{"product_id":"chemistry-of-the-carbonyl-group-isbn-9781119459569","title":"Chemistry of the Carbonyl Group","description":"\u003cp\u003e\u003cb\u003eTeaches and enables students to build confidence in drawing and manipulating curly arrows, a fundamental skill for all organic chemists\u003c\/b\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThis book is an interactive approach to learning about chemistry of the carbonyl group—inviting students to work through its pages with pencil and paper in hand. It educates with the belief that the most effective way to learn is by practice and interaction. With this in mind, the reader is asked to predict what would happen under a specific set of reaction conditions. The book is divided into frames: each frame poses a question and invites the reader to predict what will happen. Subsequent frames give the solution but then pose more questions to develop a theme further.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eChemistry of the Carbonyl Group: A Programmed Approach to Organic Reaction Mechanisms, Revised Edition\u003c\/i\u003e provides a solid grounding in the fundamental reactions of carbonyls. Presented in full colour to enhance the understanding of mechanisms within chemistry, the chapters of this step-by-step guide cover: nucleophilic addition to the carbonyl group; nucleophilic substitution; nucleophilic substitution at the carbonyl group with complete removal of carbonyl oxygen; carbanions and enolisation; and building organic molecules from carbonyl compounds.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eA must-have book for undergraduate chemists to emphasise understanding in carbonyl group chemistry\u003c\/li\u003e \u003cli\u003eGoes through all the stages of basic carbonyl chemistry, detailing even the simplest mechanisms\u003c\/li\u003e \u003cli\u003eA step-by-step learning guide to synthetic chemistry for the first year of a chemistry degree, with all the information needed for independent learning\u003c\/li\u003e \u003cli\u003eProvides a solid grounding in the fundamental reactions of carbonyls which will inform the understanding of many other organic chemistry reactions  \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eChemistry of the Carbonyl Group: A Programmed Approach to Organic Reaction Mechanisms - Revised Edition\u003c\/i\u003e is packed with all the information on synthetic chemistry that every first-year student will need in order to learn independently. \u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eAcknowledgements xiii\u003c\/p\u003e \u003cp\u003eSome Help That You May Need xv\u003c\/p\u003e \u003cp\u003eWhat Do You Need to Know Before You Start? xvii\u003c\/p\u003e \u003cp\u003eIntroduction xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Nucleophilic Addition to the Carbonyl Group 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNucleophilic addition: what it is and how it happens 3\u003c\/p\u003e \u003cp\u003eAlcohols as nucleophiles: acetal formation 6\u003c\/p\u003e \u003cp\u003eSome carbon–carbon bond-forming reactions with carbon nucleophiles: cyanide ion, acetylide ion and Grignard reagents 10\u003c\/p\u003e \u003cp\u003eHydride ion and its derivatives LiAlH\u003csub\u003e4 \u003c\/sub\u003eand NaBH\u003csub\u003e4\u003c\/sub\u003e Reduction of aldehydes and ketones 17\u003c\/p\u003e \u003cp\u003eMeerwein–Ponndorf reduction and Oppenauer oxidation, with a branch program on how to draw transition states 19\u003c\/p\u003e \u003cp\u003eTwo general revision problems 25\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Nucleophilic Substitution 29\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSubstitution: how it happens 31\u003c\/p\u003e \u003cp\u003eLiAlH\u003csub\u003e4\u003c\/sub\u003e reduction of esters 33\u003c\/p\u003e \u003cp\u003eReaction of Grignard reagents with esters 34\u003c\/p\u003e \u003cp\u003eAlkaline hydrolysis of esters 38\u003c\/p\u003e \u003cp\u003eAcid hydrolysis of amides 39\u003c\/p\u003e \u003cp\u003eSummary of acid and base catalysis 41\u003c\/p\u003e \u003cp\u003eReaction between carboxylic acids and thionyl chloride 41\u003c\/p\u003e \u003cp\u003eSynthesis of esters and anhydrides from carboxylic acids 43\u003c\/p\u003e \u003cp\u003eReview questions 45\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Nucleophilic Subsitution at the Carbonyl Group with Complete Removal of Carbonyl Oxygen 49\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eImine formation from aldehydes and ketones 51\u003c\/p\u003e \u003cp\u003eOxime formation and the structure of oximes 53\u003c\/p\u003e \u003cp\u003eHydrazone and semicarbazone formation 54\u003c\/p\u003e \u003cp\u003eReduction of C=O to CH\u003csub\u003e2\u003c\/sub\u003e 56\u003c\/p\u003e \u003cp\u003eConversion of C=O to CCl\u003csub\u003e2\u003c\/sub\u003e 60\u003c\/p\u003e \u003cp\u003eDDT synthesis 64\u003c\/p\u003e \u003cp\u003eChloromethylation of aromatic compounds 65\u003c\/p\u003e \u003cp\u003eReview questions 66\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Carbanions and Enolisation 69\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCarbanions 71\u003c\/p\u003e \u003cp\u003eTautomerism 72\u003c\/p\u003e \u003cp\u003eEquilibration and racemisation of ketones by enolisation 73\u003c\/p\u003e \u003cp\u003eHalogenation of ketones 78\u003c\/p\u003e \u003cp\u003eFormation of bromo-acid derivatives 83\u003c\/p\u003e \u003cp\u003eOrgano-zinc derivatives and their use in synthesis 85\u003c\/p\u003e \u003cp\u003eReview questions 87\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Building Organic Molecules from Carbonyl Compounds 89\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eUsing enols as nucleophiles to attack other carbonyl groups 92\u003c\/p\u003e \u003cp\u003eThe aldol reaction 92\u003c\/p\u003e \u003cp\u003eThe Claisen ester condensation 93\u003c\/p\u003e \u003cp\u003eAcid catalysed condensation of acetone 94\u003c\/p\u003e \u003cp\u003eSelf-condensation reactions 96\u003c\/p\u003e \u003cp\u003eElaboration of a skeleton in synthesis 97\u003c\/p\u003e \u003cp\u003eCross-condensations with molecules which cannot enolise 98\u003c\/p\u003e \u003cp\u003eMannich reaction 103\u003c\/p\u003e \u003cp\u003ePerkin reaction 105\u003c\/p\u003e \u003cp\u003eStable enols from β-dicarbonyl compounds 108\u003c\/p\u003e \u003cp\u003eKnoevenagel reaction 110\u003c\/p\u003e \u003cp\u003eAlkylation of β-dicarbonyl compounds 113\u003c\/p\u003e \u003cp\u003eMichael reaction 116\u003c\/p\u003e \u003cp\u003eDecarboxylation 125\u003c\/p\u003e \u003cp\u003eBase cleavage of β-dicarbonyl compounds 131\u003c\/p\u003e \u003cp\u003eCyclisation reactions: the Dieckmann condensation 134\u003c\/p\u003e \u003cp\u003eCyclisation of diketones 136\u003c\/p\u003e \u003cp\u003eThe dimedone synthesis 137\u003c\/p\u003e \u003cp\u003eRing opening by base cleavage of β-dicarbonyl compounds 141\u003c\/p\u003e \u003cp\u003eRevision questions 142\u003c\/p\u003e \u003cp\u003eExamples of syntheses: two steroid syntheses 145\u003c\/p\u003e \u003cp\u003eStork’s cedrene synthesis 150\u003c\/p\u003e \u003cp\u003eIndex 155 \u003c\/p\u003e   \u003cp\u003e\u003cb\u003eTIMOTHY K. DICKENS, FRSC,\u003c\/b\u003e is Official Fellow, College Lecturer and Director of Studies in Chemistry at Peterhouse, Cambridge. Dr Dickens graduated from the University of Kent in 1982, and, after two years' research at Oxford, he joined Glaxo where he spent 24 years in both scientific and technology senior roles. In 2008, he joined the University of Cambridge, where his research has focused on Ring Currents in conjugated systems. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSTUART WARREN, P\u003csmall\u003eH\u003c\/small\u003eD,\u003c\/b\u003e is the author of the textbooks \u003ci\u003eOrganic Chemistry, Organic Synthesis: The Disconnection Approach\u003c\/i\u003e and \u003ci\u003eOrganic Synthesis\u003c\/i\u003e. He retired from Churchill College, Department of Chemistry, University of Cambridge in 2006, having fostered some of the most successful organic chemistry academics in the UK.    \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTEACHES AND ENABLES STUDENTS TO BUILD CONFIDENCE IN DRAWING AND MANIPULATING CURLY ARROWS, A FUNDAMENTAL SKILL FOR ALL ORGANIC CHEMISTS\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eThis book is an interactive approach to learning about chemistry of the carbonyl group—inviting students to work through its pages with pencil and paper in hand. It educates with the belief that the most effective way to learn is by practice and interaction. With this in mind, the reader is asked to predict what would happen under a specific set of reaction conditions. The book is divided into frames: each frame poses a question and invites the reader to predict what will happen. Subsequent frames give the solution but then pose more questions to develop a theme further. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eChemistry of the Carbonyl Group: A Step-by-Step Approach to Understanding Organic Reaction Mechanisms\u003c\/i\u003e provides a solid grounding in the fundamental reactions of carbonyls. Presented in full colour to enhance the understanding of mechanisms within chemistry, the chapters of this step-by-step guide cover: nucleophilic addition to the carbonyl group; nucleophilic substitution; nucleophilic substitution at the carbonyl group with complete removal of carbonyl oxygen; carbanions and enolisation; and building organic molecules from carbonyl compounds. \u003c\/p\u003e\u003cul\u003e \u003cli\u003eA must-have book for undergraduate chemists to emphasise understanding in carbonyl group chemistry\u003c\/li\u003e \u003cli\u003eGoes through all the stages of basic carbonyl chemistry, detailing even the simplest mechanisms\u003c\/li\u003e \u003cli\u003eA step-by-step learning guide to synthetic chemistry for the first year of a chemistry degree, with all the information needed for independent learning\u003c\/li\u003e \u003cli\u003eProvides a solid grounding in the fundamental reactions of carbonyls which will inform the understanding of many other organic chemistry reactions\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eChemistry of the Carbonyl Group: A Step-by-Step Approach to Understanding Organic Reaction Mechanisms\u003c\/i\u003e is packed with all the information on synthetic chemistry that every first-year student will need in order to learn independently.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988909867237,"sku":"NP9781119459569","price":40.5,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119459569.jpg?v=1761782014","url":"https:\/\/k12savings.com\/products\/chemistry-of-the-carbonyl-group-isbn-9781119459569","provider":"K12savings","version":"1.0","type":"link"}