{"product_id":"chemical-synthesis-of-nucleoside-analogues-isbn-9781118007518","title":"Chemical Synthesis of Nucleoside Analogues","description":"\u003cp\u003e\u003ci\u003e\u003cb\u003eCompiles current tested and proven approaches to synthesize novel nucleoside analogues\u003c\/b\u003e\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eFeaturing contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eChanges to the heterocyclic base\u003c\/li\u003e \u003cli\u003eModification of substituents at the sugar ring\u003c\/li\u003e \u003cli\u003eReplacement of the furanose ring by a different carbo- or heterocyclic ring\u003c\/li\u003e \u003cli\u003eIntroduction of conformational restrictions\u003c\/li\u003e \u003cli\u003eSynthesis of enantiomers\u003c\/li\u003e \u003cli\u003ePreparation of hydrolitically stable C-nucleosides\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eChemical Synthesis of Nucleoside Analogues\u003c\/i\u003e covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds.\u003c\/p\u003e \u003cp\u003eThroughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field.\u003c\/p\u003e \u003cp\u003eSynthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With \u003ci\u003eChemical Synthesis of Nucleoside Analogues\u003c\/i\u003e as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.\u003c\/p\u003e  \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003eForeword xiii\u003c\/p\u003e \u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003e1 Biocatalytic Methodologies for Selective Modified Nucleosides 1\u003cbr\u003e \u003ci\u003eMiguel Ferrero, Susana Fern´andez, and Vicente Gotor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Nucleosides Modified at the Base Moiety 49\u003cbr\u003e \u003ci\u003eO. Sari, V. Roy, and L. A. Agrofoglio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Chemical Synthesis of Acyclic Nucleosides 103\u003cbr\u003e \u003ci\u003eHai-Ming Guo, Shan Wu, Hong-Ying Niu, Ge Song, and Gui-Rong Qu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Phosphonated Nucleoside Analogues 163\u003cbr\u003e \u003ci\u003eRoberto Romeo, Caterina Carnovale, Antonio Rescifina, and Maria Assunta Chiacchio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Chemical Syntheses of Nucleoside Triphosphates 209\u003cbr\u003e \u003ci\u003eLina Weinschenk and Chris Meier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Mononucleotide Prodrug Synthetic Strategies 229\u003cbr\u003e \u003ci\u003eSuzanne Peyrottes and Christian P´erigaud\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Synthesis of C-Nucleosides 263\u003cbr\u003e \u003ci\u003eOmar Boutureira, M. Isabel Matheu, Yolanda D´ýaz, and Sergio Castill´on\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Methodologies for the Synthesis of Isomeric Nucleosides and Nucleotides of Antiviral Significance 317\u003cbr\u003e \u003ci\u003eMaurice Okello and Vasu Nair\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Synthesis of Conformationally Constrained Nucleoside Analogues 345\u003cbr\u003e \u003ci\u003eEsma Maougal, Jean-Marc Escudier, Christophe Len, Didier Dubreuil, and Jacques Lebreton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Synthesis of 3-Spiro-Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives 427\u003cbr\u003e \u003ci\u003eMar´ýa-Jos´e Camarasa, Sonsoles Vel´azquez, Ana San-F´elix, and Mar´ýa-Jes´us P´erez-P´erez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 l-Nucleosides 473\u003cbr\u003e \u003ci\u003eDaniela Perrone and Massimo L. Capobianco\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Chemical Synthesis of Carbocyclic Analogues of Nucleosides 535\u003cbr\u003e \u003ci\u003eE. Leclerc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Uncommon Three-, Four-, and Six-Membered Nucleosides 605\u003cbr\u003e \u003ci\u003eE. Groaz and P. Herdewijn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Recent Advances in Synthesis and Biological Activity of 4-Thionucleosides 655\u003cbr\u003e \u003ci\u003eVarughese A. Mulamoottil, Mahesh S. Majik, Girish Chandra, and Lak Shin Jeong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Recent Advances in the Chemical Synthesis of Aza-Nucleosides 699\u003cbr\u003e \u003ci\u003eTom´as Tejero, Ignacio Delso, and Pedro Merino\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Stereoselective Methods in the Synthesis of Bioactive Oxathiolane and Dioxolane Nucleosides 727\u003cbr\u003e \u003ci\u003eD. D’Alonzo and A. Guaragna\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Isoxazolidinyl Nucleosides 781\u003cbr\u003e \u003ci\u003eUgo Chiacchio, Antonino Corsaro, Salvatore Giofr`e, and Giovanni Romeo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Synthetic Studies on Antifungal Peptidyl Nucleoside Antibiotics 819\u003cbr\u003e \u003ci\u003eApurba Datta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Chemical Synthesis of Conformationally Constrained PNA Monomers 847\u003cbr\u003e \u003ci\u003ePedro Merino and Rosa Matute\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 881\u003c\/p\u003e  \u003cp\u003e\u003cb\u003ePEDRO MERINO, PhD,\u003c\/b\u003e is the Director of the Department of Synthesis and Structure of Biomolecules of the Institute of Chemical Synthesis and Homogenous Catalysis at the University of Zaragoza. Dr. Merino has authored more than 200 publications, including several reviews and book chapters. His research spans asymmetric synthesis, target-oriented synthesis, organometallic chemistry, and asymmetric metal-assisted and organic catalysis. Recently, he has been investigating the use of computational chemistry to better understand reaction mechanisms.\u003c\/p\u003e  \u003cp\u003e\u003ci\u003e\u003cb\u003eCompiles current tested and proven approaches to synthesize novel nucleoside analogues\u003c\/b\u003e\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eFeaturing contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eChanges to the heterocyclic base\u003c\/li\u003e \u003cli\u003eModification of substituents at the sugar ring\u003c\/li\u003e \u003cli\u003eReplacement of the furanose ring by a different carbo- or heterocyclic ring\u003c\/li\u003e \u003cli\u003eIntroduction of conformational restrictions\u003c\/li\u003e \u003cli\u003eSynthesis of enantiomers\u003c\/li\u003e \u003cli\u003ePreparation of hydrolitically stable C-nucleosides\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eChemical Synthesis of Nucleoside Analogues\u003c\/i\u003e covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds.\u003c\/p\u003e \u003cp\u003eThroughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field.\u003c\/p\u003e \u003cp\u003eSynthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With \u003ci\u003eChemical Synthesis of Nucleoside Analogues\u003c\/i\u003e as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988907639013,"sku":"NP9781118007518","price":216.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118007518.jpg?v=1761782005","url":"https:\/\/k12savings.com\/products\/chemical-synthesis-of-nucleoside-analogues-isbn-9781118007518","provider":"K12savings","version":"1.0","type":"link"}