{"product_id":"biological-psychiatry-isbn-9780470688946","title":"Biological Psychiatry","description":"Biological psychiatry has dominated psychiatric thinking for the past 40 years, but the knowledge base of the discipline has increased substantially more recently, particularly with advances in genetics and neuroimaging. The third edition of \u003ci\u003eBiological Psychiatry\u003c\/i\u003e has been thoroughly updated taking into account these developments. As in the earlier editions of the book, there are comprehensive reviews and explanations of the latest advances in neurochemistry, neuroanatomy, genetics and brain imaging— descriptions not only of methodologies but also of the application of these in clinical settings. It is within this context that there is a considerable emphasis in the book on brain–behaviour relationships both within and without the clinical setting.  \u003cp\u003eThis edition has been enhanced by the inclusion of new chapters, one on anxiety and another on motivation and the addictions. The chapter that relates to treatments has been extended to include the latest information on brain stimulation techniques. The overall book is well illustrated in order to help with an understanding of the text.\u003c\/p\u003e \u003cp\u003eFor the third edition, Professor Michael Trimble has been joined by Professor Mark George as co-author. These are two of the world's leading biological psychiatrists who both have considerable clinical as well as research experience which they have brought to the book. Unlike multiauthored texts, it has a continuity running through it which aids understanding and prevents repetition.\u003c\/p\u003e \u003cp\u003eThis book is strongly recommended for all practising psychiatrists and trainees wishing for an up-to-date, authoritative, easy to digest and acessible review of the latest advances and conceptualizations in the field. It will also appeal to neurologists interested in neuropsychiatry and biological psychiatry or the psychiatric aspects of neurological disorders, as well as other practising clinicians (psychologists, social workers, nurses) in the mental health field.\u003c\/p\u003e \u003cp\u003eAcknowledgements xi\u003c\/p\u003e \u003cp\u003eQuotations xiii\u003c\/p\u003e \u003cp\u003ePreface to the First Edition xv\u003c\/p\u003e \u003cp\u003ePreface to the Second Edition xix\u003c\/p\u003e \u003cp\u003eIntroduction and Preface to the Third Edition xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Principles of Brain Function and Structure: 1 Genetics, Physiology and Chemistry \u003c\/b\u003e\u003cb\u003e1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 1\u003c\/p\u003e \u003cp\u003eGenetics 1\u003c\/p\u003e \u003cp\u003eBrain chemistry and metabolism 8\u003c\/p\u003e \u003cp\u003eThe metabolism of glucose 9\u003c\/p\u003e \u003cp\u003eProteins and fatty acids 9\u003c\/p\u003e \u003cp\u003eCell membranes 10\u003c\/p\u003e \u003cp\u003eSynapses 12\u003c\/p\u003e \u003cp\u003eReceptors 14\u003c\/p\u003e \u003cp\u003eNeurones 21\u003c\/p\u003e \u003cp\u003eNeurotransmitters 24\u003c\/p\u003e \u003cp\u003eInterrelationships among transmitters 29\u003c\/p\u003e \u003cp\u003eTransmitter dispersal 29\u003c\/p\u003e \u003cp\u003eCNS inflammation 29\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Principles of Brain Function and Structure: 2 Anatomy \u003c\/b\u003e\u003cb\u003e31\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 31\u003c\/p\u003e \u003cp\u003eThe neuroanatomy of emotion 32\u003c\/p\u003e \u003cp\u003eIndividual anatomical structures 41\u003c\/p\u003e \u003cp\u003eAscending and descending limbic-system connections 53\u003c\/p\u003e \u003cp\u003eMacrosystems 55\u003c\/p\u003e \u003cp\u003eThe basal ganglia and the re-entrant circuits 57\u003c\/p\u003e \u003cp\u003eThe ventral striatum and ‘limbic striatum’ 58\u003c\/p\u003e \u003cp\u003eThe ascending cholinergic systems 60\u003c\/p\u003e \u003cp\u003eCortical regions of interest 60\u003c\/p\u003e \u003cp\u003eThe cerebellum 63\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Important Brain–Behaviour Relationships \u003c\/b\u003e\u003cb\u003e65\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 65\u003c\/p\u003e \u003cp\u003eImportant anatomical structures for understanding behaviour 68\u003c\/p\u003e \u003cp\u003eSome specific behaviours 74\u003c\/p\u003e \u003cp\u003eLimbic lobe disorders in a clinical context 77\u003c\/p\u003e \u003cp\u003eRe-entrant circuits in a clinical context 78\u003c\/p\u003e \u003cp\u003eThe frontal lobes in a clinical context 79\u003c\/p\u003e \u003cp\u003eLaterality 81\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Classifications and Clinical Investigations \u003c\/b\u003e\u003cb\u003e83\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 83\u003c\/p\u003e \u003cp\u003eSigns, symptoms, syndromes and disease 84\u003c\/p\u003e \u003cp\u003eClassification in psychiatry 84\u003c\/p\u003e \u003cp\u003eClinical investigation 87\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Personality Disorders \u003c\/b\u003e\u003cb\u003e113\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGeneral introduction 113\u003c\/p\u003e \u003cp\u003eIntroduction to the concept of personality 113\u003c\/p\u003e \u003cp\u003eGenetics 118\u003c\/p\u003e \u003cp\u003eSomatic variables 121\u003c\/p\u003e \u003cp\u003eMetabolic and biochemical findings 121\u003c\/p\u003e \u003cp\u003eNeurophysiological and neurological data 123\u003c\/p\u003e \u003cp\u003eSome outstanding issues 127\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Anxiety Disorders \u003c\/b\u003e\u003cb\u003e131\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 131\u003c\/p\u003e \u003cp\u003eGenetics 134\u003c\/p\u003e \u003cp\u003eSomatic variables 135\u003c\/p\u003e \u003cp\u003eMetabolic and biochemical findings 135\u003c\/p\u003e \u003cp\u003eNeurochemical investigations 137\u003c\/p\u003e \u003cp\u003eNeurophysiological and neurological data 140\u003c\/p\u003e \u003cp\u003eImaging 140\u003c\/p\u003e \u003cp\u003eObsessive–compulsive disorder 142\u003c\/p\u003e \u003cp\u003ePost-traumatic stress disorder 143\u003c\/p\u003e \u003cp\u003eSome outstanding issues 144\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 The Schizophrenias \u003c\/b\u003e\u003cb\u003e147\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 147\u003c\/p\u003e \u003cp\u003eGenetics 150\u003c\/p\u003e \u003cp\u003eSomatic variables 153\u003c\/p\u003e \u003cp\u003eMetabolic and biochemical findings 154\u003c\/p\u003e \u003cp\u003eNeurochemical investigations 159\u003c\/p\u003e \u003cp\u003eNeurophysiological and neurological data 164\u003c\/p\u003e \u003cp\u003eSome outstanding issues 176\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Affective Disorders \u003c\/b\u003e\u003cb\u003e183\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 183\u003c\/p\u003e \u003cp\u003eGenetics 184\u003c\/p\u003e \u003cp\u003eMetabolic and biochemical findings 186\u003c\/p\u003e \u003cp\u003eNeurochemical investigations 198\u003c\/p\u003e \u003cp\u003eNeurophysiological and neurological data 200\u003c\/p\u003e \u003cp\u003eSome outstanding issues 209\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 The Addictions and Disorders of Motivation \u003c\/b\u003e\u003cb\u003e215\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 215\u003c\/p\u003e \u003cp\u003eDisorders of motivation 216\u003c\/p\u003e \u003cp\u003eConditioning 217\u003c\/p\u003e \u003cp\u003eGenetics 219\u003c\/p\u003e \u003cp\u003eMetabolic and biochemical findings 221\u003c\/p\u003e \u003cp\u003eNeurophysiological and neurological data 223\u003c\/p\u003e \u003cp\u003eSome outstanding issues 228\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Epilepsy \u003c\/b\u003e\u003cb\u003e231\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 231\u003c\/p\u003e \u003cp\u003ePrevalence and clinical characteristics 231\u003c\/p\u003e \u003cp\u003eClassification 231\u003c\/p\u003e \u003cp\u003eGenetics 235\u003c\/p\u003e \u003cp\u003eSymptomatic epilepsy 235\u003c\/p\u003e \u003cp\u003eBiochemical findings 236\u003c\/p\u003e \u003cp\u003eInvestigation and differential diagnosis 237\u003c\/p\u003e \u003cp\u003ePsychiatric disorders in epilepsy 237\u003c\/p\u003e \u003cp\u003eCognitive deterioration and epilepsy 254\u003c\/p\u003e \u003cp\u003eSome outstanding issues 255\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 The Dementias \u003c\/b\u003e\u003cb\u003e257\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 257\u003c\/p\u003e \u003cp\u003eDefinition 257\u003c\/p\u003e \u003cp\u003ePrevalence 258\u003c\/p\u003e \u003cp\u003eDiagnosis and classification 258\u003c\/p\u003e \u003cp\u003eAlzheimer’s disease 259\u003c\/p\u003e \u003cp\u003eDementia of frontal-lobe type 267\u003c\/p\u003e \u003cp\u003eFocal cortical atrophies 268\u003c\/p\u003e \u003cp\u003eDementia with Lewy bodies 268\u003c\/p\u003e \u003cp\u003eVascular dementias 269\u003c\/p\u003e \u003cp\u003eOther forms of dementia 271\u003c\/p\u003e \u003cp\u003eFurther causes of dementia 275\u003c\/p\u003e \u003cp\u003eSome outstanding issues 275\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Biological Treatments \u003c\/b\u003e\u003cb\u003e281\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 281\u003c\/p\u003e \u003cp\u003ePharmacology: pharmacokinetics and pharmacodynamics 281\u003c\/p\u003e \u003cp\u003eAntidepressants 284\u003c\/p\u003e \u003cp\u003eAntipsychotic drugs 296\u003c\/p\u003e \u003cp\u003eAnxiolytics and hypnotics 304\u003c\/p\u003e \u003cp\u003eBeta-Adrenergic blockers 308\u003c\/p\u003e \u003cp\u003eLithium 308\u003c\/p\u003e \u003cp\u003eAnticonvulsants 310\u003c\/p\u003e \u003cp\u003eDrugs for the treatment of dementia 316\u003c\/p\u003e \u003cp\u003eMedications for the addictions 317\u003c\/p\u003e \u003cp\u003eBrain-stimulation therapies 318\u003c\/p\u003e \u003cp\u003eSleep-deprivation therapy 329\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Epilogue: Progress toward a Neuroanatomically, Biological-psychiatrically Informed Classification Scheme in Psychiatry 331\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 335\u003c\/p\u003e \u003cp\u003eIndex 395\u003c\/p\u003e  \u003cp\u003e“This book therefore may be valuable to those engaged in clinical practice who wish to familiarize themselves with some of the basic concepts behind modern biological psychiatric research and the recent history of the field.”  (\u003ci\u003ePsychological Medicine\u003c\/i\u003e, 2012)\u003c\/p\u003e \"If you are going to choose where to fork out the money, it would be here, for the most practical understanding of brain-behavior science, and these authors I am sure will continue to be leaders in this field, with perhaps only Lishman challenging them for the buck.\" (Metapsychology, 25 June 2011)  \u003cp\u003e \"As in the earlier editions of the book, there are comprehensive reviews and explanations of the latest advances in neurochemistry, neuroanatomy, genetics and brain imaging descriptions not only of methodologies but also of the application of these in clinical settings.\" (AllVoices, 16 February 2011)\u003c\/p\u003e \u003cp\u003e\"An important contribution that should be read by psychopharmacologists, psychiatrists, neurologists and neuroscientists who wish to obtain an interesting and well-written account of the subject.\" (\u003ci\u003eHuman Psychopharmacology, 2010\u003c\/i\u003e)\u003c\/p\u003e \u003cp\u003e\"Writing for medical students and for researchers and practitioners in fields that touch upon mental health, they begin by exploring principles of brain function and structure from perspectives of genetics, physiology, chemistry, and anatomy. Then they consider important brain-behavior relationships, and classifications and clinical investigations. Having set the stage, they proceed to describe biological aspects of personality disorders, anxiety disorders, the schizophrenias, affective disorders, the addictions and disorders of motivation, epilepsy, and the dementias.\" (\u003ci\u003eSciTech Book News\u003c\/i\u003e, December 2010)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cbr\u003e \u003cbr\u003e  \u003cp\u003e\u003cb\u003eProfessor Trimble\u003c\/b\u003e was for many years Professor of Behavioural Neurology and Consultant Physician to the Department of Psychological Medicine at the National Hospital Queen Square, London. He now holds emeritus status at the above institutions. He studied general medicine, obtaining membership of the Royal College of Physicians before going to the National Hospital Queen Square and then the Maudsley Hospital to advance his training in neurology and psychiatry. Following an internship in psychiatry at the Johns Hopkins Hospital, Baltimore, he returned to the National Hospital to pursue a career in neuropsychiatry. He set up a research group with main interests in the interface disorders between neurology and psychiatry, reflected in the developing recognition of neuropsychiatry and behavioural neurology as independent disciplines. The research group (Raymond-Way Unit) explored the behavioural consequences of neurological disorders and their treatment, with a major interest in epilepsy and movement disorders. His current writing and academic interests involve teaching and lecturing on neuroanatomical concepts relevant to understanding behaviour and its variations, in particular with an interest in neuroaesthetics and neurotheology, namely the cerebral basis of artistic and religious experiences. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eDr. George\u003c\/b\u003e received his medical degree from the Medical University of South Carolina in Charleston in 1985, where he continued with dual residencies in neurology and psychiatry. He is board certified in both areas. He worked for one year (1990-91) as a Visiting Research Fellow in the Raymond Way Neuropsychiatry Research Group at the Institute of Neurology, London. He and Professor Trimble used pharmacology and imaging to study the overlaps between Obsessive-Compulsive Disorder and Gilles de la Tourette Syndrome. During this year he also worked on new functional imaging techniques (SPECT and PET) at the Institute of Nuclear Medicine, University College of London and Middlesex School of Medicine, London. He wrote one of the first textbooks in the new area of brain activation and imaging. Dr George then moved to Washington, DC, working with Dr. Robert Post in the Biological Psychiatry Branch of the Intramural National Institute of Mental Health. He was one of the first to use functional imaging (particularly oxygen PET) to assess brain changes associated with normal emotions, as well as using imaging to understand brain changes which occur in depression and mania. This imaging work directly led to his pioneering use of transcranial magnetic stimulation (TMS) as a probe of neuronal circuits regulating mood, and to clinical trials using TMS as an antidepressant. In 2008 prefrontal TMS was FDA approved as an antidepressant treatment. In 1995 he moved back to Charleston and built the functional neuroimaging division and brain stimulation laboratories. This imaging group has grown into the MUSC Center for Advanced Imaging Research, which is now part of the SC Brain Imaging Center of Excellence. He continues to use imaging and non-invasive stimulation, either separately or more recently in combination, to understand the brain regions involved in emotion regulation in health and disease. In 1998, he pioneered another new treatment for resistant depression, vagus nerve stimulation, that was recently FDA approved. He and his group have used MRI imaging to understand brain stimulation brain effects. He is on several editorial review boards, and has published over 200 scientific articles, and has written or edited 5 books. He is the editor-in-chief of a new journal, \u003ci\u003eBrain Stimulation.\u003c\/i\u003e \u003c\/p\u003e\u003cp\u003eHe has received several international awards, including the World Federation of Societies of Biological Psychiatry Lifetime Achievement Award (2007), the NARSAD Falcone Award (2008) and he was honored as one of 14 'Pioneers of Medical Progress' saluted in the August 2009 edition of US News \u0026amp; World Report.   \u003c\/p\u003e\u003cp\u003eBiological psychiatry has dominated psychiatric thinking for the past 40 years, but the knowledge base of the discipline has increased substantially more recently, particularly with advances in genetics and neuroimaging. The third edition of \u003ci\u003eBiological Psychiatry\u003c\/i\u003e has been thoroughly updated taking into account these developments. As in the earlier editions of the book, there are comprehensive reviews and explanations of the latest advances in neurochemistry, neuroanatomy, genetics and brain imaging— descriptions not only of methodologies but also of the application of these in clinical settings. It is within this context that there is a considerable emphasis in the book on brain–behaviour relationships both within and without the clinical setting. \u003c\/p\u003e\u003cp\u003eThis edition has been enhanced by the inclusion of new chapters, one on anxiety and another on motivation and the addictions. The chapter that relates to treatments has been extended to include the latest information on brain stimulation techniques. The overall book is well illustrated in order to help with an understanding of the text. \u003c\/p\u003e\u003cp\u003eFor the third edition, Professor Michael Trimble has been joined by Professor Mark George as co-author. These are two of the world's leading biological psychiatrists who both have considerable clinical as well as research experience which they have brought to the book. Unlike multiauthored texts, it has a continuity running through it which aids understanding and prevents repetition. \u003c\/p\u003e\u003cp\u003eThis book is strongly recommended for all practising psychiatrists and trainees wishing for an up-to-date, authoritative, easy to digest and acessible review of the latest advances and conceptualizations in the field. It will also appeal to neurologists interested in neuropsychiatry and biological psychiatry or the psychiatric aspects of neurological disorders, as well as other practising clinicians (psychologists, social workers, nurses) in the mental health field.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988823949541,"sku":"NP9780470688946","price":116.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470688946.jpg?v=1761781715","url":"https:\/\/k12savings.com\/products\/biological-psychiatry-isbn-9780470688946","provider":"K12savings","version":"1.0","type":"link"}