{"product_id":"clinical-trials-in-older-adults-isbn-9781118323496","title":"Clinical Trials in Older Adults","description":"Clinical Trials in Older Adults is the first book to consider the methodological issues underlying the evaluation of new treatments in older people.\u003cbr\u003e\u003cbr\u003e \u003cul\u003e \u003cli\u003eProvides information on the methodology, monitoring and regulations for those planning to conduct a clinical trials involving older adults\u003c\/li\u003e \u003cli\u003eContains examples of ongoing trials involving older adults, and presents the main characteristics of many recently published\u003c\/li\u003e \u003cli\u003eDepicts how the issues regarding older adults in clinical trials could be properly addressed with the appropriate study design and conduct\u003c\/li\u003e \u003cli\u003eIdentifies key issues in performing clinical trials in older patients with common geriatric conditions, i.e. Alzheimer’s dementia, depression, low muscle mass, cancer\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eContributors vii\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I: The frame\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The exclusion of older subjects from clinical trials: the PREDICT study 3\u003cbr\u003e\u003ci\u003eAntonio Cherubini \u0026amp; Peter Crome\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Clinical trials in older adults: a point of view from the industry 23\u003cbr\u003e\u003ci\u003eSusanna Del Signore \u0026amp; Philippe Guillet\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Ethical issues in clinical trials involving older subjects: the right to participate in clinical trials and have access to care; the protection of vulnerable subjects and the issue of informed consent 45\u003cbr\u003e\u003ci\u003eEmmanuel Hirsch \u0026amp; Paul]Loup Weil]Dubuc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: The implementation\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 Mastering the design of clinical trials for older persons: the tension between external validity and feasibility 63\u003cbr\u003e\u003ci\u003eLuigi Ferrucci \u0026amp; Stephanie Studenski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Pharmacokinetic and pharmacodynamic studies in older adults 79\u003cbr\u003e\u003ci\u003eArduino A. Mangoni, Paul A.F. Jansen \u0026amp; Stephen H.D. Jackson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 The role of comprehensive geriatric assessment (CGA) of older adults in clinical studies 95\u003cbr\u003e\u003ci\u003eGraziano Onder, Agnese Collamati, Andrea Poscia \u0026amp; Roberto Bernabei\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Statistical issues in designing and interpreting clinical trials in older adults 107\u003cbr\u003e\u003ci\u003eHeather Allore, Mark A. Espeland \u0026amp; Michael E. Miller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: The examples\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Challenges in implementing large]scale clinical trials in moderately functioning older adults 127\u003cbr\u003e\u003ci\u003eStephen D. Anton, Sandrine Sourdet, Marco Pahor \u0026amp; Todd Manini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Clinical trials in Alzheimer’s disease 153\u003cbr\u003e\u003ci\u003eJulien Delrieu \u0026amp; Bruno Vellas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Clinical trials in late]life mood disorders 173\u003cbr\u003e\u003ci\u003eLucio Ghio, Werner Natta, Marco Vaggi \u0026amp; Luigi Ferrannini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Clinical trials for conditions of low muscle mass and strength 197\u003cbr\u003e\u003ci\u003eStephanie Studenski, Rosaly Correa-de-Araujo \u0026amp; Luigi Ferrucci\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Clinical trials of cancer treatment in the elderly 219\u003cbr\u003e\u003ci\u003eLodovico Balducci. Iordanis Gravanis \u0026amp; Francesco Pignatti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Clinical trials in nursing homes: challenges and practical solutions 231\u003cbr\u003e\u003ci\u003eSandra Simmons, Barbara Resnick, John Schnelle \u0026amp; Joseph G. Ouslander\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 255\u003c\/p\u003e “Clinical Trials in Older Adults” is essential reading for anyone developing drugs or medical devices that could be useful treatments for the elderly.\" (Journal of Clinical Research Best Practices 2016) \u003cb\u003eAntonio Cherubini, \u003c\/b\u003eis Director of Geriatrics and Geriatric Emergency Care at IRCCS-INRCA, Ancona, Italy. He is Associate Professor of Gerontology and Geriatrics at the Perugia University Medical School. He was research fellow at the department of Neurology, Massachusetts General Hospital, Harvard Medical School, from 1997-1998. He is co-author of several books of geriatric medicine in Italy. He is author of more than 200 papers in peer reviewed international journals. He is currently member of the Geriatric Expert Group of the European Medicine Agency.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eRoberto Bernabei,\u003c\/b\u003e Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eLuigi Ferrucci \u003c\/b\u003eis the Scientific Director of the National Institute of Aging, NIH, Baltimore, MD, USA.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eNiccolò Marchionni,\u003c\/b\u003e Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatric Medicine, University of Florence and Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eBruno Vellas,\u003c\/b\u003e Gerontopole de Toulouse. Department of Geriatric Medicine, Toulouse University Hospital, Toulouse; INSERM Unit 1027. University Toulouse III. Toulouse, France.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eStephanie Studenski\u003c\/b\u003e, Professor of Medicine and Director of Research, Division of Geriatric Medicine, Program Director, Pittsburgh Pepper Center; Director, AOC in Geriatric Medicine, Staff Physician at the GRECC, VA Pittsburgh Healthcare System. \u003cp\u003eThe concept of clinical trials in older adults is a relatively new field of research that is now rapidly expanding; with a need that is unmet there are currently no reference books specifically on this subject. A key question being asked by physicians about the worlds ageing population is whether an increase in life expectancy will be accompanied by a postponement of functional limitations and disability. Older subjects traditionally have limited involvement in mainstream clinical trials, even though research shows that they are more at risk from the adverse side effects of drugs.\u003cbr\u003e\u003cbr\u003eOlder adults have typically been excluded from mainstream clinical trials that test new medications and interventions. It is therefore critical that researchers begin systematically studying the effects of new therapies in older patients as our population ages.\u003cbr\u003e\u003cbr\u003eClinical Trials in Older Adults is the first book to consider the methodological issues underlying the evaluation of new treatments in older people:\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003eProvides information on the methodology, monitoring and regulations for those planning to conduct clinical trials involving older adults\u003c\/li\u003e \u003cli\u003eContains examples of ongoing and recently completed trials involving older adults\u003c\/li\u003e \u003cli\u003eDepicts how the issues regarding older adults in clinical trials could be properly addressed with the appropriate study design and conduct\u003c\/li\u003e \u003cli\u003eIdentifies key issues in performing clinical trials in older patients with common geriatric conditions, i.e. Alzheimer’s dementia, depression, low muscle mass, cancer\u003c\/li\u003e \u003c\/ul\u003e \u003cbr\u003ePhysicians and researchers involved in clinical trials, regulators, members of ethical committees all need to have access to this key information.","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47988935622885,"sku":"NP9781118323496","price":82.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118323496.jpg?v=1761782117","url":"https:\/\/k12savings.com\/products\/clinical-trials-in-older-adults-isbn-9781118323496","provider":"K12savings","version":"1.0","type":"link"}