{"product_id":"bioinorganic-chemistry-inorganic-elements-in-the-chemistry-of-life-isbn-9780470975237","title":"Bioinorganic Chemistry -- Inorganic Elements in the Chemistry of Life","description":"\u003cp\u003eThe field of Bioinorganic Chemistry has grown significantly in recent years; now one of the major sub-disciplines of Inorganic Chemistry, it has also pervaded other areas of the life sciences due to its highly interdisciplinary nature.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eBioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Second Edition\u003c\/i\u003e provides a detailed introduction to the role of inorganic elements in biology, taking a systematic element-by-element approach to the topic. The second edition of this classic text has been fully revised and updated to include new structure information, emerging developments in the field, and an increased focus on medical applications of inorganic compounds. New topics have been added including materials aspects of bioinorganic chemistry, elemental cycles, bioorganometallic chemistry, medical imaging and therapeutic advances.\u003cbr\u003e \u003cbr\u003e \u003c\/p\u003e \u003cp\u003eTopics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eMetals at the center of photosynthesis\u003c\/li\u003e \u003cli\u003eUptake, transport, and storage of essential elements\u003c\/li\u003e \u003cli\u003eCatalysis through hemoproteins\u003c\/li\u003e \u003cli\u003eBiological functions of molybdenum, tungsten, vanadium and chromium\u003c\/li\u003e \u003cli\u003eFunction and transport of alkaline and alkaline earth metal cations\u003c\/li\u003e \u003cli\u003eBiomineralization\u003c\/li\u003e \u003cli\u003eBiological functions of the non-metallic inorganic elements\u003c\/li\u003e \u003cli\u003eBioinorganic chemistry of toxic metals\u003c\/li\u003e \u003cli\u003eBiochemical behavior of radionuclides and medical imaging using inorganic compounds\u003c\/li\u003e \u003cli\u003eChemotherapy involving non-essential elements \u003c\/li\u003e \u003c\/ul\u003e This full color text provides a concise and comprehensive review of bioinorganic chemistry for advanced students of chemistry, biochemistry, biology, medicine and environmental science.  \u003cp\u003ePreface to the Second Edition xi\u003c\/p\u003e \u003cp\u003ePreface to the First Edition xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Historical Background, Current Relevance and Perspectives 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 6\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Some General Principles 7\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Occurrence and Availability of Inorganic Elements in Organisms 7\u003c\/p\u003e \u003cp\u003eInsertion: The Chelate Effect 14\u003c\/p\u003e \u003cp\u003eInsertion: “Hard” and “Soft” Coordination Centers 14\u003c\/p\u003e \u003cp\u003e2.2 Biological Functions of Inorganic Elements 14\u003c\/p\u003e \u003cp\u003e2.3 Biological Ligands for Metal Ions 16\u003c\/p\u003e \u003cp\u003e2.3.1 Coordination by Proteins: Comments on Enzymatic Catalysis 17\u003c\/p\u003e \u003cp\u003eInsertion: The “Entatic State” in Enzymatic Catalysis 20\u003c\/p\u003e \u003cp\u003e2.3.2 Tetrapyrrole Ligands and Other Macrocycles 22\u003c\/p\u003e \u003cp\u003eInsertion: Electron Spin States in Transition Metal Ions  28\u003c\/p\u003e \u003cp\u003e2.3.3 Nucleobases, Nucleotides and Nucleic Acids (RNA, DNA) as Ligands 31\u003c\/p\u003e \u003cp\u003eInsertion: Secondary Bonding 32\u003c\/p\u003e \u003cp\u003e2.4 Relevance of Model Compounds 34\u003c\/p\u003e \u003cp\u003eReferences 34\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Cobalamins, Including Vitamin and Coenzyme B12 37\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 History and Structural Characterization 37\u003c\/p\u003e \u003cp\u003eInsertion: Bioorganometallics I [1] 38\u003c\/p\u003e \u003cp\u003e3.2 General Reactions of Alkylcobalamins 41\u003c\/p\u003e \u003cp\u003e3.2.1 One-electron Reduction and Oxidation 41\u003c\/p\u003e \u003cp\u003e3.2.2 Co–C Bond Cleavage 42\u003c\/p\u003e \u003cp\u003eInsertion: Electron Paramagnetic Resonance I 43\u003c\/p\u003e \u003cp\u003e3.3 Enzyme Functions of Cobalamins 45\u003c\/p\u003e \u003cp\u003e3.3.1 Adenosylcobalamin (AdoCbl)-dependent Isomerases 45\u003c\/p\u003e \u003cp\u003eInsertion: Organic Redox Coenzymes 48\u003c\/p\u003e \u003cp\u003e3.3.2 Alkylation Reactions of Methylcobalamin (MeCbl)-dependent Alkyl Transferases 51\u003c\/p\u003e \u003cp\u003e3.4 Model Systems and the Enzymatic Activation of the Co–C Bond 52\u003c\/p\u003e \u003cp\u003eReferences 53\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Metals at the Center of Photosynthesis: Magnesium and Manganese 57\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Volume and Efficiency of Photosynthesis 57\u003c\/p\u003e \u003cp\u003e4.2 Primary Processes in Photosynthesis 59\u003c\/p\u003e \u003cp\u003e4.2.1 Light Absorption (Energy Acquisition) 59\u003c\/p\u003e \u003cp\u003e4.2.2 Exciton Transport (Directed Energy Transfer) 59\u003c\/p\u003e \u003cp\u003e4.2.3 Charge Separation and Electron Transport 62\u003c\/p\u003e \u003cp\u003eInsertion: Structure Determination by X-ray Diffraction 62\u003c\/p\u003e \u003cp\u003e4.3 Manganese-catalyzed Oxidation of Water to O2 68\u003c\/p\u003e \u003cp\u003eInsertion: Spin–Spin Coupling 73\u003c\/p\u003e \u003cp\u003eReferences 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The Dioxygen Molecule, O2: Uptake, Transport and Storage of an Inorganic Natural Product 77\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Molecular and Chemical Properties of Dioxygen, O2 77\u003c\/p\u003e \u003cp\u003e5.2 Oxygen Transport and Storage through Hemoglobin and Myoglobin 82\u003c\/p\u003e \u003cp\u003e5.3 Alternative Oxygen Transport in Some Lower Animals: Hemerythrin and Hemocyanin 92\u003c\/p\u003e \u003cp\u003e5.3.1 Magnetism 92\u003c\/p\u003e \u003cp\u003e5.3.2 Light Absorption 93\u003c\/p\u003e \u003cp\u003e5.3.3 Vibrational Spectroscopy 93\u003c\/p\u003e \u003cp\u003eInsertion: Resonance Raman Spectroscopy 93\u003c\/p\u003e \u003cp\u003e5.3.4 M¨ossbauer Spectroscopy 94\u003c\/p\u003e \u003cp\u003eInsertion: M¨ossbauer Spectroscopy 94\u003c\/p\u003e \u003cp\u003e5.3.5 Structure 95\u003c\/p\u003e \u003cp\u003e5.4 Conclusion 96\u003c\/p\u003e \u003cp\u003eReferences 96\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Catalysis through Hemoproteins: Electron Transfer, Oxygen Activation and Metabolism of Inorganic Intermediates  99\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Cytochromes 101\u003c\/p\u003e \u003cp\u003e6.2 Cytochrome P-450: Oxygen Transfer from O2 to Nonactivated Substrates 103\u003c\/p\u003e \u003cp\u003e6.3 Peroxidases: Detoxification and Utilization of Doubly Reduced Dioxygen 108\u003c\/p\u003e \u003cp\u003e6.4 Controlling the Reaction Mechanism of the Oxyheme Group: Generation and Function of Organic Free Radicals  110\u003c\/p\u003e \u003cp\u003e6.5 Hemoproteins in the Catalytic Transformation of Partially Reduced Nitrogen and Sulfur Compounds 112\u003c\/p\u003e \u003cp\u003eInsertion: Gasotransmitters 113\u003c\/p\u003e \u003cp\u003eReferences 114\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Iron–Sulfur and Other Non-heme Iron Proteins 117\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Biological Relevance of the Element Combination Iron–Sulfur 117\u003c\/p\u003e \u003cp\u003eInsertion: Extremophiles and Bioinorganic Chemistry 118\u003c\/p\u003e \u003cp\u003e7.2 Rubredoxins 122\u003c\/p\u003e \u003cp\u003e7.3 [2Fe-2S] Centers 122\u003c\/p\u003e \u003cp\u003e7.4 Polynuclear Fe\/S Clusters: Relevance of the Protein Environment and Catalytic Activity 123\u003c\/p\u003e \u003cp\u003e7.5 Model Systems for Fe\/S Proteins 128\u003c\/p\u003e \u003cp\u003e7.6 Iron-containing Enzymes without Porphyrin or Sulfide Ligands 130\u003c\/p\u003e \u003cp\u003e7.6.1 Iron-containing Ribonucleotide Reductase 130\u003c\/p\u003e \u003cp\u003e7.6.2 Soluble Methane Monooxygenase 132\u003c\/p\u003e \u003cp\u003e7.6.3 Purple Acid Phosphatases (Fe\/Fe and Fe\/Zn) 133\u003c\/p\u003e \u003cp\u003e7.6.4 Mononuclear Non-heme Iron Enzymes 133\u003c\/p\u003e \u003cp\u003eReferences 135\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Uptake, Transport and Storage of an Essential Element, as Exemplified by Iron 139\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eInsertion: Metallome 139\u003c\/p\u003e \u003cp\u003e8.1 The Problem of Iron Mobilization: Oxidation States, Solubility and Medical Relevance 140\u003c\/p\u003e \u003cp\u003e8.2 Siderophores: Iron Uptake by Microorganisms 141\u003c\/p\u003e \u003cp\u003eInsertion: Optical Isomerism in Octahedral Complexes 144\u003c\/p\u003e \u003cp\u003e8.3 Phytosiderophores: Iron Uptake by Plants 149\u003c\/p\u003e \u003cp\u003e8.4 Transport and Storage of Iron 150\u003c\/p\u003e \u003cp\u003e8.4.1 Transferrin 152\u003c\/p\u003e \u003cp\u003e8.4.2 Ferritin 155\u003c\/p\u003e \u003cp\u003e8.4.3 Hemosiderin 159\u003c\/p\u003e \u003cp\u003eReferences  160\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Nickel-containing Enzymes: The Remarkable Career of a Long-overlooked Biometal 163\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Overview 163\u003c\/p\u003e \u003cp\u003e9.2 Urease 164\u003c\/p\u003e \u003cp\u003e9.3 Hydrogenases 166\u003c\/p\u003e \u003cp\u003e9.4 CO Dehydrogenase = CO Oxidoreductase = Acetyl-CoA Synthase 169\u003c\/p\u003e \u003cp\u003e9.5 Methyl-coenzyme M Reductase (Including the F430 Cofactor) 172\u003c\/p\u003e \u003cp\u003eInsertion: Natural and Artificial (Industrial) C1 Chemistry 174\u003c\/p\u003e \u003cp\u003eInsertion: Bioorganometallics II: The Organometallic Chemistry of Cobalt and Nickel 176\u003c\/p\u003e \u003cp\u003e9.6 Superoxide Dismutase 177\u003c\/p\u003e \u003cp\u003e9.7 Model Compounds 178\u003c\/p\u003e \u003cp\u003eFurther Reading 178\u003c\/p\u003e \u003cp\u003eReferences 179\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Copper-containing Proteins: An Alternative to Biological Iron 183\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Type 1: “Blue” Copper Centers 186\u003c\/p\u003e \u003cp\u003eInsertion: Electron Paramagnetic Resonance II 187\u003c\/p\u003e \u003cp\u003e10.2 Type 2 and Type 3 Copper Centers in O2-activating Proteins: Oxygen Transport and Oxygenation 191\u003c\/p\u003e \u003cp\u003e10.3 Copper Proteins as Oxidases\/Reductases 195\u003c\/p\u003e \u003cp\u003e10.4 Cytochrome c Oxidase 200\u003c\/p\u003e \u003cp\u003e10.5 Cu,Zn- and Other Superoxide Dismutases: Substrate-specific Antioxidants 203\u003c\/p\u003e \u003cp\u003eReferences 207\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Biological Functions of the “Early” Transition Metals: Molybdenum, Tungsten, Vanadium and Chromium  211\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Oxygen Transfer through Tungsten- and Molybdenum-containing Enzymes 211\u003c\/p\u003e \u003cp\u003e11.1.1 Overview 211\u003c\/p\u003e \u003cp\u003e11.1.2 Oxotransferase Enzymes Containing the Molybdopterin or Tungstopterin Cofactor  213\u003c\/p\u003e \u003cp\u003eInsertion: “Oxidation” 214\u003c\/p\u003e \u003cp\u003e11.2 Metalloenzymes in the Biological Nitrogen Cycle: Molybdenum-dependent Nitrogen Fixation  219\u003c\/p\u003e \u003cp\u003e11.3 Alternative Nitrogenases 226\u003c\/p\u003e \u003cp\u003e11.4 Biological Vanadium Outside of Nitrogenases 229\u003c\/p\u003e \u003cp\u003e11.5 Chromium(III) in the Metabolism? 231\u003c\/p\u003e \u003cp\u003eReferences 232\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Zinc: Structural and Gene-regulatory Functions and the Enzymatic Catalysis of\u003c\/b\u003e \u003cb\u003eHydrolysis and Condensation Reactions 235\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Overview 235\u003c\/p\u003e \u003cp\u003e12.2 Carboanhydrase 238\u003c\/p\u003e \u003cp\u003e12.3 Carboxypeptidase A and Other Hydrolases 243\u003c\/p\u003e \u003cp\u003e12.4 Catalysis of Condensation Reactions by Zinc-containing Enzymes 248\u003c\/p\u003e \u003cp\u003e12.5 Alcohol Dehydrogenase and Related Enzymes  249\u003c\/p\u003e \u003cp\u003e12.6 The “Zinc Finger” and Other Gene-regulatory Zinc Proteins 251\u003c\/p\u003e \u003cp\u003e12.7 Insulin, hGH, Metallothionein and DNA Repair Systems as Zinc-containing Proteins 253\u003c\/p\u003e \u003cp\u003eReferences 254\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Unequally Distributed Electrolytes: Function and Transport of Alkali and Alkaline Earth\u003c\/b\u003e \u003cb\u003eMetal Cations 257\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Characterization and Biological Roles of K+, Na+, Ca2+ and Mg2+ 257\u003c\/p\u003e \u003cp\u003eInsertion: Heteroatom Nuclear Magnetic Resonance 262\u003c\/p\u003e \u003cp\u003e13.2 Complexes of Alkali and Alkaline Earth Metal Ions with Macrocycles 264\u003c\/p\u003e \u003cp\u003e13.3 Ion Channels 267\u003c\/p\u003e \u003cp\u003e13.4 Ion Pumps 270\u003c\/p\u003e \u003cp\u003eFurther Reading 273\u003c\/p\u003e \u003cp\u003eReferences 273\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Catalysis and Regulation of Bioenergetic Processes by the Alkaline Earth Metal Ions\u003c\/b\u003e \u003cb\u003eMg2+ and Ca2+ 277\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Magnesium: Catalysis of Phosphate Transfer by Divalent Ions 277\u003c\/p\u003e \u003cp\u003e14.2 The Ubiquitous Regulatory Role of Ca2+ 283\u003c\/p\u003e \u003cp\u003eFurther Reading 291\u003c\/p\u003e \u003cp\u003eReferences 291\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Biomineralization: The Controlled Assembly of “Advanced Materials” in Biology 295\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Overview 295\u003c\/p\u003e \u003cp\u003e15.2 Nucleation and Crystal Growth 299\u003c\/p\u003e \u003cp\u003eInsertion: Dimensions 300\u003c\/p\u003e \u003cp\u003e15.3 Examples of Biominerals 301\u003c\/p\u003e \u003cp\u003e15.3.1 Calcium Phosphate in the Bones of Vertebrates and the Global P Cycle 301\u003c\/p\u003e \u003cp\u003eInsertion: The Global P Cycle 305\u003c\/p\u003e \u003cp\u003e15.3.2 Calcium Carbonate and the Global Inorganic C Cycle  306\u003c\/p\u003e \u003cp\u003eInsertion: The Global C Cycle and the Marine Inorganic C Cycle 307\u003c\/p\u003e \u003cp\u003e15.3.3 Amorphous Silica 308\u003c\/p\u003e \u003cp\u003e15.3.4 Iron Biominerals 309\u003c\/p\u003e \u003cp\u003e15.3.5 Strontium and Barium Sulfates 310\u003c\/p\u003e \u003cp\u003e15.4 Biomimetic Materials 310\u003c\/p\u003e \u003cp\u003eFurther Reading 311\u003c\/p\u003e \u003cp\u003eReferences 311\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Biological Functions of the Nonmetallic Inorganic Elements 315\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16.1 Overview 315\u003c\/p\u003e \u003cp\u003e16.2 Boron 315\u003c\/p\u003e \u003cp\u003e16.3 Silicon 315\u003c\/p\u003e \u003cp\u003e16.4 Arsenic and Trivalent Phosphorus 316\u003c\/p\u003e \u003cp\u003e16.5 Bromine 317\u003c\/p\u003e \u003cp\u003e16.6 Fluorine 317\u003c\/p\u003e \u003cp\u003e16.7 Iodine 318\u003c\/p\u003e \u003cp\u003e16.8 Selenium 320\u003c\/p\u003e \u003cp\u003eReferences 324\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 The Bioinorganic Chemistry of the Quintessentially Toxic Metals 327\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17.1 Overview 327\u003c\/p\u003e \u003cp\u003e17.2 Lead 329\u003c\/p\u003e \u003cp\u003e17.3 Cadmium 332\u003c\/p\u003e \u003cp\u003e17.4 Thallium 334\u003c\/p\u003e \u003cp\u003e17.5 Mercury 335\u003c\/p\u003e \u003cp\u003e17.6 Aluminum 340\u003c\/p\u003e \u003cp\u003e17.7 Beryllium 342\u003c\/p\u003e \u003cp\u003e17.8 Chromium and Tungsten 343\u003c\/p\u003e \u003cp\u003e17.9 Toxicity of Nanomaterials 344\u003c\/p\u003e \u003cp\u003eFurther Reading 345\u003c\/p\u003e \u003cp\u003eReferences 345\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Biochemical Behavior of Radionuclides and Medical Imaging Using Inorganic Compounds 349\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18.1 Radiation Risks and Medical Benefits from Natural and Synthetic Radionuclides 349\u003c\/p\u003e \u003cp\u003e18.1.1 The Biochemical Impact of Ionizing Radiation from Radioactive Isotopes 349\u003c\/p\u003e \u003cp\u003e18.1.2 Natural and Synthetic Radioisotopes 350\u003c\/p\u003e \u003cp\u003e18.1.3 Bioinorganic Chemistry of Radionuclides 351\u003c\/p\u003e \u003cp\u003eInsertion: Fukushima Daiichi, Chernobyl, Hiroshima and Nuclear Weapons Testing 353\u003c\/p\u003e \u003cp\u003e18.1.4 Radiopharmaceuticals 356\u003c\/p\u003e \u003cp\u003e18.1.5 Technetium: A “Synthetic Bioinorganic Element” 359\u003c\/p\u003e \u003cp\u003e18.1.6 Radiotracers for the Investigation of the Metallome 362\u003c\/p\u003e \u003cp\u003e18.2 Medical Imaging Based on Nonradioactive Inorganic Compounds 362\u003c\/p\u003e \u003cp\u003e18.2.1 Magnetic Resonance Imaging 362\u003c\/p\u003e \u003cp\u003e18.2.2 X-ray Contrast Agents 364\u003c\/p\u003e \u003cp\u003eFurther Reading 364\u003c\/p\u003e \u003cp\u003eReferences 365\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Chemotherapy Involving Nonessential Elements 369\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19.1 Overview 369\u003c\/p\u003e \u003cp\u003e19.2 Platinum Complexes in Cancer Therapy 369\u003c\/p\u003e \u003cp\u003e19.2.1 Discovery, Application and Structure–Effect Relationships 369\u003c\/p\u003e \u003cp\u003e19.2.2 Cisplatin: Mode of Action 372\u003c\/p\u003e \u003cp\u003e19.3 New Anticancer Drugs Based on Transition Metal Complexes 378\u003c\/p\u003e \u003cp\u003e19.3.1 Overview and Aims for Drug Development 378\u003c\/p\u003e \u003cp\u003e19.3.2 Nonplatinum Anticancer Drugs 379\u003c\/p\u003e \u003cp\u003e19.4 Further Inorganic Compounds in (Noncancer) Chemotherapy 383\u003c\/p\u003e \u003cp\u003e19.4.1 Gold-containing Drugs Used in the Therapy of Rheumatoid Arthritis 383\u003c\/p\u003e \u003cp\u003e19.4.2 Lithium in Psychopharmacologic Drugs 384\u003c\/p\u003e \u003cp\u003e19.4.3 Bismuth Compounds against Ulcers 385\u003c\/p\u003e \u003cp\u003e19.4.4 Vanadium-containing Insulin Mimetics and V-containing Anti-HIV Drugs 386\u003c\/p\u003e \u003cp\u003e19.4.5 Sodium Nitroprusside 386\u003c\/p\u003e \u003cp\u003e19.5 Bioorganometallic Chemistry of Nonessential Elements 387\u003c\/p\u003e \u003cp\u003eFurther Reading 389\u003c\/p\u003e \u003cp\u003eReferences 389\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eProfessor Dr Wolfgang Kaim, Institute of Inorganic Chemistry, University of Stuttgart, Germany\u003c\/strong\u003e\u003cbr\u003eWolfgang Kaim was born in 1951 near Frankfurt am Main, Germany, and studied chemistry at the universities of Frankfurt and Konstanz. After obtaining his PhD with H. Bock in 1978 he spent a postdoctoral year with F.A. Cotton at the University of Texas A\u0026amp;M University. In 1987 he moved from the University of Frankfurt to a Full Professorship at the University of Stuttgart. His main research interests focus on the charge and electron transfer reactivity of molecular compounds and various aspects of coordination chemistry. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDr Brigitte Schwederski, Institute of Inorganic Chemistry, University of Stuttgart, Germany\u003c\/strong\u003e\u003cbr\u003eBrigitte Schwederski was born in 1959 in Recklinghausen, Germany. From 1977 to 1983 she studied chemistry and biology at the University of Bochum and in 1988 completed her PhD in the research group of Dale W. Margerum at Purdue University, Indiana. Since 1988 she has been a Research Assistant at the University of Stuttgart. Her main research interests include inorganic model complexes of bioinorganic systems, their characteristics and reactivity. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProfessor Dr. Axel Klein, Universitaet zu Koeln, Institut fuer Anorganische Chemie, Germany\u003c\/strong\u003e\u003cbr\u003eAxel Klein is a Professor of Inorganic Chemistry at the University of Cologne, Germany. His research interests lie in the preparation and investigation of novel coordination compounds including organometallic derivatives, aiming at the rational design, preparation and use of coordination units with specific properties in mononuclear or oligonuclear complexes or as part of materials.   \u003c\/p\u003e\u003cp\u003eThe field of Bioinorganic Chemistry has grown significantly in recent years; now one of the major sub-disciplines of Inorganic Chemistry, it has also pervaded other areas of the life sciences due to its highly interdisciplinary nature.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eBioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Second Edition\u003c\/i\u003e provides a detailed introduction to the role of inorganic elements in biology, taking a systematic element-by-element approach to the topic. The second edition of this classic text has been fully revised and updated to include new structure information, emerging developments in the field, and an increased focus on medical applications of inorganic compounds. New topics have been added including materials aspects of bioinorganic chemistry, elemental cycles, bioorganometallic chemistry, medical imaging and therapeutic advances.\u003cbr\u003e \u003cbr\u003e \u003c\/p\u003e \u003cp\u003eTopics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eMetals at the center of photosynthesis\u003c\/li\u003e \u003cli\u003eUptake, transport, and storage of essential elements\u003c\/li\u003e \u003cli\u003eCatalysis through hemoproteins\u003c\/li\u003e \u003cli\u003eBiological functions of molybdenum, tungsten, vanadium and chromium\u003c\/li\u003e \u003cli\u003eFunction and transport of alkaline and alkaline earth metal cations\u003c\/li\u003e \u003cli\u003eBiomineralization\u003c\/li\u003e \u003cli\u003eBiological functions of the non-metallic inorganic elements\u003c\/li\u003e \u003cli\u003eBioinorganic chemistry of toxic metals\u003c\/li\u003e \u003cli\u003eBiochemical behavior of radionuclides and medical imaging using inorganic compounds\u003c\/li\u003e \u003cli\u003eChemotherapy involving non-essential elements \u003c\/li\u003e \u003c\/ul\u003e This full color text provides a concise and comprehensive review of bioinorganic chemistry for advanced students of chemistry, biochemistry, biology, medicine and environmental science.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988822868197,"sku":"NP9780470975237","price":64.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470975237.jpg?v=1761781710","url":"https:\/\/k12savings.com\/products\/bioinorganic-chemistry-inorganic-elements-in-the-chemistry-of-life-isbn-9780470975237","provider":"K12savings","version":"1.0","type":"link"}