{"product_id":"electrospray-and-maldi-mass-spectrometry-isbn-9780471741077","title":"Electrospray and MALDI Mass Spectrometry","description":"\u003cb\u003eDiscover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas\u003c\/b\u003e  \u003cp\u003eElectrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption\/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research.\u003c\/p\u003e \u003cp\u003eElectrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003ePart A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePart B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePart C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePart D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePart E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.\u003c\/p\u003e  Foreword: Desorption Ionization and Spray Ionization: Connections and Progress (\u003ci\u003eR. Graham Cooks\u003c\/i\u003e).  \u003cp\u003eForeword to the First Edition (\u003ci\u003eJohn B. Fenn\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003ePreface (\u003ci\u003eRichard B. Cole\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eContributors.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Fundamentals of ES.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1. On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS) (\u003ci\u003ePaul Kebarle and Udo H. Verkerk\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2. Selectivity in Electrospray Ionization Mass Spectrometry (\u003ci\u003eNadja B. Cech and Christie G. Enke\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3. Electrochemistry of the Electrospray Ion Source (\u003ci\u003eGary J. Van Berkel and Vilmos Kertesz\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4. ESI Source Design (\u003ci\u003eAndries P. Bruins\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Fundamentals of MALDI.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5. MALDI Ionization Mechanisms: an Overview (\u003ci\u003eRichard Knochenmuss\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6. The Development of Matrix-Assisted Laser Desorption\/Ionization Sources (\u003ci\u003ePeter B. O'Connor\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7. A Comparison of MALDI Matrices (\u003ci\u003eMahmud Hossain and Patrick A. Limbach\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8. MALDI Imaging Mass Spectrometry (\u003ci\u003eAlain Brunelle and Olivier Lapré\u003c\/i\u003e\u003ci\u003evote\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III ES and MALDI Coupling to Mass Spectrometry Instrumentation.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9. Coupling ESI and MALDI Sources to the Quadrupole Mass Filter, Quadrupole Ion Trap, Linear Quadrupole Ion Trap, and Orbitrap Mass Analyzers (\u003ci\u003eMark E. Bier\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10. Time-of-Flight Mass Spectrometry (\u003ci\u003eRobert J. Cotter\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11. Fourier Transform Ion Cyclotron Resonance and Magnetic Sector Analyzers for ESI and MALDI (\u003ci\u003eJeremy J. Wolff and I. Jonathan Amster\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12. Ion Mobility–Mass Spectrometry (\u003ci\u003eJohn A. McLean, J. Albert Schultz, and Amina S. Woods\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Practical Aspects of ES and MALDI.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13. ESI, APCI, and MALDI A Comparison of the Central Analytical Figures of Merit: Sensitivity, Reproducibility, and Speed (\u003ci\u003eThomas R. Covey, Bradley B. Schneider, Hassan Javaheri, J.C. Yves LeBlanc, Gordana Ivosev, Jay J. Corr, and Peter Kovarik\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14. Charge State Distributions in Electrospray and MALDI (\u003ci\u003eYan Li and Richard B. Cole\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15. Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption\/Ionization (\u003ci\u003eSonal Mathur, Alexis Nazabal, and Renato Zenobi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e16. Ion Activation Methods for Tandem Mass Spectrometry (\u003ci\u003eKristina Håa\u003c\/i\u003e\u003ci\u003ekansson and John S. Klassen\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e17. Dissociation of Even-Electron Ions (\u003ci\u003eCarlos Afonso, Richard B. Cole, and Jean-Claude Tabet\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Biological Applications of ES and MALDI.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18. The Role of Mass Spectrometry for Peptide, Protein, and Proteome Characterization (\u003ci\u003eA. Jimmy Ytterberg, Jason Dunsmore, Shirley H. Lomeli, Mario Thevis, Yongming Xie, Rachel R. Ogorzalek Loo, and Joseph A. Loo\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e19. Carbohydrate Analysis by ESI and MALDI (\u003ci\u003eDavid J. Harvey\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e20. Applications of ESI and MALDI to Lipid Analysis (\u003ci\u003eXianlin Han\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e21. In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery (\u003ci\u003eDaniel B. Kassel\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e \"Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, this volume will help researchers fully leverage the power\u003cbr\u003eof electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry\". (Anticancer Research, 1 August 2010)\u003cbr\u003e \u003cb\u003eRICHARD B. COLE, PHD,\u003c\/b\u003e is a University Research Professor in The Department of Chemistry at The University of New Orleans. He has spent more than twenty-five years working in the field of mass spectrometry. His research interests include analytical\/bio-organic chemistry as well as fundamentals and applications of mass spectrometry, with a focus on the development of novel analytical methods employing electrospray and MALDI.  \u003cb\u003eDiscover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas\u003c\/b\u003e  \u003cp\u003e\u003ci\u003eElectrospray and MALDI Mass Spectrometry\u003c\/i\u003e brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption\/ionization (MALDI) mass spectrometry. In particular, this \u003ci\u003eSecond Edition\u003c\/i\u003e highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eElectrospray and MALDI Mass Spectrometry\u003c\/i\u003e, SECOND EDITION is divided into five parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003ePart A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePart B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePart C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePart D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePart E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, \u003ci\u003eElectrospray and MALDI Mass Spectrometry\u003c\/i\u003e will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989118271717,"sku":"NP9780471741077","price":203.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471741077.jpg?v=1761782869","url":"https:\/\/k12savings.com\/products\/electrospray-and-maldi-mass-spectrometry-isbn-9780471741077","provider":"K12savings","version":"1.0","type":"link"}