{"product_id":"boron-based-compounds-isbn-9781119275558","title":"Boron-Based Compounds","description":"\u003cp\u003e\u003cb\u003eNoted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics\u003c\/b\u003e \u003c\/p\u003e \u003cp\u003e\u003ci\u003eBoron-Based Compounds\u003c\/i\u003e offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. \u003c\/p\u003e \u003cp\u003eThe authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, \u003ci\u003eBoron-Based Compounds:\u003c\/i\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003eContains contributions from a panel of internationally renowned experts in the field\u003c\/li\u003e \u003cli\u003eOffers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics\u003c\/li\u003e \u003cli\u003eHighlights the range and capacity of boron-based compounds in medical applications\u003c\/li\u003e \u003cli\u003eIncludes information on boron neutron capture therapy and diagnostics\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eDesigned for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.\u003c\/p\u003e \u003cp\u003eList of Contributors vii\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Design of New Boron‐based Drugs 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Carboranes as Hydrophobic Pharmacophores: Applications for Design of Nuclear Receptor Ligands 3\u003cbr\u003e\u003ci\u003eYasuyuki Endo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.2 Boron Cluster Modifications with Antiviral, Anticancer, and Modulation of Purinergic Receptors’ Activities Based on Nucleoside Structures 20\u003cbr\u003e\u003ci\u003eAnna Adamska‐Bartłomiejczyk, Katarzyna Bednarska, Magdalena Białek‐Pietras, Zofia M. Kiliańska, Adam\u003c\/i\u003e \u003ci\u003eMieczkowski, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Zofia Sułowska, Jolanta\u003c\/i\u003e \u003ci\u003eD. Żołnierczyk, and Zbigniew J. Lesnikowski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.3 Design of Carborane‐Based Hypoxia‐Inducible Factor Inhibitors 35\u003cbr\u003e\u003ci\u003eGuangzhe Li, Hyun Seung Ban, and Hiroyuki Nakamura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.4 Half‐ and Mixed‐Sandwich Transition Metal Dicarbollides and nido‐Carboranes(–1) for Medicinal Applications 60\u003cbr\u003e\u003ci\u003eBenedikt Schwarze, Marta Gozzi, and Evamarie Hey‐Hawkins\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.5 Ionic Boron Clusters as Superchaotropic Anions: Implications for Drug Design 109\u003cbr\u003e\u003ci\u003eKhaleel I. Assaf, Joanna Wilinska, and Detlef Gabel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.6 Quantum Mechanical and Molecular Mechanical Calculations on Substituted Boron Clusters and Their Interactions with Proteins 126\u003cbr\u003e\u003ci\u003eJindřich Fanfrlík, Adam Pecina, Jan Řezáč, Pavel Hobza, and Martin Lepšík\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Boron Compounds in Drug Delivery and Imaging 139\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Closomers: An Icosahedral Platform for Drug Delivery 141\u003cbr\u003e\u003ci\u003eSatish S. Jalisatgi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.2 Cobaltabisdicarbollide‐based Synthetic Vesicles: From Biological Interaction to in vivo Imaging 159\u003cbr\u003e\u003ci\u003eClara Viñas, Francesc Teixidor, and Adrian J. Harwood\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.3 Boronic Acid–Based Sensor for Determination of Sugars 174\u003cbr\u003e\u003ci\u003eIgor B. Sivaev and Vladimir I. Bregadze\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.4 Boron Compounds in Molecular Imaging 205\u003cbr\u003e\u003ci\u003eBhaskar C. Das, Devi Prasan Ojha, Sasmita Das, and Todd Evans\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.5 Radiolabeling Strategies for Boron Clusters: Toward Fast Development and Efficient Assessment of BNCT Drug Candidates 232\u003cbr\u003e\u003ci\u003eKiran B. Gona, Vanessa Gómez‐Vallejo, Irina Manea, Jonas Malmquist, Jacek Koziorowski, and Jordi Llop\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Boron Compounds for Boron Neutron Capture Therapy 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Twenty Years of Research on 3‐Carboranyl Thymidine Analogs (3CTAs): A Critical Perspective 271\u003cbr\u003e\u003ci\u003eWerner Tjarks\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.2 Recent Advances in Boron Delivery Agents for Boron Neutron Capture Therapy (BNCT) 298\u003cbr\u003e\u003ci\u003eSunting Xuan and Maria da Graça H. Vicente\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.3 Carborane Derivatives of Porphyrins and Chlorins for Photodynamic and Boron Neutron Capture Therapies: Synthetic Strategies 343\u003cbr\u003e\u003ci\u003eValentina A. Ol’shevskaya, Andrei V. Zaitsev, and Alexander A. Shtil\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.4 Nanostructured Boron Compounds for Boron Neutron Capture Therapy (BNCT) in Cancer Treatment 371\u003cbr\u003e\u003ci\u003eShanmin Gao, Yinghuai Zhu, and Narayan Hosmane\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.5 New Boronated Compounds for an Imaging-Guided Personalized Neutron Capture Therapy 389\u003cbr\u003e\u003ci\u003eNicoletta Protti, Annamaria Deagostino, Paolo Boggio, Diego Alberti, and Simonetta Geninatti Crich\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.6 Optimizing the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) for Different Pathologies: Research in Animal Models Employing Different Boron Compounds and Administration Strategies 416\u003cbr\u003e\u003ci\u003eAmanda E. Schwint, Andrea Monti Hughes, Marcela A. Garabalino, Emiliano C.C. Pozzi, Elisa M. Heber, and Veronica A. Trivillin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e   \u003cp\u003e\u003cb\u003eProf. Dr. Evamarie Hey-Hawkins\u003c\/b\u003e has been a Full Professor of Inorganic Chemistry at Leipzig University since 1993. Her research interests include the synthesis of novel reagents for BNCT and use of boron clusters as pharmacophores or modulators for biomolecules. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eProf. Dr. Clara Viñas Teixidor\u003c\/b\u003e is a Research Professor at the Institut de Ciència de Materials de Barcelona, Spanish Council for Scientific Research, Spain. Her fields of research involve synthesis and derivatisation of boron clusters to be applied in medicine and biosensing, among others. Previously, she worked in industry and at public institutions involved in food science analysis as well as environmental control.     \u003c\/p\u003e\u003cp\u003e\u003cb\u003eNoted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003eBoron-Based\u003c\/i\u003e \u003ci\u003eCompounds\u003c\/i\u003e offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules. This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. \u003c\/p\u003e\u003cp\u003eThe authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, \u003ci\u003eBoron-Based Compounds\u003c\/i\u003e: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eContains contributions from a panel of internationally renowned experts in the field\u003c\/li\u003e \u003cli\u003eOffers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnosticse\u003c\/li\u003e \u003cli\u003eHighlights the range and capacity of boron-based compounds in medical applications\u003c\/li\u003e \u003cli\u003eIncludes information on boron neutron capture therapy and diagnostics\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eDesigned for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988852064485,"sku":"NP9781119275558","price":193.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119275558.jpg?v=1761781777","url":"https:\/\/k12savings.com\/products\/boron-based-compounds-isbn-9781119275558","provider":"K12savings","version":"1.0","type":"link"}