{"product_id":"click-chemistry-in-glycoscience-isbn-9781118275337","title":"Click Chemistry in Glycoscience","description":"\u003cp\u003e\u003cb\u003eLays the foundation for new methods and applications of carbohydrate click chemistry\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClick Chemistry in Glycoscience\u003c\/i\u003e examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eClick chemistry strategies and decoupling\u003c\/li\u003e \u003cli\u003eThio-click chemistry of carbohydrates\u003c\/li\u003e \u003cli\u003eCarbohydrate click chemistry for novel synthetic targets\u003c\/li\u003e \u003cli\u003eCarbohydrate click chemistry in biomedical sciences\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics.\u003c\/p\u003e \u003cp\u003eThe application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.\u003c\/p\u003e  \u003cp\u003eFOREWORD vii\u003c\/p\u003e \u003cp\u003ePREFACE ix\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xiii\u003c\/p\u003e \u003cp\u003eLIST OF ABBREVIATIONS xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eI CLICK CHEMISTRY STRATEGIES AND DECOUPLING\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling 3\u003cbr\u003e \u003ci\u003eRoman Bielski and Zbigniew J. Witczak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eII THIO-CLICK CHEMISTRY OF CARBOHYDRATES\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2 Thio-Click Chemistry in Glycoscience: Overview and Perspectives 33\u003cbr\u003e \u003ci\u003eZbigniew J. Witczak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Free-Radical Thiol-ene and Thiol-yne Couplings as Click Processes for Glycoconjugation 45\u003cbr\u003e \u003ci\u003eAlessandro Dondoni and Alberto Marra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIII CARBOHYDRATE CLICK CHEMISTRY FOR NOVEL SYNTHETIC TARGETS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions 79\u003cbr\u003e \u003ci\u003eMichael D. Best\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds 107\u003cbr\u003e \u003ci\u003eMaria Laura Uhrig and Jos´e Kovensky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces 143\u003cbr\u003e \u003ci\u003eCarmen Ortiz Mellet, Alejandro M´endez-Ardoy, and Jos´e Manuel Garc´©¥a Fern´andez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Toward Imaging Glycotools by Click Coupling 183\u003cbr\u003e \u003ci\u003eYves Chapleur, Christine Vala, Franc¸oise Chr´etien, and Sandrine Lamand´e-Langle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Bioorthogonal Reactions for Labeling Glycoconjugates 211\u003cbr\u003e \u003ci\u003eFr´ed´eric Friscourt and Geert-Jan Boons\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 “Sweet” Sucrose Macrocycles via a “Click Chemistry” Route 235\u003cbr\u003e \u003ci\u003eMykhaylo A. Potopnyk and S©©awomir Jarosz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIV CARBOHYDRATE CLICK CHEMISTRY IN BIOMEDICAL SCIENCES\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10 Neoglycoprotein Synthesis Using the Copper-Catalyzed Azide–Alkyne Click Reaction and Native Chemical Ligation 253\u003cbr\u003e \u003ci\u003eJoanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent, and Margaret A. Brimble\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Biomedical Applications of “Click”-Modified Cyclodextrins 271\u003cbr\u003e \u003ci\u003eZhenshan Jia, Rakesh K. Singh, and Dong Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Triazolyl Glycoconjugates in Medicinal Chemistry 293\u003cbr\u003e \u003ci\u003eRama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha, and Vinod Kumar Tiwari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Click Chemistry Applied to Carbohydrate-Based Drug Discovery 325\u003cbr\u003e \u003ci\u003eVanessa Leiria Campo and Ivone Carvalho\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 359\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eZBIGNIEW J. WITCZAK, PhD,\u003c\/b\u003e is Professor in the Department of Pharmaceutical Sciences of the Nesbitt School of Pharmacy at Wilkes University. He has published over ninety research papers and holds six patents. His research focuses on carbohydrate synthons, including levoglucosenone and L-arabinose, as templates for carbohydrate-based therapeutics. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award from the ACS Division of Carbohydrate Chemistry.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eROMAN BIELSKI, PhD,\u003c\/b\u003e is Senior Scientist at Value Recovery, Inc., Partner in Cheminnolab, LLC, and Adjunct Professor in the Department of Pharmaceutical Sciences at Wilkes University. His research investigates the origin of homochirality, modification of carbohydrates, solutions to environmental issues, and sustainability. As part of his achievements, Dr. Bielski co-developed a method of enantiomers' resolution, which might have been involved in prebiotic homochirality, since it would not require the use of chiral compounds.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eLays the foundation for new methods and applications of carbohydrate click chemistry\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClick Chemistry in Glycoscience\u003c\/i\u003e examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eClick chemistry strategies and decoupling\u003c\/li\u003e \u003cli\u003eThio-click chemistry of carbohydrates\u003c\/li\u003e \u003cli\u003eCarbohydrate click chemistry for novel synthetic targets\u003c\/li\u003e \u003cli\u003eCarbohydrate click chemistry in biomedical sciences\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics.\u003c\/p\u003e \u003cp\u003eThe application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988928282853,"sku":"NP9781118275337","price":153.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118275337.jpg?v=1761782087","url":"https:\/\/k12savings.com\/products\/click-chemistry-in-glycoscience-isbn-9781118275337","provider":"K12savings","version":"1.0","type":"link"}