{"product_id":"wnt-signaling-in-development-and-disease-isbn-9781118444160","title":"Wnt Signaling in Development and Disease","description":"\u003ci\u003eWnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions\u003c\/i\u003e reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network. \u003cbr\u003e \u003cbr\u003e • A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field.\u003cbr\u003e \u003cbr\u003e • Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases\u003cbr\u003e \u003cbr\u003e • Reviews the complex processes of signal integration and regulation\u003cbr\u003e \u003cbr\u003e • Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.  \u003cp\u003eContributors vii\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Molecular Signaling Mechanisms: From Pathways to Networks 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Wnt Signal Production, Secretion, and Diffusion 3\u003cbr\u003e \u003ci\u003eMadelon M. Maurice and Hendrik C. Korswagen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Wnt Signaling at the Membrane 15\u003cbr\u003e \u003ci\u003eGary Davidson and Christof Niehrs\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Wnt Signal Transduction in the Cytoplasm: an Introduction to the Destruction Complex 33\u003cbr\u003e \u003ci\u003eTony W. Chen, Heather A. Wallace, Yashi Ahmed, and Ethan Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 An Overview of Gene Regulation by Wnt\/β-Catenin Signaling 51\u003cbr\u003e \u003ci\u003eChen U. Zhang and Ken M. Cadigan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Finding a Needle in a Genomic Haystack: Genome-Wide Approaches to Identify Wnt\/TCF Transcriptional Targets 73\u003cbr\u003e \u003ci\u003eChandan Bhambhani and Ken M. Cadigan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Introduction to β-Catenin-Independent Wnt Signaling Pathways 89\u003cbr\u003e \u003ci\u003eSusanne Kühl and Michael Kühl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Molecular Mechanisms of Wnt Pathway Specificity 101\u003cbr\u003e \u003ci\u003eAlexandra Schambony, Guido J.R. Zaman, and Folkert Verkaar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Modulation of Wnt Signaling by Endocytosis of Receptor Complexes 113\u003cbr\u003e \u003ci\u003eAkira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, and Akira Sato\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 New Insights from Proteomic Analysis of Wnt Signaling 125\u003cbr\u003e \u003ci\u003eMatthew P. Walker, Dennis Goldfarb, and Michael B. Major\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 New Insights about Wnt\/β-Catenin Pathway Mechanisms from Global siRNA Screens 137\u003cbr\u003e \u003ci\u003eTenzin Gocha and Ramanuj DasGupta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Mathematical Models of Wnt Signaling Pathways 153\u003cbr\u003e \u003ci\u003eMichael Kühl, Barbara Kracher, Alexander Groß, and Hans A. Kestler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 The Wnt’s Tale: On the Evolution of a Signaling Pathway 161\u003cbr\u003e \u003ci\u003eJenifer C. Croce and Thomas W. Holstein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Selected Key Molecules in Wnt Signaling 177\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 Secreted Wnt Inhibitors or Modulators 179\u003cbr\u003e \u003ci\u003ePaola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve, and Herbert Steinbeisser\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Frizzleds as G Protein-Coupled Receptors 195\u003cbr\u003e \u003ci\u003eGunnar Schulte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Dishevelled at the Crossroads of Pathways 207\u003cbr\u003e \u003ci\u003eVítìzslav Bryja and Ondøej Bernatík\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 β-Catenin: a Key Player in Both Cell Adhesion and Wnt Signaling 217\u003cbr\u003e \u003ci\u003eJonathan Pettitt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Evolutionary Diversification of Vertebrate TCF\/LEF Structure, Function, and Regulation 225\u003cbr\u003e \u003ci\u003eStefan Hoppler and Marian L. Waterman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Insights from Structural Analysis of Protein–Protein Interactions by Wnt Pathway Components and Functional Multiprotein Complex Formation 239\u003cbr\u003e \u003ci\u003eZhihong Cheng and Wenqing Xu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Wnt Signaling in Embryonic Development and Adult Tissue Homeostasis 251\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19 Wnt Signaling in Early Vertebrate Development: From Fertilization to Gastrulation 253\u003cbr\u003e \u003ci\u003eEliza Zylkiewicz, Sergei Y. Sokol, and Stefan Hoppler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Wnt\/β-Catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development 267\u003cbr\u003e \u003ci\u003eKathryn C. Davidson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Wnt Signaling in Neural Development 279\u003cbr\u003e \u003ci\u003eRichard I. Dorsky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Wnt Signaling in Heart Organogenesis 293\u003cbr\u003e \u003ci\u003eStefan Hoppler, Silvia Mazzotta, and Michael Kühl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Wnt Signaling in Kidney Organogenesis 303\u003cbr\u003e \u003ci\u003eKimmo Halt and Seppo Vainio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer 315\u003cbr\u003e \u003ci\u003eTheodora Fifis, Bang M. Tran, Renate H.M. Schwab, Timothy M. Johanson, Nadia Warner, Nick Barker, and Elizabeth Vincan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003e25 Wnt Signaling in Adult Stem Cells: Tissue Homeostasis and Regeneration 329\u003c\/i\u003e\u003cbr\u003e \u003ci\u003eFrank J.T. Staal and Riccardo Fodde\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury 339\u003cbr\u003e \u003ci\u003eGünes Özhan and Gilbert Weidinger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 4 Wnt Signaling in Chronic Disease 357\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e27 Wnt Signaling and Colorectal Cancer 359\u003cbr\u003e \u003ci\u003eKevin Myant and Owen J. Sansom\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 Wnt Signaling in Melanoma 369\u003cbr\u003e \u003ci\u003eJamie N. Anastas and Andy J. Chien\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Wnt Signaling in Mood and Psychotic Disorders 379\u003cbr\u003e \u003ci\u003eStephen J. Haggarty, Karun Singh, Roy H. Perlis, and  Rakesh Karmacharya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 Neuropsychiatric Disease-Associated Genetic Variation in the Wnt Pathway 393\u003cbr\u003e \u003ci\u003eStephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 Wnt Signaling in Dementia 411\u003cbr\u003e \u003ci\u003eStephen J. Haggarty\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e32 Therapeutic Targeting of the Wnt Signaling Network 421\u003cbr\u003e \u003ci\u003eFelicity Rudge and Trevor Dale\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 445\u003c\/p\u003e \u003cb\u003eStefan P. Hoppler\u003c\/b\u003e, PhD, is Professor in Developmental Biology at the School of Medical Sciences at the University of Aberdeen. In addition to his teaching duties Prof. Hoppler runs research programs looking at Wnt inhibitors in heart muscle differentiation and tissue-specific regulation of gene expression by Wnt\/beta-catenin signalling, and he also serves on the editorial board for the journal \u003ci\u003eDevelopmental Dynamics\u003c\/i\u003e. \u003cp\u003e\u003cb\u003eRandall T. Moon\u003c\/b\u003e, PhD, is Professor of Pharmacology at the University of Washington School of Medicine. His lab focuses on identifying the normal roles of Wnt signaling in embryos and adults and applying that knowledge to develop therapies for acute and chronic medical conditions involving Wnt signaling. Dr. Moon is Founding Director of the University of Washington Institute for Stem Cell and Regenerative Medicine, and a member of the Paul Allen Brain Institute Cell Networks Advisory Council, the HHMI Medical Research Fellows Program panel, and College of CSR Reviewers for NIH.\u003c\/p\u003e  \u003ci\u003eWnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions\u003c\/i\u003e reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network. \u003cbr\u003e \u003cbr\u003e • A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field.\u003cbr\u003e \u003cbr\u003e • Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases\u003cbr\u003e \u003cbr\u003e • Reviews the complex processes of signal integration and regulation\u003cbr\u003e \u003cbr\u003e • Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990500655333,"sku":"NP9781118444160","price":197.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118444160.jpg?v=1761788079","url":"https:\/\/k12savings.com\/es\/products\/wnt-signaling-in-development-and-disease-isbn-9781118444160","provider":"K12savings","version":"1.0","type":"link"}