{"product_id":"carbon-monoxide-in-drug-discovery-isbn-9781119783404","title":"Carbon Monoxide in Drug Discovery","description":"\u003cb\u003eCARBON MONOXIDE IN DRUG DISCOVERY\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eAn insightful reference for the latest physiological and therapeutic studies of carbon monoxide\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eIn \u003ci\u003eCarbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential,\u003c\/i\u003e a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials. \u003c\/p\u003e\u003cp\u003eOrganized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes. \u003c\/p\u003e\u003cp\u003eThe editors of \u003ci\u003eCarbon Monoxide in Drug Discovery\u003c\/i\u003e have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eA thorough introduction to the background and physiological actions of carbon monoxide, including endogenous CO production in sickness and in health\u003c\/li\u003e \u003cli\u003eComprehensive explorations of CO delivery forms, including non-carrier formulations, metal-carbonyl complexes, and organic CO donors\u003c\/li\u003e \u003cli\u003ePractical discussions of carbon monoxide sensing and scavenging, including fluorescent probes for intracellular carbon monoxide detection\u003c\/li\u003e \u003cli\u003eIn-depth examinations of the therapeutic applications of CO, including CO in solid organ transplantation\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003ePerfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, \u003ci\u003eCarbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential \u003c\/i\u003eis also an invaluable resource for industrial scientists in these areas. \u003c\/p\u003e\u003cp\u003eList of Contributors viii\u003c\/p\u003e \u003cp\u003ePreface: Carbon Monoxide: Promises and Challenges in Its Pharmaceutical Development xii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I General Background and Physiological Actions 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Endogenous CO Production in Sickness and in Health 3\u003cbr\u003e \u003ci\u003eLadie Kimberly De La Cruz and Binghe Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Molecular Mechanisms of Actions for CO: An Overview 27\u003cbr\u003e \u003ci\u003eRodrigo W. Alves de Souza, Leo E. Otterbein, and Nils Schallner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Pharmacokinetic Characteristics of Carbon Monoxide 44\u003cbr\u003e \u003ci\u003eXiaoxiao Yang, Mingjia Wang, Chalet Tan, Wen Lu, and Binghe Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Carbon Monoxide and Energy Metabolism 88\u003cbr\u003e \u003ci\u003eDaniela Dias-Pedroso, Nuno Soares, and Helena L.A. Vieira\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Role of CO in Circadian Clock 97\u003cbr\u003e \u003ci\u003eHiroaki Kitagishi and Ikuko Sagami\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Carbon Monoxide and Mitochondria 108\u003cbr\u003e \u003ci\u003eClaude A. Piantadosi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Carbon Monoxide, Oxygen, and Pseudohypoxia 118\u003cbr\u003e \u003ci\u003eGrace E. Otterbein, Michael S. Tift, and Ghee Rye Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Nitric Oxide in Human Physiology: Production, Regulation, and Interaction\u003c\/p\u003e \u003cp\u003ewith Carbon Monoxide Signaling 136\u003cbr\u003e \u003ci\u003eMaryam K. Mohammed and Brian S. Zuckerbraun\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 When Carbon Monoxide Meets Hydrogen Sulfide 160\u003cbr\u003e \u003ci\u003eRui Wang Copyrighted Material\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Biliverdin and Bilirubin as Parallel Products of CO Formation: Not Just Bystanders 175\u003cbr\u003e \u003ci\u003eLibor Vitek\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II Delivery Forms 195\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11 Delivery Systems and Noncarrier Formulations 197\u003cbr\u003e \u003ci\u003eJames Byrne, Christoph Steiger, Jakob Wollborn, and Giovanni Traverso\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Metal-Based Carbon Monoxide-Releasing Molecules (CO-RMs) as Pharmacologically Active Therapeutics 203\u003cbr\u003e \u003ci\u003eRoberta Foresti, Djamal Eddine Benrahla, Shruti Mohan, and Roberto Motterlini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Organic CO Donors that Rely on Photolysis for CO Release 223\u003cbr\u003e \u003ci\u003eYi Liao\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Organic Carbon Monoxide Prodrugs that Release CO Under Physiological Conditions 232\u003cbr\u003e \u003ci\u003eZhengnan Yuan and Binghe Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Targeted Delivery of Carbon Monoxide 259\u003cbr\u003e \u003ci\u003eLisa M. Berreau\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Anesthesia-Related Carbon Monoxide Exposure 286\u003cbr\u003e \u003ci\u003eRichard J. Levy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Natural Products that Generate Carbon Monoxide: Chemistry and Nutritional Implications 302\u003cbr\u003e \u003ci\u003eLadie Kimberly De La Cruz and Binghe Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III Carbon Monoxide Sensing and Scavenging 319\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18 Fluorescent Probes for Intracellular Carbon Monoxide Detection 321\u003cbr\u003e \u003ci\u003eRyan R. Walvoord, Morgan R. Schneider, and Brian W. Michel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV Therapeutic Applications 345\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19 CO in Solid Organ Transplantation 347\u003cbr\u003e \u003ci\u003eRoberta Foresti, Roberto Motterlini, and Stephan Immenschuh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Carbon Monoxide in Lung Injury and Disease 360\u003cbr\u003e \u003ci\u003eStefan W. Ryter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Carbon Monoxide in Acute Brain Injury and Brain Protection 377\u003cbr\u003e \u003ci\u003eAlexandra Mazur, Madison Fangman, Rani Ashouri, Hannah Pamplin, Shruti Patel, and Sylvain Doré\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 CO as a Protective Mediator of Liver Injury: The Role of PERK in HO-1\/ CO-Mediated Maintenance of Cellular Homeostasis in the Liver 385\u003cbr\u003e \u003ci\u003eYeonsoo Joe, Jeongmin Park, Mihyang Do, Stefan W. Ryter, Young-Joon Surh, Uh-Hyun Kim, and Hun Taeg Chung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 CO and Cancer 401\u003cbr\u003e \u003ci\u003eJames N. Arnold and Joanne E. Anstee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 CO and Diabetes 423\u003cbr\u003e \u003ci\u003eRebecca P. Chow and Hongjun Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Carbon Monoxide and Acute Kidney Injury 434\u003cbr\u003e \u003ci\u003eMark de Caestecker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 CO as an Antiplatelet Agent: An Energy Metabolism Perspective 453\u003cbr\u003e \u003ci\u003ePatrycja Kaczara, Kamil Przyborowski, Roberto Motterlini, and Stefan Chlopicki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 CO in Gastrointestinal Physiology and Protection 466\u003cbr\u003e \u003ci\u003eKatarzyna Magierowska and Marcin Magierowski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 Carbon Monoxide and Sickle Cell Disease 482\u003cbr\u003e \u003ci\u003eEdward Gomperts, John Belcher, Howard Levy, and Greg Vercellotti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 CO and Pain Management 497\u003cbr\u003e \u003ci\u003eOlga Pol\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 Clinical Trials of Low-Dose Carbon Monoxide 511\u003cbr\u003e \u003ci\u003eEdward Gomperts, Andrew Gomperts, and Howard Levy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 528\u003c\/p\u003e \u003cp\u003e\u003cb\u003eBinghe Wang, PhD,\u003c\/b\u003e is Regents’ Professor of Chemistry, Georgia Research Alliance Eminent Scholar, and Director for the Center for Diagnostics and Therapeutics at Georgia State University.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eLeo E. Otterbein, PhD,\u003c\/b\u003e is Professor of Surgery at Harvard Medical School.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eAn insightful reference for the latest physiological and therapeutic studies of carbon monoxide\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIn \u003ci\u003eCarbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential,\u003c\/i\u003e a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials. \u003c\/p\u003e\u003cp\u003eOrganized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes. \u003c\/p\u003e\u003cp\u003eThe editors of \u003ci\u003eCarbon Monoxide in Drug Discovery\u003c\/i\u003e have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eA thorough introduction to the background and physiological actions of carbon monoxide, including endogenous CO production in sickness and in health\u003c\/li\u003e \u003cli\u003eComprehensive explorations of CO delivery forms, including non-carrier formulations, metal-carbonyl complexes, and organic CO donors\u003c\/li\u003e \u003cli\u003ePractical discussions of carbon monoxide sensing and scavenging, including fluorescent probes for intracellular carbon monoxide detection\u003c\/li\u003e \u003cli\u003eIn-depth examinations of the therapeutic applications of CO, including CO in solid organ transplantation\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003ePerfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, \u003ci\u003eCarbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential \u003c\/i\u003eis also an invaluable resource for industrial scientists in these areas.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988885520613,"sku":"NP9781119783404","price":250.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119783404.jpg?v=1761781917","url":"https:\/\/k12savings.com\/products\/carbon-monoxide-in-drug-discovery-isbn-9781119783404","provider":"K12savings","version":"1.0","type":"link"}