{"product_id":"applications-of-ion-chromatography-for-pharmaceutical-and-biological-products-isbn-9780470467091","title":"Applications of Ion Chromatography for Pharmaceutical and Biological Products","description":"This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument manufacturing, presents the different perspectives, experience, and expertise of the thought leaders of IC in a comprehensive manner. It explores potential IC applications in different aspects of product development and quality control testing. In addition, an appendix section gives information on critical physical and chromatographic parameters related to IC and information on current manufacturers of IC systems, columns, and other components. \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Principles, Mechanism, and Instrumentation 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Ion Chromatography—principles and Applications 3\u003cbr\u003e \u003ci\u003eLokesh Bhattacharyya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Retention Processes in Ion-exclusion Chromatography: a New Perspective 23\u003cbr\u003e \u003ci\u003eMilko Novič and Paul R. Haddad\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Pulsed Electrochemical Detection in Ion Chromatography 49\u003cbr\u003e \u003ci\u003eWilliam R. LaCourse\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Suppressor Design and Detection for Ion Chromatography 91\u003cbr\u003e \u003ci\u003eKannan Srinivasan, Sheetal Bhardwaj, Rong Lin, and Christopher Pohl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Modelling and Optimization of Ion Chromatographic Separations of Pharmaceutically RelevantOrganic Ions 107\u003cbr\u003e \u003ci\u003ePhilip Zakaria, Greg Dicinoski, Melissa Hanna-Brown, and Paul R. Haddad\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Pharmaceutical Applications 135\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6 Ion Chromatography in Pharmaceutical Drug Analysis 137\u003cbr\u003e \u003ci\u003eLokesh Bhattacharyya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Analysis for Impurities by Ion Chromatography 159\u003cbr\u003e \u003ci\u003eShreekant V. Karmarkar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Ion Chromatography Analysis of Aminoglycoside Antibiotics 175\u003cbr\u003e \u003ci\u003eValoran P. Hanko and Jeffrey S. Rohrer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Use of Cation-exchange Ion Chromatography in the Analysis of Pharmaceuticals 193\u003cbr\u003e \u003ci\u003eChristopher Pohl, Maria Rey, and Rosanne Slingsby\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Comprehensive Approaches for Measurement of Active Pharmaceutical Ingredients, Counter-ions,and Excipients Using HPLC with Charged Aerosol Detection 221\u003cbr\u003e \u003ci\u003eChristopher Crafts, Bruce Bailey, Paul Gamache, Xiaodong Liu, and Ian Acworth\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 High Performance Ion Chromatographic Analysis of Cholinergic Compounds: Carbachol andBethanechol, and Associated Degradation Products 237\u003cbr\u003e \u003ci\u003eDavid Trowbridge\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Ion Chromatographic Analysis of Pharmaceuticals for Authenticity and Adulteration 247\u003cbr\u003e \u003ci\u003eDavid S. Jackson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Ion Chromatography of Drug Product Counter-ions and other Ions in Drug Products 259\u003cbr\u003e \u003ci\u003eBrian M. De Borba and Jeffrey S. Rohrer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Sample Preparation Techniques in Ion Chromatography for Pharmaceutical Applications 271\u003cbr\u003e \u003ci\u003eJay Gandhi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Validation of Ion Chromatographic Methods 285\u003cbr\u003e \u003ci\u003eShreekant V. Karmarkar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Pharmacopeial Applications of Ion Chromatography 309\u003cbr\u003e \u003ci\u003eRavi Ravichandran\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Biotechnology Applications 321\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17 Glycan Analysis by High Performance Anion Exchange Chromatography with Pulsed AmperometricDetection 323\u003cbr\u003e \u003ci\u003eLokesh Bhattacharyya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Monosaccharide Analysis of Glycoproteins By High-performance Anion-exchange Chromatographywith Pulsed Amperometric Detection 339\u003cbr\u003e \u003ci\u003eJeffrey S. Rohrer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Two-dimensional Ion Chromatography for Simultaneous Determination of Amino Acids andCarbohydrates 351\u003cbr\u003e \u003ci\u003ePetr Jandik and Jun Cheng\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Monitoring Protein N-glycosylation Consistency Using Hpaec-pad 365\u003cbr\u003e \u003ci\u003eCarl Grey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Oligosaccharide Analysis by High-performance Anion-exchange Chromatography Hyphenated toIntegrated Pulsed Amperometric Detection and On-line Ion-trap Mass Spectrometry 379\u003cbr\u003e \u003ci\u003eCees Bruggink\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Vaccine Applications 393\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e22 Applications of Ion Chromatography in Biological Product Analyses 395\u003cbr\u003e \u003ci\u003eAlfred V. Del Grosso and Brandon Duong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 High Performance Anion-exchange Chromatography With Pulsed Amperometric Detection (hpaec-pad) Analysis of Gbs Glycoconjugate Vaccines: From Fermentation to Final Product 423\u003cbr\u003e \u003ci\u003eStefano Ricci, Barbara Fabbri, Sara Giannini, Silvia Bernardini, Marcello Morelli, and Sandro D’Ascenzi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Stability Studies and Characterization of Meningococcal A, C, Y, and W 135 Glycoconjugate Vaccine435\u003cbr\u003e \u003ci\u003eValeria Carinci, Alberto Bernardini, Cristiana Campa, Claudia Magagnoli, Francesca Beccai, and Sandro D’Ascenzi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Appendices 449\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAppendix 1 DISSOCIATION CONSTANTS (pK\u003csub\u003ea\u003c\/sub\u003e) OF ORGANIC Acids (at 20\u003csup\u003e◦\u003c\/sup\u003eC) 451\u003c\/p\u003e \u003cp\u003eAppendix 2 DISSOCIATION CONSTANTS (pK\u003csub\u003ea\u003c\/sub\u003e) OF COMMON Sugars and Alcohols 455\u003c\/p\u003e \u003cp\u003eIndex 457\u003c\/p\u003e  \u003cp\u003e“This book is a model of what can be achieved with a well-developed plan and the support of expert authors.”  (\u003ci\u003eChromatographia\u003c\/i\u003e, 2012)\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eLokesh Bhattacharyya i\u003c\/b\u003es a Lab Chief at the Center for Biologics\u003cb\u003e \u003c\/b\u003eEvaluation and Research (CBER) at the U.S. Food and Drug Administration (FDA). Prior to beginning his FDA work in 2006, he had over fourteen years of industry experience as an analytical chemist and biochemist. Dr. Bhattacharyya has thirty-nine papers, nine review articles, and nearly thirty conferences as speaker or session chair to his credit.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJeffrey S. Rohrer\u003c\/b\u003e is the Director of Applications Development for Thermo Fisher Scientific, Dionex Products. In this position he directs the work of three corporate applications laboratories in California, China, and Thailand. These labs develop HPLC, IC, HPAE-PAD, and other LC-based assays. Dr. Rohrer is an author of over fifty peer-reviewed publications. He is also a member of the United States Pharmacopeia Expert Committee on Monograph Development for Antibiotics, Antivirals, and Antimicrobials.\u003c\/p\u003e  \u003cp\u003eThorough coverage of the applications of ion chromatography to the analysis of pharmaceutical drugs and biologicals\u003c\/p\u003e \u003cp\u003eSince its introduction in the mid-1970s, ion chromatography (IC), a high-performance liquid chromatography technique, has developed into an important analytical methodology for a number of applications in the pharmaceutical, biotechnology, and environmental industries.\u003c\/p\u003e \u003cp\u003eWith contributors from academia, the pharmaceutical and biotech industries, and instrument manufacturers, this book takes a comprehensive approach to this steadily growing field to present different perspectives, experiences, and expertise influencing the development of IC.\u003c\/p\u003e \u003cp\u003eThis book features:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003ePotential IC applications in different aspects of development, characterization, and quality control testing of pharmaceutical and biological drug products, and vaccines\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eRecent advances in IC technology and applications, case studies, investigations and trouble-shooting experiences, and issues of current regulatory compliance\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eAn appendix with critical physical and chromatographic parameters related to IC\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eA close look at technology that has permitted IC to be coupled with mass spectrometry, which is a critical milestone for a wider interest in IC as a product characterization tool\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eA valuable learning tool for beginners and a comprehensive reference for seasoned professionals, Applications of Ion Chromatography for Pharmaceutical and Biological Products brings important new insight to pharmaceutical and biotechnology science.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988748452069,"sku":"NP9780470467091","price":153.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470467091.jpg?v=1761781436","url":"https:\/\/k12savings.com\/products\/applications-of-ion-chromatography-for-pharmaceutical-and-biological-products-isbn-9780470467091","provider":"K12savings","version":"1.0","type":"link"}