{"product_id":"comprehensive-chromatography-in-combination-with-mass-spectrometry-isbn-9780470434079","title":"Comprehensive Chromatography in Combination with Mass Spectrometry","description":"This book provides a detailed description of various multidimensional chromatographic separation techniques. The editor first provides an introduction to the area and then dives right into the various complex separation techniques. While still not used routinely comprehensive chromatography techniques will help acquaint the readers with the fundamentals and possible benefits of multi-dimensional separations coupled with mass spectrometry.  \u003cp\u003e The topics include a wide range of material that will appease all interested in either entering the field of multidimensional chromatography and those looking to gain a better understanding of the topic.\u003c\/p\u003e  \u003cb\u003eContributors ix\u003c\/b\u003e  \u003cp\u003e\u003cb\u003ePreface xi\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLuigi Mondello, Peter Q. Tranchida, and Keith D. Bartle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Two-Dimensional Chromatography–Mass Spectrometry: A 50-Year-Old Combination, 2\u003c\/p\u003e \u003cp\u003e1.2 Shortcomings of One-Dimensional Chromatography, 3\u003c\/p\u003e \u003cp\u003e1.3 Benefits of Two-Dimensional Chromatography, 6\u003c\/p\u003e \u003cp\u003e1.4 Book Content, 7\u003c\/p\u003e \u003cp\u003e1.5 Final Considerations, 11\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Multidimensional Gas Chromatography: Theoretical Considerations 13\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLeonid M. Blumberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Symbols, 15\u003c\/p\u003e \u003cp\u003e2.2 One-Dimensional GC, 17\u003c\/p\u003e \u003cp\u003e2.3 Comprehensive GC × GC, 31\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Multidimensional Liquid Chromatography: Theoretical Considerations 65\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePavel Jandera\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Two-Dimensional LC Techniques, 66\u003c\/p\u003e \u003cp\u003e3.2 Peak Capacity in HPLC: One- and Multidimensional Separations, 69\u003c\/p\u003e \u003cp\u003e3.3 Orthogonality in Two-Dimensional LC–LC Systems, 73\u003c\/p\u003e \u003cp\u003e3.4 Sample Dimensionality and Structural Correlations, 75\u003c\/p\u003e \u003cp\u003e3.5 Separation Selectivity and Selection of Phase Systems in Two-Dimensional LC–LC, 79\u003c\/p\u003e \u003cp\u003e3.6 Programmed Elution in Two-Dimensional HPLC, 81\u003c\/p\u003e \u003cp\u003e3.7 Fraction Transfer Modulation in Comprehensive LC × LC: Additional Band Broadening, 87\u003c\/p\u003e \u003cp\u003e3.8 Future Perspectives, 89\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 History, Evolution, and Optimization Aspects of Comprehensive Two-Dimensional Gas Chromatography 93\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAhmed Mostafa, Tadeusz G´orecki, Peter Q. Tranchida, and Luigi Mondello\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Fundamentals of GC × GC, 94\u003c\/p\u003e \u003cp\u003e4.2 Modulation, 96\u003c\/p\u003e \u003cp\u003e4.3 GC × GC Data Interpretation, 97\u003c\/p\u003e \u003cp\u003e4.4 GC × GC Instrumentation, 100\u003c\/p\u003e \u003cp\u003e4.5 Thermal Modulators, 101\u003c\/p\u003e \u003cp\u003e4.6 Comprehensive Two-Dimensional GC Method Optimization, 115\u003c\/p\u003e \u003cp\u003e4.7 Final Remarks, 140\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Flow-Modulated Comprehensive Two-Dimensional Gas Chromatography 145\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJohn V. Seeley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Timing Requirements of GC × GC Modulators, 145\u003c\/p\u003e \u003cp\u003e5.2 Criteria for Evaluating Modulators, 150\u003c\/p\u003e \u003cp\u003e5.3 Forms of Modulation, 151\u003c\/p\u003e \u003cp\u003e5.4 Single-Stage Flow Modulation, 152\u003c\/p\u003e \u003cp\u003e5.5 Two-Stage Flow Modulation, 157\u003c\/p\u003e \u003cp\u003e5.6 Summary of Flow Modulators, 167\u003c\/p\u003e \u003cp\u003e5.7 Brief Comparison to Thermal Modulation, 169\u003c\/p\u003e \u003cp\u003e5.8 Concluding Remarks, 169\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Comprehensive Two-Dimensional Gas Chromatography Combined with Mass Spectrometry 171\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePeter Q. Tranchida, Luigi Mondello, Samuel D. H. Poynter, and Robert A. Shellie\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Instrument Requirements for GC × GC–MS, 173\u003c\/p\u003e \u003cp\u003e6.2 Data Processing of GC × GC–TOF MS Results, 180\u003c\/p\u003e \u003cp\u003e6.3 Method Translation in GC × GC–MS, 181\u003c\/p\u003e \u003cp\u003e6.4 GC × MS, 181\u003c\/p\u003e \u003cp\u003e6.5 Conventional and Alternative Modulation Techniques for GC × GC–MS, 184\u003c\/p\u003e \u003cp\u003e6.6 GC × GC–MS Applications, 187\u003c\/p\u003e \u003cp\u003e6.7 Concluding Remarks, 232\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Detector Technologies and Applications in Comprehensive Two-Dimensional Gas Chromatography 243\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePhilip J. Marriott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Detection in GC × GC, 244\u003c\/p\u003e \u003cp\u003e7.2 Comments on GC × GC with Mass Spectrometry, 249\u003c\/p\u003e \u003cp\u003e7.3 Flame Ionization Detection in GC × GC, 250\u003c\/p\u003e \u003cp\u003e7.4 Electron Capture Detection in GC × GC, 254\u003c\/p\u003e \u003cp\u003e7.5 Sulfur Chemiluminescence Detection in GC × GC, 260\u003c\/p\u003e \u003cp\u003e7.6 Nitrogen Chemiluminescence Detection in GC × GC, 263\u003c\/p\u003e \u003cp\u003e7.7 Atomic Emission Detection in GC × GC, 265\u003c\/p\u003e \u003cp\u003e7.8 Thermionic Detection in GC × GC, 267\u003c\/p\u003e \u003cp\u003e7.9 Flame Photometric Detection in GC × GC, 269\u003c\/p\u003e \u003cp\u003e7.10 Case Study of GC × GC with Selective Detection, 272\u003c\/p\u003e \u003cp\u003e7.11 Dual Detection with GC × GC, 274\u003c\/p\u003e \u003cp\u003e7.12 Conclusions, 275\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 History, Evolution, and Optimization Aspects of Comprehensive Two-Dimensional Liquid Chromatography 281\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eIsabelle Fran¸cois, Koen Sandra, and Pat Sandra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Method Development and Instrumentation, 282\u003c\/p\u003e \u003cp\u003e8.2 Technical Problems in Comprehensive Liquid Chromatography, 309\u003c\/p\u003e \u003cp\u003e8.3 Detection, 314\u003c\/p\u003e \u003cp\u003e8.4 Data Representation, 315\u003c\/p\u003e \u003cp\u003e8.5 Instrumentation, 316\u003c\/p\u003e \u003cp\u003e8.6 Milestones in Comprehensive Liquid Chromatography, 317\u003c\/p\u003e \u003cp\u003e8.7 Applications, 320\u003c\/p\u003e \u003cp\u003e8.8 Beyond Two-Dimensional Chromatography, 320\u003c\/p\u003e \u003cp\u003e8.9 Comparison of LC × LC and Off-Line 2D LC, 321\u003c\/p\u003e \u003cp\u003e8.10 Conclusions, 325\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Comprehensive Two-Dimensional Liquid Chromatography Combined with Mass Spectrometry 331\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePaola Dugo, Luigi Mondello, Francesco Cacciola, and Paola Donato\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 HPLC–MS, 332\u003c\/p\u003e \u003cp\u003e9.2 LC × LC–MS Instrumentation and Method Development, 334\u003c\/p\u003e \u003cp\u003e9.3 LC × LC–MS Applications, 336\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Comprehensive Two-Dimensional Liquid Chromatography Applications 391\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePaola Dugo, Luigi Mondello, Francesco Cacciola, and Paola Donato\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Comprehensive 2D LC Separation of Synthetic and Natural Polymers, 392\u003c\/p\u003e \u003cp\u003e10.2 Comprehensive 2D LC Separation of Natural Products and Antioxidants, 399\u003c\/p\u003e \u003cp\u003e10.3 Comprehensive 2D LC Separation of Pharmaceutical and Environmental Compounds, 412\u003c\/p\u003e \u003cp\u003e10.4 Comprehensive 2D LC Separation of Proteins and Peptides, 417\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Other Comprehensive Chromatography Methods 429\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eIsabelle Fran¸cois, Pat Sandra, Danilo Sciarrone, and Luigi Mondello\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Online Two-Dimensional Liquid Chromatography–Gas Chromatography, 430\u003c\/p\u003e \u003cp\u003e11.2 Online Two-Dimensional Supercritical Fluid Chromatography–Gas Chromatography, 440\u003c\/p\u003e \u003cp\u003e11.3 Online Two-Dimensional Supercritical Fluid Chromatography–Supercritical Fluid Chromatography, 440\u003c\/p\u003e \u003cp\u003e11.4 Online Two-Dimensional Supercritical Fluid Chromatography-Liquid Chromatography, 442\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Comprehensive Chromatography Data Interpretation Technologies 449\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eElizabeth M. Humston and Robert E. Synovec\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Higher-Order Data Structure, 450\u003c\/p\u003e \u003cp\u003e12.2 Modifications of First-Order Data-Handling Approaches, 453\u003c\/p\u003e \u003cp\u003e12.3 Visualization, 456\u003c\/p\u003e \u003cp\u003e12.4 Mass Spectral Detection, 461\u003c\/p\u003e \u003cp\u003e12.5 Chemometrics, 463\u003c\/p\u003e \u003cp\u003e12.6 Summary of Data Interpretation Technologies, 472\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex 477\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e“It offers comprehensive coverage of the topic of comprehensive multidimensional separations, at a level that makes it a useful reference for scientists working in the field, or as a primary textbook for a graduate-level course on advanced separation techniques.”  (\u003ci\u003eAnal Bioanal Chem\u003c\/i\u003e, 2012)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e  \u003cp\u003eLuigi Mondello is an expert in the field of multidimensional chromatography. He has published a number of books and papers in his field and has been an invited speaker at a number of conferences. He is Editor of the Journal of Separation Science (Wiley). Recently he was awarded The Chromatographic Society's Silver Jubilee Medal award for his work in the field of chromatography and the COLACRO Medal for his contribution to the development and diffusion of the Chromatographic Techniques, and the HTC-Award for the most outstanding and innovative work in the field of hyphenated chromatographic techniques from the Flemish Chemical Society. He is currently Full Professor of Analytical Chemistry at the the University of Messina in Italy and permanent member of the scientific committee of the International Symposium on Capillary Chromatography (ISCC); the International Symposium on Essential Oils (ISEO); the International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-11); the Brazilian Symposium on Chromatography and Related Techniques (SIMCRO); and the Congresso Latino-Americano de Cromatografia e Técnicas Relacionades (COLACRO).\u003c\/p\u003e  \u003cp\u003eA clear, concise, and all-encompassing approach to comprehensive chromatography methodologies\u003c\/p\u003e \u003cp\u003eAn excellent primer to the field of comprehensive chromatography (CC), this book provides a detailed description of various multidimensional chromatographic separation techniques in an effort to acquaint readers with the fundamentals and possible benefits of multidimensional separations coupled with mass spectrometry—an expanding topic, and one of the most rapidly developing areas in analytical chemistry.\u003c\/p\u003e \u003cp\u003eAmong the first and most up-to-date books dealing with CC methodologies, this single-volume reference gathers and combines studies from a multitude of scientific literature to discuss a wide range of important topics. In-depth coverage of separation techniques such as comprehensive 2D GC, LC and LC-GC shows how these and various other combinations are ideal for the separation and analysis of complex mixtures in the pharmaceutical, biological, industrial, environmental, and clinical fields. Other subjects explored in this text include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eThe theoretical considerations of multidimensional gas and liquid chromatography\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe history, evolution, and optimization aspects of comprehensive two-dimensional gas and liquid chromatography\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eUp-to-date comprehensive chromatography data interpretation technologies\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe feedback gained from comprehensive chromatographic techniques, though promising, still remains an emerging contributor to the research field. With the goal of extracting the enormous potential embedded in CC methodologies, Comprehensive Chromatography in Combination with Mass Spectrometry provides insight that takes a great leap forward in advancing exploration into this highly complex—yet highly powerful—analytical tool.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988961181925,"sku":"NP9780470434079","price":153.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470434079.jpg?v=1761782220","url":"https:\/\/k12savings.com\/products\/comprehensive-chromatography-in-combination-with-mass-spectrometry-isbn-9780470434079","provider":"K12savings","version":"1.0","type":"link"}