis book will be a valuable reference for students in biological sciences and biochemistry, taking a core course in enzymology.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989149139173,"sku":"NP9781119155386","price":100.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119155386.jpg?v=1761782994","url":"https:\/\/k12savings.com\/products\/enzyme-regulation-in-metabolic-pathways-isbn-9781119155386","provider":"K12savings","version":"1.0","type":"link"}