{"product_id":"a-textbook-of-modern-toxicology-isbn-9780470462065","title":"A Textbook of Modern Toxicology","description":"\u003ci\u003eA Textbook of Modern Toxicology\u003c\/i\u003e is a unique resource that provides both students and practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses in environmental, pharmacological, medical, and veterinary toxicology, this essential text features chapters written by experts who address a range of key topics.  \u003cp\u003eThe Fourth Edition includes additional chapters on new approaches to toxicology - molecular methods (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and systems biology – and continues the legacy of its predecessors to provide up-to-date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity testing, ecological risk assessment, and many other areas of toxicology that help foster a solid comprehension of the field.\u003c\/p\u003e \u003cp\u003eAlso featured in the Fourth Edition are end-of-chapter questions and a Solutions Manual available separately for academic adopters.\u003c\/p\u003e \u003cp\u003ePREFACE TO THE FOURTH EDITION xxi\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xxiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I INTRODUCTION 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. Introduction to Toxicology 3\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Definition and Scope 3\u003c\/p\u003e \u003cp\u003e1.2 Relationship to Other Sciences 9\u003c\/p\u003e \u003cp\u003e1.3 A Brief History of Toxicology 10\u003c\/p\u003e \u003cp\u003e1.4 Dose–Response Relationships 11\u003c\/p\u003e \u003cp\u003e1.5 Sources of Toxic Compounds 12\u003c\/p\u003e \u003cp\u003e1.6 Movement of Toxicants in the Environment 12\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 13\u003c\/p\u003e \u003cp\u003eSample Questions 14\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Introduction to Biochemical and Molecular Methods in Toxicology 15\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson, Gerald A. Leblanc, Sharon A. Meyer, and Robert C. Smart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 15\u003c\/p\u003e \u003cp\u003e2.2 Cell Culture Techniques 15\u003c\/p\u003e \u003cp\u003e2.3 Molecular Techniques 19\u003c\/p\u003e \u003cp\u003e2.4 Immunochemical Techniques 23\u003c\/p\u003e \u003cp\u003e2.5 Proteomics 26\u003c\/p\u003e \u003cp\u003e2.6 Metabolomics 26\u003c\/p\u003e \u003cp\u003e2.7 Bioinformatics 26\u003c\/p\u003e \u003cp\u003e2.8 Summary and Conclusions 27\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 27\u003c\/p\u003e \u003cp\u003eSample Questions 27\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II CLASSES OF TOXICANTS 29\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. Exposure Classes, Toxicants in Air, Water, Soil, Domestic, and Occupational Settings 31\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eW. Gregory Cope\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Air Pollutants 31\u003c\/p\u003e \u003cp\u003e3.2 Water and Soil Pollutants 38\u003c\/p\u003e \u003cp\u003e3.3 Occupational Toxicants 42\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 46\u003c\/p\u003e \u003cp\u003eAir Pollutants 46\u003c\/p\u003e \u003cp\u003eWater and Soil Pollutants 47\u003c\/p\u003e \u003cp\u003eOccupational Toxicants 47\u003c\/p\u003e \u003cp\u003eSample Questions 47\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Classes of Toxicants: Use Classes 49\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eW. Gregory Cope and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 49\u003c\/p\u003e \u003cp\u003e4.2 Metals 49\u003c\/p\u003e \u003cp\u003e4.3 Agricultural Chemicals (Pesticides) 55\u003c\/p\u003e \u003cp\u003e4.4 Food Additives and Contaminants 65\u003c\/p\u003e \u003cp\u003e4.5 Toxins 66\u003c\/p\u003e \u003cp\u003e4.6 Solvents 71\u003c\/p\u003e \u003cp\u003e4.7 Therapeutic Drugs 71\u003c\/p\u003e \u003cp\u003e4.8 Drugs of Abuse 72\u003c\/p\u003e \u003cp\u003e4.9 Combustion Products 72\u003c\/p\u003e \u003cp\u003e4.10 Cosmetics 74\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 74\u003c\/p\u003e \u003cp\u003eGeneral 74\u003c\/p\u003e \u003cp\u003eMetals 74\u003c\/p\u003e \u003cp\u003ePesticides 75\u003c\/p\u003e \u003cp\u003eToxins 75\u003c\/p\u003e \u003cp\u003eSolvents 75\u003c\/p\u003e \u003cp\u003eTherapeutic Drugs 75\u003c\/p\u003e \u003cp\u003eSample Questions 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III TOXICANT PROCESSING IN VIVO 77\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Absorption and Distribution of Toxicants 79\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRonald E. Baynes and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 79\u003c\/p\u003e \u003cp\u003e5.2 Cell Membranes 80\u003c\/p\u003e \u003cp\u003e5.3 Mechanisms of Transport 82\u003c\/p\u003e \u003cp\u003e5.4 Physicochemical Properties Relevant to Diffusion 87\u003c\/p\u003e \u003cp\u003e5.5 Routes of Absorption 90\u003c\/p\u003e \u003cp\u003e5.6 Toxicant Distribution 99\u003c\/p\u003e \u003cp\u003e5.7 Toxicokinetics 108\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 112\u003c\/p\u003e \u003cp\u003eSample Questions 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Metabolism of Toxicants 115\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson and Randy L. Rose\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 115\u003c\/p\u003e \u003cp\u003e6.2 Phase I Reactions 116\u003c\/p\u003e \u003cp\u003e6.3 Phase II Reactions 143\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 154\u003c\/p\u003e \u003cp\u003eSample Questions 155\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Reactive Metabolites 157\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson and Randy L. Rose\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 157\u003c\/p\u003e \u003cp\u003e7.2 Activation Enzymes 158\u003c\/p\u003e \u003cp\u003e7.3 Nature and Stability of Reactive Metabolites 160\u003c\/p\u003e \u003cp\u003e7.4 Fate of Reactive Metabolites 161\u003c\/p\u003e \u003cp\u003e7.5 Factors Affecting Toxicity of Reactive Metabolites 162\u003c\/p\u003e \u003cp\u003e7.6 Reactive Oxygen Species 163\u003c\/p\u003e \u003cp\u003e7.7 Examples of Activating Reactions 164\u003c\/p\u003e \u003cp\u003e7.8 Summary and Conclusions 170\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 171\u003c\/p\u003e \u003cp\u003eSample Questions 171\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Chemical and Physiological Effects on Xenobiotic Metabolism 173\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAndrew D. Wallace and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 173\u003c\/p\u003e \u003cp\u003e8.2 Nutritional Effects 173\u003c\/p\u003e \u003cp\u003e8.3 Physiological Effects 176\u003c\/p\u003e \u003cp\u003e8.4 Comparative and Genetic Effects 182\u003c\/p\u003e \u003cp\u003e8.5 Chemical Effects 191\u003c\/p\u003e \u003cp\u003e8.6 Environmental Effects 207\u003c\/p\u003e \u003cp\u003e8.7 Summary and Conclusions 209\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 210\u003c\/p\u003e \u003cp\u003eSample Questions 211\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Elimination of Toxicants 213\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 213\u003c\/p\u003e \u003cp\u003e9.2 Transport 215\u003c\/p\u003e \u003cp\u003e9.3 Renal Elimination 216\u003c\/p\u003e \u003cp\u003e9.4 Hepatic Elimination 217\u003c\/p\u003e \u003cp\u003e9.5 Respiratory Elimination 220\u003c\/p\u003e \u003cp\u003e9.6 Conclusion 221\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 221\u003c\/p\u003e \u003cp\u003eSample Questions 222\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV TOXIC ACTION 223\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Acute Toxicity 225\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 225\u003c\/p\u003e \u003cp\u003e10.2 Acute Exposure and Effect 225\u003c\/p\u003e \u003cp\u003e10.3 Dose–Response Relationships 227\u003c\/p\u003e \u003cp\u003e10.4 Nonconventional Dose–Response Relationships 229\u003c\/p\u003e \u003cp\u003e10.5 Alternative Methods 230\u003c\/p\u003e \u003cp\u003e10.6 Mechanisms of Acute Toxicity 231\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 236\u003c\/p\u003e \u003cp\u003eSample Questions 236\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. Chemical Carcinogenesis and Mutagenesis 237\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRobert C. Smart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 DNA Damage and Mutagenesis 237\u003c\/p\u003e \u003cp\u003e11.2 General Aspects of Cancer 239\u003c\/p\u003e \u003cp\u003e11.3 Human Cancer 242\u003c\/p\u003e \u003cp\u003e11.4 Classes of Agents That Are Associated with Carcinogenesis 251\u003c\/p\u003e \u003cp\u003e11.5 General Aspects of Chemical Carcinogenesis 254\u003c\/p\u003e \u003cp\u003e11.6 Oncogenes 259\u003c\/p\u003e \u003cp\u003e11.7 Tumor Suppressor Genes 262\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 264\u003c\/p\u003e \u003cp\u003eSample Questions 264\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Teratogenesis 265\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJill A. Barnes and Ida M. Washington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 265\u003c\/p\u003e \u003cp\u003e12.2 Overview of Embryonic Development 266\u003c\/p\u003e \u003cp\u003e12.3 Principles of Teratogenesis 268\u003c\/p\u003e \u003cp\u003e12.4 Mechanisms of Teratogenesis 268\u003c\/p\u003e \u003cp\u003e12.5 Future Considerations 272\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 272\u003c\/p\u003e \u003cp\u003eSample Questions 272\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V ORGAN TOXICITY 275\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13. Hepatotoxicity 277\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAndrew D. Wallace and Sharon A. Meyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 277\u003c\/p\u003e \u003cp\u003e13.2 Susceptibility of the Liver 279\u003c\/p\u003e \u003cp\u003e13.3 Types of Liver Injury 279\u003c\/p\u003e \u003cp\u003e13.4 Mechanisms of Hepatotoxicity 283\u003c\/p\u003e \u003cp\u003e13.5 Examples of Hepatotoxicants 285\u003c\/p\u003e \u003cp\u003e13.6 Metabolic Activation of Hepatotoxicants 288\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 289\u003c\/p\u003e \u003cp\u003eSample Questions 289\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14. Nephrotoxicity 291\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJoan B. Tarloff and Andrew D. Wallace\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 291\u003c\/p\u003e \u003cp\u003e14.2 Factors Contributing to Nephrotoxicity 292\u003c\/p\u003e \u003cp\u003e14.3 Examples of Nephrotoxicants 293\u003c\/p\u003e \u003cp\u003e14.4 Summary 301\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 301\u003c\/p\u003e \u003cp\u003eSample Questions 302\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15. Toxicology of the Nervous System 303\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eBonita L. Blake\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 303\u003c\/p\u003e \u003cp\u003e15.2 The Nervous System 303\u003c\/p\u003e \u003cp\u003e15.3 Toxicant Effects on the Nervous System 312\u003c\/p\u003e \u003cp\u003e15.4 Neurotoxicity Testing 317\u003c\/p\u003e \u003cp\u003e15.5 Summary 321\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 322\u003c\/p\u003e \u003cp\u003eSample Questions 322\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16. Reproductive System 323\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHeather Patisaul\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 323\u003c\/p\u003e \u003cp\u003e16.2 The Hypothalamic-Pituitary-Gonadal Axis 324\u003c\/p\u003e \u003cp\u003e16.3 Male Reproductive Physiology 326\u003c\/p\u003e \u003cp\u003e16.4 Disruption of Male Reproduction By Toxicants 330\u003c\/p\u003e \u003cp\u003e16.5 Female Reproductive Physiology 332\u003c\/p\u003e \u003cp\u003e16.6 Disruption of Female Reproduction by Toxicants 335\u003c\/p\u003e \u003cp\u003e16.7 Summary 341\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 341\u003c\/p\u003e \u003cp\u003eSample Questions 343\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17. Endocrine Toxicology 345\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 345\u003c\/p\u003e \u003cp\u003e17.2 Endocrine System 345\u003c\/p\u003e \u003cp\u003e17.3 Endocrine Disruption 352\u003c\/p\u003e \u003cp\u003e17.4 Incidents of Endocrine Toxicity 358\u003c\/p\u003e \u003cp\u003e17.5 Conclusion 361\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 362\u003c\/p\u003e \u003cp\u003eSample Questions 362\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18. Respiratory Toxicology 363\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJames C. Bonner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction 363\u003c\/p\u003e \u003cp\u003e18.2 Anatomy and Function of the Respiratory Tract 363\u003c\/p\u003e \u003cp\u003e18.3 Toxicant-Induced Lung Injury, Remodeling, and Repair 373\u003c\/p\u003e \u003cp\u003e18.4 Occupational and Environmental Lung Diseases 380\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 385\u003c\/p\u003e \u003cp\u003eSample Questions 385\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19. Immune System 387\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMaryJane K. Selgrade\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 387\u003c\/p\u003e \u003cp\u003e19.2 The Immune System 388\u003c\/p\u003e \u003cp\u003e19.3 Immune Suppression 391\u003c\/p\u003e \u003cp\u003e19.4 Classification of Immune-Mediated Injury (Hypersensitivity) 396\u003c\/p\u003e \u003cp\u003e19.5 Effects of Chemicals on Allergic Disease 398\u003c\/p\u003e \u003cp\u003e19.6 Other Issues: Autoimmunity and the Developing\u003c\/p\u003e \u003cp\u003eImmune System 403\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 404\u003c\/p\u003e \u003cp\u003eSample Questions 404\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VI APPLIED TOXICOLOGY 407\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20. Toxicity Testing 409\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson and Helen Cunny\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 Introduction 409\u003c\/p\u003e \u003cp\u003e20.2 Experimental Administration of Toxicants 412\u003c\/p\u003e \u003cp\u003e20.3 Chemical and Physical Properties 414\u003c\/p\u003e \u003cp\u003e20.4 Exposure and Environmental Fate 414\u003c\/p\u003e \u003cp\u003e20.5 In Vivo Tests 415\u003c\/p\u003e \u003cp\u003e20.6 In Vitro and Other Short-Term Tests 442\u003c\/p\u003e \u003cp\u003e20.7 Ecological Effects 451\u003c\/p\u003e \u003cp\u003e20.8 Risk Analysis 453\u003c\/p\u003e \u003cp\u003e20.9 The Future of Toxicity Testing 453\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 454\u003c\/p\u003e \u003cp\u003eSample Questions 455\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21. Forensic and Clinical Toxicology 457\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSharon A. Meyer and Bonita L. Blake\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21.1 Introduction 457\u003c\/p\u003e \u003cp\u003e21.2 Forensic Toxicology 457\u003c\/p\u003e \u003cp\u003e21.3 Clinical Toxicology 462\u003c\/p\u003e \u003cp\u003e21.4 Analytical Methods in Forensic and Clinical Toxicology 469\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 472\u003c\/p\u003e \u003cp\u003eSample Questions 473\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22. Prevention of Toxicity 475\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22.1 Introduction 475\u003c\/p\u003e \u003cp\u003e22.2 Legislation and Regulation 475\u003c\/p\u003e \u003cp\u003e22.3 Prevention in Different Environments 482\u003c\/p\u003e \u003cp\u003e22.4 Education 485\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 486\u003c\/p\u003e \u003cp\u003eSample Questions 487\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23. Human Health Risk Assessment 489\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRonald E. Baynes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23.1 Introduction 489\u003c\/p\u003e \u003cp\u003e23.2 Risk Assessment Methods 490\u003c\/p\u003e \u003cp\u003e23.3 Noncancer Risk Assessment 493\u003c\/p\u003e \u003cp\u003e23.4 Cancer Risk Assessment 500\u003c\/p\u003e \u003cp\u003e23.5 PBPK Modeling 503\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 504\u003c\/p\u003e \u003cp\u003eSample Questions 505\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VII ENVIRONMENTAL TOXICOLOGY 507\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24. Toxicant Analysis: Analytical Methods and Quality Assurance 509\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eChris Hofelt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24.1 Introduction 509\u003c\/p\u003e \u003cp\u003e24.2 Environmental Sample Collection Methods 510\u003c\/p\u003e \u003cp\u003e24.3 Analytical Techniques 514\u003c\/p\u003e \u003cp\u003e24.4 Quantifi cation, QA, and QC 525\u003c\/p\u003e \u003cp\u003e24.5 Summary 528\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 528\u003c\/p\u003e \u003cp\u003eSample Questions 529\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25. Basics of Environmental Toxicology 531\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc and David B. Buchwalter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25.1 Introduction 531\u003c\/p\u003e \u003cp\u003e25.2 Environmental Persistence 532\u003c\/p\u003e \u003cp\u003e25.3 Bioaccumulation 535\u003c\/p\u003e \u003cp\u003e25.4 Toxicity 539\u003c\/p\u003e \u003cp\u003e25.5 Conclusion 546\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 547\u003c\/p\u003e \u003cp\u003eSample Questions 547\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26. Transport and Fate of Toxicants in the Environment 549\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eDamian Shea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26.1 Introduction 549\u003c\/p\u003e \u003cp\u003e26.2 Sources of Toxicants to the Environment 550\u003c\/p\u003e \u003cp\u003e26.3 Transport Processes 553\u003c\/p\u003e \u003cp\u003e26.4 Equilibrium Partitioning 557\u003c\/p\u003e \u003cp\u003e26.5 Transformation Processes 560\u003c\/p\u003e \u003cp\u003e26.6 Environmental Fate Models 567\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 569\u003c\/p\u003e \u003cp\u003eSample Questions 569\u003c\/p\u003e \u003cp\u003e\u003cb\u003e27. Environmental Risk Assessment 571\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eDamian Shea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27.1 Introduction 571\u003c\/p\u003e \u003cp\u003e27.2 Formulating the Problem 573\u003c\/p\u003e \u003cp\u003e27.3 Analyzing Exposure and Effects Information 578\u003c\/p\u003e \u003cp\u003e27.4 Characterizing Risk 582\u003c\/p\u003e \u003cp\u003e27.5 Managing Risk 587\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 588\u003c\/p\u003e \u003cp\u003eSample Questions 589\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VIII NEW APPROACHES IN TOXICOLOGY 591\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e28. Perspectives on Informatics in Toxicology 593\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSeth W. Kullman, Carolyn J. Mattingly, Joel N. Meyer, and Andrew Whitehead\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28.1 Introduction 593\u003c\/p\u003e \u003cp\u003e28.2 Transcriptomics 594\u003c\/p\u003e \u003cp\u003e28.3 Annotation Resources 595\u003c\/p\u003e \u003cp\u003e28.4 Genome Sequencing, Resequencing and Genotyping 597\u003c\/p\u003e \u003cp\u003e28.5 Epigenomic Profi ling 598\u003c\/p\u003e \u003cp\u003e28.6 Computational Toxicology 599\u003c\/p\u003e \u003cp\u003e28.7 Informatics Tools in Toxicology 601\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 602\u003c\/p\u003e \u003cp\u003eSample Question 605\u003c\/p\u003e \u003cp\u003e\u003cb\u003e29. Future Considerations 607\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29.1 Introduction 607\u003c\/p\u003e \u003cp\u003e29.2 Risk Assessment 609\u003c\/p\u003e \u003cp\u003e29.3 Risk Management 613\u003c\/p\u003e \u003cp\u003e29.4 Risk Communication 613\u003c\/p\u003e \u003cp\u003e29.5 In Vivo Toxicity 614\u003c\/p\u003e \u003cp\u003e29.6 In Vitro Toxicity 614\u003c\/p\u003e \u003cp\u003e29.7 Molecular and Biochemical Toxicology 614\u003c\/p\u003e \u003cp\u003e29.8 Development of Selective Toxicants 615\u003c\/p\u003e \u003cp\u003e29.9 Summary and Conclusions 616\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 616\u003c\/p\u003e \u003cp\u003eSample Questions 617\u003c\/p\u003e \u003cp\u003eGLOSSARY 619\u003c\/p\u003e \u003cp\u003eINDEX 638\u003c\/p\u003e \"The book assumes a good knowledge of general toxicology and some knowledge of specialist areas, and would be a useful aid if studying for a higher degree where basic understanding has been.\" (British Toxicology Society, Winter 2010) \u003cb\u003eERNEST HODGSON, PhD,\u003c\/b\u003e is Distinguished Professor Emeritus of Toxicology at North Carolina State University. In addition to the previous editions of \u003ci\u003eA Textbook of Modern Toxicology,\u003c\/i\u003e he coedited \u003ci\u003eMolecular and Biochemical Toxicology, Fourth Edition\u003c\/i\u003e (Wiley) and its prior editions. Dr. Hodgson is the Editor of the \u003ci\u003eJournal of Biochemical and Molecular Toxicology.\u003c\/i\u003e  \u003cb\u003eA State-of-the-Art Toxicology Textbook Ideal for Students and Professionals\u003c\/b\u003e  \u003cp\u003eCritical Acclaim for the \u003ci\u003eThird Edition\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\"A good, easy-to-read and comprehensive reference work for all safety professionals involved in toxicology or those wishing to broaden their knowledge of the field.\"\u003cbr\u003e \u003ci\u003e—Journal of Chemical Health and Safety,\u003c\/i\u003e March-April 2005\u003c\/p\u003e \u003cp\u003e\"A useful introductory text, and the new chapters are a valuable addition to the old edition.\"\u003cbr\u003e \u003ci\u003e—Toxicology,\u003c\/i\u003e No. 27, Winter 2005\u003c\/p\u003e \u003cp\u003e\"An excellent modern textbook that benefits from the current writings of experts in all the key topics of modern toxicology.\"\u003cbr\u003e \u003ci\u003e—Veterinary and Human Toxicology,\u003c\/i\u003e 46 (4) August 2004\u003c\/p\u003e \u003cp\u003eNow in its \u003ci\u003eFourth Edition,\u003c\/i\u003e this unique resource provides both students and practitioners with a wide-ranging, accessible overview of the discipline. Designed for general toxicology courses and also suitable for those in environmental, pharmacological, medical and veterinary toxicology, this essential text offers chapters written by experts who address a range of key topics.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eA Textbook of Modern Toxicology, Fourth Edition\u003c\/i\u003e continues from prior editions with coverage of basic concepts in toxicology and expands its scope by adding chapters on molecular methods, bioinformatics and systems biology. Up-to-date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity testing, ecological risk assessment and many other areas of toxicology help distinguish this book as a leader in the field.\u003c\/p\u003e \u003cp\u003eFeaturing end-of-chapter questions and an online solutions manual for college instructors adopting the text for their classes, \u003ci\u003eA Textbook of Modern Toxicology\u003c\/i\u003e devises learning strategies that build on the fundamentals to aid readers in tackling the current and future trends associated with this developing area of study.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47988646445285,"sku":"NP9780470462065","price":107.5,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470462065.jpg?v=1761781103","url":"https:\/\/k12savings.com\/products\/a-textbook-of-modern-toxicology-isbn-9780470462065","provider":"K12savings","version":"1.0","type":"link"}