{"product_id":"acetaldehyde-related-pathology-isbn-9780470057667","title":"Acetaldehyde-Related Pathology","description":"Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer’s.  \u003cp\u003e\u003cb\u003e\u003ci\u003eAcetaldehyde-Related Pathology\u003c\/i\u003e\u003c\/b\u003e describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. \u003cb\u003e\u003ci\u003eAcetaldehyde-Related Pathology\u003c\/i\u003e\u003c\/b\u003e features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology.\u003c\/p\u003e \u003cp\u003eThis book is essential reading for anyone interested in the effects of this compound - pathologists, biochemists, toxicologists, cell and molecular biologists.\u003c\/p\u003e \u003cp\u003eSymposium on Acetaldehyde-related pathology: bridging the trans-disciplinary divide, held at the Novartis Foundation, London 5–7th September 2006\u003cbr\u003e\u003cbr\u003eEditors: Derek J. Chadwick (Organizer) and Jamie Goode\u003c\/p\u003e \u003cp\u003eThis symposium is based on a proposal made by Victor Preedy, Peter Emery and Mikko Salaspuro\u003c\/p\u003e \u003cp\u003ePeter Emery Chair’s introduction 1\u003c\/p\u003e \u003cp\u003eDavid W. Crabb and Suthat Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes 4\u003c\/p\u003e \u003cp\u003eDiscussion 16\u003c\/p\u003e \u003cp\u003eRichard A. Deitrich, Dennis Petersen and Vasilis Vasiliou Removal of acetaldehyde from the body 23\u003c\/p\u003e \u003cp\u003eDiscussion 40\u003c\/p\u003e \u003cp\u003eShih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the cardiovascular system 52\u003c\/p\u003e \u003cp\u003eDiscussion 63\u003c\/p\u003e \u003cp\u003eJun Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models 69\u003c\/p\u003e \u003cp\u003eDiscussion 76\u003c\/p\u003e \u003cp\u003eMikko Salaspuro Interrelationship between alcohol, smoking, acetaldehyde and cancer 80\u003c\/p\u003e \u003cp\u003eDiscussion 89\u003c\/p\u003e \u003cp\u003eHiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde on human airway constriction and inflammation 97\u003c\/p\u003e \u003cp\u003eDiscussion 106\u003c\/p\u003e \u003cp\u003eHelmut K. Seitz The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract 110\u003cbr\u003eDiscussion 119\u003c\/p\u003e \u003cp\u003eRobert Tardif The determination of acetaldehyde in exhaled breath 125\u003c\/p\u003e \u003cp\u003eDiscussion 133\u003c\/p\u003e \u003cp\u003eMostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain 137\u003c\/p\u003e \u003cp\u003eDiscussion 141\u003c\/p\u003e \u003cp\u003eVille Salaspuro Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde 145\u003c\/p\u003e \u003cp\u003eDiscussion 153\u003c\/p\u003e \u003cp\u003eVictor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic myopathy and acetaldehyde 158\u003c\/p\u003e \u003cp\u003eDiscussion 177\u003c\/p\u003e \u003cp\u003eOnni Niemelä Acetaldehyde adducts in circulation 183\u003c\/p\u003e \u003cp\u003eDiscussion 193\u003c\/p\u003e \u003cp\u003eGeneral discussion 198\u003c\/p\u003e \u003cp\u003eM. Apte, J. McCarroll, R. Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde 200\u003c\/p\u003e \u003cp\u003eDiscussion 211\u003c\/p\u003e \u003cp\u003eShivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R. Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes 217\u003c\/p\u003e \u003cp\u003eDiscussion 224\u003c\/p\u003e \u003cp\u003ePaul J. Thornalley Endogenous „´-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage 229\u003c\/p\u003e \u003cp\u003eDiscussion 243\u003c\/p\u003e \u003cp\u003eC. J. Peter Eriksson Measurement of acetaldehyde: what levels occur naturally and in response to alcohol? 247\u003c\/p\u003e \u003cp\u003eDiscussion 256\u003c\/p\u003e \u003cp\u003eFinal discussion 261\u003c\/p\u003e \u003cp\u003eContributors Index 265\u003c\/p\u003e \u003cp\u003eSubject index 267\u003c\/p\u003e \"…will be found on the shelves of most scientific biomedical libraries.\" (\u003ci\u003eDoody's Book Reviews\u003c\/i\u003e)  \u003cb\u003eThe Novartis Foundation\u003c\/b\u003e is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.\u003cbr\u003e Chairman: Peter Emery  Acetaldehyde contributes to pathologies ranging from cancer to asthma. It affects the whole body, the architecture of the cell and molecular control mechanisms. The origins of acetaldehyde vary from bacteria in the oral cavity and intestinal tract to atmospheric acetaldehyde as an environmental pollutant. Significant amounts of acetaldehyde are also derived from cigarette smoke and alcohol, both of which are major contributors to disease globally.  \u003cp\u003eAcetaldehyde has deleterious effects in the liver, brain and skeletal muscle. It has also been shown that bacteria can generate significant amounts of acetaldehyde in the gastrointestinal tract, thus contributing to carcinogenesis in this tissue.  Many of the toxic effects of ethanol ingestion are mediated through acetaldehyde and there is increasing awareness that acetaldehyde is a principal disease-forming agent in tobacco-related illnesses.\u003c\/p\u003e \u003cp\u003eAlcohol is metabolized by conversion to acetaldehyde, which in turn is converted to acetate by aldehyde dehydrogenase (ALDH).  There are a number of forms of ALDH of which the mitochondrial isoform (ALDH2) is particularly important. The \u003ci\u003eALDH2\u003c\/i\u003e gene has a functional polymorphism: homozygous subjects have little or no ALDH2 activity compared to their wild-type counterparts. Heterozygotes generally also have low ALDH2 activity. Epidemiological studies have found increased risk of certain diseases, including cancer of the gastrointestinal tract, alcoholic liver disease and late-onset Alzheimer’s disease in subjects with ALDH2 deficiency. \u003c\/p\u003e \u003cp\u003eThis book features contributions from researchers working on all aspects of acetaldehyde-related pathology. From their expert accounts and the lively discussions accompanying each chapter, we can derive a better understanding of the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988655030501,"sku":"NP9780470057667","price":253.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470057667.jpg?v=1761781135","url":"https:\/\/k12savings.com\/products\/acetaldehyde-related-pathology-isbn-9780470057667","provider":"K12savings","version":"1.0","type":"link"}