Ascites and Renal Dysfunction in Liver Disease

There has been very little written on the interaction of the liver and kidney. This book addresses the increasing incidence and significance of diseases, such as ascites, renal dysfunction, cirrhosis and hypertension where both organs are involved.

This textbook is essential, even for confirmed practitioners and contains current information regarding treatment and therapy for patients with cirrhosis and ascites, clearly and effectively presented by the top international experts within this field.

The second edition is entirely revised and updated and places greater emphasis on therapy.

Contributors.

Preface to the Second Edition.Part 1. Regulation of Extracellular Fluid Volume and Renal and Splanchnic Circulation.

1. Extracellualr Fluid Volume Homeostasis (Brian D. Poole, William T. Abraham and Robert W. Schrier).

2. Physiology of the Renal Circulation (Roland C. Blantz and Francis B. Gabbai).

3. Physiology of the Gastrointestinal Circulation (Thomas Petnehazy, Thorsten Vowinkel and D. Neil Granger)Part 2. Factors Involved in the Pathogenesis of Renal Dysfunction and Ascites in Cirrhosis.

4. The Renin-Angiotensin-Aldosterone System in Cirrhosis (Mauro Bernardi and Marco Domenicali).

5. The Sympathetic Nervous System in Cirrhosis (Francis J. Dudley and Murray D. Esler).

6. Atrial Natriuretic Peptide and other Natriuretic Factors in Cirrhosis.

7. Arachidonic Acid Metabolites and the Kidney in Cirrhosis (Silvia Ippolito and Kevin P. Moore).

8. Nitric Oxide and Systemic and Renal Hemodynamic Disturbances in Cirrhosis (Manuel Morales-Ruiz and Wladimiro Jiménez).

9. Endothelin and Systemic, Renal and Hepatic Hemodynamic Disturbances in Cirrhosis (Veit Gülberg and Alexander L. Gernes).

10. Carbon Monoxide and the Heme Oxygenase System in Cirrhosis (Richard W. Lambrecht, Mercedes Fernández, Ying Shan, and Herbert L. Bonkovsky)Part 3. Systemic and Splanchnic Hemo-dynamic Abnormalities in Cirrhosis.

11. The Systemic Circulation in Cirrhosis (Søren Møller and Jens Henriksen).

12. The Splanchnic Circulation in Cirrhosis (Jaine Bosch and Juan carlos Garcia-Ragán).

13. Physiology of Hepatic Circulation in Cirrhosis (Roberto J. Griszmann and maurico R. Loureiro-Silva).

14. Alterations of Hepatic and Splanchnic Microvascular Exchange in Cirrhosis: Local Factors in the Formation of Ascites (Jens H. Henriksen and Søren Møller).

15. The Heart in Cirrhosis (Hongqun Liu and Samuel S. Lee)Part 4. Ascites and Sodium Retention in Cirrhosis.

16. Pathogenesis of Sodium Retention in Cirrhosis. The Arterial Vasodilation Hypotheses of Ascites Formation (Patricia Fernández de la Llama, Pere Ginès and Robert W. Schrier).

17. Experimental Models of Cirrhosis and Ascites (Joan Clària and Wladimiro Jiménez).

18. Medical Treatment of Ascites in Cirrhosis (Paolo Angeli and Angelo Gatta).

19. Paracentesis for Cirrhotic Ascites (Rosa María Morillas, Justiniano Santos, Silvia Montoliu and Ramon Planas).

20. Transjugular Intrahepatic Portosystemic Shunts (TIPS) for the Management of Refractory Ascites in Cirrhosis (Guadalupe Garcia-Tsao).

21. Prognosis of Patients with Cirrhosis and Ascites (Mónica Guevara, Andrés Cárdenas, Juan Uríz and Pere Ginès).

22. Liver Transplantation for Patients with Cirrhosis and Ascites (Antoni Rimola, Miguel Navasa, Luis Grande and Juan-Carlos Garcia-Valdecasas).

23. A Practical Approach to Treatment of Patients with Cirrhosis and Ascites (Andrés Cárdenas and Pere Ginès).

24. Etiology, Diagnosis, and Managment of Non-cirrhotic Ascites (Egbert Frick and Jürgen Schölmerich)Part 5. Hyponatremia and Water Retention in Cirrhosis.

25. Pathogenesis of Hyponatremia. The Role of Argenine Vasopressin (San-e Ishikawa and Robert W. Schrier).

26. Management of Hyponatremia in Cirrhosis (Andrés Cárdenas and Pere Ginès)Part 6. Renal Failure and Hepatorenal Syndrome in Liver Disease.

27. Pathogenesis of Renal Vasoconstriction in Cirrhosis (Mónica Guevara, Rolando Ortego, Pere Ginès and Juan Rodés).

28. Hepatorenal Syndrome in Cirrhosis: Clinical, Features, diagnosis, and Management (Vincente Arroyo, Carlos Terra, Aldo Torre and Pere Ginès).

29. Glomerular Disease in Cirrhosis (Brian D. Poole, Robert W. Schrier and Alkesh Jani).

30. Drug-induced Renal Failure in Cirrhosis (Francesco Salerno and Salvatore Badalamenti).

31. Clinical Disorders of Renal Function in Acute Liver Failure (John G. O’Grady).

32. Renal Dysfunction in Obstructive Jaundice (Antonio Sitges-Serra and Javier Padillo)Part 7. Spontaneous Bacterial Peritonitis in Cirrhosis.

33. Experimental Models of Spontaneous Bacterial Peritonitis (Agustin Albillos, Antonio de la Hera and Melchor Alvarez-Mon).

34. Pathogenesis and Clinical Features of Spontaneous Bacterial Peritonitis (José Such, Carlos Guarner and Bruce Runyon).

35. Treatment and Prohylaxis of Spontaneous Bacterial Peritonitis (Alejandro Blasco Pelicano and Miguel Navasa).

Index.

"As a specialist with a strong interest in the topics covered in this book, I consider it to be the best available book in the field. I also strongly recommend it as the ultimate manual for any physician who is interested in guidance in mastering the art and science of diagnosis and management of ascites and renal dysfunction in cirrhosis." NEJM - Nathan M Bass, MD, PhD

"This book is a great resource for researchers and clinicians interested in this topic"
Heliobacter - Bhupinderjit S Anand, MD

"This is a very useful text that will be helpful to clinicians caring for patients with liver disease. Anyone in the field of internal medicine, gastroenterology, hepatology, and nephrology who decides to buy this book can be sure of having done the right thing."
Digestive and Liver Disease - M. Lazzaroni

Reviews of first edition:
‘There is no doubt that this textbook is essential, even for confirmed practitioners’
Acta Gastro-enterologica Belgica

‘Current information regarding treatment and therapy for patients with cirrhosis and ascites is clearly and effectively presented by the top international experts within this field’.
Scandinavian Journal of Gastroenterology

Professor Vincente Arroyo, Professor of Medicine, School of Medicine, Hospital Clinic, University of Barcelona, Casanova 143, Barcelona 08036, Spain.

Dr Pere Gines, Liver Unit, School of Medicine, Hospital Clinic, University of Barcelona, Casanova 143, Barcelona 08036, Spain.

Professor Juan Rodes, Professor of Medicine, School of Medicine, Hospital Clinic, University of Barcelona, Casanova 143, Barcelona 08036, Spain.

Professor Robert W. Schrier, Professor and Chairman, Department of Medicine, University Hospital, University of Colorado, Denver, Colorado, USA.

With the four editors based in the leading clinic in the field, Ascites and Renal Dysfunction in Liver Disease, 2nd edition still represents the only comprehensive book available in the subject area. The book is not only aimed at clinical researchers interest in complications of cirrhosis but also for those clinicians, whether they be gastroenterologists, transplant hepatologists, nephrologists, or internists caring for patients with liver diseases.

This second edition has been extensively revised and updated

• More clinically orientated than the first edition
• Contents place a greater emphasis on therapy
• International author team
• Contains 8 new chapters, including:
• Physiology of the hepatic circulation
• The heart in cirrhosis
• TIPS for the management of refractory ascites in cirrhosis
• A practical approach to treatment of patients with cirrhosis and ascites
• Management of Hyponatremia in cirrhosis
• The aquaretic drugs