Cancer and its Management

Now in its seventh edition, this highly-regarded book is designed as an introductory and reference text on the principles of diagnosis, staging, and treatment of tumors. As for the last 6 editions of the book, the aim and scope of the new edition are once again to provide a thorough yet reasonably brief account of the whole field of oncology, focusing on the latest principles of cancer management.

The book is already well established, having been first published in 1986 and in continuous print since then. The authors are rightfully proud of their strong legacy of providing carefully revised new editions of this standard and well-received cancer text for audiences in the UK and abroad. Oncology is a very rapidly changing speciality, with many new treatments and even treatment modalities coming on stream with bewildering speed. Besides a thorough general updating of the text, figures, and tables, the new seventh edition adds a new chapter on Molecular Targeted Therapy, making the book 30 chapters in total. This accessible and practical resource is invaluable to trainees and specialists alike in oncology, palliative care and general medicine, as well as specialist nurses, general practitioners, medical students, and professions allied to medicine.

Preface ix

Acknowedgements xi

Abbreviations xiii

1 The Modern Management of Cancer: An Introductory Note 1

2 Epidemiology, Cure, Treatment Trials and Screening 7

3 Biology of Cancer 25

4 Staging of Tumours 44

5 Radiotherapy 60

6 Systemic Treatment for Cancer 81

7 Supportive Care and Symptom Relief 113

8 Medical Problems and Radiotherapy Emergencies 130

9 Paraneoplastic Syndromes 148

10 Cancer of the Head and Neck 158

11 Brain and Spinal Cord 184

12 Tumours of the Lung and Mediastinum 209

13 Breast Cancer 237

14 Cancer of the Oesophagus and Stomach 275

15 Cancer of the Liver, Biliary Tract and Pancreas 290

16 Tumours of the Small and Large Bowel 308

17 Gynaecological Cancer 321

18 Genitourinary Cancer 355

19 Testicular Cancer 388

20 Thyroid and Adrenal Cancer 406

21 Cancer from an Unknown Primary Site 421

22 Skin Cancer 426

23 Bone and Soft-Tissue Sarcomas 446

24 Paediatric Malignancies 470

25 Hodgkin’s Lymphoma 497

26 Non-Hodgkin’s Lymphomas 516

27 Myeloma and Other Paraproteinaemias 545

28 Leukaemia 560

Index 585

Daniel Hochhauser, DPhil, FRCP, is Kathleen Ferrier Professor of Medical Oncology at University College London and Consultant in Medical Oncology, University College Hospital, London, UK.

Jeffrey Tobias, MD, FRCP, FRCR, is Professor in Cancer Medicine at The Meyerstein Institute of Oncology, The Middlesex Hospital, London, UK.

Now in its seventh edition, this highly-regarded book is designed as an introductory and reference text on the principles of diagnosis, staging, and treatment of tumours.

Oncology is a very rapidly changing specialty, and for the cancer physician and allied healthcare staff, keeping abreast of clinical and research advances and the impact they will have on day-to-day patient management can be extremely challenging. As with previous editions, the aim of Cancer and its Management is to provide a thorough yet reasonably brief account of the whole field of oncology, focusing on the latest principles of cancer management.

The first part of the book is devoted to the mechanisms of tumour development and cancer treatment. This is followed by a systematic account of the current management of individual major cancers. For each tumour site, the authors supply details of the pathology, mode of spread, clinical presentation and staging, together with an overview of available treatment strategies including radiotherapy, chemotherapy, and surgery.

Accessible and practical, this resource will be invaluable to trainees and specialists in oncology, palliative care and general medicine, as well as specialist nurses, general practitioners, medical students, and the many professions allied to medicine.

The Seventh edition:

• Includes up-to-date information on the most recent techniques and therapies available,
• Emphasises the importance of multidisciplinary teamwork in the care of cancer patients,
• Highlights frequent dilemmas and difficulties encountered during cancer management,
• Discusses controversial topics including screening, genetic testing, prevention and AIDS-related cancers,
• New colour design and figures.