{"product_id":"chemical-synthetic-biology-isbn-9780470713976","title":"Chemical Synthetic Biology","description":"Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, \u003ci\u003eChemical Synthetic Biology\u003c\/i\u003e shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.  \u003cb\u003eList of Contributors.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eIntroduction (\u003c\/b\u003e\u003ci\u003ePier Luigi Luisi).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart One: Nucleic Acids.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Searching for Nucleic Acid Alternatives (\u003c\/b\u003e\u003ci\u003eAlbert Eschenmoser).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Never-Born RNAs: Versatile Modules for Chemical Synthetic Biology (\u003c\/b\u003e\u003ci\u003eDavide De Lucrezia, Fabrizio Anella, Cristiano Chiarabelli, and Pier Luigi Luisi).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Synthetic Biology, Tinkering Biology, and Artificial Biology: A Perspective from Chemistry (\u003c\/b\u003e\u003ci\u003eSteven A. Benner, Fei Chen, and Zunyi Yang).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Peptide Nucleic Acids (PNAs) as a Tool in Chemical Biology (\u003c\/b\u003e\u003ci\u003ePeter E. Nielsen).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Two: Peptides and Proteins.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 High Solubility of Random-Sequence Proteins Consisting of Five Kinds of Primitive Amino Acids (\u003c\/b\u003e\u003ci\u003eNobuhide Doi, Koichi Kakukawa, Yuko Oishi, and Hiroshi Yanagawa).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Experimental Approach for Early Evolution of Protein Function (\u003c\/b\u003e\u003ci\u003eHitoshi Toyota, Yuuki Hayashi, Asao Yamauchi, Takuyo Aita, and Tetsuya Yomo).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Searching for \u003ci\u003ede novo\u003c\/i\u003e Totally Random Amino Acid Sequences (\u003c\/b\u003e\u003ci\u003eCristiano Chiarabelli, Cecilia Portela Pallares, and Anna Quintarelli).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Three: Complex Systems.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Synthetic Genetic Codes as the Basis of Synthetic Life (\u003c\/b\u003e\u003ci\u003eJ. Tze-Fei Wong and Hong Xue).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids (\u003c\/b\u003e\u003ci\u003ePiet Herdewijn and Philippe Marliere).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 The Minimal Ribosome (\u003c\/b\u003e\u003ci\u003eHiroshi Yamamoto, Markus Pech, Daniela Wittek, Isabella Moll, and Knud H. Nierhaus).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Semi-Synthetic Minimal Living Cells (\u003c\/b\u003e\u003ci\u003ePasquale Stano, Francesca Ferri, and Pier Luigi Luisi).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Four: General Problems.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Replicators: Components for Systems Chemistry (\u003c\/b\u003e\u003ci\u003eOlga Taran and Günter von Kiedrowski).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Dealing with the Outer Reaches of Synthetic Biology Biosafety, Biosecurity, IPR, and Ethical Challenges of Chemical Synthetic Biology (\u003c\/b\u003e\u003ci\u003eMarkus Schmidt, Malcolm Dando, and Anna Deplazes).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 The Synthetic Approach in Biology: Epistemological Notes for Synthetic Biology (\u003c\/b\u003e\u003ci\u003ePier Luigi Luisi).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e“Indeed, this book is a valuable addition to the pertinent literature and an excellent resource for students and researchers of chemical synthetic biology and related disciplines.”  (\u003ci\u003eScience Progress\u003c\/i\u003e, 1 September 2012)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003eProfessor Dr Pier Luigi Luisi\u003c\/b\u003e is an acknowledged expert in the field of synthetic biology and supramolecular chemistry, with over 400 scientific papers to his name. He is the author of seven books, including \u003ci\u003eThe Emergence of Life. From Chemical Origins to Synthetic Biology\u003c\/i\u003e (CUP, 2006). He is now based at Univ. Roma 3, Italy where his research interests are the never-born proteins, and the construction of vesicle-based bioreactors that simulate the main functions of biological cells.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDr. Cristiano Chiarabelli\u003c\/b\u003e, Università degli Studi di Roma Tre, Rome, Italy.\u003c\/p\u003e \u003cp\u003eChemistry plays an important role in the emerging field of synthetic biology, providing the technologies that enable much of the research. In particular, chemical synthetic biology is concerned with the synthesis of new biological macromolecular structures (proteins and nucleic acids) and minimal life forms (semi-synthetic minimal cells) not found in nature, and - in contrast to other aspects of synthetic biology - without the use of genetic manipulation.\u003c\/p\u003e \u003cp\u003eWith contributions from leading internationals experts in the field, \u003ci\u003eChemical Synthetic Biology\u003c\/i\u003e shows how chemistry underpins synthetic biology. Topics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ewhat roles do chemical tools perform in synthetic biology?\u003c\/li\u003e \u003cli\u003esynthetic nucleic acids, including never born RNAs and peptide nucleic acids (PNAs)\u003c\/li\u003e \u003cli\u003esearching for \u003ci\u003ede novo\u003c\/i\u003e totally random amino acid sequences\u003c\/li\u003e \u003cli\u003erandom-sequence proteins consisting of five kinds of primitive amino acids\u003c\/li\u003e \u003cli\u003eexperimental approaches for early evolution of protein function\u003c\/li\u003e \u003cli\u003esynthetic genetic codes as the basis of synthetic life\u003c\/li\u003e \u003cli\u003etowards safe genetically modified organisms through the chemical diversification of nucleic acids\u003c\/li\u003e \u003cli\u003ethe minimal ribosome\u003c\/li\u003e \u003cli\u003esemi-synthetic minimal living cells\u003c\/li\u003e \u003cli\u003ereplicators: components for systems chemistry\u003c\/li\u003e \u003cli\u003ebiosafety, biosecurity, IPR and ethical challenges of chemical synthetic biology\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eChemical Synthetic Biology\u003c\/i\u003e is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics and bioinformatics.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988907868389,"sku":"NP9780470713976","price":158.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470713976.jpg?v=1761782007","url":"https:\/\/k12savings.com\/products\/chemical-synthetic-biology-isbn-9780470713976","provider":"K12savings","version":"1.0","type":"link"}