{"product_id":"antibiotics-isbn-9781555819309","title":"Antibiotics","description":"\u003cp\u003e\u003cb\u003eA chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eAntibiotics: Challenges, Mechanisms, Opportunities\u003c\/i\u003e focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.\u003c\/p\u003e \u003cp\u003eThis textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. \u003ci\u003eAntibiotics\u003c\/i\u003e also covers the biosynthetic machinery for the major classes of natural product antibiotics.\u003c\/p\u003e \u003cp\u003eAuthors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eWhat are antibiotics?\u003c\/li\u003e \u003cli\u003eWhere do antibiotics come from?\u003c\/li\u003e \u003cli\u003eHow do antibiotics work?\u003c\/li\u003e \u003cli\u003eWhy do antibiotics stop working?\u003c\/li\u003e \u003cli\u003eHow should our limited inventory of effective antibiotics be addressed?\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eAntibiotics\u003c\/i\u003e is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.\u003c\/p\u003e \u003cp\u003ePreface ix–x\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I Challenges for Antibiotics 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Antibiotics: Initial Concepts and Considerations 4\u003c\/p\u003e \u003cp\u003e2 Major Classes of Antibiotics and Their Modes of Action 16\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II Mechanisms: Antibiotic Action by Bacterial Target Class 33\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3 Assembly of the Peptidoglycan Layer of Bacterial Cell Walls 36\u003c\/p\u003e \u003cp\u003e4 Antibiotics That Block Peptidoglycan Assembly and Integrity 68\u003c\/p\u003e \u003cp\u003e5 Antibiotics That Disrupt Membrane Integrity 102\u003c\/p\u003e \u003cp\u003e6 Antibiotics That Block Protein Synthesis 114\u003c\/p\u003e \u003cp\u003e7 Antibiotics That Target DNA and RNA Information Transfer 148\u003c\/p\u003e \u003cp\u003e8 Antibiotics That Block Biosynthesis of the DNA Building Block Deoxythymidylate 164\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III Mechanisms: Bacterial Resistance to Antibiotics 177\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9 Bacterial Antibiotic Resistance: Overview 180\u003c\/p\u003e \u003cp\u003e10 Antibiotic Resistance: Modification or Destruction of the Antibiotic 198\u003c\/p\u003e \u003cp\u003e11 Antibiotic Resistance via Membrane Efflux Pumps 220\u003c\/p\u003e \u003cp\u003e12 Resistance via Target Modification 230\u003c\/p\u003e \u003cp\u003e13 Tuberculosis: A Formidable Challenge for Antibiotic Therapy 252\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV Mechanisms: Antibiotic Biosynthesis 273\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14 Antibiotic Biosynthesis: Principles 276\u003c\/p\u003e \u003cp\u003e15 Biosynthesis of Peptide Antibiotics 288\u003c\/p\u003e \u003cp\u003e16 Biosynthesis of Polyketide Antibiotics 320\u003c\/p\u003e \u003cp\u003e17 Biosynthesis of Oligosaccharide, Isoprenoid, and C-P Antibiotic Classes 344\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection V Opportunities 363\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18 Underexploited Pathways and Targets for Antibiotics 366\u003c\/p\u003e \u003cp\u003e19 Prospects for New Molecules and New Targets 398\u003c\/p\u003e \u003cp\u003eReferences 421\u003c\/p\u003e \u003cp\u003eIndex 455\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eAntibiotics\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eSecond Edition \u003c\/p\u003e\u003cp\u003e\u003ci\u003eA chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance\u003c\/i\u003e  \u003c\/p\u003e\u003cp\u003e\u003ci\u003eAntibiotics: Challenges, Mechanisms, Opportunities\u003c\/i\u003e focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. \u003c\/p\u003e\u003cp\u003eThis textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. \u003ci\u003eAntibiotics\u003c\/i\u003e also covers the biosynthetic machinery for the major classes of natural product antibiotics. \u003c\/p\u003e\u003cp\u003eAuthors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eWhat are antibiotics?\u003c\/li\u003e \u003cli\u003eWhere do antibiotics come from?\u003c\/li\u003e \u003cli\u003eHow do antibiotics work?\u003c\/li\u003e \u003cli\u003eWhy do antibiotics stop working?\u003c\/li\u003e \u003cli\u003eHow should our limited inventory of effective antibiotics be addressed?\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eAntibiotics\u003c\/i\u003e is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.\u003c\/p\u003e","brand":"ASM Press","offers":[{"title":"Default Title","offer_id":47988745175269,"sku":"NP9781555819309","price":133.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781555819309.jpg?v=1761781423","url":"https:\/\/k12savings.com\/products\/antibiotics-isbn-9781555819309","provider":"K12savings","version":"1.0","type":"link"}