{"product_id":"arsenic-isbn-9781118511145","title":"Arsenic","description":"This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives.\u003cbr\u003e\u003cbr\u003e•    Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world\u003cbr\u003e•    Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models\u003cbr\u003e•    Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity\u003cbr\u003e•    Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists\u003cbr\u003e•    Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Fundamentals of Arsenic Exposure and Metabolism 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 History of Arsenic as a Poison and a Medicinal Agent 3\u003cbr\u003e \u003ci\u003eMichael F. Hughes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils: Distribution, Nature, Origin, and Human Exposure Routes 23\u003cbr\u003e \u003ci\u003eDavid A. Polya and Michael Lawson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Remediation of Arsenic in Drinking Water 61\u003cbr\u003e \u003ci\u003eCathleen J. Webb and Arden D. Davis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 The Chemistry and Metabolism of Arsenic 81\u003cbr\u003e \u003ci\u003eDavid J. Thomas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Epidemiology and Disease Manifestations of Arsenic Exposure 111\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5 Human Population Studies and Nutritional Intervention 113\u003cbr\u003e \u003ci\u003eYu Chen and Fen Wu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Skin Manifestations of Chronic Arsenicosis 127\u003cbr\u003e \u003ci\u003eNilendu Sarma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Lung Cancer and Other Pulmonary Diseases 137\u003cbr\u003e \u003ci\u003eCara L. Sherwood and R. Clark Lantz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Bladder Cancer and Arsenic 163\u003cbr\u003e \u003ci\u003eMatthew K. Medeiros and A. Jay Gandolfi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Neurological Effects of Arsenic Exposure 193\u003cbr\u003e \u003ci\u003eDominic B. Fee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Diabetes Mellitus 221\u003cbr\u003e \u003ci\u003eMiroslav Styblo and Christelle Douillet\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Hepatotoxicity 249\u003cbr\u003e \u003ci\u003eGavin E. Arteel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Genetic Epidemiology of Susceptibility to Arsenic‐Induced Diseases 267\u003cbr\u003e \u003ci\u003eMayukh Banerjee and Ashok K. Giri\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Mechanisms of Toxicity 289\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 Arsenic Interaction with Zinc Finger Motifs 291\u003cbr\u003e \u003ci\u003eLaurie G. Hudson, Karen L. Cooper, Susan R. Atlas,\u003c\/i\u003e \u003ci\u003eBrenee S. King and Ke Jian Liu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Role in Chemotherapy 315\u003cbr\u003e \u003ci\u003eKoren K. Mann and Maryse Lemaire\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Genotoxicity 347\u003cbr\u003e \u003ci\u003eAna Maria Salazar and Patricia Ostrosky‐Wegman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Arsenic and Signal Transduction 369\u003cbr\u003e \u003ci\u003eIngrid L. Druwe and Richard R. Vaillancourt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Stem Cell Targeting and Alteration by Arsenic 397\u003cbr\u003e \u003ci\u003eYuanyuan Xu, Erik J. Tokar and Michael P. Waalkes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Epigenetics and Arsenic Toxicity 421\u003cbr\u003e \u003ci\u003eSomnath Paul and Pritha Bhattacharjee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Models for Arsenic Toxicology and Risk Assessment 439\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19 Cancer Induced by Exposure to Arsenicals in Animals 441\u003cbr\u003e \u003ci\u003eErik J. Tokar, Yuanyuan Xu and Michael P. Waalkes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Arsenic‐Induced Cardiovascular Disease 453\u003cbr\u003e \u003ci\u003eAaron Barchowsky and J. Christopher States\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Invertebrate Models in Arsenic Research: Past, Present, and Future 469\u003cbr\u003e \u003ci\u003eIain L. Cartwright\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Toxicokinetics and Pharmacokinetic Modeling of Arsenic 495\u003cbr\u003e \u003ci\u003eElaina M. Kenyon and Harvey J. Clewell, III\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Considerations for a Biologically Based Risk Assessment for Arsenic 511\u003cbr\u003e \u003ci\u003eHarvey J. Clewell, III, P. Robinan Gentry and Janice W. Yager\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Translating Experimental Data to Human Populations 535\u003cbr\u003e \u003ci\u003eJ. Christopher States\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 549\u003c\/p\u003e \u003cb\u003eJ. Christopher States, PhD, \u003c\/b\u003eis Professor, University Scholar and Vice Chair for Graduate Education  in the Department of Pharmacology and Toxicology, and Associate Dean for Research in the University of Louisville School of Medicine, Louisville, Kentucky. He is a Past President of the Society of Toxicology Metals Specialty Section, on the editorial board of several leading journals, and regularly serves as a reviewer of manuscripts and National Institutes of Health grants. He has organized symposia and workshops and chaired sessions on arsenic exposure and toxicology at international conferences and published over 100 articles. Although used in pesticides and wood preservatives, arsenic is potentially fatal at high levels and creates a toxicological concern around the world – according to one study, over 140 million people in more than 70 countries are affected by arsenic contamination of drinking water. Exposure to high levels of arsenic also occurs in workplaces and near hazardous waste sites, and long-term exposure is often associated with several types of cancer and death from other chronic diseases. Despite the known effects of arsenic and regulatory guidelines to deal with it, there are increasing reports and evidential research that indicate more health risks and growing concerns.\u003cbr\u003e\u003cbr\u003eThis book discusses arsenic’s fundamentals, exposure sources, epidemiology and disease, and toxic mechanisms. It illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, population studies, experimental data, and future perspectives. It illustrates the chemistry, toxicology, and health effects of arsenic so that readers will come away with an understanding about the potential health risks and ways that toxicological research can improve and contribute to characterization and risk assessment of arsenic exposure. \u003cbr\u003e\u003cbr\u003eAn invaluable resource and reference for toxicologists, environmental chemists, and risk assessors; this book offers:\u003cbr\u003e\u003cbr\u003ePopulation studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models\u003cbr\u003e\u003cbr\u003eDiscussion of outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, and cardiovascular and pulmonary diseases\u003cbr\u003e\u003cbr\u003eFuture perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988762476773,"sku":"NP9781118511145","price":218.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118511145.jpg?v=1761781493","url":"https:\/\/k12savings.com\/products\/arsenic-isbn-9781118511145","provider":"K12savings","version":"1.0","type":"link"}