Biomolecular Free Radical Toxicity

Biomolecular Free Radical Toxicity: Causes and Prevention provides a comprehensive overview of biomolecular injury. By discussing recent research and providing interpretations of the available data, this unique and timely book explores the causes of biomolecular injury and the possible routes to its prevention. Split into three sections, the book covers:
* macromolecular mechanisms of injury and the role of antioxidants;
* gene expression and cell mediated mechanisms of toxicity expression; and,
* human and environmental health effects.
Written by experts in the field, Biomolecular Free Radical Toxicity: Causes and Prevention will be invaluable to researchers specialising in food and nutrition-based toxicology, biomolecular sciences, biochemistry, genetics, environmental biomonitoring, drug metabolism and carcinogenesis.In diesem Band geht es um Schädigungen biologischer Moleküle (wie der DNA) durch reaktive Spezies, insbesondere freie Radikale. Derartige Angriffe reaktiver Sauerstoff- und Stickstoffspezies gehören wahrscheinlich zu den Auslösern verschiedener Krankheiten, darunter Krebs, Arthritis und Diabetes. Die Autoren wenden sich insbesondere an Spezialisten aus dem Bereich der Nahrungsmitteltoxikologie und erklären aktuelle Fakten aus einem breiten Themenspektrum leserfreundlich und gut verständlich. (10/00) MACROMOLECULAR MECHANISMS OF INJURY AND THE ROLE OF ANTIOXIDANTS.

Membrane Lipid and Lipoprotein Injury: Prevention by Antioxidants (H. Wiseman & T. Ridgway).

DNA Injury: Prevention by Antioxidants (R. Hambly).

Protein Injury: Prevention by Antioxidants (B. Evans & J. Woodward).

GENE EXPRESSION AND CELL MEDIATED MECHANISMS OF TOXICITY EXPRESSION.

Xenobiotic Metabolism and Bioactivation by Cytochromes P-450 (C. Ioannides).

Apoptosis Triggered by Free Radicals: Role in Human Diseases (G. Kass, et al.).

HUMAN AND ENVIRONMENTAL HEALTH EFFECTS.

Dietary Phytoestrogens, Oestrogens and Tamoxifen: Mechanisms of Action in Modulation of Breast Cancer Risk and Prevention of Heart Disease (H. Wiseman).

Strategies for the Removal of Ecotoxicants: Environmental Oestrogens and Oestrogen-Mimics (T. Ridgway & H. Wiseman).

Index.

Helen Wiseman is Lecturer in Nutritional Sciences in the Diabetes and Nutritional Sciences Division at King's College London.

Peter Goldfarb is professor of molecular biology at the School of Biosciences and Medicine, University of Surrey. His research interests include Molecular Toxicology and Pharmacogenetics.

Tim Ridgway is the author of Biomolecular Free Radical Toxicity: Causes and Prevention, published by Wiley.

Alan Wiseman is the author of Biomolecular Free Radical Toxicity: Causes and Prevention, published by Wiley.

Biomolecular Free Radical Toxicity: Causes and Prevention provides a comprehensive overview of biomolecular injury. By discussing recent research and providing interpretations of the available data, this unique and timely book explores the causes of biomolecular injury and the possible routes to its prevention. Split into three sections, the book covers:
* macromolecular mechanisms of injury and the role of antioxidants;

* gene expression and cell mediated mechanisms of toxicity expression; and,

* human and environmental health effects.
Written by experts in the field, Biomolecular Free Radical Toxicity: Causes and Prevention will be invaluable to researchers specialising in food and nutrition-based toxicology, biomolecular sciences, biochemistry, genetics, environmental biomonitoring, drug metabolism and carcinogenesis.