Capillary Electrophoresis in Chiral Analysis

Capillary Electrophoresis in Chiral Analysis Bezhan Chankvetadze Tbilisi State University, Republic of Georgia The application of capillary electrophoresis (CE) to the field of chiral analysis has exploded recently. The advantages of capillary electrophoresis - extremely high peak efficiency, excellent compatibility with biological samples, short analysis time, simplicity, versatility and low cost - are perfect for the accurate measurement of optical purity, increasingly important in the regulation-ruled pharmaceutical industry. Although there have been a number of books on capillary electrophoresis and chiral analysis separately, as yet there has been no dedicated monograph on the application of capillary electrophoresis to chiral analysis. This book bridges the gap. Capillary Electrophoresis in Chiral Analysis charts the evolution of chiral capillary electrophoresis and describes new types of chiral selectors and mechanistic aspects of chiral recognition. While on the one hand, it is an excellent introduction to newcomers, on the other, it is of practical use to experienced researchers in the field wishing to solve a particular separation problem. It includes an alphabetical list of chiral compounds resolved using CE with appropriate references, which any one working in the field will find invaluable.Das weltweite Interesse an der Trennung von Enantiomeren, Spiegelbildern ein und derselben chemischen Verbindung, nimmt zu, da diese Formen beispielsweise verschiedene physiologische Wirkungen hervorrufen können. Eine hochaktuelle Technik der Stofftrennung in diesem Zusammenhang ist die Kapillarelektrophorese, die hier von den theoretischen Grundlagen bis hin zu analytischen Details und Anbieterlisten ausführlich beschrieben wird. Partial table of contents:

Basics of Capillary Electrophoresis.

Chiral Metal Complexes as Selectors in Capillary Electrophoresis.

Enantioseparation Using Micellar Electrokinetic Chromatography (MEKC).

Crown Ethers as Chiral Selectors in Capillary Electrophoresis.

Macrocyclic Antibiotics as Chiral Selectors in Capillary Electrophoresis.

Enantioseparation in Capillary Electrochromatography (CEC).

Enantiomer Migration Order in Chiral Capillary Electrophoresis.

Appendix.

Index. Aus dem Inhalt:
Basics of Capillary Electrohoresis;
Basic Theory of Chiral Separations in Capillary Electrophoresis;
Chiral Metal Complexes as Selectors in Capillary Electrophoresis;
Native and Derivatized Cyclodextrins as Chiral Selectors in Capillary Electrophoresis;
Enantioseparation using Micellar Electrokinetic Chromatography;
Crown Ethers as Chiral Selectors in Capillary Electrophoresis;
Macrocyclic Antibiotics as Chiral Selectors in Capillary Electrophoresis;
Noncyclic Oligomers and Polymers as Chiral Selectors in Capillary Electrophoresis;
Enantioseparations in Capillary Electrochromatography;
Indirect Enatioseparation in Capillary Electrophoresis;
Enantioseparations using other Capillary Electrophoretic Techniques;
Enantiomer Migration Order in Chiral Capillary Electrophoresis.

Bezhan Chankvetadze is Full Professor for Physical Chemistry and director of the Institute of Physical and Analytical Chemistry at the Tbilisi State University in Tbilisi, Georgia. Between 1991-2005 B. Chankvetadze held research and teaching positions at the Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Germany.

Capillary Electrophoresis in Chiral Analysis Bezhan Chankvetadze Tbilisi State University, Republic of Georgia The application of capillary electrophoresis (CE) to the field of chiral analysis has exploded recently. The advantages of capillary electrophoresis - extremely high peak efficiency, excellent compatibility with biological samples, short analysis time, simplicity, versatility and low cost - are perfect for the accurate measurement of optical purity, increasingly important in the regulation-ruled pharmaceutical industry. Although there have been a number of books on capillary electrophoresis and chiral analysis separately, as yet there has been no dedicated monograph on the application of capillary electrophoresis to chiral analysis. This book bridges the gap. Capillary Electrophoresis in Chiral Analysis charts the evolution of chiral capillary electrophoresis and describes new types of chiral selectors and mechanistic aspects of chiral recognition. While on the one hand, it is an excellent introduction to newcomers, on the other, it is of practical use to experienced researchers in the field wishing to solve a particular separation problem. It includes an alphabetical list of chiral compounds resolved using CE with appropriate references, which any one working in the field will find invaluable.