{"product_id":"abc-transporters-and-multidrug-resistance-isbn-9780470227343","title":"ABC Transporters and Multidrug Resistance","description":"\u003cb\u003eA comprehensive review of the most current scientific research on ABC transporters and multidrug resistance\u003c\/b\u003e  \u003cp\u003eATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eABC Transporters and Multidrug Resistance\u003c\/i\u003e offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.\u003c\/p\u003e \u003cp\u003eThis comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.\u003c\/p\u003e \u003cp\u003ePREFACE ix\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003eINTRODUCTION: WHAT IS MULTIDRUG RESISTANCE? 1\u003cbr\u003e\u003ci\u003eJonathan A. Sheps and Victor Ling\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION OF THE STRUCTURE, GENOME, NORMAL TISSUE EXPRESSION, PHYSIOLOGICAL ASPECT, AND MECHANISM OF ACTION 15\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The P-glycoprotein 170: Just a multidrug resistance protein or a protean molecule? 17\u003cbr\u003e\u003ci\u003eFabienne Grandjean-Forestier, Christophe Stenger, Jacques Robert, Mireille Verdier, and Marie-Hélène Ratinaud\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Multidrug resistance-associated protein (MRP\/ABCC proteins) 47\u003cbr\u003e\u003ci\u003eMylène Honorat, Charles Dumontet, and Lea Payen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 ABCG2: A new challenge in cancer drug resistance 83\u003cbr\u003e\u003ci\u003eOrsolya Polgar, Robert W. Robey, Kin Wah To, John Deeken, Patricia A. Fetsch, and Susan E. Bates\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II ABC PROTEINS AND ONCOLOGY: EXPRESSION, DETECTION, AND IMPLICATION OF ABC PROTEINS IN HEMATOLOGICAL MALIGNANCIES AND SOLID TUMORS 119\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 Expression, detection, and implication of ABC proteins in acute myeloblastic leukemia 121\u003cbr\u003e\u003ci\u003eOllivier Legrand, Ruo-Ping Tang, and Jean-Pierre Marie\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 ABC proteins and oncology: Expression, detection, and implication of ABC proteins in solid tumors 143\u003cbr\u003e\u003ci\u003eJean François Bernaudin, Anne Fajac, Jocelyne Fleury-Feith, Khaldoun Kerrou, and Roger Lacave\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III ABC PROTEINS AND PATHOGENIC MICROORGANISMS 177\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6 ABC transporters and resistance to antibiotics 179\u003cbr\u003e\u003ci\u003eSerge Michalet and Marie-Geneviève Dijoux-Franca\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 ABC proteins involved in protozoan parasite resistance 195\u003cbr\u003e\u003ci\u003eBruno Pradines\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV MULTIDRUG RESISTANCE (MDR) MODULATION THROUGH INHIBITION OF ABC TRANSPORTERS: DESIGN OF INHIBITORS AND MECHANISM OF ACTION 239\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Reversal agents for P-glycoprotein-mediated multidrug resistance 241\u003cbr\u003e\u003ci\u003eHamid Morjani and Claudie Madoulet\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Reversal agents of multidrug resistance mediated by multidrug resistance-associated proteins (MRPs) 261\u003cbr\u003e\u003ci\u003eAhcène Boumendjel, Anne Florin, and Jean Boutonnat\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Reversal agents for breast cancer resistance protein (BCRP)-mediated multidrug resistance 289\u003cbr\u003e\u003ci\u003eJean Boutonnat, Anne Florin, and Ahcène Boumendjel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Strategies to overcome drug resistance in acute and chronic leukemias 315\u003cbr\u003e\u003ci\u003eEric Solary, Vincent Ribrag, and Stéphane de Botton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Multidrug resistance reversal in solid tumors 349\u003cbr\u003e\u003ci\u003eTatiana Bogush and Jacques Robert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V BIOLOGICAL AND CLINICAL ASPECTS OF MULTIDRUG RESISTANCE: THE ROLE OF THE TRANSPORTERS AT THE MAIN PROTECTION BARRIERS (ABCB1, ABCC1, ABCC2, ABCG2) ON THE BIOAVAILABILITY OF MANY TYPES OF DRUGS AND MEDICATIONS 363\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 ABC superfamily transporters at the human blood–brain barrier 365\u003cbr\u003e\u003ci\u003eJean-Michel Scherrmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 The role of ABC transporters at the intestinal barrier 385\u003cbr\u003e\u003ci\u003eRoos L. Oostendorp, Jos H. Beijnen, and Jan H.M. Schellens\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Genetic polymorphisms in ABC transporters 411\u003cbr\u003e\u003ci\u003eLeslie W. Chinn and Deanna L. Kroetz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003ePERSPECTIVES 437\u003c\/p\u003e \u003cp\u003eINDEX 441\u003c\/p\u003e  \"The book is both interesting for both novice and experienced researches in the field.\" (\u003ci\u003eChemMedChem,\u003c\/i\u003e July 2010)\u003cbr\u003e \u003cbr\u003e  \u003cb\u003eAhcéne Boumendjel\u003c\/b\u003e is Professor of Medicinal Chemistry at the University of Grenoble School of Pharmacy, France.  \u003cp\u003e\u003cb\u003eJean Boutonnat\u003c\/b\u003e is an Assistant Professor and Hospital Practitioner at the Grenoble Medical School and Université Joseph Fourier of Grenoble, France.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJacques Robert\u003c\/b\u003e is Professor and Head of the Laboratory of Pharmacology of Anticancer Agents at Institut Bergonié and Université Victor Segalen Bordeaux 2, France.\u003c\/p\u003e  \u003cb\u003eA comprehensive review of the most current scientific research on ABC transporters and multidrug resistance\u003c\/b\u003e  \u003cp\u003eATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eABC Transporters and Multidrug Resistance\u003c\/i\u003e offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.\u003c\/p\u003e \u003cp\u003eThis comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988650475749,"sku":"NP9780470227343","price":179.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470227343.jpg?v=1761781118","url":"https:\/\/k12savings.com\/products\/abc-transporters-and-multidrug-resistance-isbn-9780470227343","provider":"K12savings","version":"1.0","type":"link"}